dbPTM

SIPA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIPA1_HUMAN
UniProt AC	Q96FS4
Protein Name	Signal-induced proliferation-associated protein 1
Gene Name	SIPA1
Organism	Homo sapiens (Human).
Sequence Length	1042
Subcellular Localization	Nucleus . Cytoplasm, perinuclear region . Endomembrane system Peripheral membrane protein . Mostly localized in the perinuclear membraneous region.
Protein Description	GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. [PubMed: 9346962 Affects cell cycle progression (By similarity]
Protein Sequence	MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGPASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGSLVWGVRAAPGARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDLYHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVTHVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRRSFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADSETPLTQDRPGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLEDEWQAISEIASTCNTILESLSREGQPIPESGDPKGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSPTADLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	AGGVGSPRRGMAPAS CCCCCCCCCCCCCCC	49.86	115391815
13	Methylation	GGVGSPRRGMAPAST CCCCCCCCCCCCCCH	42.49	54559297
19	Phosphorylation	RRGMAPASTDDLFAR CCCCCCCCHHHHHHH	31.17	23401153
20	Phosphorylation	RGMAPASTDDLFARK CCCCCCCHHHHHHHH	35.32	23401153
27	Acetylation	TDDLFARKLRQPARP HHHHHHHHHCCCCCC	44.59	12650523
47	Dimethylation	TFEPRPVRGPLLRSG CCCCCCCCCCCCCCC	43.63	-
47	Methylation	TFEPRPVRGPLLRSG CCCCCCCCCCCCCCC	43.63	54539415
53	Phosphorylation	VRGPLLRSGSDAGEA CCCCCCCCCCCCCCC	42.49	29255136
55	Phosphorylation	GPLLRSGSDAGEARP CCCCCCCCCCCCCCC	26.07	29255136
61	Methylation	GSDAGEARPPTPASP CCCCCCCCCCCCCCH	33.17	115916989
64	Phosphorylation	AGEARPPTPASPRAR CCCCCCCCCCCHHHH	33.88	23401153
67	Phosphorylation	ARPPTPASPRARAHS CCCCCCCCHHHHCCC	19.00	29255136
74	Phosphorylation	SPRARAHSHEEASRP CHHHHCCCCHHHCCC	31.44	23401153
79	Phosphorylation	AHSHEEASRPAATST CCCCHHHCCCCCCCH	41.92	29978859
84	Phosphorylation	EASRPAATSTRLFTD HHCCCCCCCHHHCCC	32.51	29978859
85	Phosphorylation	ASRPAATSTRLFTDP HCCCCCCCHHHCCCH	13.55	29978859
86	Phosphorylation	SRPAATSTRLFTDPL CCCCCCCHHHCCCHH	27.34	23312004
148	Phosphorylation	ASSGTLASAEDQAAS CCCCCCCCHHHHHHH	34.99	-
182	Phosphorylation	LGLGGPASPPVPPAL CCCCCCCCCCCCCCC	32.63	24275569
226	Ubiquitination	YRKYFYGKEHQNFFG HHHHHCCCCCCCCCC	40.41	29967540
260	Phosphorylation	SGGGTLHSYRVIVRT CCCCCCEEEEEEEEE	20.11	28857561
267	Phosphorylation	SYRVIVRTTQLRTLR EEEEEEEECCCEECC	14.17	29496963
268	Phosphorylation	YRVIVRTTQLRTLRG EEEEEEECCCEECCC	18.29	29496963
294	Ubiquitination	PRGLSPRKLLEHVAP CCCCCHHHHHHHHHH	61.89	-
304	Phosphorylation	EHVAPQLSPSCLRLG HHHHHHCCHHHHHCC	14.98	24732914
306	Phosphorylation	VAPQLSPSCLRLGSA HHHHCCHHHHHCCCC	23.54	24732914
312	Phosphorylation	PSCLRLGSASPKVPR HHHHHCCCCCCCCCC	30.11	23186163
314	Phosphorylation	CLRLGSASPKVPRTL HHHCCCCCCCCCCEE	27.27	23403867
316	Ubiquitination	RLGSASPKVPRTLLT HCCCCCCCCCCEEEE	63.48	29967540
323	Phosphorylation	KVPRTLLTLDEQVLS CCCCEEEEHHHHHHH	34.96	18452278
330	Phosphorylation	TLDEQVLSFQRKVGI EHHHHHHHHHHHHEE	22.07	24719451
334	Ubiquitination	QVLSFQRKVGILYCR HHHHHHHHHEEEEEE	33.75	-
389	Phosphorylation	QLDTKTDSTGTHSLY EEECCCCCCCCCCEE	33.69	-
510	Ubiquitination	FRAFLLAKALNGEQA HHHHHHHHHHCCCCH	54.07	-
559	Phosphorylation	ASRFGLPSLGGRRRA HHHHCCCCCCCCCCC	44.69	30576142
580	Phosphorylation	AELQAAGSLVWGVRA HHHHCCCCEEEEEEE	18.28	24732914
664	Phosphorylation	ITLRFDGSPGQAVGE EEEEECCCCCCHHHH	27.92	20068231
680	Phosphorylation	VARLQLVSRGCETRE HHHHHHHHCCCCEEE	31.39	20068231
685	Phosphorylation	LVSRGCETRELALPR HHHCCCCEEEEECCC	33.26	20068231
738	Phosphorylation	VCGQTLPSLRPEAAA HCCCCCCCCCHHHHH	39.87	24719451
770	Phosphorylation	ESGRPRRSFSELYTL CCCCCCCCHHHHEEE	34.11	29888752
772	Phosphorylation	GRPRRSFSELYTLSL CCCCCCHHHHEEEEC	28.12	29888752
775	Phosphorylation	RRSFSELYTLSLQEP CCCHHHHEEEECCCC	11.11	29888752
776	Phosphorylation	RSFSELYTLSLQEPS CCHHHHEEEECCCCC	23.61	29888752
778	Phosphorylation	FSELYTLSLQEPSRR HHHHEEEECCCCCCC	21.87	29888752
805	Ubiquitination	VTLLPTTKQLLHLCL EEEECCHHHHHHHHH	41.23	29967540
817	Phosphorylation	LCLQDGGSPPGPGDL HHHHCCCCCCCCCCH	33.19	23401153
829	Phosphorylation	GDLAEERTEFLHSQN CCHHHHHHHHHHHCC	34.08	23927012
834	Phosphorylation	ERTEFLHSQNSLSPR HHHHHHHHCCCCCCC	32.95	30266825
837	Phosphorylation	EFLHSQNSLSPRSSL HHHHHCCCCCCCCCC	23.69	23927012
839	Phosphorylation	LHSQNSLSPRSSLSD HHHCCCCCCCCCCCC	20.35	25159151
842	Phosphorylation	QNSLSPRSSLSDEAP CCCCCCCCCCCCCCC	38.73	26657352
843	Phosphorylation	NSLSPRSSLSDEAPV CCCCCCCCCCCCCCC	32.92	26657352
845	Phosphorylation	LSPRSSLSDEAPVLP CCCCCCCCCCCCCCC	35.04	30108239
854	Phosphorylation	EAPVLPNTTPDLLLA CCCCCCCCCCCEEEE	37.45	26074081
862	Phosphorylation	TPDLLLATTAKPSVP CCCEEEECCCCCCCC	27.53	26074081
863	Phosphorylation	PDLLLATTAKPSVPS CCEEEECCCCCCCCC	27.38	26074081
867	Phosphorylation	LATTAKPSVPSADSE EECCCCCCCCCCCCC	46.05	20873877
870	Phosphorylation	TAKPSVPSADSETPL CCCCCCCCCCCCCCC	42.42	23898821
873	Phosphorylation	PSVPSADSETPLTQD CCCCCCCCCCCCCCC	42.98	23401153
875	Phosphorylation	VPSADSETPLTQDRP CCCCCCCCCCCCCCC	27.79	30266825
878	Phosphorylation	ADSETPLTQDRPGSP CCCCCCCCCCCCCCC	29.63	23401153
884	Phosphorylation	LTQDRPGSPSGSEDK CCCCCCCCCCCCCCC	20.69	29255136
886	Phosphorylation	QDRPGSPSGSEDKGN CCCCCCCCCCCCCCC	57.56	30266825
888	Phosphorylation	RPGSPSGSEDKGNPA CCCCCCCCCCCCCCC	47.13	30266825
901	Phosphorylation	PAPELRASFLPRTLS CCHHHHHHHCHHHHH	22.38	23312004
906	Phosphorylation	RASFLPRTLSLRNSI HHHHCHHHHHHHHHH	20.82	23403867
908	Phosphorylation	SFLPRTLSLRNSISR HHCHHHHHHHHHHHH	25.35	22617229
912	Phosphorylation	RTLSLRNSISRIMSE HHHHHHHHHHHHHHH	18.59	23401153
914	Phosphorylation	LSLRNSISRIMSEAG HHHHHHHHHHHHHHC	18.64	23403867
956	Phosphorylation	EGQPIPESGDPKGTP CCCCCCCCCCCCCCC	43.04	30108239
962	Phosphorylation	ESGDPKGTPKSDAEP CCCCCCCCCCCCCCC	33.40	21712546
965	Phosphorylation	DPKGTPKSDAEPEPG CCCCCCCCCCCCCCC	43.17	21712546
1008	Phosphorylation	ALEEEVRSLRHNNRR HHHHHHHHHHHHCHH	34.62	27251275
1022	Phosphorylation	RLQAESESAATRLLL HHHHHCHHHHHHHHH	32.27	26074081
1025	Phosphorylation	AESESAATRLLLASK HHCHHHHHHHHHHHH	22.90	26074081
1031	Phosphorylation	ATRLLLASKQLGSPT HHHHHHHHHHHCCCC	22.39	26074081
1032	Ubiquitination	TRLLLASKQLGSPTA HHHHHHHHHHCCCCC	43.89	29967540
1036	Phosphorylation	LASKQLGSPTADLA- HHHHHHCCCCCCCC-	27.89	30266825
1038	Phosphorylation	SKQLGSPTADLA--- HHHHCCCCCCCC---	34.20	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:21502543

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIPA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIPA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BRD4_HUMAN	BRD4	physical	15456879

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIPA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-55; THR-64;SER-67 AND SER-839, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-839, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.	17081983 [Abstract]