dbPTM

SSRD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SSRD_HUMAN
UniProt AC	P51571
Protein Name	Translocon-associated protein subunit delta
Gene Name	SSR4
Organism	Homo sapiens (Human).
Sequence Length	173
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type I membrane protein.
Protein Description	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins..
Protein Sequence	MAAMASLGALALLLLSSLSRCSAEACLEPQITPSYYTTSDAVISTETVFIVEISLTCKNRVQNMALYADVGGKQFPVTRGQDVGRYQVSWSLDHKSAHAGTYEVRFFDEESYSLLRKAQRNNEDISIIPPLFTVSVDHRGTWNGPWVSTEVLAAAIGLVIYYLAFSAKSHIQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAMASLGALALL --CHHHHHHHHHHHH	17.79	24043423
10	Ubiquitination	AMASLGALALLLLSS HHHHHHHHHHHHHHH	3.07	23000965
16	Phosphorylation	ALALLLLSSLSRCSA HHHHHHHHHHCCCCH	29.24	24043423
17	Phosphorylation	LALLLLSSLSRCSAE HHHHHHHHHCCCCHH	30.27	24043423
19	Phosphorylation	LLLLSSLSRCSAEAC HHHHHHHCCCCHHHH	32.94	24043423
32	Ubiquitination	ACLEPQITPSYYTTS HHCCCCCCCCEEECC	10.84	21963094
37	Phosphorylation	QITPSYYTTSDAVIS CCCCCEEECCCCEEE	16.16	22468782
38	Phosphorylation	ITPSYYTTSDAVIST CCCCEEECCCCEEEC	14.42	22468782
39	Phosphorylation	TPSYYTTSDAVISTE CCCEEECCCCEEECC	18.77	22468782
58	Ubiquitination	VEISLTCKNRVQNMA EEEEEEECCCCEEEE	42.42	-
64	Sulfoxidation	CKNRVQNMALYADVG ECCCCEEEEEEEEEC	1.20	28183972
67	Phosphorylation	RVQNMALYADVGGKQ CCEEEEEEEEECCEE	7.39	-
73	Acetylation	LYADVGGKQFPVTRG EEEEECCEEEEEECC	42.72	163919
73	Ubiquitination	LYADVGGKQFPVTRG EEEEECCEEEEEECC	42.72	23000965
78	Phosphorylation	GGKQFPVTRGQDVGR CCEEEEEECCCCCCE	29.35	29978859
81	Ubiquitination	QFPVTRGQDVGRYQV EEEEECCCCCCEEEE	38.64	23000965
84	Ubiquitination	VTRGQDVGRYQVSWS EECCCCCCEEEEEEE	30.76	23000965
95	Ubiquitination	VSWSLDHKSAHAGTY EEEECCCCCCCCCEE	49.34	21963094
101	Phosphorylation	HKSAHAGTYEVRFFD CCCCCCCEEEEEEEC	19.79	28152594
102	Phosphorylation	KSAHAGTYEVRFFDE CCCCCCEEEEEEECH	16.12	28152594
103	Ubiquitination	SAHAGTYEVRFFDEE CCCCCEEEEEEECHH	27.36	21963094
106	Ubiquitination	AGTYEVRFFDEESYS CCEEEEEEECHHHHH	12.51	21963094
111	Phosphorylation	VRFFDEESYSLLRKA EEEECHHHHHHHHHH	20.27	28152594
112	Phosphorylation	RFFDEESYSLLRKAQ EEECHHHHHHHHHHH	13.45	28152594
113	Phosphorylation	FFDEESYSLLRKAQR EECHHHHHHHHHHHH	30.15	28152594
122	Phosphorylation	LRKAQRNNEDISIIP HHHHHHCCCCCCCCC	50.97	-
123	Phosphorylation	RKAQRNNEDISIIPP HHHHHCCCCCCCCCC	61.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SSRD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SSRD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SSRD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HECW1_HUMAN	HECW1	physical	14684739
TCPH_HUMAN	CCT7	physical	22939629
TIM10_HUMAN	TIMM10	physical	22939629
ARL8B_HUMAN	ARL8B	physical	26344197
IPO9_HUMAN	IPO9	physical	26344197
KDSR_HUMAN	KDSR	physical	26344197
MAGT1_HUMAN	MAGT1	physical	26344197
NCLN_HUMAN	NCLN	physical	26344197
RPN2_HUMAN	RPN2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300934	Congenital disorder of glycosylation 1Y (CDG1Y)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SSRD_HUMAN

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-73, AND MASSSPECTROMETRY.	18781797 [Abstract]