CLVS2_HUMAN - dbPTM
CLVS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLVS2_HUMAN
UniProt AC Q5SYC1
Protein Name Clavesin-2
Gene Name CLVS2
Organism Homo sapiens (Human).
Sequence Length 327
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Early endosome membrane
Peripheral membrane protein .
Protein Description Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)..
Protein Sequence MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEYNVDSYSMPVKEVEKELSPKSMKRSQSVVDPTVLKRMDKNEEENMQPLLSLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15UbiquitinationLSPETLEKARLELNE
CCHHHHHHHHHHHCC		41.7530230243
131PhosphorylationANWDQSRYTLVDILR
CCCCCHHHHHHHHHH		15.07-
173PhosphorylationNFTFKQASKLTPSML
CCCCHHHHCCCHHHH		26.2122210691
176PhosphorylationFKQASKLTPSMLRLA
CHHHHCCCHHHHHHH		19.6322210691
211PhosphorylationPWYIHALYTVIRPFL
CCHHHHHHHHHHHHH		10.3522210691
212PhosphorylationWYIHALYTVIRPFLK
CHHHHHHHHHHHHHC		15.4222210691
264PhosphorylationDMGTWARTLLDHEYD
CCCHHHHHHHCCCCC		24.7527732954
270PhosphorylationRTLLDHEYDDDSEYN
HHHHCCCCCCCCCCC		22.6627732954
274PhosphorylationDHEYDDDSEYNVDSY
CCCCCCCCCCCCCCC		49.3127732954
276PhosphorylationEYDDDSEYNVDSYSM
CCCCCCCCCCCCCCC		25.1627732954
280PhosphorylationDSEYNVDSYSMPVKE
CCCCCCCCCCCCHHH		18.1527732954
281PhosphorylationSEYNVDSYSMPVKEV
CCCCCCCCCCCHHHH		12.4327732954
282PhosphorylationEYNVDSYSMPVKEVE
CCCCCCCCCCHHHHH		22.1427732954
293PhosphorylationKEVEKELSPKSMKRS
HHHHHHCCHHHHCCC		31.2326852163
300PhosphorylationSPKSMKRSQSVVDPT
CHHHHCCCCCCCCHH		22.6827732954
302PhosphorylationKSMKRSQSVVDPTVL
HHHCCCCCCCCHHHH		25.9227732954
307PhosphorylationSQSVVDPTVLKRMDK
CCCCCCHHHHHHCCC		33.7229083192
325PhosphorylationENMQPLLSLD-----
HHCCCCCCCC-----		37.87-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLVS2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLVS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLVS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLVS2_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLVS2_HUMAN

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Related Literatures of Post-Translational Modification

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