| UniProt ID | RFXK_HUMAN | |
|---|---|---|
| UniProt AC | O14593 | |
| Protein Name | DNA-binding protein RFXANK | |
| Gene Name | RFXANK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 260 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. [PubMed: 9806546] | |
| Protein Sequence | MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 (in isoform 2) | Phosphorylation | - | 30.81 | 27273156 | |
| 46 | Phosphorylation | VLSLFPCTPEPVNPE EEEEEECCCCCCCCC | 30.81 | 26074081 | |
| 57 | Phosphorylation | VNPEPDASVSSPQAG CCCCCCCCCCCCCCC | 29.88 | 26074081 | |
| 59 | Phosphorylation | PEPDASVSSPQAGSS CCCCCCCCCCCCCCC | 33.53 | 26074081 | |
| 60 (in isoform 2) | Phosphorylation | - | 20.90 | - | |
| 60 | Phosphorylation | EPDASVSSPQAGSSL CCCCCCCCCCCCCCC | 20.90 | 26074081 | |
| 65 | Phosphorylation | VSSPQAGSSLKHSTT CCCCCCCCCCCCCCC | 35.20 | 26074081 | |
| 66 | Phosphorylation | SSPQAGSSLKHSTTL CCCCCCCCCCCCCCC | 40.28 | 26074081 | |
| 83 | Phosphorylation | RQRGNEVSALPATLD CCCCCCCCCCCCCHH | 20.22 | 27174698 | |
| 88 | Phosphorylation | EVSALPATLDSLSIH CCCCCCCCHHHHCHH | 29.20 | 27174698 | |
| 91 | Phosphorylation | ALPATLDSLSIHQLA CCCCCHHHHCHHHHH | 27.42 | 27174698 | |
| 93 | Phosphorylation | PATLDSLSIHQLAAQ CCCHHHHCHHHHHHC | 23.21 | 27174698 | |
| 96 (in isoform 2) | Ubiquitination | - | 31.00 | - | |
| 97 | Ubiquitination | DSLSIHQLAAQGELD HHHCHHHHHHCCCHH | 2.36 | - | |
| 107 | Ubiquitination | QGELDQLKEHLRKGD CCCHHHHHHHHHCCC | 37.14 | - | |
| 112 | Ubiquitination | QLKEHLRKGDNLVNK HHHHHHHCCCCCCCC | 76.58 | - | |
| 119 | Ubiquitination | KGDNLVNKPDERGFT CCCCCCCCCCCCCCC | 46.49 | - | |
| 132 (in isoform 2) | Ubiquitination | - | 14.77 | 21890473 | |
| 133 | Ubiquitination | TPLIWASAFGEIETV CCEEHHHCCCCCCHH | 14.55 | 21890473 | |
| 155 | Ubiquitination | ADPHILAKERESALS CCHHHHHHHHHHHHH | 54.59 | 21890473 | |
| 155 (in isoform 1) | Ubiquitination | - | 54.59 | 21890473 | |
| 204 (in isoform 1) | Ubiquitination | - | 25.63 | 21890473 | |
| 204 | Ubiquitination | AVRGNHVKCVEALLA EECCCHHHHHHHHHH | 25.63 | 21906983 | |
| 222 | Phosphorylation | DLTTEADSGYTPMDL CCCCCCCCCCCHHHH | 40.52 | 23898821 | |
| 224 | Phosphorylation | TTEADSGYTPMDLAV CCCCCCCCCHHHHHH | 16.18 | 23898821 | |
| 237 | Ubiquitination | AVALGYRKVQQVIEN HHHHCCHHHHHHHHH | 35.59 | - | |
| 248 | Ubiquitination | VIENHILKLFQSNLV HHHHHHHHHHHCCCC | 46.80 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFXK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFXK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFXK_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 209920 | Bare lymphocyte syndrome 2 (BLS2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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