PRP17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRP17_HUMAN
• UniProt AC: O60508
• Protein Name: Pre-mRNA-processing factor 17
• Gene Name: CDC40
• Organism: Homo sapiens (Human).
• Sequence Length: 579
• Subcellular Localization: Nucleus .
• Protein Description: Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing..
• Protein Sequence: MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAAIAALA ------CHHHHHHHH	26.80	20068231
11	Phosphorylation	AIAALAASYGSGSGS HHHHHHHHHCCCCCC	25.15	30108239
12	Phosphorylation	IAALAASYGSGSGSE HHHHHHHHCCCCCCC	15.58	30108239
14	Phosphorylation	ALAASYGSGSGSESD HHHHHHCCCCCCCCC	22.89	24043423
16	Phosphorylation	AASYGSGSGSESDSD HHHHCCCCCCCCCCC	40.62	24043423
18	Phosphorylation	SYGSGSGSESDSDSE HHCCCCCCCCCCCCC	35.31	24043423
20	Phosphorylation	GSGSGSESDSDSESS CCCCCCCCCCCCCCC	44.08	24043423
22	Phosphorylation	GSGSESDSDSESSRC CCCCCCCCCCCCCCC	52.92	24043423
24	Phosphorylation	GSESDSDSESSRCPL CCCCCCCCCCCCCCC	43.24	30108239
26	Phosphorylation	ESDSDSESSRCPLPA CCCCCCCCCCCCCCH	27.34	30108239
27	Phosphorylation	SDSDSESSRCPLPAA CCCCCCCCCCCCCHH	33.57	30108239
36	Phosphorylation	CPLPAADSLMHLTKS CCCCHHHHHHHHHCC	23.90	26074081
41	Phosphorylation	ADSLMHLTKSPSSKP HHHHHHHHCCCCCCC	18.13	26074081
43	Phosphorylation	SLMHLTKSPSSKPSL HHHHHHCCCCCCCCE	25.44	29255136
45	Phosphorylation	MHLTKSPSSKPSLAV HHHHCCCCCCCCEEE	59.07	29255136
46	Phosphorylation	HLTKSPSSKPSLAVA HHHCCCCCCCCEEEE	52.55	29255136
47	Acetylation	LTKSPSSKPSLAVAV HHCCCCCCCCEEEEE	42.85	26051181
49	Phosphorylation	KSPSSKPSLAVAVDS CCCCCCCCEEEEECC	32.47	30278072
56	Phosphorylation	SLAVAVDSAPEVAVK CEEEEECCCCCEEEC	38.84	25159151
81	Phosphorylation	PAVKEVQYNPTYETM HHHCEEECCCCCCCC	28.43	-
84	Phosphorylation	KEVQYNPTYETMFAP CEEECCCCCCCCCCC	30.28	28796482
85	Phosphorylation	EVQYNPTYETMFAPE EEECCCCCCCCCCCC	15.62	28796482
87	Phosphorylation	QYNPTYETMFAPEFG ECCCCCCCCCCCCCC	13.74	28796482
114	Phosphorylation	PRNMLSGYAEPAHIN CCCHHHCCCCCHHHC	12.38	27642862
131	Phosphorylation	MFEQQRRTFATYGYA HHHHHHHHHHHCCEE	21.58	28555341
134	Phosphorylation	QQRRTFATYGYALDP HHHHHHHHCCEECCC	17.18	29978859
135	Phosphorylation	QRRTFATYGYALDPS HHHHHHHCCEECCCC	12.52	29978859
137	Phosphorylation	RTFATYGYALDPSLD HHHHHCCEECCCCCC	8.12	29978859
142	Phosphorylation	YGYALDPSLDNHQVS CCEECCCCCCCCCCC	48.28	28555341
170	Phosphorylation	QGLTVFETGQKKTEK CCCEEEECCCCHHHH	33.19	28555341
175	Phosphorylation	FETGQKKTEKRKKFK EECCCCHHHHHHHHC	54.50	28555341
187	Phosphorylation	KFKENDASNIDGFLG HHCCCCCCCCCCCHH	36.86	20068231
198	Ubiquitination	GFLGPWAKYVDEKDV CCHHHHHHHCCHHHC	41.77	29967540
222	Ubiquitination	ELDEITAKRQKKGKQ HHHHHHHHHHHCCCC	46.87	32015554
226	Acetylation	ITAKRQKKGKQEEEK HHHHHHHCCCCCCCC	64.10	7910527
228	Acetylation	AKRQKKGKQEEEKPG HHHHHCCCCCCCCCC	64.51	7910537
244	Ubiquitination	EKTILHVKEMYDYQG CCEEEEEEEEECCCC	26.47	32015554
268	Phosphorylation	VGVNLRSTMPPEKCY CCCCCCCCCCHHHCC	27.54	30576142
307	S-palmitoylation	SGHLLLSCSMDCKIK CCCEEHHEECCCEEE	3.84	29575903
311	S-palmitoylation	LLSCSMDCKIKLWEV EHHEECCCEEEEEEE	3.53	29575903
314	Acetylation	CSMDCKIKLWEVYGE EECCCEEEEEEECCH	32.80	25953088
380	Ubiquitination	RKVPYCVKFNPDEDK CCCCEEEECCCCHHH	35.54	29967540
387	Ubiquitination	KFNPDEDKQNLFVAG ECCCCHHHCCEEEEE	38.75	29967540
399	Acetylation	VAGMSDKKIVQWDIR EEECCCCEEEEEECC	53.77	18585733
435	Phosphorylation	DENRRFVSTSDDKSL ECCCCEEECCCCCCE	21.34	21406692
436	Phosphorylation	ENRRFVSTSDDKSLR CCCCEEECCCCCCEE	30.76	21406692
440	Ubiquitination	FVSTSDDKSLRVWEW EEECCCCCCEEEEEE	57.28	24816145
541	Acetylation	IWDWKTTKLYSRFKA EEEECCHHHHHHHHH	51.14	25953088
544	Phosphorylation	WKTTKLYSRFKAHDK ECCHHHHHHHHHCCC	41.50	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRP17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRP17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRP17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP19_HUMAN	PRPF19	physical	22365833
CCD12_HUMAN	CCDC12	physical	26344197
CRNL1_HUMAN	CRNKL1	physical	26344197
U5S1_HUMAN	EFTUD2	physical	26344197
ISY1_HUMAN	ISY1	physical	26344197
SF3B3_HUMAN	SF3B3	physical	26344197
SNW1_HUMAN	SNW1	physical	26344197
SRPK3_HUMAN	SRPK3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-16; SER-18;SER-20; SER-22 AND SER-24, AND MASS SPECTROMETRY.
PubMed: 17081983