RFXAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFXAP_HUMAN
• UniProt AC: O00287
• Protein Name: Regulatory factor X-associated protein
• Gene Name: RFXAP
• Organism: Homo sapiens (Human).
• Sequence Length: 272
• Subcellular Localization: Nucleus.
• Protein Description: Part of the RFX complex that binds to the X-box of MHC II promoters..
• Protein Sequence: MEAQGVAEGAGPGAASGVPHPAALAPAAAPTLAPASVAAAASQFTLLVMQPCAGQDEAAAPGGSVGAGKPVRYLCEGAGDGEEEAGEDEADLLDTSDPPGGGESAASLEDLEDEETHSGGEGSSGGARRRGSGGGSMSKTCTYEGCSETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALNCGGTASTGSAGNVKLEESADNILSIVKQRTGSFGDRPARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFPGTSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	DEADLLDTSDPPGGG CHHHCCCCCCCCCCC	34.69	27251275
96	Phosphorylation	EADLLDTSDPPGGGE HHHCCCCCCCCCCCC	48.03	27251275
104	Phosphorylation	DPPGGGESAASLEDL CCCCCCCCCCCHHHH	32.20	28348404
107	Phosphorylation	GGGESAASLEDLEDE CCCCCCCCHHHHCCC	31.82	28348404
116	Phosphorylation	EDLEDEETHSGGEGS HHHCCCCCCCCCCCC	21.21	28348404
118	Phosphorylation	LEDEETHSGGEGSSG HCCCCCCCCCCCCCC	56.78	22817901
124	Phosphorylation	HSGGEGSSGGARRRG CCCCCCCCCCCCCCC	52.70	22210691
132	Phosphorylation	GGARRRGSGGGSMSK CCCCCCCCCCCCCCC	32.24	28985074
138	Phosphorylation	GSGGGSMSKTCTYEG CCCCCCCCCCCCCCC	26.89	-
143	Phosphorylation	SMSKTCTYEGCSETT CCCCCCCCCCCCCCH	16.69	-
170	Phosphorylation	KKHRNKMYKDKYKKK HHHHHHHCHHHHCCC	20.04	26657352
174	Phosphorylation	NKMYKDKYKKKKSDQ HHHCHHHHCCCCCCC	37.87	26657352
179	Phosphorylation	DKYKKKKSDQALNCG HHHCCCCCCCCCCCC	43.78	28985074
188	Phosphorylation	QALNCGGTASTGSAG CCCCCCCCCCCCCCC	11.61	17929957
190	Phosphorylation	LNCGGTASTGSAGNV CCCCCCCCCCCCCCE	32.89	25627689
193	Phosphorylation	GGTASTGSAGNVKLE CCCCCCCCCCCEEHH	32.84	25627689
198	Sumoylation	TGSAGNVKLEESADN CCCCCCEEHHHCHHH	54.93	28112733
202	Phosphorylation	GNVKLEESADNILSI CCEEHHHCHHHHHHH	31.39	21815630
211	Ubiquitination	DNILSIVKQRTGSFG HHHHHHHHHHHCCCC	32.18	29967540
214	Phosphorylation	LSIVKQRTGSFGDRP HHHHHHHHCCCCCCC	34.38	27690223
216	Phosphorylation	IVKQRTGSFGDRPAR HHHHHHCCCCCCCCC	25.99	27251275
225	Phosphorylation	GDRPARPTLLEQVLN CCCCCCHHHHHHHHC	38.12	27251275
237	Phosphorylation	VLNQKRLSLLRSPEV HHCHHHHHHHCCHHH	29.41	25159151
241	Phosphorylation	KRLSLLRSPEVVQFL HHHHHHCCHHHHHHH	25.94	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFXAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFXAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFXAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX5_HUMAN	RFX5	physical	9118943
HDAC4_HUMAN	HDAC4	physical	15964851

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 209920: Bare lymphocyte syndrome 2 (BLS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.