OST48_HUMAN - dbPTM
OST48_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OST48_HUMAN
UniProt AC P39656
Protein Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Gene Name DDOST
Organism Homo sapiens (Human).
Sequence Length 456
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type I membrane protein .
Protein Description Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation..
Protein Sequence MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationRRRKMEPSTAARAWA
CCCCCCHHHHHHHHH		19.8522210691
22PhosphorylationRRKMEPSTAARAWAL
CCCCCHHHHHHHHHH		34.7422210691
47PhosphorylationVCASGPRTLVLLDNL
HHHCCCCEEEEEECC		25.0920068231
59PhosphorylationDNLNVRETHSLFFRS
ECCCHHHHHHHEHHH		13.2420068231
61PhosphorylationLNVRETHSLFFRSLK
CCHHHHHHHEHHHHH		34.0020068231
77UbiquitinationRGFELTFKTADDPSL
CCCEEEEEECCCCCC		37.2521906983
85PhosphorylationTADDPSLSLIKYGEF
ECCCCCCEEEEECEE		32.1724719451
143PhosphorylationDPLRELGSECGIEFD
HHHHHHHHHCCCCCC		42.1925338102
152UbiquitinationCGIEFDEEKTAVIDH
CCCCCCCCCEEEEEC		58.5121890473
182UbiquitinationADTENLLKAPTIVGK
ECCCHHHCCCEEECC		56.3321906983
189UbiquitinationKAPTIVGKSSLNPIL
CCCEEECCCCCCCCC		26.4421906983
189UbiquitinationKAPTIVGKSSLNPIL
CCCEEECCCCCCCCC		26.4421890473
189AcetylationKAPTIVGKSSLNPIL
CCCEEECCCCCCCCC		26.4425825284
190PhosphorylationAPTIVGKSSLNPILF
CCEEECCCCCCCCCC		33.8421712546
231O-linked_GlycosylationFFPDKPITQYPHAVG
CCCCCCCCCCCCCCC		30.49OGP
264UbiquitinationFSGSLDFFSDSFFNS
EECCCHHCCHHHHHH		8.7221890473
275UbiquitinationFFNSAVQKAAPGSQR
HHHHHHHHHCCCCCC		39.66-
283PhosphorylationAAPGSQRYSQTGNYE
HCCCCCCCCCCCCHH		9.4828152594
284PhosphorylationAPGSQRYSQTGNYEL
CCCCCCCCCCCCHHH		24.3728152594
286PhosphorylationGSQRYSQTGNYELAV
CCCCCCCCCCHHHHH		22.8125599653
289PhosphorylationRYSQTGNYELAVALS
CCCCCCCHHHHHHHH		17.4228152594
296PhosphorylationYELAVALSRWVFKEE
HHHHHHHHHEEECCC		17.8520068231
301UbiquitinationALSRWVFKEEGVLRV
HHHHEEECCCCCEEE		45.2821890473
301UbiquitinationALSRWVFKEEGVLRV
HHHHEEECCCCCEEE		45.2821906983
301AcetylationALSRWVFKEEGVLRV
HHHHEEECCCCCEEE		45.2825825284
312PhosphorylationVLRVGPVSHHRVGET
CEEEECCCCCCCCCC		19.4026437602
365MethylationVRIDPFVRTFLKKKG
EEECHHHHHHHHHCC		21.82-
385PhosphorylationQFKLPDVYGVFQFKV
EEECCCCEEEEEEEE		18.23-
391UbiquitinationVYGVFQFKVDYNRLG
CEEEEEEEEECCCCC		24.3421906983
403PhosphorylationRLGYTHLYSSTQVSV
CCCCEEEEECCEEEE		7.93-
404PhosphorylationLGYTHLYSSTQVSVR
CCCEEEEECCEEEEE		33.01-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OST48_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OST48_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OST48_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STT3B_HUMANSTT3Bphysical
22939629
SSRD_HUMANSSR4physical
22939629
SSRG_HUMANSSR3physical
22939629
VDAC2_HUMANVDAC2physical
22939629
SRS11_HUMANSRSF11physical
21988832
NXT1_HUMANNXT1physical
21988832
CALX_HUMANCANXphysical
26344197
MAGT1_HUMANMAGT1physical
26344197
PHB_HUMANPHBphysical
26344197
RPN1_HUMANRPN1physical
26344197
S61A1_HUMANSEC61A1physical
26344197
SEC63_HUMANSEC63physical
26344197
SSRG_HUMANSSR3physical
26344197
SSRD_HUMANSSR4physical
26344197
QCR2_HUMANUQCRC2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614507Congenital disorder of glycosylation 1R (CDG1R)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OST48_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory