HECW1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HECW1_HUMAN
• UniProt AC: Q76N89
• Protein Name: E3 ubiquitin-protein ligase HECW1
• Gene Name: HECW1
• Organism: Homo sapiens (Human).
• Sequence Length: 1606
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS..
• Protein Sequence: MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	LLHLCSVKNLYQNRF CHHHHCCCHHHCCCH	25.58	29967540
24	Phosphorylation	LGLAAMASPSRNSQS HHHHHHCCCCCCHHH	15.43	-
26	Phosphorylation	LAAMASPSRNSQSRR HHHHCCCCCCHHHHH	41.41	30576142
29	Phosphorylation	MASPSRNSQSRRRCK HCCCCCCHHHHHHCC	28.55	30576142
31	Phosphorylation	SPSRNSQSRRRCKEP CCCCCHHHHHHCCCC	27.81	30576142
41	Phosphorylation	RCKEPLRYSYNPDQF HCCCCCCCCCCHHHC	24.16	27642862
42	Phosphorylation	CKEPLRYSYNPDQFH CCCCCCCCCCHHHCC	16.40	27422710
43	Phosphorylation	KEPLRYSYNPDQFHN CCCCCCCCCHHHCCC	23.06	28555341
61	Ubiquitination	RGGPHDGVTIPRSTS CCCCCCCCCCCCCCC	5.66	22817900
66	Phosphorylation	DGVTIPRSTSDTDLV CCCCCCCCCCCCCCC	27.23	23663014
67	Phosphorylation	GVTIPRSTSDTDLVT CCCCCCCCCCCCCCC	31.72	23663014
68	Phosphorylation	VTIPRSTSDTDLVTS CCCCCCCCCCCCCCC	39.50	25159151
70	Phosphorylation	IPRSTSDTDLVTSDS CCCCCCCCCCCCCCC	30.88	23663014
74	Phosphorylation	TSDTDLVTSDSRSTL CCCCCCCCCCCCCEE	33.83	29396449
75	Phosphorylation	SDTDLVTSDSRSTLM CCCCCCCCCCCCEEE	26.55	29396449
77	Phosphorylation	TDLVTSDSRSTLMVS CCCCCCCCCCEEEEE	28.09	27251275
150	Phosphorylation	WKIDASSYFVEPETK EEEECHHEECCCCCE	14.78	25690035
167	Ubiquitination	FKYYHGVSGALRATT EEECCCCCCCCEECC	23.96	22817900
180	Ubiquitination	TTPSVTVKNSAAPIF CCCCEEECCCCCCCH	35.50	30230243
188	Ubiquitination	NSAAPIFKSIGADET CCCCCCHHHCCCCCC	41.71	21906983
188	Ubiquitination	NSAAPIFKSIGADET CCCCCCHHHCCCCCC	41.71	21906983
189	Ubiquitination	SAAPIFKSIGADETV CCCCCHHHCCCCCCC	18.59	22817900
219	Ubiquitination	FQAMGLKKGMFFNPD HHHCCCCCCCCCCCC	61.73	30230243
220	Ubiquitination	QAMGLKKGMFFNPDP HHCCCCCCCCCCCCC	19.28	22817900
228	Phosphorylation	MFFNPDPYLKISIQP CCCCCCCCCEEEECC	28.18	-
290	Phosphorylation	VKDKFAKSRPIIKRF EEHHHHHCCHHHHHH	39.60	24719451
300	Ubiquitination	IIKRFLGKLSMPVQR HHHHHHHHCCCHHHH	39.26	-
335	Ubiquitination	PTDHVSGQLQFRFEI CCCCCCEEEEEEEEE	25.28	22817900
378	Ubiquitination	NLMESGSGEPRSEAP HHHCCCCCCCCCCCC	53.07	22817900
400	Phosphorylation	PEQLGEGSVPDGPGN HHHCCCCCCCCCCCC	26.61	23879269
409	Phosphorylation	PDGPGNQSIELSRPA CCCCCCCCEEECCCH	23.25	23879269
423	Ubiquitination	AEEAAVITEAGDQGM HHHHEEEEECCCCCC	17.12	22817900
428	Ubiquitination	VITEAGDQGMVSVGP EEEECCCCCCEEECC	40.75	22817900
466	Ubiquitination	AEQLDLGEEASALLL HHHCCCCHHHHHHHH	58.65	22817900
471	Ubiquitination	LGEEASALLLEDGEA CCHHHHHHHHCCCCC	5.34	22817900
481	Phosphorylation	EDGEAPASTKEEPLE CCCCCCCCCCCCCCC	38.66	26657352
482	Phosphorylation	DGEAPASTKEEPLEE CCCCCCCCCCCCCCH	44.58	26657352
484	Ubiquitination	EAPASTKEEPLEEEA CCCCCCCCCCCCHHH	66.01	22817900
492	Phosphorylation	EPLEEEATTQSRAGR CCCCHHHHHHHHCCC	28.75	26657352
493	Phosphorylation	PLEEEATTQSRAGRE CCCHHHHHHHHCCCH	31.43	26657352
493	O-linked_Glycosylation	PLEEEATTQSRAGRE CCCHHHHHHHHCCCH	31.43	29351928
495	Phosphorylation	EEEATTQSRAGREEE CHHHHHHHHCCCHHH	23.23	23403867
504	Ubiquitination	AGREEEEKEQEEEGD CCCHHHHHHHHCCCC	68.90	-
504	Ubiquitination	AGREEEEKEQEEEGD CCCHHHHHHHHCCCC	68.90	21906983
505	Ubiquitination	GREEEEKEQEEEGDV CCHHHHHHHHCCCCC	67.51	22817900
506	Ubiquitination	REEEEKEQEEEGDVS CHHHHHHHHCCCCCC	74.58	22817900
527	Phosphorylation	GRLQLRASVKRKSRP CCEEEEEEECCCCCC	23.03	27422710
536	Ubiquitination	KRKSRPCSLPVSELE CCCCCCCCCCHHHHH	38.09	22817900
537	Ubiquitination	RKSRPCSLPVSELET CCCCCCCCCHHHHHH	6.55	22817900
555	Phosphorylation	SACGDPETPRTHYIR HHHCCCCCCCCEEEE	24.37	27273156
560	Phosphorylation	PETPRTHYIRIHTLL CCCCCCEEEEEEHHH	7.41	22210691
572	Ubiquitination	TLLHSMPSAQGGSAA HHHHHCCCCCCCCCC	25.28	22817900
577	Ubiquitination	MPSAQGGSAAEEEDG CCCCCCCCCCCCCCC	31.00	22817900
592	Ubiquitination	AEEESTLKDSSEKDG CCCCHHCCCCCCCCC	56.50	-
592	Ubiquitination	AEEESTLKDSSEKDG CCCCHHCCCCCCCCC	56.50	22817900
593	Ubiquitination	EEESTLKDSSEKDGL CCCHHCCCCCCCCCC	61.58	22817900
594	Ubiquitination	EESTLKDSSEKDGLS CCHHCCCCCCCCCCC	38.52	22817900
597	Ubiquitination	TLKDSSEKDGLSEVD HCCCCCCCCCCCCCC	60.07	22817900
598	Ubiquitination	LKDSSEKDGLSEVDT CCCCCCCCCCCCCCE	60.25	22817900
599	Ubiquitination	KDSSEKDGLSEVDTV CCCCCCCCCCCCCEE	42.02	22817900
624	Ubiquitination	REEPEGATPGTAHPG CCCCCCCCCCCCCCC	32.86	22817900
625	Ubiquitination	EEPEGATPGTAHPGH CCCCCCCCCCCCCCC	37.29	22817900
629	Ubiquitination	GATPGTAHPGHSGGH CCCCCCCCCCCCCCC	28.81	22817900
630	Ubiquitination	ATPGTAHPGHSGGHF CCCCCCCCCCCCCCC	39.46	22817900
720	Phosphorylation	FASHTRFSSVDSAKI CCCCCCCCCCCCCCC	26.59	23312004
721	Phosphorylation	ASHTRFSSVDSAKIS CCCCCCCCCCCCCCC	27.51	30624053
724	Phosphorylation	TRFSSVDSAKISEST CCCCCCCCCCCCCCC	29.34	23312004
783	Phosphorylation	PSGHVERSPEGLESP CCCCCCCCCCCCCCC	17.50	30266825
789	Phosphorylation	RSPEGLESPVAGPSN CCCCCCCCCCCCCCC	29.71	30266825
795	Phosphorylation	ESPVAGPSNRREGEC CCCCCCCCCCCCCCC	41.89	30266825
808	Phosphorylation	ECPILHNSQPVSQLP CCCCCCCCCCHHHCC	25.72	26074081
812	Phosphorylation	LHNSQPVSQLPSLRP CCCCCCHHHCCCCCC	32.46	26074081
816	Phosphorylation	QPVSQLPSLRPEHHH CCHHHCCCCCCCCCC	45.67	24719451
847	Phosphorylation	DSHGRVFYVDHVNRT CCCCCEEEEECCCCC	11.34	29759185
854	Phosphorylation	YVDHVNRTTTWQRPT EEECCCCCCCCCCCC	24.31	-
872	Phosphorylation	TPDGMRRSGSIQQME CCCCHHCCCHHHHHH	26.91	25850435
874	Phosphorylation	DGMRRSGSIQQMEQL CCHHCCCHHHHHHHH	20.62	25850435
919	Phosphorylation	GGGGGGGSDSEAESS CCCCCCCCHHHHHHH	41.04	28985074
921	Phosphorylation	GGGGGSDSEAESSQS CCCCCCHHHHHHHCC	40.16	-
937	Phosphorylation	LDLRREGSLSPVNSQ CHHHHCCCCCCCCHH	22.41	23663014
939	Phosphorylation	LRREGSLSPVNSQKI HHHCCCCCCCCHHHE	28.62	23663014
943	Phosphorylation	GSLSPVNSQKITLLL CCCCCCCHHHEEEEE	32.84	28450419
959	Phosphorylation	SPAVKFITNPEFFTV CCCEEEECCHHHHHH	48.10	-
993	Ubiquitination	MILKVRRDARNFERY HHHHHHHHHHCHHHH	39.04	30230243
999	Ubiquitination	RDARNFERYQHNRDL HHHHCHHHHHCCHHH	32.07	30230243
1027	Ubiquitination	LPRGWEIKTDQQGKS CCCCEEEEECCCCCE	34.24	30230243
1033	Ubiquitination	IKTDQQGKSFFVDHN EEECCCCCEEEECCC	39.49	30230243
1073	Phosphorylation	QHLQRLRSYSAGEAS HHHHHHHHCCCCCCH	28.21	21815630
1074	Phosphorylation	HLQRLRSYSAGEASE HHHHHHHCCCCCCHH	8.98	26699800
1075	Phosphorylation	LQRLRSYSAGEASEV HHHHHHCCCCCCHHH	30.92	22617229
1080	Phosphorylation	SYSAGEASEVSRNRG HCCCCCCHHHHHHCC	33.94	24425749
1089	Phosphorylation	VSRNRGASLLARPGH HHHHCCCHHHCCCCH	27.09	24719451
1344	Phosphorylation	HLEWFRFSGRILGLA HHHHHHHHHHHHHHH	23.94	27966365
1429	Phosphorylation	LKSGGANTQVTEKNK HHCCCCCCCCCHHHH	24.71	19845377
1473	Phosphorylation	VVDSRLVSVFDAREL HHHHEEEEEEEHHHE	22.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HECW1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HECW1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HECW1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DVL1_HUMAN	DVL1	physical	14684739
ACK1_HUMAN	TNK2	physical	19144635
P53_HUMAN	TP53	physical	18223681
FXL15_HUMAN	FBXL15	physical	21572392
UBC_HUMAN	UBC	physical	25723849
UB2D1_HUMAN	UBE2D1	physical	25723849
UB2D2_HUMAN	UBE2D2	physical	25723849
UB2D3_HUMAN	UBE2D3	physical	25723849
UB2L3_HUMAN	UBE2L3	physical	25723849
HECW1_HUMAN	HECW1	physical	26949039
UB2J2_HUMAN	UBE2J2	physical	26949039

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.