| UniProt ID | NEDD4_HUMAN | |
|---|---|---|
| UniProt AC | P46934 | |
| Protein Name | E3 ubiquitin-protein ligase NEDD4 | |
| Gene Name | NEDD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1319 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Peripheral membrane protein. Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes |
|
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. [PubMed: 23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR] | |
| Protein Sequence | MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAPLIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKDGIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGSYTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDDLEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFIISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNTPRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTSACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 (in isoform 4) | Acetylation | - | 20.97 | 22223895 | |
| 43 (in isoform 4) | Phosphorylation | - | 23.19 | - | |
| 57 (in isoform 4) | Phosphorylation | - | 8.06 | 20068231 | |
| 58 (in isoform 4) | Phosphorylation | - | 5.99 | 20068231 | |
| 61 (in isoform 4) | Phosphorylation | - | 7.90 | 20068231 | |
| 63 | Ubiquitination | TALAPLIKENVQSQE HHHHHHHHHHHHHCC | 51.42 | 29967540 | |
| 63 (in isoform 4) | Phosphorylation | - | 51.42 | 20068231 | |
| 71 | Ubiquitination | ENVQSQERSSVPSSE HHHHHCCCCCCCCCC | 26.96 | 29967540 | |
| 73 | Ubiquitination | VQSQERSSVPSSENV HHHCCCCCCCCCCCC | 44.24 | 23000965 | |
| 82 | Ubiquitination | PSSENVNKKSSCLQI CCCCCCCCCCCCEEE | 50.15 | 33845483 | |
| 147 | Ubiquitination | LVSSPAICSGSLSNF CCCCCCCCCCCCCCC | 4.02 | 23000965 | |
| 169 | Ubiquitination | YSSNGSDFGSCASIT CCCCCCCCCCCEEEC | 9.21 | 23000965 | |
| 173 | Phosphorylation | GSDFGSCASITSGGS CCCCCCCEEECCCCC | 12.98 | 32142685 | |
| 181 | Phosphorylation | SITSGGSYTNSVISD EECCCCCCCCCEECC | 17.14 | 32142685 | |
| 195 | Ubiquitination | DSSSYTFPPSDDTFL CCCCEECCCCCCCCC | 21.49 | 23000965 | |
| 220 | Ubiquitination | NRSVPNRNTTPCEIF CCCCCCCCCCCCEEE | 55.75 | 23000965 | |
| 263 | Phosphorylation | TKIPLKRYSSLVIFP CCCCCCCCCEEEEEE | 10.87 | 26852163 | |
| 264 | Phosphorylation | KIPLKRYSSLVIFPR CCCCCCCCEEEEEEC | 22.64 | 25954137 | |
| 265 | Phosphorylation | IPLKRYSSLVIFPRS CCCCCCCEEEEEECC | 20.09 | 29116813 | |
| 274 | Phosphorylation | VIFPRSPSTTRPTSP EEEECCCCCCCCCCC | 43.59 | 25954137 | |
| 275 | Phosphorylation | IFPRSPSTTRPTSPT EEECCCCCCCCCCCC | 30.15 | 25954137 | |
| 283 | Phosphorylation | TRPTSPTSLCTLLSK CCCCCCCCHHHHHHC | 25.49 | 25954137 | |
| 289 | Phosphorylation | TSLCTLLSKGSYQTS CCHHHHHHCCCCCCC | 37.78 | 24719451 | |
| 298 | Ubiquitination | GSYQTSHQFIISPSE CCCCCCEEEEECHHH | 30.88 | 23000965 | |
| 308 | Ubiquitination | ISPSEIAHNEDGTSA ECHHHHCCCCCCCCC | 43.82 | 33845483 | |
| 316 | Ubiquitination | NEDGTSAKGFLSTAV CCCCCCCHHHHHHHH | 50.38 | 23000965 | |
| 320 | Phosphorylation | TSAKGFLSTAVNGLR CCCHHHHHHHHCCEE | 16.44 | 20068231 | |
| 328 | Phosphorylation | TAVNGLRLSKTICTP HHHCCEEECCEEECC | 8.07 | 32142685 | |
| 350 | Ubiquitination | PLHRKGSLQKKIVLS CCCCCCCCCCEEEEC | 13.59 | 21890473 | |
| 353 | Ubiquitination | RKGSLQKKIVLSNNT CCCCCCCEEEECCCC | 25.70 | 29967540 | |
| 372 | Ubiquitination | VCEKSSEGYSCVSVH EEECCCCCCEEEEEE | 22.92 | 23000965 | |
| 388 | Ubiquitination | TQRKAATLDCETTNG ECCEEEECCCCCCCC | 6.42 | 24816145 | |
| 390 | Ubiquitination | RKAATLDCETTNGDC CEEEECCCCCCCCCC | 5.87 | 23000965 | |
| 394 | Ubiquitination | TLDCETTNGDCKPEM ECCCCCCCCCCCCCH | 52.29 | 23000965 | |
| 395 | Ubiquitination | LDCETTNGDCKPEMS CCCCCCCCCCCCCHH | 39.33 | 23503661 | |
| 399 | Ubiquitination | TTNGDCKPEMSEIKL CCCCCCCCCHHEEEC | 49.18 | 23503661 | |
| 408 | Phosphorylation | MSEIKLNSDSEYIKL HHEEECCCCHHHHHH | 53.61 | 29052541 | |
| 410 | Phosphorylation | EIKLNSDSEYIKLMH EEECCCCHHHHHHHH | 31.92 | 29052541 | |
| 412 | Phosphorylation | KLNSDSEYIKLMHRT ECCCCHHHHHHHHHC | 13.81 | 29052541 | |
| 412 | Ubiquitination | KLNSDSEYIKLMHRT ECCCCHHHHHHHHHC | 13.81 | 23000965 | |
| 420 | Ubiquitination | IKLMHRTSACLPSSQ HHHHHHCCCCCCCCC | 19.55 | 23000965 | |
| 424 | Ubiquitination | HRTSACLPSSQNVDC HHCCCCCCCCCCCEE | 31.64 | 21890473 | |
| 438 | Ubiquitination | CQININGELERPHSQ EEEEECCCCCCCHHH | 42.86 | 23000965 | |
| 445 | Ubiquitination | ELERPHSQMNKNHGI CCCCCHHHCCCCCCE | 36.11 | 23000965 | |
| 446 | Ubiquitination | LERPHSQMNKNHGIL CCCCHHHCCCCCCEE | 9.63 | 21890473 | |
| 455 | Ubiquitination | KNHGILRRSISLGGA CCCCEEHHHEECCCC | 34.59 | 33845483 | |
| 456 | Phosphorylation | NHGILRRSISLGGAY CCCEEHHHEECCCCC | 15.30 | 22617229 | |
| 458 | Phosphorylation | GILRRSISLGGAYPN CEEHHHEECCCCCCC | 23.39 | 28509920 | |
| 462 | Ubiquitination | RSISLGGAYPNISCL HHEECCCCCCCHHHH | 18.14 | 24816145 | |
| 463 | Phosphorylation | SISLGGAYPNISCLS HEECCCCCCCHHHHH | 10.49 | 28509920 | |
| 463 | Ubiquitination | SISLGGAYPNISCLS HEECCCCCCCHHHHH | 10.49 | 23000965 | |
| 467 | Phosphorylation | GGAYPNISCLSSLKH CCCCCCHHHHHHHCC | 18.69 | 28509920 | |
| 469 | Ubiquitination | AYPNISCLSSLKHNC CCCCHHHHHHHCCCC | 2.88 | 23503661 | |
| 470 | Phosphorylation | YPNISCLSSLKHNCS CCCHHHHHHHCCCCC | 37.64 | 24719451 | |
| 472 | Ubiquitination | NISCLSSLKHNCSKG CHHHHHHHCCCCCCC | 6.17 | 21890473 | |
| 473 | Ubiquitination | ISCLSSLKHNCSKGG HHHHHHHCCCCCCCC | 34.42 | 23503661 | |
| 477 | Phosphorylation | SSLKHNCSKGGPSQL HHHCCCCCCCCCCEE | 39.39 | 29083192 | |
| 482 | Phosphorylation | NCSKGGPSQLLIKFA CCCCCCCCEEEEEEC | 36.41 | 29083192 | |
| 484 | Ubiquitination | SKGGPSQLLIKFASG CCCCCCEEEEEECCC | 6.65 | 24816145 | |
| 491 | Ubiquitination | LLIKFASGNEGKVDN EEEEECCCCCCCCCC | 32.55 | 23503661 | |
| 495 | Ubiquitination | FASGNEGKVDNLSRD ECCCCCCCCCCCCCC | 39.99 | 33845483 | |
| 497 | Ubiquitination | SGNEGKVDNLSRDSN CCCCCCCCCCCCCCC | 54.56 | 21890473 | |
| 497 (in isoform 4) | Ubiquitination | - | 54.56 | 21890473 | |
| 510 | Ubiquitination | SNRDCTNELSNSCKT CCCHHHHHHHHHCCC | 35.11 | 24816145 | |
| 517 | Ubiquitination | ELSNSCKTRDDFLGQ HHHHHCCCCCCCCCC | 43.59 | 23503661 | |
| 521 | Ubiquitination | SCKTRDDFLGQVDVP HCCCCCCCCCCCCCC | 10.93 | 23503661 | |
| 530 | Phosphorylation | GQVDVPLYPLPTENP CCCCCCCCCCCCCCC | 9.17 | - | |
| 535 | Ubiquitination | PLYPLPTENPRLERP CCCCCCCCCCCCCCC | 64.40 | 24816145 | |
| 542 | Ubiquitination | ENPRLERPYTFKDFV CCCCCCCCEEECCEE | 24.12 | 23503661 | |
| 546 | Ubiquitination | LERPYTFKDFVLHPR CCCCEEECCEEECCC | 42.32 | 23503661 | |
| 557 | Phosphorylation | LHPRSHKSRVKGYLR ECCCCCCHHHCEEEE | 36.56 | 28555341 | |
| 563 | Ubiquitination | KSRVKGYLRLKMTYL CHHHCEEEEEEEEEC | 7.63 | 21906983 | |
| 566 | Acetylation | VKGYLRLKMTYLPKT HCEEEEEEEEECCCC | 23.82 | 25953088 | |
| 567 | Ubiquitination | KGYLRLKMTYLPKTS CEEEEEEEEECCCCC | 3.35 | 23000965 | |
| 568 | Phosphorylation | GYLRLKMTYLPKTSG EEEEEEEEECCCCCC | 21.96 | 30206219 | |
| 569 | Phosphorylation | YLRLKMTYLPKTSGS EEEEEEEECCCCCCC | 19.94 | 30206219 | |
| 576 | Phosphorylation | YLPKTSGSEDDNAEQ ECCCCCCCCCCCHHH | 37.30 | - | |
| 580 | Ubiquitination | TSGSEDDNAEQAEEL CCCCCCCCHHHHHHC | 58.67 | 33845483 | |
| 582 | Ubiquitination | GSEDDNAEQAEELEP CCCCCCHHHHHHCCC | 57.49 | 29967540 | |
| 622 | Ubiquitination | GWEERQDILGRTYYV CHHHHHHHCCCEEEC | 3.12 | 23000965 | |
| 623 | Ubiquitination | WEERQDILGRTYYVN HHHHHHHCCCEEECC | 5.23 | 23000965 | |
| 623 (in isoform 2) | Ubiquitination | - | 5.23 | - | |
| 639 | Ubiquitination | ESRRTQWKRPTPQDN HHCCCCCCCCCCCCC | 38.39 | 23000965 | |
| 648 | Phosphorylation | PTPQDNLTDAENGNI CCCCCCCCCCCCCCC | 39.14 | 21082442 | |
| 664 | Phosphorylation | LQAQRAFTTRRQISE HHHHHHHHCHHHHCC | 20.57 | 22210691 | |
| 665 | Phosphorylation | QAQRAFTTRRQISEE HHHHHHHCHHHHCCC | 19.87 | 22210691 | |
| 667 | Phosphorylation | QRAFTTRRQISEETE HHHHHCHHHHCCCCC | 35.77 | 32142685 | |
| 670 | Phosphorylation | FTTRRQISEETESVD HHCHHHHCCCCCCCC | 22.50 | 25159151 | |
| 673 | Phosphorylation | RRQISEETESVDNRE HHHHCCCCCCCCCCC | 29.52 | 30242111 | |
| 675 | Phosphorylation | QISEETESVDNRESS HHCCCCCCCCCCCCC | 42.04 | 18669648 | |
| 722 | Phosphorylation | HLAEELNARLTIFGN HHHHHHHHCEEEECC | 22.08 | 32142685 | |
| 723 | Phosphorylation | LAEELNARLTIFGNS HHHHHHHCEEEECCC | 31.15 | 32142685 | |
| 725 | Phosphorylation | EELNARLTIFGNSAV HHHHHCEEEECCCCC | 14.54 | 20068231 | |
| 727 | Ubiquitination | LNARLTIFGNSAVSQ HHHCEEEECCCCCCC | 6.80 | 33845483 | |
| 729 | Ubiquitination | ARLTIFGNSAVSQPA HCEEEECCCCCCCCC | 18.95 | 29967540 | |
| 730 | Phosphorylation | RLTIFGNSAVSQPAS CEEEECCCCCCCCCC | 30.35 | 23927012 | |
| 731 | Phosphorylation | LTIFGNSAVSQPASS EEEECCCCCCCCCCC | 14.69 | 32142685 | |
| 733 | Phosphorylation | IFGNSAVSQPASSSN EECCCCCCCCCCCCC | 30.11 | 23927012 | |
| 737 | Phosphorylation | SAVSQPASSSNHSSR CCCCCCCCCCCCCCC | 40.77 | 23401153 | |
| 738 | O-linked_Glycosylation | AVSQPASSSNHSSRR CCCCCCCCCCCCCCC | 36.95 | 30379171 | |
| 738 | Phosphorylation | AVSQPASSSNHSSRR CCCCCCCCCCCCCCC | 36.95 | 23401153 | |
| 739 | Phosphorylation | VSQPASSSNHSSRRG CCCCCCCCCCCCCCC | 35.75 | 30278072 | |
| 742 | Phosphorylation | PASSSNHSSRRGSLQ CCCCCCCCCCCCEEE | 29.77 | 30278072 | |
| 743 | Phosphorylation | ASSSNHSSRRGSLQA CCCCCCCCCCCEEEE | 20.60 | 30278072 | |
| 747 | Phosphorylation | NHSSRRGSLQAYTFE CCCCCCCEEEEEECC | 18.59 | 28731282 | |
| 751 | Phosphorylation | RRGSLQAYTFEEQPT CCCEEEEEECCCCCC | 10.05 | 23927012 | |
| 752 | Phosphorylation | RGSLQAYTFEEQPTL CCEEEEEECCCCCCC | 27.82 | 30206219 | |
| 758 | Phosphorylation | YTFEEQPTLPVLLPT EECCCCCCCCEEEEC | 43.31 | 23663014 | |
| 783 | Phosphorylation | KQDERGRSYYVDHNS CCCCCCCEEEEECCC | 24.52 | 27642862 | |
| 784 | Phosphorylation | QDERGRSYYVDHNSR CCCCCCEEEEECCCC | 13.22 | 28796482 | |
| 785 | Phosphorylation | DERGRSYYVDHNSRT CCCCCEEEEECCCCC | 10.72 | 28796482 | |
| 792 | Ubiquitination | YVDHNSRTTTWTKPT EEECCCCCCEECCCE | 28.53 | 23000965 | |
| 802 | Ubiquitination | WTKPTVQATVETSQL ECCCEEEEEEEHHHC | 14.85 | 33845483 | |
| 810 | Ubiquitination | TVETSQLTSSQSSAG EEEHHHCCCCCCCCC | 20.78 | 23000965 | |
| 844 | Ubiquitination | IEQGFLPKGWEVRHA HCCCCCCCCEEEEEC | 77.97 | 21890473 | |
| 844 (in isoform 3) | Ubiquitination | - | 77.97 | 21890473 | |
| 847 | Ubiquitination | GFLPKGWEVRHAPNG CCCCCCEEEEECCCC | 38.04 | 23000965 | |
| 848 | Ubiquitination | FLPKGWEVRHAPNGR CCCCCEEEEECCCCC | 4.36 | 23000965 | |
| 857 | Ubiquitination | HAPNGRPFFIDHNTK ECCCCCEEEEECCCC | 8.92 | 33845483 | |
| 858 | Ubiquitination | APNGRPFFIDHNTKT CCCCCEEEEECCCCC | 7.70 | 33845483 | |
| 864 | Ubiquitination | FFIDHNTKTTTWEDP EEEECCCCCCCCCCC | 49.55 | 23000965 | |
| 865 | Ubiquitination | FIDHNTKTTTWEDPR EEECCCCCCCCCCCC | 27.67 | 23000965 | |
| 866 | Ubiquitination | IDHNTKTTTWEDPRL EECCCCCCCCCCCCC | 31.31 | 23000965 | |
| 866 (in isoform 2) | Ubiquitination | - | 31.31 | - | |
| 867 | Phosphorylation | DHNTKTTTWEDPRLK ECCCCCCCCCCCCCC | 31.89 | 27470641 | |
| 874 | Ubiquitination | TWEDPRLKIPAHLRG CCCCCCCCCCHHHCC | 48.17 | 33845483 | |
| 882 | Ubiquitination | IPAHLRGKTSLDTSN CCHHHCCCCCCCCCC | 28.62 | 23000965 | |
| 883 | Phosphorylation | PAHLRGKTSLDTSND CHHHCCCCCCCCCCC | 37.03 | 25159151 | |
| 884 | Phosphorylation | AHLRGKTSLDTSNDL HHHCCCCCCCCCCCC | 27.94 | 25159151 | |
| 887 | Phosphorylation | RGKTSLDTSNDLGPL CCCCCCCCCCCCCCC | 34.42 | 25627689 | |
| 888 | Phosphorylation | GKTSLDTSNDLGPLP CCCCCCCCCCCCCCC | 28.19 | 25159151 | |
| 889 | Ubiquitination | KTSLDTSNDLGPLPP CCCCCCCCCCCCCCC | 51.09 | 23503661 | |
| 893 | Ubiquitination | DTSNDLGPLPPGWEE CCCCCCCCCCCCCCE | 49.33 | 23503661 | |
| 899 | Ubiquitination | GPLPPGWEERTHTDG CCCCCCCCEECCCCC | 43.44 | 21890473 | |
| 900 | Ubiquitination | PLPPGWEERTHTDGR CCCCCCCEECCCCCC | 57.27 | 21890473 | |
| 900 (in isoform 2) | Ubiquitination | - | 57.27 | 21890473 | |
| 910 | Phosphorylation | HTDGRIFYINHNIKR CCCCCEEEEECCCCC | 9.84 | 27642862 | |
| 916 | 2-Hydroxyisobutyrylation | FYINHNIKRTQWEDP EEEECCCCCCCCCCC | 55.50 | - | |
| 916 | Ubiquitination | FYINHNIKRTQWEDP EEEECCCCCCCCCCC | 55.50 | 23000965 | |
| 916 (in isoform 1) | Ubiquitination | - | 55.50 | 21890473 | |
| 937 | Ubiquitination | ITGPAVPYSRDYKRK EECCCCCCCCHHHHH | 15.11 | 24816145 | |
| 938 | Ubiquitination | TGPAVPYSRDYKRKY ECCCCCCCCHHHHHH | 16.77 | 24816145 | |
| 944 | Ubiquitination | YSRDYKRKYEFFRRK CCCHHHHHHHHHHHH | 45.00 | 23503661 | |
| 945 | Ubiquitination | SRDYKRKYEFFRRKL CCHHHHHHHHHHHHH | 23.23 | 23503661 | |
| 945 (in isoform 2) | Ubiquitination | - | 23.23 | - | |
| 948 | Ubiquitination | YKRKYEFFRRKLKKQ HHHHHHHHHHHHHHC | 5.02 | 23503661 | |
| 949 | Ubiquitination | KRKYEFFRRKLKKQN HHHHHHHHHHHHHCC | 39.90 | 23503661 | |
| 954 | Ubiquitination | FFRRKLKKQNDIPNK HHHHHHHHCCCCCCH | 65.84 | 24816145 | |
| 961 | Acetylation | KQNDIPNKFEMKLRR HCCCCCCHHHHHHHH | 37.03 | 26051181 | |
| 961 | Ubiquitination | KQNDIPNKFEMKLRR HCCCCCCHHHHHHHH | 37.03 | 23503661 | |
| 965 | Ubiquitination | IPNKFEMKLRRATVL CCCHHHHHHHHHHHH | 31.48 | 23503661 | |
| 976 | Phosphorylation | ATVLEDSYRRIMGVK HHHHHHHHHHHHCCC | 19.07 | - | |
| 1004 | Phosphorylation | DGEKGLDYGGVAREW CCCCCCCCCCHHHHH | 22.33 | - | |
| 1066 | Phosphorylation | RVAGMAVYHGKLLDG HHHCCEEECCCCCCC | 8.70 | - | |
| 1074 | Ubiquitination | HGKLLDGFFIRPFYK CCCCCCCEECHHHHH | 4.61 | 33845483 | |
| 1076 | Ubiquitination | KLLDGFFIRPFYKMM CCCCCEECHHHHHHH | 5.23 | 29967540 | |
| 1103 | Phosphorylation | VDSEYYNSLRWILEN CCHHHHHHHHHHHHC | 11.82 | 30576142 | |
| 1129 | Ubiquitination | DEELFGQTHQHELKN CHHHHCCCCEEHHHC | 24.71 | 33845483 | |
| 1130 | Ubiquitination | EELFGQTHQHELKNG HHHHCCCCEEHHHCC | 21.07 | 33845483 | |
| 1131 | Ubiquitination | ELFGQTHQHELKNGG HHHCCCCEEHHHCCC | 34.83 | 29967540 | |
| 1132 | Ubiquitination | LFGQTHQHELKNGGS HHCCCCEEHHHCCCC | 34.45 | 29967540 | |
| 1139 | Phosphorylation | HELKNGGSEIVVTNK EHHHCCCCEEEEECC | 26.08 | 30576142 | |
| 1144 | Phosphorylation | GGSEIVVTNKNKKEY CCCEEEEECCCCCEE | 29.58 | 30576142 | |
| 1146 | Ubiquitination | SEIVVTNKNKKEYIY CEEEEECCCCCEEEE | 61.86 | 33845483 | |
| 1148 | Ubiquitination | IVVTNKNKKEYIYLV EEEECCCCCEEEEEE | 48.90 | 29967540 | |
| 1238 | 2-Hydroxyisobutyrylation | VLMMDSEKRIRLLQF HHHCCHHHHHHHHHH | 58.01 | - | |
| 1247 | Phosphorylation | IRLLQFVTGTSRVPM HHHHHHHHCCCCCCC | 35.71 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 43 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 111 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 332 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 585 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 647 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | NEDD4 | P46934 | PMID:18772139 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEDD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEDD4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747, AND MASSSPECTROMETRY. | |
