dbPTM

RAB5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB5B_HUMAN
UniProt AC	P61020
Protein Name	Ras-related protein Rab-5B
Gene Name	RAB5B
Organism	Homo sapiens (Human).
Sequence Length	215
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Early endosome membrane Lipid-anchor . Melanosome . Enriched in stage I melanosomes.
Protein Description	Protein transport. Probably involved in vesicular traffic (By similarity)..
Protein Sequence	MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSRSTARP ------CCCCCCCCC	32.61	19413330
5	Phosphorylation	---MTSRSTARPNGQ ---CCCCCCCCCCCC	26.62	20071362
6	Phosphorylation	--MTSRSTARPNGQP --CCCCCCCCCCCCC	26.10	-
16	Phosphorylation	PNGQPQASKICQFKL CCCCCCHHHHCCEEE	19.80	29083192
17	Acetylation	NGQPQASKICQFKLV CCCCCHHHHCCEEEE	50.98	25953088
17	Ubiquitination	NGQPQASKICQFKLV CCCCCHHHHCCEEEE	50.98	-
22	Acetylation	ASKICQFKLVLLGES HHHHCCEEEEEECCC	16.29	129675
29	Phosphorylation	KLVLLGESAVGKSSL EEEEECCCCCCCCHH	26.84	23911959
33	Ubiquitination	LGESAVGKSSLVLRF ECCCCCCCCHHHHHH	30.21	-
35	Phosphorylation	ESAVGKSSLVLRFVK CCCCCCCHHHHHHHC	26.44	20860994
82	Phosphorylation	DTAGQERYHSLAPMY ECCCCCCCHHHCCCH	8.60	25106551
84	Phosphorylation	AGQERYHSLAPMYYR CCCCCCHHHCCCHHC	19.79	28857561
88	Sulfoxidation	RYHSLAPMYYRGAQA CCHHHCCCHHCCCCE	3.69	28183972
116	Ubiquitination	ARAKTWVKELQRQAS HHHHHHHHHHHHHCC	44.24	-
123	Phosphorylation	KELQRQASPSIVIAL HHHHHHCCCCEEEEE	15.73	25159151
125	Phosphorylation	LQRQASPSIVIALAG HHHHCCCCEEEEECC	27.30	29514088
134	Ubiquitination	VIALAGNKADLANKR EEEECCCHHHHCHHH	42.22	-
140	Ubiquitination	NKADLANKRMVEYEE CHHHHCHHHHCCHHH	35.94	-
168	Sulfoxidation	ETSAKTAMNVNDLFL ECCCCCCCCHHHHHH	7.52	21406390
184	Phosphorylation	IAKKLPKSEPQNLGG HHHHCCCCCCCCCCC	53.20	20068231
196	Phosphorylation	LGGAAGRSRGVDLHE CCCCCHHHCCCCHHH	32.25	20068231
205	Phosphorylation	GVDLHEQSQQNKSQC CCCHHHHHHHHHHHH	30.65	25159151
210	Phosphorylation	EQSQQNKSQCCSN-- HHHHHHHHHHCCC--	35.68	29083192
212	Geranylgeranylation	SQQNKSQCCSN---- HHHHHHHHCCC----	3.38	-
213	Geranylgeranylation	QQNKSQCCSN----- HHHHHHHCCC-----	3.20	-
214	Phosphorylation	QNKSQCCSN------ HHHHHHCCC------	53.88	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
6	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
84	S	Phosphorylation	Kinase	LRRK2	Q5S007	Uniprot
123	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	S	Phosphorylation		29125462
Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIN1_HUMAN	RIN1	physical	11703925
LRRK2_HUMAN	LRRK2	physical	18445495
VPS4B_HUMAN	VPS4B	physical	22939629
SUN2_HUMAN	SUN2	physical	21988832
REEP5_HUMAN	REEP5	physical	21988832
PRAF1_HUMAN	RABAC1	physical	21988832
ARF1_HUMAN	ARF1	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
CATD_HUMAN	CTSD	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
RAB2A_HUMAN	RAB2A	physical	26344197
RAB8A_HUMAN	RAB8A	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB5B_HUMAN

Related Literatures of Post-Translational Modification

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