| UniProt ID | SRPK3_HUMAN | |
|---|---|---|
| UniProt AC | Q9UPE1 | |
| Protein Name | SRSF protein kinase 3 | |
| Gene Name | SRPK3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 567 | |
| Subcellular Localization | ||
| Protein Description | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).. | |
| Protein Sequence | MSASTGGGGDSGGSGGSSSSSQASCGPESSGSELALATPVPQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAEDSGLRLDGGSGSTSSSGCHPGGARAGPSPASSSPAPGGGRSLSAGSQTSGFSGSLFSPASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLNP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSASTGGGG ------CCCCCCCCC | 30.81 | - | |
| 4 | Phosphorylation | ----MSASTGGGGDS ----CCCCCCCCCCC | 21.93 | - | |
| 5 | Phosphorylation | ---MSASTGGGGDSG ---CCCCCCCCCCCC | 39.29 | - | |
| 50 | Phosphorylation | MLQGLLGSDDEEQED HHHHHHCCCCCCCCC | 41.69 | - | |
| 128 | Ubiquitination | VDEIKLLKCVRDSDP HHHHHHHHHHHCCCC | 40.91 | - | |
| 173 | Ubiquitination | VLGHQLLKWIIKSNY HHHHHHHHHHHHCCC | 44.96 | 22817900 | |
| 177 | Ubiquitination | QLLKWIIKSNYQGLP HHHHHHHHCCCCCCC | 24.42 | 22817900 | |
| 206 (in isoform 2) | Phosphorylation | - | 3.93 | 20068231 | |
| 209 (in isoform 2) | Phosphorylation | - | 1.42 | 20068231 | |
| 210 (in isoform 2) | Phosphorylation | - | 22.44 | 20068231 | |
| 217 (in isoform 2) | Phosphorylation | - | 38.44 | 20068231 | |
| 221 (in isoform 2) | Phosphorylation | - | 2.63 | 20068231 | |
| 246 | Phosphorylation | QAGAPPPSRSIVSTA HCCCCCCCCCCCCCC | 44.42 | 22468782 | |
| 248 (in isoform 4) | Phosphorylation | - | 31.51 | 20068231 | |
| 248 | Phosphorylation | GAPPPSRSIVSTAPQ CCCCCCCCCCCCCCH | 31.51 | 22468782 | |
| 248 (in isoform 3) | Phosphorylation | - | 31.51 | 20068231 | |
| 251 (in isoform 4) | Phosphorylation | - | 19.72 | 20068231 | |
| 251 | Phosphorylation | PPSRSIVSTAPQEVL CCCCCCCCCCCHHHH | 19.72 | 22468782 | |
| 251 (in isoform 3) | Phosphorylation | - | 19.72 | 20068231 | |
| 252 (in isoform 4) | Phosphorylation | - | 31.31 | 20068231 | |
| 252 | Phosphorylation | PSRSIVSTAPQEVLQ CCCCCCCCCCHHHHH | 31.31 | 22468782 | |
| 252 (in isoform 3) | Phosphorylation | - | 31.31 | 20068231 | |
| 259 (in isoform 4) | Phosphorylation | - | 54.07 | 20068231 | |
| 259 (in isoform 3) | Phosphorylation | - | 54.07 | 20068231 | |
| 263 (in isoform 4) | Phosphorylation | - | 10.49 | 20068231 | |
| 263 (in isoform 3) | Phosphorylation | - | 10.49 | 20068231 | |
| 279 | Ubiquitination | RRKRKQQKRLLEERL HHHHHHHHHHHHHHH | 42.38 | - | |
| 330 | Phosphorylation | GGARAGPSPASSSPA CCCCCCCCCCCCCCC | 31.98 | 26437602 | |
| 333 | Phosphorylation | RAGPSPASSSPAPGG CCCCCCCCCCCCCCC | 34.43 | 26437602 | |
| 334 | Phosphorylation | AGPSPASSSPAPGGG CCCCCCCCCCCCCCC | 42.31 | 22673903 | |
| 335 | Phosphorylation | GPSPASSSPAPGGGR CCCCCCCCCCCCCCC | 23.68 | 26437602 | |
| 343 | Phosphorylation | PAPGGGRSLSAGSQT CCCCCCCCCCCCCCC | 29.92 | 24719451 | |
| 345 | Phosphorylation | PGGGRSLSAGSQTSG CCCCCCCCCCCCCCC | 31.65 | 28348404 | |
| 348 | Phosphorylation | GRSLSAGSQTSGFSG CCCCCCCCCCCCCCC | 29.96 | 28348404 | |
| 350 | Phosphorylation | SLSAGSQTSGFSGSL CCCCCCCCCCCCCCC | 32.30 | 28348404 | |
| 351 | Phosphorylation | LSAGSQTSGFSGSLF CCCCCCCCCCCCCCC | 30.15 | 27251275 | |
| 375 | Phosphorylation | GSSNQRETGGLLSPS CCCCCCCCCCCCCCC | 38.44 | 22673903 | |
| 380 | Phosphorylation | RETGGLLSPSTPFGA CCCCCCCCCCCCCCC | 23.11 | 22673903 | |
| 382 | Phosphorylation | TGGLLSPSTPFGASN CCCCCCCCCCCCCCC | 45.39 | 22673903 | |
| 383 | Phosphorylation | GGLLSPSTPFGASNL CCCCCCCCCCCCCCC | 26.48 | 24719451 | |
| 388 | Phosphorylation | PSTPFGASNLLVNPL CCCCCCCCCCCCCCC | 28.52 | 22673903 | |
| 418 | Acetylation | GNACWVHKHFTEDIQ HCCEEEEHHHCCCHH | 30.69 | - | |
| 418 | Ubiquitination | GNACWVHKHFTEDIQ HCCEEEEHHHCCCHH | 30.69 | - | |
| 421 | Phosphorylation | CWVHKHFTEDIQTRQ EEEEHHHCCCHHHCH | 32.25 | 23403867 | |
| 426 | Phosphorylation | HFTEDIQTRQYRAVE HHCCCHHHCHHEEEE | 21.77 | 29255136 | |
| 427 | Methylation | FTEDIQTRQYRAVEV HCCCHHHCHHEEEEH | 18.37 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRPK3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRPK3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRPK3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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