DVL1_HUMAN - dbPTM
DVL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DVL1_HUMAN
UniProt AC O14640
Protein Name Segment polarity protein dishevelled homolog DVL-1
Gene Name DVL1
Organism Homo sapiens (Human).
Sequence Length 695
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members..
Protein Description Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)..
Protein Sequence MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAETKIIYHMD
----CCCEEEEEECC		20.2923663014
8PhosphorylationMAETKIIYHMDEEET
CCCEEEEEECCCCCC		8.4523663014
15PhosphorylationYHMDEEETPYLVKLP
EECCCCCCCEEEEEC		22.1023663014
17PhosphorylationMDEEETPYLVKLPVA
CCCCCCCEEEEECCC		31.3923663014
34UbiquitinationRVTLADFKNVLSNRP
CCCHHHHHHHHHCCC		46.8529967540
51PhosphorylationAYKFFFKSMDQDFGV
HHHHHHCCCCCCCCE		23.5722199227
79PhosphorylationCFNGRVVSWLVLAEG
CCCCEEEEEEEEECC		16.31-
89PhosphorylationVLAEGAHSDAGSQGT
EEECCCCCCCCCCCC		28.7320873877
93PhosphorylationGAHSDAGSQGTDSHT
CCCCCCCCCCCCCCC		27.4520873877
96PhosphorylationSDAGSQGTDSHTDLP
CCCCCCCCCCCCCCC		27.0520873877
98PhosphorylationAGSQGTDSHTDLPPP
CCCCCCCCCCCCCCC		28.2920873877
100PhosphorylationSQGTDSHTDLPPPLE
CCCCCCCCCCCCCCC		43.0920873877
109PhosphorylationLPPPLERTGGIGDSR
CCCCCCCCCCCCCCC		30.31-
115PhosphorylationRTGGIGDSRPPSFHP
CCCCCCCCCCCCCCC		41.2828555341
119PhosphorylationIGDSRPPSFHPNVAS
CCCCCCCCCCCCCCC		38.5828857561
126PhosphorylationSFHPNVASSRDGMDN
CCCCCCCCCCCCCCC		22.9429449344
127PhosphorylationFHPNVASSRDGMDNE
CCCCCCCCCCCCCCC		25.3429449344
183PhosphorylationDSASTALSSELESSS
CCHHHHHHHHHHHCC		21.2128176443
184PhosphorylationSASTALSSELESSSF
CHHHHHHHHHHHCCC		47.2328176443
188PhosphorylationALSSELESSSFVDSD
HHHHHHHHCCCCCCC		43.8628176443
189PhosphorylationLSSELESSSFVDSDE
HHHHHHHCCCCCCCC		20.5828176443
190PhosphorylationSSELESSSFVDSDED
HHHHHHCCCCCCCCC		38.2728176443
194PhosphorylationESSSFVDSDEDGSTS
HHCCCCCCCCCCCCC		37.2828176443
199PhosphorylationVDSDEDGSTSRLSSS
CCCCCCCCCCCCCCC		35.2228176443
200PhosphorylationDSDEDGSTSRLSSST
CCCCCCCCCCCCCCC		24.3228176443
201PhosphorylationSDEDGSTSRLSSSTE
CCCCCCCCCCCCCCC		32.6828176443
204PhosphorylationDGSTSRLSSSTEQST
CCCCCCCCCCCCCCH		22.5722210691
205PhosphorylationGSTSRLSSSTEQSTS
CCCCCCCCCCCCCHH		45.9622210691
206PhosphorylationSTSRLSSSTEQSTSS
CCCCCCCCCCCCHHH		32.3722210691
207PhosphorylationTSRLSSSTEQSTSSR
CCCCCCCCCCCHHHH		39.7428985074
235PhosphorylationLRQADRASSFSSITD
HHHHHHHHCCHHHCC		32.5829255136
236PhosphorylationRQADRASSFSSITDS
HHHHHHHCCHHHCCC		28.3229255136
238PhosphorylationADRASSFSSITDSTM
HHHHHCCHHHCCCCC		23.8429255136
239PhosphorylationDRASSFSSITDSTMS
HHHHCCHHHCCCCCE		27.7429255136
241PhosphorylationASSFSSITDSTMSLN
HHCCHHHCCCCCEEE		26.3329255136
243PhosphorylationSFSSITDSTMSLNIV
CCHHHCCCCCEEEEE		19.8429255136
244PhosphorylationFSSITDSTMSLNIVT
CHHHCCCCCEEEEEE		17.3729255136
246PhosphorylationSITDSTMSLNIVTVT
HHCCCCCEEEEEEEE		20.5329255136
279PhosphorylationDRGDGGIYIGSIMKG
CCCCCCEEEEEEEEC		11.5122817900
282PhosphorylationDGGIYIGSIMKGGAV
CCCEEEEEEEECCEE		15.22-
285 (in isoform 1)Ubiquitination-53.1521906983
285 (in isoform 2)Ubiquitination-53.1521906983
285UbiquitinationIYIGSIMKGGAVAAD
EEEEEEEECCEEEEC		53.1521963094
337UbiquitinationPISLTVAKCWDPTPR
CEEEEEEECCCCCCC		31.36-
345PhosphorylationCWDPTPRSYFTVPRA
CCCCCCCCCEEECCC		26.2928555341
346PhosphorylationWDPTPRSYFTVPRAD
CCCCCCCCEEECCCC		12.4427642862
348PhosphorylationPTPRSYFTVPRADPV
CCCCCCEEECCCCCC		22.7423312004
380PhosphorylationALPRYGTSPCSSAVT
CCCCCCCCCCCCCCE		21.3921815630
389PhosphorylationCSSAVTRTSSSSLTS
CCCCCEECCCCCCCC		24.4822468782
390PhosphorylationSSAVTRTSSSSLTSS
CCCCEECCCCCCCCC		25.57-
391PhosphorylationSAVTRTSSSSLTSSV
CCCEECCCCCCCCCC		24.27-
393PhosphorylationVTRTSSSSLTSSVPG
CEECCCCCCCCCCCC		37.3022468782
395PhosphorylationRTSSSSLTSSVPGAP
ECCCCCCCCCCCCCC		22.3922468782
416PhosphorylationLTVKSDMSAVVRVMQ
CEECCCHHHHEEEEE		23.9327251275
444UbiquitinationLKITIANAVIGADVV
HHHHHHHHHHCHHHH		5.81-
469UbiquitinationKERREARKYASSLLK
HHHHHHHHHHHHHHH		52.82-
473PhosphorylationEARKYASSLLKHGFL
HHHHHHHHHHHHCCH		29.5524719451
575PhosphorylationQQSEGSKSSGSTRSS
CCCCCCCCCCCCCCC		41.4524719451
577PhosphorylationSEGSKSSGSTRSSRR
CCCCCCCCCCCCCCC		39.8827251275
579PhosphorylationGSKSSGSTRSSRRAP
CCCCCCCCCCCCCCC		37.7933259812
600PhosphorylationRAAGAGGSGSESDHT
HCCCCCCCCCCCCCC		37.9225159151
601MethylationAAGAGGSGSESDHTA
CCCCCCCCCCCCCCC		38.41-
602PhosphorylationAGAGGSGSESDHTAP
CCCCCCCCCCCCCCC		35.3125159151
604PhosphorylationAGGSGSESDHTAPSG
CCCCCCCCCCCCCCC		36.0725159151
607PhosphorylationSGSESDHTAPSGVGS
CCCCCCCCCCCCCCC		45.3025159151
610PhosphorylationESDHTAPSGVGSSWR
CCCCCCCCCCCCCCC		43.5829978859
614PhosphorylationTAPSGVGSSWRERPA
CCCCCCCCCCCCCCC		25.0729978859
615PhosphorylationAPSGVGSSWRERPAG
CCCCCCCCCCCCCCC		24.9929978859
625PhosphorylationERPAGQLSRGSSPRS
CCCCCCCCCCCCCHH		27.0623403867
626MethylationRPAGQLSRGSSPRSQ
CCCCCCCCCCCCHHH		58.57-
626PhosphorylationRPAGQLSRGSSPRSQ
CCCCCCCCCCCCHHH		58.5727642862
649PhosphorylationPPPHPTTKAYTVVGG
CCCCCCCCEEEEECC		41.7024719451
651PhosphorylationPHPTTKAYTVVGGPP
CCCCCCEEEEECCCC		11.1325159151
654PhosphorylationTTKAYTVVGGPPGGP
CCCEEEEECCCCCCC		5.9024719451
674PhosphorylationAAVPPELTGSRQSFQ
HCCCHHHCCCHHHHH		31.3030266825
676PhosphorylationVPPELTGSRQSFQKA
CCHHHCCCHHHHHHH		23.1630266825
679PhosphorylationELTGSRQSFQKAMGN
HHCCCHHHHHHHHCC		28.6530266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseHECW1Q76N89
PMID:14684739
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DVL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DVL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSK21_HUMANCSNK2A1physical
10806215
CTNB1_HUMANCTNNB1physical
10806215
AXIN1_HUMANAXIN1physical
10428961
EPS8_HUMANEPS8physical
10581192
DVL3_HUMANDVL3physical
10330181
AXIN1_RATAxin1physical
10330181
DVL1_HUMANDVL1physical
10330181
NEDD4_HUMANNEDD4physical
22467858
ITCH_HUMANITCHphysical
22826439
LRRK2_HUMANLRRK2physical
19625296
PSA3_HUMANPSMA3physical
21988832
SIPA1_HUMANSIPA1physical
21988832
HUWE1_HUMANHUWE1physical
24643799
DVL2_HUMANDVL2physical
24643799
NCK2_HUMANNCK2physical
25416956
TRI69_HUMANTRIM69physical
25416956
WWTR1_HUMANWWTR1physical
20412773
FLNC_HUMANFLNCphysical
26186194
DVL2_HUMANDVL2physical
26186194
CSK21_HUMANCSNK2A1physical
25241761
CTNB1_HUMANCTNNB1physical
25241761
DVL2_HUMANDVL2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616331Robinow syndrome, autosomal dominant 2 (DRS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DVL1_HUMAN

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Related Literatures of Post-Translational Modification

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