LRRK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRK2_HUMAN
• UniProt AC: Q5S007
• Protein Name: Leucine-rich repeat serine/threonine-protein kinase 2
• Gene Name: LRRK2
• Organism: Homo sapiens (Human).
• Sequence Length: 2527
• Subcellular Localization: Membrane; Peripheral membrane protein. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane
• Protein Description: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease..
• Protein Sequence: MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASGSCQGCE -----CCCCCCCCCC	43.00	-
5	Phosphorylation	---MASGSCQGCEED ---CCCCCCCCCCCC	10.77	-
205	Phosphorylation	EFVENKDYMILLSAL HHHHCCCHHHHHHHH	6.40	26270265
210	Phosphorylation	KDYMILLSALTNFKD CCHHHHHHHHHCCCC	20.14	26270265
213	Phosphorylation	MILLSALTNFKDEEE HHHHHHHHCCCCHHH	38.02	26270265
358	Phosphorylation	EACYKALTWHRKNKH HHHHHHHHHHHCCHH	24.88	24719451
424	Phosphorylation	ASANALSTLLEQNVN HHHHHHHHHHHHCCC	35.89	22817900
489	Phosphorylation	AVVPKILTVMKRHET HHHHHHHHHHHHCCC	23.25	-
496	Phosphorylation	TVMKRHETSLPVQLE HHHHHCCCCHHHHHH	29.46	-
524	Phosphorylation	PEESREDTEFHHKLN CHHHHCCHHHHHHHH	35.48	22817900
588	Phosphorylation	SLEGAMDSVLHTLQM CHHHHHHHHHHHHHH	17.31	25332170
592	Phosphorylation	AMDSVLHTLQMYPDD HHHHHHHHHHHCCCC	17.96	25332170
633	Phosphorylation	LLAKILVSSLYRFKD HHHHHHHHHHHHCCC	15.92	-
634	Phosphorylation	LAKILVSSLYRFKDV HHHHHHHHHHHCCCH	23.18	-
636	Phosphorylation	KILVSSLYRFKDVAE HHHHHHHHHCCCHHH	18.89	22817900
661	Phosphorylation	AILKLSASFSKLLVH HHHHHCHHHHHHHHH	27.03	24719451
707	Phosphorylation	AKVAMDDYLKNVMLE HHHHHHHHHHHHHHH	18.47	-
776	Phosphorylation	QDVRKALTISIGKGD HHHHHHEEEEECCCH	19.96	22817900
784	Phosphorylation	ISIGKGDSQIISLLL EEECCCHHHHHHHHH	31.76	-
788	Phosphorylation	KGDSQIISLLLRRLA CCHHHHHHHHHHHHH	18.00	-
826	Phosphorylation	GPLFPDKTSNLRKQT CCCCCCCCCCHHHHH	30.17	22817900
833	Phosphorylation	TSNLRKQTNIASTLA CCCHHHHHCHHHHHH	31.46	22817900
837	Phosphorylation	RKQTNIASTLARMVI HHHHCHHHHHHHHHH	21.84	-
838	Phosphorylation	KQTNIASTLARMVIR HHHCHHHHHHHHHHH	18.53	22817900
850	Phosphorylation	VIRYQMKSAVEEGTA HHHHHHHHHHHHCCC	32.00	22817900
858	Phosphorylation	AVEEGTASGSDGNFS HHHHCCCCCCCCCCC	38.37	22817900
860	Phosphorylation	EEGTASGSDGNFSED HHCCCCCCCCCCCHH	39.59	22817900
865	Phosphorylation	SGSDGNFSEDVLSKF CCCCCCCCHHHHHCC	36.57	22817900
895	Phosphorylation	AQSDDLDSEGSEGSF ECCCCCCCCCCCCCE	51.67	22817900
898	Phosphorylation	DDLDSEGSEGSFLVK CCCCCCCCCCCEEEE	34.43	22817900
908	Phosphorylation	SFLVKKKSNSISVGE CEEEEECCCCCEECH	44.69	28450419
910	Phosphorylation	LVKKKSNSISVGEFY EEEECCCCCEECHHH	24.27	20058876
912	Phosphorylation	KKKSNSISVGEFYRD EECCCCCEECHHHHH	24.72	27174698
917	Phosphorylation	SISVGEFYRDAVLQR CCEECHHHHHHHHHH	11.86	27174698
926	Phosphorylation	DAVLQRCSPNLQRHS HHHHHHCCCCHHHHC	21.00	22817900
933	Phosphorylation	SPNLQRHSNSLGPIF CCCHHHHCCCCCCCC	30.24	28450419
935	Phosphorylation	NLQRHSNSLGPIFDH CHHHHCCCCCCCCCH	37.40	22617229
954	Phosphorylation	KRKRKILSSDDSLRS HHHHHHHCCCCHHHH	34.88	30108239
955	Phosphorylation	RKRKILSSDDSLRSS HHHHHHCCCCHHHHH	41.83	30108239
958	Phosphorylation	KILSSDDSLRSSKLQ HHHCCCCHHHHHHHH	30.58	30108239
962	Phosphorylation	SDDSLRSSKLQSHMR CCCHHHHHHHHHHHC	30.83	-
971	Phosphorylation	LQSHMRHSDSISSLA HHHHHCCCHHHHHHH	23.76	30108239
973	Phosphorylation	SHMRHSDSISSLASE HHHCCCHHHHHHHHH	27.64	22617229
975	Phosphorylation	MRHSDSISSLASERE HCCCHHHHHHHHHHH	24.21	30108239
976	Phosphorylation	RHSDSISSLASEREY CCCHHHHHHHHHHHH	26.70	30108239
979	Phosphorylation	DSISSLASEREYITS HHHHHHHHHHHHHHH	42.34	30108239
1007	Phosphorylation	LSQKCCISVHLEHLE HHHHHHHHHHHHHHH	6.92	23663014
1024	Phosphorylation	ELHQNALTSFPQQLC HHHHHHHHHHHHHHH	26.38	22817900
1025	Phosphorylation	LHQNALTSFPQQLCE HHHHHHHHHHHHHHH	35.46	22817900
1052	Phosphorylation	NKFTSFPSYLLKMSC CCCCCCHHHHHHHHH	26.80	24719451
1053	Phosphorylation	KFTSFPSYLLKMSCI CCCCCHHHHHHHHHH	19.11	24719451
1058	Phosphorylation	PSYLLKMSCIANLDV HHHHHHHHHHHCCCC	10.77	-
1118	Ubiquitination	QLILEGNKISGICSP HHHHCCCCCCCCCCH	49.45	-
1120	Phosphorylation	ILEGNKISGICSPLR HHCCCCCCCCCCHHH	24.58	30550624
1124	Phosphorylation	NKISGICSPLRLKEL CCCCCCCCHHHHCCC	25.67	22817900
1129	Ubiquitination	ICSPLRLKELKILNL CCCHHHHCCCHHHCC	55.34	-
1157	Phosphorylation	EACPKVESFSARMNF HHCCCCCHHHHHHHH	27.73	-
1159	Phosphorylation	CPKVESFSARMNFLA CCCCCHHHHHHHHHH	25.01	-
1176	Phosphorylation	PFLPPSMTILKLSQN CCCCCCCEEEECCCC	27.74	-
1219	Phosphorylation	PGPAHWKSLNLRELL CCCHHHHHCCHHHHH	19.80	-
1228	Phosphorylation	NLRELLFSHNQISIL CHHHHHHCCCCEEEE	22.84	-
1253	Phosphorylation	RVEKLHLSHNKLKEI HHHHHHCCCHHHCCC	17.80	22817900
1283	Phosphorylation	SYNLELRSFPNEMGK CCCEEECCCCCCCCC	58.65	22817900
1292	Phosphorylation	PNEMGKLSKIWDLPL CCCCCCCHHHCCCCC	26.11	22817900
1332	Phosphorylation	RLKKAVPYNRMKLMI HHHHCCCCCCEEEEE	14.59	22817900
1343	Phosphorylation	KLMIVGNTGSGKTTL EEEEECCCCCCHHHH	27.13	22817900
1345	Phosphorylation	MIVGNTGSGKTTLLQ EEECCCCCCHHHHHH	34.77	22817900
1348	Phosphorylation	GNTGSGKTTLLQQLM CCCCCCHHHHHHHHH	26.63	22817900
1349	Phosphorylation	NTGSGKTTLLQQLMK CCCCCHHHHHHHHHH	29.02	22817900
1357	Phosphorylation	LLQQLMKTKKSDLGM HHHHHHHHCCHHCCC	29.73	22817900
1368	Phosphorylation	DLGMQSATVGIDVKD HCCCCCCEECCCCCC	25.22	22817900
1402	Phosphorylation	FAGREEFYSTHPHFM CCCCHHHHCCCCCHH	18.88	22817900
1403	Phosphorylation	AGREEFYSTHPHFMT CCCHHHHCCCCCHHH	26.09	22817900
1404	Phosphorylation	GREEFYSTHPHFMTQ CCHHHHCCCCCHHHH	28.22	22817900
1410	Phosphorylation	STHPHFMTQRALYLA CCCCCHHHHHHHHHH	17.60	22817900
1443	Phosphorylation	FNIKARASSSPVILV HHHHHCCCCCCEEEE	26.29	22817900
1444	Phosphorylation	NIKARASSSPVILVG HHHHCCCCCCEEEEE	37.36	28202711
1445	Phosphorylation	IKARASSSPVILVGT HHHCCCCCCEEEEEE	22.23	22817900
1452	Phosphorylation	SPVILVGTHLDVSDE CCEEEEEEECCCCHH	16.28	22817900
1457	Phosphorylation	VGTHLDVSDEKQRKA EEEECCCCHHHHHHH	39.45	22817900
1467	Phosphorylation	KQRKACMSKITKELL HHHHHHHHHHHHHHH	22.31	22817900
1470	Phosphorylation	KACMSKITKELLNKR HHHHHHHHHHHHHHC	23.39	22817900
1485	Phosphorylation	GFPAIRDYHFVNATE CCCCCCCCCCCCCCC	6.31	22817900
1491	Phosphorylation	DYHFVNATEESDALA CCCCCCCCCCCHHHH	34.77	22817900
1503	Phosphorylation	ALAKLRKTIINESLN HHHHHHHHHHHHHCC	22.21	23403867
1508	Phosphorylation	RKTIINESLNFKIRD HHHHHHHHCCCCCCC	24.91	23403867
1536	Phosphorylation	ELEKIILSERKNVPI EEHHHHHHCCCCCCC	25.58	22817900
1612	Phosphorylation	KIMAQILTVKVEGCP HHHHHHHCCEECCCC	21.65	22817900
1627	Phosphorylation	KHPKGIISRRDVEKF CCCCCCCCHHHHHHH	21.24	-
1647	Phosphorylation	KFPKNYMSQYFKLLE CCCHHHHHHHHHHHH	16.03	22817900
1718	Phosphorylation	RLLEISPYMLSGRER HHHHHCHHHCCCCHH	12.14	24719451
1721	O-linked_Glycosylation	EISPYMLSGRERALR HHCHHHCCCCHHHCC	21.19	30379171
1721	Phosphorylation	EISPYMLSGRERALR HHCHHHCCCCHHHCC	21.19	24719451
1761	Phosphorylation	VLDNHPESFLKITVP HHCCCCHHHHEEECC	40.09	24719451
1833	Ubiquitination	LLDDLMKKAEEGDLL HHHHHHHHHHHCCCC	47.25	-
1849	Phosphorylation	NPDQPRLTIPISQIA CCCCCCCEEEHHHCC	26.45	22817900
1853	Phosphorylation	PRLTIPISQIAPDLI CCCEEEHHHCCCHHH	15.35	22817900
1912	Phosphorylation	VKIFNKHTSLRLLRQ HHHHCCCHHHHHHHH	30.94	22817900
1913	Phosphorylation	KIFNKHTSLRLLRQE HHHCCCHHHHHHHHH	15.94	22817900
1967	Phosphorylation	QQDKASLTRTLQHRI HHCHHHHHHHHHHHH	21.07	22817900
1969	Phosphorylation	DKASLTRTLQHRIAL CHHHHHHHHHHHHHH	26.07	22817900
2023	Phosphorylation	ADYGIAQYCCRMGIK HHHHHHHHHHHCCCC	5.63	22817900
2031	Phosphorylation	CCRMGIKTSEGTPGF HHHCCCCCCCCCCCC	30.04	22817900
2032	Phosphorylation	CRMGIKTSEGTPGFR HHCCCCCCCCCCCCC	29.09	22817900
2035	Phosphorylation	GIKTSEGTPGFRAPE CCCCCCCCCCCCCCH	19.04	22817900
2166	Phosphorylation	HHNSRNASIWLGCGH CCCCCCEEEEEECCC	20.18	-
2237	Phosphorylation	EDGKKRHTLEKMTDS CCCCEEEEHHHHHCC	40.42	-
2252	Phosphorylation	VTCLYCNSFSKQSKQ EEHHHCCCCCCCCCC	27.60	24719451
2257	Phosphorylation	CNSFSKQSKQKNFLL CCCCCCCCCCCCEEE	40.57	22817900
2297	Phosphorylation	ILNIGNVSTPLMCLS EEEECCCCCCEEEEC	28.45	22210691
2325	Phosphorylation	GCGTKIFSFSNDFTI CCCCEEEEECCCCHH	31.10	29507054
2327	Phosphorylation	GTKIFSFSNDFTIQK CCEEEEECCCCHHHH	34.00	29507054
2331	Phosphorylation	FSFSNDFTIQKLIET EEECCCCHHHHHHHH	25.92	29507054
2449	Phosphorylation	RRLIRVIYNFCNSVR HHHHHHHHHHHHHHH	10.18	-
2460	Phosphorylation	NSVRVMMTAQLGSLK HHHHHHHHHHCCCCC	7.99	-
2465	Phosphorylation	MMTAQLGSLKNVMLV HHHHHCCCCCEEEEE	44.77	24719451
2475	Phosphorylation	NVMLVLGYNRKNTEG EEEEEEECCCCCCCC	13.97	25954137
2480	Phosphorylation	LGYNRKNTEGTQKQK EECCCCCCCCCHHHH	38.54	25954137
2483	Phosphorylation	NRKNTEGTQKQKEIQ CCCCCCCCHHHHHHH	26.76	25954137
2524	Phosphorylation	LAEKMRRTSVE---- HHHHHHHHCCC----	27.10	29759185
2525	Phosphorylation	AEKMRRTSVE----- HHHHHHHCCC-----	23.57	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
5	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
424	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
524	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
776	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
826	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
833	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
838	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
910	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
910	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
935	S	Phosphorylation	Kinase	PKACA	P17612	PSP
935	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
955	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
973	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1124	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1253	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1283	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1292	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1332	Y	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1343	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1345	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1348	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1357	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1368	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1402	Y	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1403	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1404	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1410	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1443	S	Phosphorylation	Kinase	PKACA	P17612	PSP
1443	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1444	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1444	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1445	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1452	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1457	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1467	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1470	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1485	Y	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1491	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1503	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1508	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1536	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1612	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1627	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1647	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1849	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1853	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1912	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1913	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1967	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
1969	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2031	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2032	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2035	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2257	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2483	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
2524	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:19196961

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
910	S	Phosphorylation	Phosphorylation of Ser-910 and either Ser-935 or Ser-1444 facilitates interaction with YWHAG.	28720718
910	S	Phosphorylation	Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN.	28720718
935	S	Phosphorylation	Phosphorylation of Ser-910 and either Ser-935 or Ser-1444 facilitates interaction with YWHAG.	28720718
935	S	Phosphorylation	Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN.	28720718
1444	S	Phosphorylation	Phosphorylation of Ser-910 and either Ser-935 or Ser-1444 facilitates interaction with YWHAG.	28202711

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
2023	Phosphorylation	2019 (4)	G ⇒ S	rs34637584	Parkinson's disease	21738487

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKN_HUMAN	PARK2	physical	16352719
SYUA_HUMAN	SNCA	physical	19878656
CHIP_HUMAN	STUB1	physical	19196961
CHIP_HUMAN	STUB1	physical	19536328
HS90A_HUMAN	HSP90AA1	physical	19536328
TBA1C_HUMAN	TUBA1C	physical	18214993
TBB5_HUMAN	TUBB	physical	18214993
RS8_HUMAN	RPS8	physical	18214993
RL23_HUMAN	RPL23	physical	18214993
1433Z_HUMAN	YWHAZ	physical	20642453
1433T_HUMAN	YWHAQ	physical	20642453
1433E_HUMAN	YWHAE	physical	20642453
1433B_HUMAN	YWHAB	physical	20642453
1433F_HUMAN	YWHAH	physical	20642453
CDC37_HUMAN	CDC37	physical	20642453
HS90A_HUMAN	HSP90AA1	physical	20642453
HS90B_HUMAN	HSP90AB1	physical	20642453
1433G_HUMAN	YWHAG	physical	20642453
SH3G2_HUMAN	SH3GL2	physical	22998870
SH3G1_HUMAN	SH3GL1	physical	22998870
SH3G3_HUMAN	SH3GL3	physical	22998870
LRRK2_HUMAN	LRRK2	physical	17260967
MBP_HUMAN	MBP	physical	17260967
LRRK2_HUMAN	LRRK2	physical	20515039
TAOK3_HUMAN	TAOK3	physical	20949042
RIPK2_HUMAN	RIPK2	physical	20949042
KPCZ_HUMAN	PRKCZ	physical	20949042
STK3_HUMAN	STK3	physical	20949042
STK24_HUMAN	STK24	physical	20949042
STK25_HUMAN	STK25	physical	20949042
HS90A_HUMAN	HSP90AA1	physical	20949042
TRAF2_HUMAN	TRAF2	physical	20949042
AGO2_HUMAN	AGO2	physical	20671708
AGO1_HUMAN	AGO1	physical	20671708
HS90A_HUMAN	HSP90AA1	physical	17400507
HS90B_HUMAN	HSP90AB1	physical	17400507
MDN1_HUMAN	MDN1	physical	17400507
CLH1_HUMAN	CLTC	physical	17400507
VIME_HUMAN	VIM	physical	17400507
SCFD1_HUMAN	SCFD1	physical	17400507
PRKDC_HUMAN	PRKDC	physical	17400507
AKAP8_HUMAN	AKAP8	physical	17400507
AGO1_HUMAN	AGO1	physical	17400507
AGO2_HUMAN	AGO2	physical	17400507
MBP_HUMAN	MBP	physical	16269541
LRRK2_HUMAN	LRRK2	physical	16269541
CH60_HUMAN	HSPD1	physical	17584768
MBP_HUMAN	MBP	physical	17584768
LRRK2_HUMAN	LRRK2	physical	17584768
LRRK2_HUMAN	LRRK2	physical	20595391
DNM1L_HUMAN	DNM1L	physical	22228096
ARFG1_HUMAN	ARFGAP1	physical	22423108
LRRK2_HUMAN	LRRK2	physical	22423108
LRRK2_HUMAN	LRRK2	physical	22952686
MAP1B_HUMAN	MAP1B	physical	21159966
LRRK2_HUMAN	LRRK2	physical	21159966
TBA1A_HUMAN	TUBA1A	physical	21159966
CDC37_HUMAN	CDC37	physical	18367605
HS90A_HUMAN	HSP90AA1	physical	18367605
HSP7C_HUMAN	HSPA8	physical	18367605
TBA1A_HUMAN	TUBA1A	physical	22303461
TAU_HUMAN	MAPT	physical	22303461
4EBP1_HUMAN	EIF4EBP1	physical	20090955
LRRK2_HUMAN	LRRK2	physical	20090955
MP2K3_HUMAN	MAP2K3	physical	20173330
HSP83_ANOGA	HSP83_ANOGA	physical	19559761
CH60_DROME	Hsp60	physical	19559761
EF1A2_DROME	Ef1alpha100E	physical	19559761
ACT1_DROME	Act5C	physical	19559761
LRRK2_HUMAN	LRRK2	physical	19559761
LRRK2_HUMAN	LRRK2	physical	19545277
HSP83_ANOGA	HSP83_ANOGA	physical	19545277
CH60_DROME	Hsp60	physical	19545277
TBB1_DROME	betaTub56D	physical	19545277
TBB4B_MOUSE	Tubb4b	physical	19545277
PRKDC_HUMAN	PRKDC	physical	19826009
DYHC1_HUMAN	DYNC1H1	physical	19826009
HS90A_HUMAN	HSP90AA1	physical	19826009
HMMR_HUMAN	HMMR	physical	19826009
HSP74_HUMAN	HSPA4	physical	19826009
HSP7C_HUMAN	HSPA8	physical	19826009
VIME_HUMAN	VIM	physical	19826009
DNJA1_HUMAN	DNAJA1	physical	19826009
LRRK2_HUMAN	LRRK2	physical	19826009
MBP_HUMAN	MBP	physical	19826009
MBP_HUMAN	MBP	physical	17706965
ARHG7_HUMAN	ARHGEF7	physical	21048939
CDC42_HUMAN	CDC42	physical	21048939
ACTBL_HUMAN	ACTBL2	physical	20876399
ACTB_HUMAN	ACTB	physical	20876399
ACTG_HUMAN	ACTG1	physical	20876399
ACTA_HUMAN	ACTA2	physical	20876399
ACTH_HUMAN	ACTG2	physical	20876399
ARP2_HUMAN	ACTR2	physical	20876399
ARP3_HUMAN	ACTR3	physical	20876399
ARC1B_HUMAN	ARPC1B	physical	20876399
ARPC2_HUMAN	ARPC2	physical	20876399
ARPC4_HUMAN	ARPC4	physical	20876399
ARPC5_HUMAN	ARPC5	physical	20876399
CAZA1_HUMAN	CAPZA1	physical	20876399
CAZA2_HUMAN	CAPZA2	physical	20876399
CAPZB_HUMAN	CAPZB	physical	20876399
TMOD3_HUMAN	TMOD3	physical	20876399
TPM1_HUMAN	TPM1	physical	20876399
TPM3_HUMAN	TPM3	physical	20876399
TPM2_HUMAN	TPM2	physical	20876399
LIMA1_HUMAN	LIMA1	physical	20876399
DREB_HUMAN	DBN1	physical	20876399
RAI14_HUMAN	RAI14	physical	20876399
PLEC_HUMAN	PLEC	physical	20876399
MYO1B_HUMAN	MYO1B	physical	20876399
MYO1C_HUMAN	MYO1C	physical	20876399
MYO1D_HUMAN	MYO1D	physical	20876399
MYO1F_HUMAN	MYO1F	physical	20876399
ML12B_HUMAN	MYL12B	physical	20876399
MYL9_HUMAN	MYL9	physical	20876399
MYL6_HUMAN	MYL6	physical	20876399
MYPT1_HUMAN	PPP1R12A	physical	20876399
MPRIP_HUMAN	MPRIP	physical	20876399
GNAI2_HUMAN	GNAI2	physical	20876399
GNA12_HUMAN	GNA12	physical	20876399
GNA13_HUMAN	GNA13	physical	20876399
MPC2_HUMAN	MPC2	physical	20876399
ATP5L_HUMAN	ATP5L	physical	20876399
EFHD2_HUMAN	EFHD2	physical	20876399
H31_HUMAN	HIST1H3A	physical	20876399
H33_HUMAN	H3F3A	physical	20876399
LRRK2_HUMAN	LRRK2	physical	18397888
LRRK2_HUMAN	LRRK2	physical	19302196
MP2K3_HUMAN	MAP2K3	physical	19302196
MP2K6_HUMAN	MAP2K6	physical	19302196
MP2K4_HUMAN	MAP2K4	physical	19302196
MP2K7_HUMAN	MAP2K7	physical	19302196
LRRK2_HUMAN	LRRK2	physical	22612223
HS90A_HUMAN	HSP90AA1	physical	22612223
CDC37_HUMAN	CDC37	physical	22612223
1433T_HUMAN	YWHAQ	physical	22612223
LRRK2_HUMAN	LRRK2	physical	21806997
MBP_HUMAN	MBP	physical	21806997
TRADD_HUMAN	TRADD	physical	19176810
FADD_HUMAN	FADD	physical	19176810
RIPK1_HUMAN	RIPK1	physical	19176810
CASP8_HUMAN	CASP8	physical	19176810
LRRK2_HUMAN	LRRK2	physical	21858031
LRRK2_HUMAN	LRRK2	physical	18701920
4EBP1_HUMAN	EIF4EBP1	physical	18701920
RAC1_HUMAN	RAC1	physical	21454543
RHOA_HUMAN	RHOA	physical	21454543
CDC42_HUMAN	CDC42	physical	21454543
AKT1_HUMAN	AKT1	physical	21658387
HS90A_HUMAN	HSP90AA1	physical	16321986
CDC37_HUMAN	CDC37	physical	16321986
LRRK2_HUMAN	LRRK2	physical	16321986
LRRK2_HUMAN	LRRK2	physical	20041156
ARFG1_HUMAN	ARFGAP1	physical	22363216
LRRK2_HUMAN	LRRK2	physical	22363216
LRRK2_HUMAN	LRRK2	physical	19733152
LRP6_HUMAN	LRP6	physical	22899650
LRRK2_HUMAN	LRRK2	physical	19712061
LRRK1_HUMAN	LRRK1	physical	19712061
DAPK1_HUMAN	DAPK1	physical	19712061
LRRK2_HUMAN	LRRK2	physical	17447891
MOES_MOUSE	Msn	physical	17447891
DPYL2_MOUSE	Dpysl2	physical	17447891
KCRM_MOUSE	Ckm	physical	17447891
MBP_MOUSE	Mbp	physical	17447891
LRRK2_HUMAN	LRRK2	physical	18230735
RAB5B_HUMAN	RAB5B	physical	18445495
STRBP_HUMAN	STRBP	physical	19001729
BAG5_HUMAN	BAG5	physical	19001729
PTN23_HUMAN	PTPN23	physical	19001729
LMBL3_HUMAN	L3MBTL3	physical	19001729
RALYL_HUMAN	RALYL	physical	19001729
FUTSC_DROME	futsch	physical	22988863
DVL2_HUMAN	DVL2	physical	19625296
DVL3_HUMAN	DVL3	physical	19625296
DVL1_HUMAN	DVL1	physical	19625296
LRRK2_HUMAN	LRRK2	physical	17095157
MP2K6_HUMAN	MAP2K6	physical	20067578
MP2K7_HUMAN	MAP2K7	physical	20067578
MP2K3_HUMAN	MAP2K3	physical	20067578
LRRK2_HUMAN	LRRK2	physical	20067578
IQGA1_HUMAN	IQGAP1	physical	21983832
XPO2_HUMAN	CSE1L	physical	21983832
TNPO1_HUMAN	TNPO1	physical	21983832
2AAA_HUMAN	PPP2R1A	physical	21983832
PSD11_HUMAN	PSMD11	physical	21983832
NFAC2_HUMAN	NFATC2	physical	21983832
LRRK1_HUMAN	LRRK1	physical	20144646
BAX_HUMAN	BAX	physical	24991765
SYEP_HUMAN	EPRS	physical	17400507
SRPK1_HUMAN	SRPK1	physical	17400507
GRP75_HUMAN	HSPA9	physical	17400507
HSP7C_HUMAN	HSPA8	physical	17400507
ATRX_HUMAN	ATRX	physical	26496610
KITH_HUMAN	TK1	physical	26496610
CHD1L_HUMAN	CHD1L	physical	26496610
CQ053_HUMAN	C17orf53	physical	26496610
HERC2_HUMAN	HERC2	physical	26355680
NEUL4_HUMAN	NEURL4	physical	26355680
HS90A_HUMAN	HSP90AA1	physical	26355680
CDC37_HUMAN	CDC37	physical	26355680
DLL1_RAT	Dll1	physical	26355680
RAB5A_HUMAN	RAB5A	physical	26355680
RAB5B_HUMAN	RAB5B	physical	26355680
RAB7A_HUMAN	RAB7A	physical	26355680
RB11A_HUMAN	RAB11A	physical	26355680
RB11B_HUMAN	RAB11B	physical	26355680
P53_HUMAN	TP53	physical	26384650
SQSTM_HUMAN	SQSTM1	physical	27631370
WSB1_HUMAN	WSB1	physical	27273569
HIF1A_HUMAN	HIF1A	physical	26751287

Drug and Disease Associations

• Kegg Disease
• H00057: Parkinson's disease (PD)
• H00066: Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
• OMIM Disease
• 607060: Parkinson disease 8 (PARK8)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.