ARL8B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL8B_HUMAN
• UniProt AC: Q9NVJ2
• Protein Name: ADP-ribosylation factor-like protein 8B
• Gene Name: ARL8B
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Late endosome membrane . Lysosome membrane . Cytoplasm, cytoskeleton, spindle. Localizes with microtubules at the spindle mid-zone during mitosis.
• Protein Description: May play a role in lysosome motility. [PubMed: 16537643]
• Protein Sequence: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLALISRL -------CHHHHHHH	4.45	22223895
61	Phosphorylation	GFNMRKVTKGNVTIK CEEEEEECCCCEEEE	35.95	-
62	Ubiquitination	FNMRKVTKGNVTIKI EEEEEECCCCEEEEE	52.02	27667366
66	Phosphorylation	KVTKGNVTIKIWDIG EECCCCEEEEEEECC	22.13	28060719
68	Ubiquitination	TKGNVTIKIWDIGGQ CCCCEEEEEEECCCC	28.51	23503661
68	Ubiquitination	TKGNVTIKIWDIGGQ CCCCEEEEEEECCCC	28.51	-
107	Phosphorylation	DREKIEASRNELHNL HHHHHHHHHHHHHHH	23.89	21406692
117	Ubiquitination	ELHNLLDKPQLQGIP HHHHHCCCHHHCCCC	34.33	-
131	Ubiquitination	PVLVLGNKRDLPNAL CEEEECCCCCCCCCC	45.55	27667366
141	Acetylation	LPNALDEKQLIEKMN CCCCCCHHHHHHHCC	50.50	26822725
141	Malonylation	LPNALDEKQLIEKMN CCCCCCHHHHHHHCC	50.50	32601280
141	Neddylation	LPNALDEKQLIEKMN CCCCCCHHHHHHHCC	50.50	32015554
141	Sumoylation	LPNALDEKQLIEKMN CCCCCCHHHHHHHCC	50.50	-
141	Ubiquitination	LPNALDEKQLIEKMN CCCCCCHHHHHHHCC	50.50	21906983
146	Ubiquitination	DEKQLIEKMNLSAIQ CHHHHHHHCCHHHHC	26.54	23000965
146	Malonylation	DEKQLIEKMNLSAIQ CHHHHHHHCCHHHHC	26.54	26320211
150	Phosphorylation	LIEKMNLSAIQDREI HHHHCCHHHHCCCEE	20.51	21815630
160	Phosphorylation	QDREICCYSISCKEK CCCEEEEEEEEECCC	12.48	28152594
161	Phosphorylation	DREICCYSISCKEKD CCEEEEEEEEECCCC	8.29	28152594
163	Phosphorylation	EICCYSISCKEKDNI EEEEEEEEECCCCCC	17.13	28152594
165	Ubiquitination	CCYSISCKEKDNIDI EEEEEEECCCCCCEE	62.09	33845483
167	Ubiquitination	YSISCKEKDNIDITL EEEEECCCCCCEEEH	41.38	33845483
182	Ubiquitination	QWLIQHSKSRRS--- HHHHHHHHHCCC---	45.95	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL8B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL8B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL8B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB5_HUMAN	TUBB	physical	15331635
A4_HUMAN	APP	physical	21832049
BT3A3_HUMAN	BTN3A3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"An N-terminally acetylated Arf-like GTPase is localised to lysosomesand affects their motility.";
Hofmann I., Munro S.;
J. Cell Sci. 119:1494-1503(2006).
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION,ACETYLATION AT MET-1, AND MUTAGENESIS OF LEU-2; 5-ILE--PHE-12 ANDGLN-75.
PubMed: 16537643