RFX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX5_HUMAN
• UniProt AC: P48382
• Protein Name: DNA-binding protein RFX5
• Gene Name: RFX5
• Organism: Homo sapiens (Human).
• Sequence Length: 616
• Subcellular Localization: Nucleus.
• Protein Description: Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters..
• Protein Sequence: MAEDEPDAKSPKTGGRAPPGGAEAGEPTTLLQRLRGTISKAVQNKVEGILQDVQKFSDNDKLYLYLQLPSGPTTGDKSSEPSTLSNEEYMYAYRWIRNHLEEHTDTCLPKQSVYDAYRKYCESLACCRPLSTANFGKIIREIFPDIKARRLGGRGQSKYCYSGIRRKTLVSMPPLPGLDLKGSESPEMGPEVTPAPRDELVEAACALTCDWAERILKRSFSSIVEVARFLLQQHLISARSAHAHVLKAMGLAEEDEHAPRERSSKPKNGLENPEGGAHKKPERLAQPPKDLEARTGAGPLARGERKKSVVESSAPGANNLQVNALVARLPLLLPRAPRSLIPPIPVSPPILAPRLSSGALKVATLPLSSRAGAPPAAVPIINMILPTVPALPGPGPGPGRAPPGGLTQPRGTENREVGIGGDQGPHDKGVKRTAEVPVSEASGQAPPAKAAKQDIEDTASDAKRKRGRPRKKSGGSGERNSTPLKSAAAMESAQSSRLPWETWGSGGEGNSAGGAERPGPMGEAEKGAVLAQGQGDGTVSKGGRGPGSQHTKEAEDKIPLVPSKVSVIKGSRSQKEAFPLAKGEVDTAPQGNKDLKEHVLQSSLSQEHKDPKATPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEDEPDAK ------CCCCCCCCC	32.71	22814378
10	Phosphorylation	EDEPDAKSPKTGGRA CCCCCCCCCCCCCCC	33.09	23401153
12	Ubiquitination	EPDAKSPKTGGRAPP CCCCCCCCCCCCCCC	67.88	24816145
13	Phosphorylation	PDAKSPKTGGRAPPG CCCCCCCCCCCCCCC	48.53	26074081
28	Phosphorylation	GAEAGEPTTLLQRLR CCCCCCCCHHHHHHH	26.27	20068231
29	Phosphorylation	AEAGEPTTLLQRLRG CCCCCCCHHHHHHHH	35.87	20068231
37	Phosphorylation	LLQRLRGTISKAVQN HHHHHHHHHHHHHHH	18.68	-
39	Phosphorylation	QRLRGTISKAVQNKV HHHHHHHHHHHHHHH	17.88	-
40	Ubiquitination	RLRGTISKAVQNKVE HHHHHHHHHHHHHHH	49.04	29967540
55	Ubiquitination	GILQDVQKFSDNDKL HHHHHHHHCCCCCEE	46.84	29967540
63	Phosphorylation	FSDNDKLYLYLQLPS CCCCCEEEEEEECCC	10.07	-
78	Phosphorylation	GPTTGDKSSEPSTLS CCCCCCCCCCCCCCC	44.68	23663014
79	Phosphorylation	PTTGDKSSEPSTLSN CCCCCCCCCCCCCCH	60.30	23663014
82	Phosphorylation	GDKSSEPSTLSNEEY CCCCCCCCCCCHHHH	37.62	23663014
83	Phosphorylation	DKSSEPSTLSNEEYM CCCCCCCCCCHHHHH	44.94	23663014
85	Phosphorylation	SSEPSTLSNEEYMYA CCCCCCCCHHHHHHH	42.14	23663014
89	Phosphorylation	STLSNEEYMYAYRWI CCCCHHHHHHHHHHH	6.83	23663014
91	Phosphorylation	LSNEEYMYAYRWIRN CCHHHHHHHHHHHHH	10.28	23663014
93	Phosphorylation	NEEYMYAYRWIRNHL HHHHHHHHHHHHHHH	6.76	23663014
94	Ubiquitination	EEYMYAYRWIRNHLE HHHHHHHHHHHHHHH	17.74	24816145
120	Phosphorylation	VYDAYRKYCESLACC HHHHHHHHHHHHCCC	7.76	-
123	Phosphorylation	AYRKYCESLACCRPL HHHHHHHHHCCCCCC	20.08	-
158	Acetylation	LGGRGQSKYCYSGIR CCCCCCCCCCCCCCC	31.30	26051181
159	Phosphorylation	GGRGQSKYCYSGIRR CCCCCCCCCCCCCCC	11.23	20068231
161	Phosphorylation	RGQSKYCYSGIRRKT CCCCCCCCCCCCCCE	13.57	20068231
162	Phosphorylation	GQSKYCYSGIRRKTL CCCCCCCCCCCCCEE	24.96	20068231
168	Phosphorylation	YSGIRRKTLVSMPPL CCCCCCCEEECCCCC	30.49	15253423
183	Phosphorylation	PGLDLKGSESPEMGP CCCCCCCCCCCCCCC	33.06	23401153
185	Phosphorylation	LDLKGSESPEMGPEV CCCCCCCCCCCCCCC	28.05	29255136
188	Sulfoxidation	KGSESPEMGPEVTPA CCCCCCCCCCCCCCC	14.24	21406390
193	Phosphorylation	PEMGPEVTPAPRDEL CCCCCCCCCCCHHHH	16.45	22167270
219	Phosphorylation	AERILKRSFSSIVEV HHHHHHHHHHHHHHH	28.08	20068231
221	Phosphorylation	RILKRSFSSIVEVAR HHHHHHHHHHHHHHH	22.02	20068231
222	Phosphorylation	ILKRSFSSIVEVARF HHHHHHHHHHHHHHH	28.74	20068231
249	Sulfoxidation	HAHVLKAMGLAEEDE HHHHHHHCCCCCCCC	4.28	21406390
260	Ubiquitination	EEDEHAPRERSSKPK CCCCCCCCHHCCCCC	53.39	24816145
265	Ubiquitination	APRERSSKPKNGLEN CCCHHCCCCCCCCCC	62.35	24816145
302	Methylation	TGAGPLARGERKKSV CCCCCCCCCCHHCCH	56.01	82954609
306	Acetylation	PLARGERKKSVVESS CCCCCCHHCCHHHHC	45.13	30591873
308	Phosphorylation	ARGERKKSVVESSAP CCCCHHCCHHHHCCC	34.14	15253423
312	Phosphorylation	RKKSVVESSAPGANN HHCCHHHHCCCCCCH	21.86	28450419
313	Phosphorylation	KKSVVESSAPGANNL HCCHHHHCCCCCCHH	25.61	28464451
321	Ubiquitination	APGANNLQVNALVAR CCCCCHHHHHHHHHH	28.66	-
321	Methylation	APGANNLQVNALVAR CCCCCHHHHHHHHHH	28.66	-
328	Dimethylation	QVNALVARLPLLLPR HHHHHHHHHCHHCCC	29.38	-
328	Methylation	QVNALVARLPLLLPR HHHHHHHHHCHHCCC	29.38	30763039
338	Methylation	LLLPRAPRSLIPPIP HHCCCCCHHCCCCCC	43.01	30763045
338	Dimethylation	LLLPRAPRSLIPPIP HHCCCCCHHCCCCCC	43.01	-
339	Phosphorylation	LLPRAPRSLIPPIPV HCCCCCHHCCCCCCC	29.59	22199227
347	Phosphorylation	LIPPIPVSPPILAPR CCCCCCCCCCCCCCC	21.43	21082442
354	Methylation	SPPILAPRLSSGALK CCCCCCCCCCCCCEE	41.41	54558737
354	Dimethylation	SPPILAPRLSSGALK CCCCCCCCCCCCCEE	41.41	-
356	Phosphorylation	PILAPRLSSGALKVA CCCCCCCCCCCEEEE	28.18	22199227
357	Phosphorylation	ILAPRLSSGALKVAT CCCCCCCCCCEEEEE	32.45	22199227
361	Ubiquitination	RLSSGALKVATLPLS CCCCCCEEEEEECCH	29.32	-
361	Methylation	RLSSGALKVATLPLS CCCCCCEEEEEECCH	29.32	23748837
369	Phosphorylation	VATLPLSSRAGAPPA EEEECCHHCCCCCCC	33.56	-
370	Methylation	ATLPLSSRAGAPPAA EEECCHHCCCCCCCH	33.39	54558741
387	Phosphorylation	IINMILPTVPALPGP HHHCCCCCCCCCCCC	35.36	-
428	Acetylation	GDQGPHDKGVKRTAE CCCCCCCCCCCCEEE	63.67	25953088
431	Ubiquitination	GPHDKGVKRTAEVPV CCCCCCCCCEEECCH	53.34	24816145
433	O-linked_Glycosylation	HDKGVKRTAEVPVSE CCCCCCCEEECCHHH	22.81	30059200
439	O-linked_Glycosylation	RTAEVPVSEASGQAP CEEECCHHHHCCCCC	22.75	30059200
442	O-linked_Glycosylation	EVPVSEASGQAPPAK ECCHHHHCCCCCCHH	27.64	30059200
460	Phosphorylation	QDIEDTASDAKRKRG CCHHHHHHHHHHHCC	39.95	25159151
473	Phosphorylation	RGRPRKKSGGSGERN CCCCCCCCCCCCCCC	51.96	25849741
476	Phosphorylation	PRKKSGGSGERNSTP CCCCCCCCCCCCCCC	40.79	28102081
481	Phosphorylation	GGSGERNSTPLKSAA CCCCCCCCCCHHHHH	37.31	24719451
482	Phosphorylation	GSGERNSTPLKSAAA CCCCCCCCCHHHHHH	35.87	29214152
492	Phosphorylation	KSAAAMESAQSSRLP HHHHHHHHHHHCCCC	20.65	-
505	Phosphorylation	LPWETWGSGGEGNSA CCCCCCCCCCCCCCC	34.88	25159151
511	Phosphorylation	GSGGEGNSAGGAERP CCCCCCCCCCCCCCC	38.86	26714015
538	Phosphorylation	AQGQGDGTVSKGGRG EECCCCCCCCCCCCC	26.75	22817900
540	Phosphorylation	GQGDGTVSKGGRGPG CCCCCCCCCCCCCCC	25.97	22817900
541	Acetylation	QGDGTVSKGGRGPGS CCCCCCCCCCCCCCC	62.13	25953088
557	Acetylation	HTKEAEDKIPLVPSK CCCCCHHCCCCCCCC	37.42	26051181
564	Acetylation	KIPLVPSKVSVIKGS CCCCCCCCEEEEECC	32.24	25953088
569	Acetylation	PSKVSVIKGSRSQKE CCCEEEEECCCCHHH	48.99	25953088
593	Acetylation	DTAPQGNKDLKEHVL CCCCCCCHHHHHHHH	71.86	25953088
602	Phosphorylation	LKEHVLQSSLSQEHK HHHHHHHHHHCHHHC	29.14	30108239
603	Phosphorylation	KEHVLQSSLSQEHKD HHHHHHHHHCHHHCC	21.05	21712546
605	Phosphorylation	HVLQSSLSQEHKDPK HHHHHHHCHHHCCCC	35.16	25159151
614	Phosphorylation	EHKDPKATPP----- HHCCCCCCCC-----	42.07	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
C2TA_HUMAN	CIITA	physical	9177217
HDAC2_HUMAN	HDAC2	physical	16464847
C2TA_HUMAN	CIITA	physical	12697811
HDAC4_HUMAN	HDAC4	physical	15964851
RM53_HUMAN	MRPL53	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
SRPRB_HUMAN	SRPRB	physical	22939629
SLIRP_HUMAN	SLIRP	physical	22939629
PPARG_HUMAN	PPARG	physical	17611194
RFXAP_HUMAN	RFXAP	physical	26496610
GGYF2_HUMAN	GIGYF2	physical	26496610
CDC73_HUMAN	CDC73	physical	26496610
RFX7_HUMAN	RFX7	physical	28514442
RFXK_HUMAN	RFXANK	physical	28514442
RFXAP_HUMAN	RFXAP	physical	28514442
ANRA2_HUMAN	ANKRA2	physical	28514442
CSTFT_HUMAN	CSTF2T	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 209920: Bare lymphocyte syndrome 2 (BLS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.