dbPTM

ZC3HE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3HE_HUMAN
UniProt AC	Q6PJT7
Protein Name	Zinc finger CCCH domain-containing protein 14
Gene Name	ZC3H14
Organism	Homo sapiens (Human).
Sequence Length	736
Subcellular Localization	Nucleus speckle . Colocalizes with poly(A) RNA in nuclear speckles. Isoform 1: Nucleus speckle. Isoform 3: Nucleus speckle. Isoform 6: Cytoplasm .
Protein Description	Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides..
Protein Sequence	MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSSDTNIFDSNVPSNKSNFSRGDERRHEAAVPPLAIPSARPEKRDSRVSTSSQESKTTNVRQTYDDGAATRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADSGVHLNRLQFQQQQNSIHAAKQLDMQSSWVYETGRLCEPEVLNSLEETYSPFFRNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEKNQGTQQRQLLSRLQIDPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCFEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEIGTEIS -------CCCHHHHH	8.37	22814378
5	Phosphorylation	---MEIGTEISRKIR ---CCCHHHHHHHHH	35.49	21406692
8	Phosphorylation	MEIGTEISRKIRSAI CCCHHHHHHHHHHHH	22.68	21406692
47 (in isoform 6)	Phosphorylation	-	6.28	25849741
47 (in isoform 8)	Phosphorylation	-	6.28	25849741
50 (in isoform 4)	Ubiquitination	-	32.18	21890473
75	O-linked_Glycosylation	GVLDKLRSVTTEPSS HHHHHHHHCCCCCHH	33.96	30059200
75 (in isoform 6)	Phosphorylation	-	33.96	-
75 (in isoform 8)	Phosphorylation	-	33.96	-
78	Phosphorylation	DKLRSVTTEPSSLKS HHHHHCCCCCHHCCC	43.68	-
78	O-linked_Glycosylation	DKLRSVTTEPSSLKS HHHHHCCCCCHHCCC	43.68	30059200
84	Ubiquitination	TTEPSSLKSSDTNIF CCCCHHCCCCCCCCC	50.27	21906983
84	Ubiquitination	TTEPSSLKSSDTNIF CCCCHHCCCCCCCCC	50.27	21890473
84 (in isoform 1)	Ubiquitination	-	50.27	21890473
84 (in isoform 2)	Ubiquitination	-	50.27	21890473
84 (in isoform 3)	Ubiquitination	-	50.27	21890473
84 (in isoform 5)	Ubiquitination	-	50.27	21890473
85	Phosphorylation	TEPSSLKSSDTNIFD CCCHHCCCCCCCCCC	38.45	-
99	Sumoylation	DSNVPSNKSNFSRGD CCCCCCCCCCCCCCC	51.63	-
99	Sumoylation	DSNVPSNKSNFSRGD CCCCCCCCCCCCCCC	51.63	28112733
99	Ubiquitination	DSNVPSNKSNFSRGD CCCCCCCCCCCCCCC	51.63	-
99	Acetylation	DSNVPSNKSNFSRGD CCCCCCCCCCCCCCC	51.63	26051181
126	Ubiquitination	IPSARPEKRDSRVST CCCCCCCCCCCCCCC	65.28	-
126 (in isoform 4)	Ubiquitination	-	65.28	21890473
129	Phosphorylation	ARPEKRDSRVSTSSQ CCCCCCCCCCCCCCC	38.32	26074081
132	Phosphorylation	EKRDSRVSTSSQESK CCCCCCCCCCCCCCC	22.82	30576142
133	Phosphorylation	KRDSRVSTSSQESKT CCCCCCCCCCCCCCC	29.55	26074081
133	O-linked_Glycosylation	KRDSRVSTSSQESKT CCCCCCCCCCCCCCC	29.55	30059200
134	O-linked_Glycosylation	RDSRVSTSSQESKTT CCCCCCCCCCCCCCC	23.63	30059200
134	Phosphorylation	RDSRVSTSSQESKTT CCCCCCCCCCCCCCC	23.63	30576142
135	Phosphorylation	DSRVSTSSQESKTTN CCCCCCCCCCCCCCC	37.75	23403867
138	Phosphorylation	VSTSSQESKTTNVRQ CCCCCCCCCCCCCCH	27.89	28102081
138	Ubiquitination	VSTSSQESKTTNVRQ CCCCCCCCCCCCCCH	27.89	21890473
139	Sumoylation	STSSQESKTTNVRQT CCCCCCCCCCCCCHH	59.63	-
139	Sumoylation	STSSQESKTTNVRQT CCCCCCCCCCCCCHH	59.63	28112733
139	Ubiquitination	STSSQESKTTNVRQT CCCCCCCCCCCCCHH	59.63	-
139	Acetylation	STSSQESKTTNVRQT CCCCCCCCCCCCCHH	59.63	26051181
140	Phosphorylation	TSSQESKTTNVRQTY CCCCCCCCCCCCHHH	32.64	-
141 (in isoform 4)	Ubiquitination	-	35.14	21890473
146	Phosphorylation	KTTNVRQTYDDGAAT CCCCCCHHHCCCHHH	20.53	-
147	Phosphorylation	TTNVRQTYDDGAATR CCCCCHHHCCCHHHH	12.05	-
156	Sulfoxidation	DGAATRLMSTVKPLR CCHHHHHHHCCCCCC	2.58	21406390
157	Phosphorylation	GAATRLMSTVKPLRE CHHHHHHHCCCCCCC	34.34	-
160	Ubiquitination	TRLMSTVKPLREPAP HHHHHCCCCCCCCCC	38.12	21906983
160 (in isoform 2)	Ubiquitination	-	38.12	21890473
160	Acetylation	TRLMSTVKPLREPAP HHHHHCCCCCCCCCC	38.12	25953088
160 (in isoform 1)	Ubiquitination	-	38.12	21890473
160 (in isoform 3)	Ubiquitination	-	38.12	21890473
160 (in isoform 5)	Ubiquitination	-	38.12	21890473
164 (in isoform 6)	Ubiquitination	-	54.20	21906983
175	Sumoylation	SEDVIDIKPEPDDLI CCCCCCCCCCCCCCC	39.31	-
175	Ubiquitination	SEDVIDIKPEPDDLI CCCCCCCCCCCCCCC	39.31	21906983
175	Sumoylation	SEDVIDIKPEPDDLI CCCCCCCCCCCCCCC	39.31	28112733
175 (in isoform 2)	Ubiquitination	-	39.31	21890473
175 (in isoform 1)	Ubiquitination	-	39.31	21890473
175 (in isoform 3)	Ubiquitination	-	39.31	21890473
175 (in isoform 5)	Ubiquitination	-	39.31	21890473
195	Phosphorylation	FVQENPLSQKKPTVT CHHHCCCCCCCCEEE	41.01	25159151
197	Ubiquitination	QENPLSQKKPTVTLT HHCCCCCCCCEEEEE	58.29	-
198	Sumoylation	ENPLSQKKPTVTLTY HCCCCCCCCEEEEEE	37.98	-
198	Sumoylation	ENPLSQKKPTVTLTY HCCCCCCCCEEEEEE	37.98	28112733
200	Phosphorylation	PLSQKKPTVTLTYGS CCCCCCCEEEEEECC	34.69	-
202	O-linked_Glycosylation	SQKKPTVTLTYGSSR CCCCCEEEEEECCCC	18.83	30059200
204	Phosphorylation	KKPTVTLTYGSSRPS CCCEEEEEECCCCCC	19.23	27251275
207	Phosphorylation	TVTLTYGSSRPSIEI EEEEEECCCCCCEEE	16.86	28857561
208	Phosphorylation	VTLTYGSSRPSIEIY EEEEECCCCCCEEEE	43.79	28857561
208	Ubiquitination	VTLTYGSSRPSIEIY EEEEECCCCCCEEEE	43.79	21890473
211	Phosphorylation	TYGSSRPSIEIYRPP EECCCCCCEEEECCC	31.57	27251275
211 (in isoform 4)	Ubiquitination	-	31.57	21890473
215	Phosphorylation	SRPSIEIYRPPASRN CCCCEEEECCCCCCC	12.32	-
220	O-linked_Glycosylation	EIYRPPASRNADSGV EEECCCCCCCCCCCC	31.66	30059200
225	Phosphorylation	PASRNADSGVHLNRL CCCCCCCCCCCHHHH	40.06	30576142
226	Ubiquitination	ASRNADSGVHLNRLQ CCCCCCCCCCHHHHH	16.06	21890473
236 (in isoform 6)	Phosphorylation	-	48.38	25159151
240	Phosphorylation	QFQQQQNSIHAAKQL HHHHHHHHHHHHHHH	16.06	23401153
240	O-linked_Glycosylation	QFQQQQNSIHAAKQL HHHHHHHHHHHHHHH	16.06	30059200
245	Ubiquitination	QNSIHAAKQLDMQSS HHHHHHHHHHHCCCC	52.78	21890473
245	Ubiquitination	QNSIHAAKQLDMQSS HHHHHHHHHHHCCCC	52.78	21890473
245	Sumoylation	QNSIHAAKQLDMQSS HHHHHHHHHHHCCCC	52.78	28112733
245 (in isoform 1)	Ubiquitination	-	52.78	21890473
245 (in isoform 2)	Ubiquitination	-	52.78	21890473
245 (in isoform 3)	Ubiquitination	-	52.78	21890473
245 (in isoform 5)	Ubiquitination	-	52.78	21890473
246	Ubiquitination	NSIHAAKQLDMQSSW HHHHHHHHHHCCCCH	37.66	21890473
249 (in isoform 4)	Ubiquitination	-	5.91	21890473
251	Phosphorylation	AKQLDMQSSWVYETG HHHHHCCCCHHHHCC	21.38	20860994
252	Phosphorylation	KQLDMQSSWVYETGR HHHHCCCCHHHHCCC	12.04	28796482
255	Phosphorylation	DMQSSWVYETGRLCE HCCCCHHHHCCCCCC	11.08	28796482
257	Phosphorylation	QSSWVYETGRLCEPE CCCHHHHCCCCCCHH	15.20	28796482
261	Glutathionylation	VYETGRLCEPEVLNS HHHCCCCCCHHHHHH	8.69	22555962
268	Phosphorylation	CEPEVLNSLEETYSP CCHHHHHHHHHHCCH	32.75	23663014
270	Ubiquitination	PEVLNSLEETYSPFF HHHHHHHHHHCCHHH	48.38	21890473
272	Phosphorylation	VLNSLEETYSPFFRN HHHHHHHHCCHHHCC	21.66	26552605
273	Phosphorylation	LNSLEETYSPFFRNN HHHHHHHCCHHHCCC	20.02	26552605
273 (in isoform 4)	Ubiquitination	-	20.02	21890473
274	Phosphorylation	NSLEETYSPFFRNNS HHHHHHCCHHHCCCC	23.73	25159151
281	Phosphorylation	SPFFRNNSEKMSMED CHHHCCCCCCCCCCC	41.99	23401153
283	Sumoylation	FFRNNSEKMSMEDEN HHCCCCCCCCCCCCC	35.77	-
283	Ubiquitination	FFRNNSEKMSMEDEN HHCCCCCCCCCCCCC	35.77	21906983
283	Sumoylation	FFRNNSEKMSMEDEN HHCCCCCCCCCCCCC	35.77	28112733
283 (in isoform 2)	Ubiquitination	-	35.77	21890473
283 (in isoform 1)	Ubiquitination	-	35.77	21890473
283 (in isoform 3)	Ubiquitination	-	35.77	21890473
283 (in isoform 5)	Ubiquitination	-	35.77	21890473
284	Sulfoxidation	FRNNSEKMSMEDENF HCCCCCCCCCCCCCH	3.96	21406390
285	Phosphorylation	RNNSEKMSMEDENFR CCCCCCCCCCCCCHH	30.04	26434776
295	Ubiquitination	DENFRKRKLPVVSSV CCCHHHCCCCCEEEE	61.24	-
295	Sumoylation	DENFRKRKLPVVSSV CCCHHHCCCCCEEEE	61.24	28112733
300	Phosphorylation	KRKLPVVSSVVKVKK HCCCCCEEEEEEEEE	20.04	30576142
300	Ubiquitination	KRKLPVVSSVVKVKK HCCCCCEEEEEEEEE	20.04	21890473
301	Phosphorylation	RKLPVVSSVVKVKKF CCCCCEEEEEEEEEC	21.22	25159151
303 (in isoform 4)	Ubiquitination	-	6.79	21890473
304	Ubiquitination	PVVSSVVKVKKFNHD CCEEEEEEEEECCCC	46.29	-
304	Acetylation	PVVSSVVKVKKFNHD CCEEEEEEEEECCCC	46.29	25953088
306	Ubiquitination	VSSVVKVKKFNHDGE EEEEEEEEECCCCCC	46.02	-
307	Ubiquitination	SSVVKVKKFNHDGEE EEEEEEEECCCCCCC	55.15	21906983
307 (in isoform 1)	Ubiquitination	-	55.15	21890473
307 (in isoform 2)	Ubiquitination	-	55.15	21890473
307 (in isoform 3)	Ubiquitination	-	55.15	21890473
307 (in isoform 5)	Ubiquitination	-	55.15	21890473
320	Ubiquitination	EEEEEDDDYGSRTGS CCCCCCCCCCCCCCC	63.11	21890473
321	Phosphorylation	EEEEDDDYGSRTGSI CCCCCCCCCCCCCCC	24.80	30576142
323	Phosphorylation	EEDDDYGSRTGSISS CCCCCCCCCCCCCCC	22.05	20873877
323	Acetylation	EEDDDYGSRTGSISS CCCCCCCCCCCCCCC	22.05	19608861
323	Ubiquitination	EEDDDYGSRTGSISS CCCCCCCCCCCCCCC	22.05	19608861
323 (in isoform 4)	Ubiquitination	-	22.05	21890473
325	Phosphorylation	DDDYGSRTGSISSSV CCCCCCCCCCCCCCC	36.66	19276368
327	Phosphorylation	DYGSRTGSISSSVSV CCCCCCCCCCCCCCC	20.77	19276368
329	Phosphorylation	GSRTGSISSSVSVPA CCCCCCCCCCCCCCC	20.47	29978859
330	Phosphorylation	SRTGSISSSVSVPAK CCCCCCCCCCCCCCC	32.84	26434776
331	Phosphorylation	RTGSISSSVSVPAKP CCCCCCCCCCCCCCC	16.18	20068231
331	O-linked_Glycosylation	RTGSISSSVSVPAKP CCCCCCCCCCCCCCC	16.18	30059200
331	Ubiquitination	RTGSISSSVSVPAKP CCCCCCCCCCCCCCC	16.18	21890473
333	Phosphorylation	GSISSSVSVPAKPER CCCCCCCCCCCCCCC	25.08	23312004
334 (in isoform 4)	Ubiquitination	-	5.11	21890473
337	Ubiquitination	SSVSVPAKPERRPSL CCCCCCCCCCCCCCC	41.14	21906983
337	Acetylation	SSVSVPAKPERRPSL CCCCCCCCCCCCCCC	41.14	26051181
337 (in isoform 1)	Ubiquitination	-	41.14	21890473
337 (in isoform 2)	Ubiquitination	-	41.14	21890473
337 (in isoform 3)	Ubiquitination	-	41.14	21890473
337 (in isoform 5)	Ubiquitination	-	41.14	21890473
341	Ubiquitination	VPAKPERRPSLPPSK CCCCCCCCCCCCCCH	24.40	21890473
343	Phosphorylation	AKPERRPSLPPSKQA CCCCCCCCCCCCHHH	52.26	25159151
344 (in isoform 4)	Ubiquitination	-	8.84	21890473
347	Phosphorylation	RRPSLPPSKQANKNL CCCCCCCCHHHCHHH	35.15	29396449
348	Ubiquitination	RPSLPPSKQANKNLI CCCCCCCHHHCHHHH	60.24	-
349	Ubiquitination	PSLPPSKQANKNLIL CCCCCCHHHCHHHHH	55.28	21890473
352	Sumoylation	PPSKQANKNLILKAI CCCHHHCHHHHHHHH	57.03	-
352	Sumoylation	PPSKQANKNLILKAI CCCHHHCHHHHHHHH	57.03	-
352	Ubiquitination	PPSKQANKNLILKAI CCCHHHCHHHHHHHH	57.03	-
352	Acetylation	PPSKQANKNLILKAI CCCHHHCHHHHHHHH	57.03	26822725
357	Acetylation	ANKNLILKAISEAQE HCHHHHHHHHHHHHH	36.36	19608861
357	Sumoylation	ANKNLILKAISEAQE HCHHHHHHHHHHHHH	36.36	-
357	Ubiquitination	ANKNLILKAISEAQE HCHHHHHHHHHHHHH	36.36	19608861
357	Sumoylation	ANKNLILKAISEAQE HCHHHHHHHHHHHHH	36.36	28112733
357 (in isoform 1)	Ubiquitination	-	36.36	21890473
357 (in isoform 2)	Ubiquitination	-	36.36	21890473
357 (in isoform 3)	Ubiquitination	-	36.36	21890473
357 (in isoform 5)	Ubiquitination	-	36.36	21890473
359	Ubiquitination	KNLILKAISEAQESV HHHHHHHHHHHHHHH	3.50	21890473
360	O-linked_Glycosylation	NLILKAISEAQESVT HHHHHHHHHHHHHHH	31.57	30059200
360	Phosphorylation	NLILKAISEAQESVT HHHHHHHHHHHHHHH	31.57	28348404
365	Phosphorylation	AISEAQESVTKTTNY HHHHHHHHHHCCCCC	24.01	21815630
365	O-linked_Glycosylation	AISEAQESVTKTTNY HHHHHHHHHHCCCCC	24.01	30059200
367	Phosphorylation	SEAQESVTKTTNYST HHHHHHHHCCCCCCC	31.77	20068231
367	O-linked_Glycosylation	SEAQESVTKTTNYST HHHHHHHHCCCCCCC	31.77	30059200
368	Ubiquitination	EAQESVTKTTNYSTV HHHHHHHCCCCCCCC	51.72	21890473
368 (in isoform 2)	Ubiquitination	-	51.72	21890473
368	Ubiquitination	EAQESVTKTTNYSTV HHHHHHHCCCCCCCC	51.72	21890473
368 (in isoform 1)	Ubiquitination	-	51.72	21890473
368 (in isoform 3)	Ubiquitination	-	51.72	21890473
368 (in isoform 5)	Ubiquitination	-	51.72	21890473
369	O-linked_Glycosylation	AQESVTKTTNYSTVP HHHHHHCCCCCCCCC	15.77	31373491
369	Phosphorylation	AQESVTKTTNYSTVP HHHHHHCCCCCCCCC	15.77	-
370	O-linked_Glycosylation	QESVTKTTNYSTVPQ HHHHHCCCCCCCCCC	33.44	31373491
370	Phosphorylation	QESVTKTTNYSTVPQ HHHHHCCCCCCCCCC	33.44	-
372	Phosphorylation	SVTKTTNYSTVPQKQ HHHCCCCCCCCCCCC	12.02	28796482
373	Phosphorylation	VTKTTNYSTVPQKQT HHCCCCCCCCCCCCC	25.62	28796482
373	O-linked_Glycosylation	VTKTTNYSTVPQKQT HHCCCCCCCCCCCCC	25.62	30059200
374	Phosphorylation	TKTTNYSTVPQKQTL HCCCCCCCCCCCCCC	26.33	28796482
376	Ubiquitination	TTNYSTVPQKQTLPV CCCCCCCCCCCCCCC	35.42	21890473
378	Ubiquitination	NYSTVPQKQTLPVAP CCCCCCCCCCCCCCC	38.90	21890473
378 (in isoform 2)	Ubiquitination	-	38.90	21890473
378	Ubiquitination	NYSTVPQKQTLPVAP CCCCCCCCCCCCCCC	38.90	21890473
378	Acetylation	NYSTVPQKQTLPVAP CCCCCCCCCCCCCCC	38.90	25953088
378	Sumoylation	NYSTVPQKQTLPVAP CCCCCCCCCCCCCCC	38.90	28112733
378 (in isoform 1)	Ubiquitination	-	38.90	21890473
378 (in isoform 3)	Ubiquitination	-	38.90	21890473
378 (in isoform 5)	Ubiquitination	-	38.90	21890473
379 (in isoform 4)	Ubiquitination	-	42.92	21890473
380	Phosphorylation	STVPQKQTLPVAPRT CCCCCCCCCCCCCCC	39.81	20068231
384 (in isoform 10)	Phosphorylation	-	5.97	25159151
387	Phosphorylation	TLPVAPRTRTSQEEL CCCCCCCCCCCHHHH	36.92	25463755
387	O-linked_Glycosylation	TLPVAPRTRTSQEEL CCCCCCCCCCCHHHH	36.92	30059200
389	Phosphorylation	PVAPRTRTSQEELLA CCCCCCCCCHHHHHH	33.86	25159151
389	O-linked_Glycosylation	PVAPRTRTSQEELLA CCCCCCCCCHHHHHH	33.86	30059200
390	Phosphorylation	VAPRTRTSQEELLAE CCCCCCCCHHHHHHH	32.10	25159151
390	O-linked_Glycosylation	VAPRTRTSQEELLAE CCCCCCCCHHHHHHH	32.10	30059200
390 (in isoform 4)	Ubiquitination	-	32.10	21890473
393 (in isoform 10)	Phosphorylation	-	41.25	29978859
396 (in isoform 10)	Phosphorylation	-	21.84	29978859
400	Ubiquitination	ELLAEVVQGQSRTPR HHHHHHHCCCCCCCC	49.75	21890473
403	Phosphorylation	AEVVQGQSRTPRISP HHHHCCCCCCCCCCC	44.97	25159151
405	Phosphorylation	VVQGQSRTPRISPPI HHCCCCCCCCCCCCC	23.36	25159151
409	Phosphorylation	QSRTPRISPPIKEEE CCCCCCCCCCCCCCC	26.38	29255136
413	Sumoylation	PRISPPIKEEETKGD CCCCCCCCCCCCCCC	65.92	-
413	Ubiquitination	PRISPPIKEEETKGD CCCCCCCCCCCCCCC	65.92	21906983
413	Sumoylation	PRISPPIKEEETKGD CCCCCCCCCCCCCCC	65.92	28112733
413 (in isoform 1)	Ubiquitination	-	65.92	21890473
413 (in isoform 2)	Ubiquitination	-	65.92	21890473
413 (in isoform 3)	Ubiquitination	-	65.92	21890473
413 (in isoform 5)	Ubiquitination	-	65.92	21890473
417	Phosphorylation	PPIKEEETKGDSVEK CCCCCCCCCCCCCCC	43.54	29255136
418	Ubiquitination	PIKEEETKGDSVEKN CCCCCCCCCCCCCCC	65.09	-
421	Phosphorylation	EEETKGDSVEKNQGT CCCCCCCCCCCCHHH	40.62	29255136
421 (in isoform 3)	Phosphorylation	-	40.62	25159151
421 (in isoform 5)	Phosphorylation	-	40.62	25159151
424	Ubiquitination	TKGDSVEKNQGTQQR CCCCCCCCCHHHHHH	53.03	21906983
424 (in isoform 1)	Ubiquitination	-	53.03	21890473
424 (in isoform 2)	Ubiquitination	-	53.03	21890473
428	Phosphorylation	SVEKNQGTQQRQLLS CCCCCHHHHHHHHHH	16.27	29978859
428 (in isoform 4)	Ubiquitination	-	16.27	21890473
430 (in isoform 3)	Phosphorylation	-	34.62	29978859
433 (in isoform 3)	Phosphorylation	-	5.23	29978859
435	Phosphorylation	TQQRQLLSRLQIDPV HHHHHHHHHHCCCHH	39.27	24719451
437 (in isoform 3)	Ubiquitination	-	4.74	21890473
446	Phosphorylation	IDPVMAETLQMSQDY CCHHHHHHHHCCCCH	16.86	-
446 (in isoform 5)	Ubiquitination	-	16.86	21890473
448 (in isoform 5)	Ubiquitination	-	36.58	21890473
450	Phosphorylation	MAETLQMSQDYYDME HHHHHHCCCCHHCHH	13.62	17525332
453	Phosphorylation	TLQMSQDYYDMESMV HHHCCCCHHCHHHHH	8.17	22817900
454	Phosphorylation	LQMSQDYYDMESMVH HHCCCCHHCHHHHHC	19.66	22817900
458	Phosphorylation	QDYYDMESMVHADTR CCHHCHHHHHCCCCH	21.33	-
464 (in isoform 5)	Ubiquitination	-	29.06	21890473
470	Ubiquitination	DTRSFILKKPKLSEE CCHHHHCCCCCCCCC	63.31	-
471	Ubiquitination	TRSFILKKPKLSEEV CHHHHCCCCCCCCCE	43.89	21906983
471 (in isoform 1)	Ubiquitination	-	43.89	21890473
471 (in isoform 2)	Ubiquitination	-	43.89	21890473
473	Sumoylation	SFILKKPKLSEEVVV HHHCCCCCCCCCEEE	73.80	-
473	Ubiquitination	SFILKKPKLSEEVVV HHHCCCCCCCCCEEE	73.80	473
473	Sumoylation	SFILKKPKLSEEVVV HHHCCCCCCCCCEEE	73.80	-
473 (in isoform 2)	Ubiquitination	-	73.80	21890473
473 (in isoform 1)	Ubiquitination	-	73.80	21890473
475	Phosphorylation	ILKKPKLSEEVVVAP HCCCCCCCCCEEECC	37.53	22199227
486	Phosphorylation	VVAPNQESGMKTADS EECCCCCCCCCHHHH	34.13	28555341
487 (in isoform 5)	Ubiquitination	-	22.36	21890473
489	Methylation	PNQESGMKTADSLRV CCCCCCCCHHHHHHH	44.05	30799911
489	Sumoylation	PNQESGMKTADSLRV CCCCCCCCHHHHHHH	44.05	-
489	Ubiquitination	PNQESGMKTADSLRV CCCCCCCCHHHHHHH	44.05	21906983
489	Sumoylation	PNQESGMKTADSLRV CCCCCCCCHHHHHHH	44.05	28112733
489 (in isoform 2)	Ubiquitination	-	44.05	21890473
489 (in isoform 1)	Ubiquitination	-	44.05	21890473
490	Phosphorylation	NQESGMKTADSLRVL CCCCCCCHHHHHHHH	27.14	23186163
493	Phosphorylation	SGMKTADSLRVLSGH CCCCHHHHHHHHHHH	18.66	23186163
498	Phosphorylation	ADSLRVLSGHLMQTR HHHHHHHHHHCCCCC	22.70	20068231
504	Phosphorylation	LSGHLMQTRDLVQPD HHHHCCCCCCCCCCC	16.52	21406692
509 (in isoform 3)	Phosphorylation	-	48.01	25159151
512	Ubiquitination	RDLVQPDKPASPKFI CCCCCCCCCCCCCEE	49.52	2190698
512	Acetylation	RDLVQPDKPASPKFI CCCCCCCCCCCCCEE	49.52	26051181
512 (in isoform 1)	Ubiquitination	-	49.52	21890473
512 (in isoform 2)	Ubiquitination	-	49.52	21890473
515	Phosphorylation	VQPDKPASPKFIVTL CCCCCCCCCCEEEEE	36.83	25159151
515 (in isoform 11)	Phosphorylation	-	36.83	25159151
521	Phosphorylation	ASPKFIVTLDGVPSP CCCCEEEEECCCCCC	17.83	20068231
527	Phosphorylation	VTLDGVPSPPGYMSD EEECCCCCCCCCCCH	41.12	25159151
531	Phosphorylation	GVPSPPGYMSDQEED CCCCCCCCCCHHHCC	10.14	22617229
533	Phosphorylation	PSPPGYMSDQEEDMC CCCCCCCCHHHCCCC	27.88	22617229
550	Phosphorylation	GMKPVNQTAASNKGL CCCCCCHHHHHCCCH	20.98	20068231
553	Phosphorylation	PVNQTAASNKGLRGL CCCHHHHHCCCHHHH	36.29	30177828
555	Ubiquitination	NQTAASNKGLRGLLH CHHHHHCCCHHHHCC	57.75	-
570	Phosphorylation	PQQLHLLSRQLEDPN HHHHHHHHHHCCCCC	25.08	20068231
579	Phosphorylation	QLEDPNGSFSNAEMS HCCCCCCCCCCHHHH	31.94	25849741
581	Phosphorylation	EDPNGSFSNAEMSEL CCCCCCCCCHHHHHC	36.51	30108239
586	Phosphorylation	SFSNAEMSELSVAQK CCCCHHHHHCHHCCC	27.22	30108239
589	Phosphorylation	NAEMSELSVAQKPEK CHHHHHCHHCCCHHH	16.03	27251275
593	Ubiquitination	SELSVAQKPEKLLER HHCHHCCCHHHHHHH	45.46	-
615	Phosphorylation	KNGDECAYHHPISPC CCCCCCEECCCCCCC	16.60	29632367
620	Phosphorylation	CAYHHPISPCKAFPN CEECCCCCCCCCCCC	28.79	22167270
623	Ubiquitination	HHPISPCKAFPNCKF CCCCCCCCCCCCCCC	57.35	-
629	Ubiquitination	CKAFPNCKFAEKCLF CCCCCCCCCCCCEEE	55.00	-
633	Sumoylation	PNCKFAEKCLFVHPN CCCCCCCCEEEECCC	32.57	-
633	Sumoylation	PNCKFAEKCLFVHPN CCCCCCCCEEEECCC	32.57	-
633	Acetylation	PNCKFAEKCLFVHPN CCCCCCCCEEEECCC	32.57	26051181
646	Ubiquitination	PNCKYDAKCTKPDCP CCCCCCCCCCCCCCC	39.27	-
649	Acetylation	KYDAKCTKPDCPFTH CCCCCCCCCCCCCCC	48.61	26051181
655	Phosphorylation	TKPDCPFTHVSRRIP CCCCCCCCCCCCCCC	13.40	25690035
658	Phosphorylation	DCPFTHVSRRIPVLS CCCCCCCCCCCCCCC	14.29	25690035
660 (in isoform 9)	Phosphorylation	-	30.01	25159151
665	Phosphorylation	SRRIPVLSPKPAVAP CCCCCCCCCCCCCCC	30.98	30266825
665 (in isoform 2)	Phosphorylation	-	30.98	25159151
667	Acetylation	RIPVLSPKPAVAPPA CCCCCCCCCCCCCCC	42.08	26051181
677	Phosphorylation	VAPPAPPSSSQLCRY CCCCCCCCHHHHHHH	41.38	23927012
678	Phosphorylation	APPAPPSSSQLCRYF CCCCCCCHHHHHHHC	28.07	20873877
679	Phosphorylation	PPAPPSSSQLCRYFP CCCCCCHHHHHHHCH	31.35	20873877
690	Sumoylation	RYFPACKKMECPFYH HHCHHCCCCCCCCCC	39.55	-
690	Sumoylation	RYFPACKKMECPFYH HHCHHCCCCCCCCCC	39.55	-
728	Sumoylation	VPPRHALKWIRPQTS CCCHHHHHHHCCCCC	41.16	-
728	Sumoylation	VPPRHALKWIRPQTS CCCHHHHHHHCCCCC	41.16	-
728	Acetylation	VPPRHALKWIRPQTS CCCHHHHHHHCCCCC	41.16	25953088
734	Phosphorylation	LKWIRPQTSE----- HHHHCCCCCC-----	37.19	30108239
735	Phosphorylation	KWIRPQTSE------ HHHCCCCCC------	35.74	30108239
735	O-linked_Glycosylation	KWIRPQTSE------ HHHCCCCCC------	35.74	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC3HE_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3HE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3HE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ZN207_HUMAN	ZNF207	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3HE_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-357, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, AND MASSSPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-515 ANDSER-620, AND MASS SPECTROMETRY.	17081983 [Abstract]