RALYL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RALYL_HUMAN
• UniProt AC: Q86SE5
• Protein Name: RNA-binding Raly-like protein
• Gene Name: RALYL
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Protein Sequence: MTGKTQTSNVTNKNDPKSINSRVFIGNLNTAIVKKVDIEAIFSKYGKIVGCSVHKGYAFVQYMSERHARAAVAGENARVIAGQPLDINMAGEPKPYRPKPGNKRPLSALYRLESKEPFLSVGGYVFDYDYYRDDFYNRLFDYHGRVPPPPRAVIPLKRPRVAVTTTRRGKGVFSMKGGSRSTASGSTGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAEAQKKQLEESLVLIQEECVSEIADHSTEEPAEGGPDADGEEMTDGIEEDFDEDGGHELFLQIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGKTQTSN ------CCCCCCCCC	47.59	-
5	Phosphorylation	---MTGKTQTSNVTN ---CCCCCCCCCCCC	38.12	21406692
7	Phosphorylation	-MTGKTQTSNVTNKN -CCCCCCCCCCCCCC	27.74	21406692
8	Phosphorylation	MTGKTQTSNVTNKND CCCCCCCCCCCCCCC	21.34	21406692
11	Phosphorylation	KTQTSNVTNKNDPKS CCCCCCCCCCCCCCC	44.73	21406692
17	Ubiquitination	VTNKNDPKSINSRVF CCCCCCCCCCCCEEE	67.82	-
17	Acetylation	VTNKNDPKSINSRVF CCCCCCCCCCCCEEE	67.82	26051181
18	Phosphorylation	TNKNDPKSINSRVFI CCCCCCCCCCCEEEE	32.18	23882029
23 (in isoform 2)	Phosphorylation	-	4.04	22468782
34 (in isoform 1)	Ubiquitination	-	40.75	21906983
34	Ubiquitination	NLNTAIVKKVDIEAI ECCCEEEEECCHHHH	40.75	21906983
35	Ubiquitination	LNTAIVKKVDIEAIF CCCEEEEECCHHHHH	33.96	-
43	Phosphorylation	VDIEAIFSKYGKIVG CCHHHHHHHHCCEEE	20.89	24719451
44	Acetylation	DIEAIFSKYGKIVGC CHHHHHHHHCCEEEE	47.47	-
45	Phosphorylation	IEAIFSKYGKIVGCS HHHHHHHHCCEEEEE	23.58	-
47	Sumoylation	AIFSKYGKIVGCSVH HHHHHHCCEEEEEEE	31.00	-
47 (in isoform 1)	Ubiquitination	-	31.00	21906983
47	Sumoylation	AIFSKYGKIVGCSVH HHHHHHCCEEEEEEE	31.00	-
47	Ubiquitination	AIFSKYGKIVGCSVH HHHHHHCCEEEEEEE	31.00	21906983
51	S-nitrosylation	KYGKIVGCSVHKGYA HHCCEEEEEEECCHH	2.38	19483679
51	S-nitrosocysteine	KYGKIVGCSVHKGYA HHCCEEEEEEECCHH	2.38	-
52	Phosphorylation	YGKIVGCSVHKGYAF HCCEEEEEEECCHHH	22.71	23312004
57	Phosphorylation	GCSVHKGYAFVQYMS EEEEECCHHHHHHHH	11.15	22817900
107	Phosphorylation	PGNKRPLSALYRLES CCCCCCCHHHHHHHC	20.93	24719451
114	Phosphorylation	SALYRLESKEPFLSV HHHHHHHCCCCCEEE	47.08	24719451
120	Phosphorylation	ESKEPFLSVGGYVFD HCCCCCEEECCEEEE	21.06	28270605
124	Phosphorylation	PFLSVGGYVFDYDYY CCEEECCEEEEEEEC	7.63	28270605
128	Phosphorylation	VGGYVFDYDYYRDDF ECCEEEEEEECCHHH	8.38	28270605
130	Phosphorylation	GYVFDYDYYRDDFYN CEEEEEEECCHHHHH	8.31	28270605
131	Phosphorylation	YVFDYDYYRDDFYNR EEEEEEECCHHHHHH	12.50	28270605
142	Phosphorylation	FYNRLFDYHGRVPPP HHHHHHHCCCCCCCC	9.99	28634120
166	Phosphorylation	PRVAVTTTRRGKGVF CEEEEEECCCCCEEE	14.70	-
170	Acetylation	VTTTRRGKGVFSMKG EEECCCCCEEEEECC	50.52	26210075
174	Phosphorylation	RRGKGVFSMKGGSRS CCCCEEEEECCCCCC	19.71	25219547
176	Acetylation	GKGVFSMKGGSRSTA CCEEEEECCCCCCCC	59.94	-
179	Phosphorylation	VFSMKGGSRSTASGS EEEECCCCCCCCCCC	31.55	25219547
181	Phosphorylation	SMKGGSRSTASGSTG EECCCCCCCCCCCCC	29.98	25219547
182	Phosphorylation	MKGGSRSTASGSTGS ECCCCCCCCCCCCCC	24.59	25219547
184	Phosphorylation	GGSRSTASGSTGSKL CCCCCCCCCCCCCCC	33.11	25219547
186	Phosphorylation	SRSTASGSTGSKLKS CCCCCCCCCCCCCCH	27.40	25219547
187	Phosphorylation	RSTASGSTGSKLKSD CCCCCCCCCCCCCHH	49.34	25219547
189	Phosphorylation	TASGSTGSKLKSDEL CCCCCCCCCCCHHHH	34.60	25219547
193	Phosphorylation	STGSKLKSDELQTIK CCCCCCCHHHHHHHH	46.91	-
201	Ubiquitination	DELQTIKKELTQIKT HHHHHHHHHHHHHHH	54.85	-
225	Acetylation	EKIEKQQKAEAEAQK HHHHHHHHHHHHHHH	45.78	25953088
248	Phosphorylation	LIQEECVSEIADHST HHHHHHHHHHHCCCC	34.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RALYL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RALYL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RALYL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RALYL_HUMAN	RALYL	physical	16189514
RALYL_HUMAN	RALYL	physical	19447967
RALYL_HUMAN	RALYL	physical	25416956
CCDC9_HUMAN	CCDC9	physical	26186194
SKA2_HUMAN	SKA2	physical	26186194
ELAV2_HUMAN	ELAVL2	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
SF3A1_HUMAN	SF3A1	physical	26186194
RBM22_HUMAN	RBM22	physical	26186194
TRAF7_HUMAN	TRAF7	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
PININ_HUMAN	PNN	physical	26186194
ZC3HE_HUMAN	ZC3H14	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
DGC14_HUMAN	DGCR14	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
RALY_HUMAN	RALY	physical	26186194
YTDC1_HUMAN	YTHDC1	physical	26186194
PRKRA_HUMAN	PRKRA	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
AQR_HUMAN	AQR	physical	26186194
C19L1_HUMAN	CWF19L1	physical	26186194
TRAF7_HUMAN	TRAF7	physical	28514442
SKA2_HUMAN	SKA2	physical	28514442
CCDC9_HUMAN	CCDC9	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
RALY_HUMAN	RALY	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
PININ_HUMAN	PNN	physical	28514442
PRKRA_HUMAN	PRKRA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.