dbPTM

NH2L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NH2L1_HUMAN
UniProt AC	P55769
Protein Name	NHP2-like protein 1
Gene Name	SNU13 {ECO:0000312\|HGNC:HGNC:7819}
Organism	Homo sapiens (Human).
Sequence Length	128
Subcellular Localization	Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus.
Protein Description	Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 28781166 Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly]
Protein Sequence	MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTEADVNP -------CCCCCCCC	7.44	19413330
2	Acetylation	------MTEADVNPK ------CCCCCCCCC	39.62	25944712
9	Ubiquitination	TEADVNPKAYPLADA CCCCCCCCHHCHHHH	56.18	-
9	2-Hydroxyisobutyrylation	TEADVNPKAYPLADA CCCCCCCCHHCHHHH	56.18	-
11	Nitration	ADVNPKAYPLADAHL CCCCCCHHCHHHHHH	12.61	-
11	Phosphorylation	ADVNPKAYPLADAHL CCCCCCHHCHHHHHH	12.61	28152594
20	Ubiquitination	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	-
20	Malonylation	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	26320211
20	2-Hydroxyisobutyrylation	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	-
20	Acetylation	LADAHLTKKLLDLVQ HHHHHHHHHHHHHHH	48.02	25953088
21	Malonylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	26320211
21	Acetylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	23954790
21	Sumoylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	-
21	Ubiquitination	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	-
21	Sumoylation	ADAHLTKKLLDLVQQ HHHHHHHHHHHHHHH	49.39	-
29	Phosphorylation	LLDLVQQSCNYKQLR HHHHHHHHCCHHHHH	6.29	20068231
30	S-nitrosylation	LDLVQQSCNYKQLRK HHHHHHHCCHHHHHH	5.84	19483679
30	Glutathionylation	LDLVQQSCNYKQLRK HHHHHHHCCHHHHHH	5.84	22555962
30	S-nitrosocysteine	LDLVQQSCNYKQLRK HHHHHHHCCHHHHHH	5.84	-
32	Phosphorylation	LVQQSCNYKQLRKGA HHHHHCCHHHHHHHH	12.39	20090780
33	Methylation	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	23583077
33	2-Hydroxyisobutyrylation	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	-
33	Ubiquitination	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	21890473
33	Acetylation	VQQSCNYKQLRKGAN HHHHCCHHHHHHHHH	28.94	25953088
37	Ubiquitination	CNYKQLRKGANEATK CCHHHHHHHHHHHHH	71.60	-
44	2-Hydroxyisobutyrylation	KGANEATKTLNRGIS HHHHHHHHHHHHHHH	59.05	-
44	Ubiquitination	KGANEATKTLNRGIS HHHHHHHHHHHHHHH	59.05	21890473
44	Acetylation	KGANEATKTLNRGIS HHHHHHHHHHHHHHH	59.05	25953088
51	Phosphorylation	KTLNRGISEFIVMAA HHHHHHHHHEEEEEC	29.31	22210691
86	2-Hydroxyisobutyrylation	PYVFVRSKQALGRAC CEEEEECHHHHHHHC	29.09	-
96	Phosphorylation	LGRACGVSRPVIACS HHHHCCCCCCEEEEE	19.02	20068231
102	Glutathionylation	VSRPVIACSVTIKEG CCCCEEEEEEEECCC	2.00	22555962
103	Phosphorylation	SRPVIACSVTIKEGS CCCEEEEEEEECCCH	17.17	20068231
105	Phosphorylation	PVIACSVTIKEGSQL CEEEEEEEECCCHHH	15.27	20068231
107	Ubiquitination	IACSVTIKEGSQLKQ EEEEEEECCCHHHHH	46.81	-
107	Acetylation	IACSVTIKEGSQLKQ EEEEEEECCCHHHHH	46.81	25953088
113	Acetylation	IKEGSQLKQQIQSIQ ECCCHHHHHHHHHHH	32.30	25953088
113	Ubiquitination	IKEGSQLKQQIQSIQ ECCCHHHHHHHHHHH	32.30	2190698
118	Phosphorylation	QLKQQIQSIQQSIER HHHHHHHHHHHHHHH	24.80	30266825
122	Phosphorylation	QIQSIQQSIERLLV- HHHHHHHHHHHHCC-	15.27	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NH2L1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NH2L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NH2L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBM10_HUMAN	RBM10	physical	16169070
XRCC6_HUMAN	XRCC6	physical	16169070
TF3C1_HUMAN	GTF3C1	physical	16169070
DPOA2_HUMAN	POLA2	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
CDN2C_HUMAN	CDKN2C	physical	16169070
NH2L1_HUMAN	NHP2L1	physical	16723661
PPIH_HUMAN	PPIH	physical	16723661
PRPF3_HUMAN	PRPF3	physical	16723661
PRP4_HUMAN	PRPF4	physical	16723661
PRP31_HUMAN	PRPF31	physical	16723661
SRSF5_HUMAN	SRSF5	physical	22939629
NOP56_HUMAN	NOP56	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
RNPS1_HUMAN	RNPS1	physical	22939629
PRP6_HUMAN	PRPF6	physical	22939629
SF3B4_HUMAN	SF3B4	physical	22939629
SRS11_HUMAN	SRSF11	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
NOP58_HUMAN	NOP58	physical	22939629
RL1D1_HUMAN	RSL1D1	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RL18A_HUMAN	RPL18A	physical	22939629
RL18_HUMAN	RPL18	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
PR40A_HUMAN	PRPF40A	physical	22939629
NOLC1_HUMAN	NOLC1	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RL15_HUMAN	RPL15	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
TRA2B_HUMAN	TRA2B	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RBM39_HUMAN	RBM39	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
SPF27_HUMAN	BCAS2	physical	22939629
SRP14_HUMAN	SRP14	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
SAP18_HUMAN	SAP18	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RRP7A_HUMAN	RRP7A	physical	22939629
SRS10_HUMAN	SRSF10	physical	22939629
SURF4_HUMAN	SURF4	physical	22939629
TRA2A_HUMAN	TRA2A	physical	22939629
ZCH18_HUMAN	ZC3H18	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
PCNA_HUMAN	PCNA	physical	22939629
SON_HUMAN	SON	physical	22939629
TRI55_HUMAN	TRIM55	physical	22939629
WDR18_HUMAN	WDR18	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
SSRG_HUMAN	SSR3	physical	22939629
PCDA2_HUMAN	PCDHA2	physical	22939629
TPR_HUMAN	TPR	physical	22939629
ZN326_HUMAN	ZNF326	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
STAG2_HUMAN	STAG2	physical	22939629
TYY1_HUMAN	YY1	physical	22939629
CAVN1_HUMAN	PTRF	physical	22939629
TPBG_HUMAN	TPBG	physical	22939629
RFXAP_HUMAN	RFXAP	physical	22939629
NOP16_HUMAN	NOP16	physical	22939629
SNW1_HUMAN	SNW1	physical	22365833
WASC5_HUMAN	KIAA0196	physical	22863883
PRP4_HUMAN	PRPF4	physical	22863883
ROCK2_HUMAN	ROCK2	physical	22863883
ZW10_HUMAN	ZW10	physical	22863883
NUFP1_HUMAN	NUFIP1	physical	24234454
CLVS2_HUMAN	CLVS2	physical	26344197
COR1A_HUMAN	CORO1A	physical	26344197
COR1B_HUMAN	CORO1B	physical	26344197
COR1C_HUMAN	CORO1C	physical	26344197
CUL4B_HUMAN	CUL4B	physical	26344197
DDB1_HUMAN	DDB1	physical	26344197
DDX56_HUMAN	DDX56	physical	26344197
DKC1_HUMAN	DKC1	physical	26344197
DPH2_HUMAN	DPH2	physical	26344197
EIF2A_HUMAN	EIF2A	physical	26344197
EMAL2_HUMAN	EML2	physical	26344197
FBRL_HUMAN	FBL	physical	26344197
GCC2_HUMAN	GCC2	physical	26344197
GCSP_HUMAN	GLDC	physical	26344197
GTPB1_HUMAN	GTPBP1	physical	26344197
HNRPK_HUMAN	HNRNPK	physical	26344197
IMDH2_HUMAN	IMPDH2	physical	26344197
KDM4B_HUMAN	KDM4B	physical	26344197
ECM29_HUMAN	KIAA0368	physical	26344197
MET16_HUMAN	METTL16	physical	26344197
NAA50_HUMAN	NAA50	physical	26344197
NOLC1_HUMAN	NOLC1	physical	26344197
NOP56_HUMAN	NOP56	physical	26344197
NOP58_HUMAN	NOP58	physical	26344197
PRP4_HUMAN	PRPF4	physical	26344197
RPAP1_HUMAN	RPAP1	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
SNUT1_HUMAN	SART1	physical	26344197
TBL1R_HUMAN	TBL1XR1	physical	26344197
NUFP1_HUMAN	NUFIP1	physical	27594683
RSA1_YEAST	RSA1	physical	27594683
NUFP1_HUMAN	NUFIP1	physical	25404746
ZNHI3_HUMAN	ZNHIT3	physical	25404746
RUVB1_HUMAN	RUVBL1	physical	25404746

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NH2L1_HUMAN

Related Literatures of Post-Translational Modification