MPC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPC2_HUMAN
• UniProt AC: O95563
• Protein Name: Mitochondrial pyruvate carrier 2
• Gene Name: MPC2
• Organism: Homo sapiens (Human).
• Sequence Length: 127
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mediates the uptake of pyruvate into mitochondria..
• Protein Sequence: MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	2-Hydroxyisobutyrylation	TYHRLLDKVELMLPE HHHHHHHHHHHHCCH	37.26	-
19	Acetylation	TYHRLLDKVELMLPE HHHHHHHHHHHHCCH	37.26	25038526
27	Ubiquitination	VELMLPEKLRPLYNH HHHHCCHHHHHHCCC	48.10	21890473
49	Acetylation	FFWAPIMKWGLVCAG EEEHHHHHHHHHHHH	38.54	7960859
85	Phosphorylation	TGFIWSRYSLVIIPK HHCHHEEEEEEEEEC	10.80	24719451
86	Phosphorylation	GFIWSRYSLVIIPKN HCHHEEEEEEEEECC	18.30	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RLA1_HUMAN	RPLP1	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.