dbPTM

S23A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	S23A2_HUMAN
UniProt AC	Q9UGH3
Protein Name	Solute carrier family 23 member 2
Gene Name	SLC23A2
Organism	Homo sapiens (Human).
Sequence Length	650
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate..
Protein Sequence	MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MMGIGKNTTSKSMEA CCCCCCCCCCCCCCC	35.61	22210691
10	O-linked_Glycosylation	GIGKNTTSKSMEAGS CCCCCCCCCCCCCCC	22.24	30379171
11	Ubiquitination	IGKNTTSKSMEAGSS CCCCCCCCCCCCCCC	52.29	21906983
11	Ubiquitination	IGKNTTSKSMEAGSS CCCCCCCCCCCCCCC	52.29	-
17	Phosphorylation	SKSMEAGSSTEGKYE CCCCCCCCCCCCCCC	40.93	21945579
18	Phosphorylation	KSMEAGSSTEGKYED CCCCCCCCCCCCCCC	29.56	21945579
19	Phosphorylation	SMEAGSSTEGKYEDE CCCCCCCCCCCCCCH	50.91	21945579
22	Ubiquitination	AGSSTEGKYEDEAKH CCCCCCCCCCCHHCC	38.95	21906983
22	Ubiquitination	AGSSTEGKYEDEAKH CCCCCCCCCCCHHCC	38.95	-
23	Phosphorylation	GSSTEGKYEDEAKHP CCCCCCCCCCHHCCC	39.20	21945579
60	Phosphorylation	DTELMAIYTTENGIA CCEEEEEEECCCCCC	9.70	25884760
70	Phosphorylation	ENGIAEKSSLAETLD CCCCCCCCHHHHHHH	23.30	20201521
71	Phosphorylation	NGIAEKSSLAETLDS CCCCCCCHHHHHHHC	42.54	23927012
75	Phosphorylation	EKSSLAETLDSTGSL CCCHHHHHHHCCCCC	30.20	23927012
78	Phosphorylation	SLAETLDSTGSLDPQ HHHHHHHCCCCCCCC	37.47	30266825
79	Phosphorylation	LAETLDSTGSLDPQR HHHHHHCCCCCCCCC	30.38	30266825
81	Phosphorylation	ETLDSTGSLDPQRSD HHHHCCCCCCCCCCC	29.68	29255136
184	Ubiquitination	RAILSLDKWKCNTTD HHHHCCCCCCCCCCC	54.57	-
188	N-linked_Glycosylation	SLDKWKCNTTDVSVA CCCCCCCCCCCEEEC	42.14	UniProtKB CARBOHYD
196	N-linked_Glycosylation	TTDVSVANGTAELLH CCCEEECCCCEEEEE	46.31	UniProtKB CARBOHYD
298	Ubiquitination	KFPLPIYKSKKGWTA CCCCCEECCCCCCEE	57.42	-
498	Ubiquitination	FCTLFGMITAVGLSN HHHHHHHHHHHCCCC	1.98	-
593	Ubiquitination	KGVGKGNKSLDGMES CCCCCCCCCCCCHHH	62.15	-
594	Phosphorylation	GVGKGNKSLDGMESY CCCCCCCCCCCHHHC	35.37	-
612	Ubiquitination	FGMNIIKKYRCFSYL CCHHHHHHHCCCEEC	27.76	-
613	Phosphorylation	GMNIIKKYRCFSYLP CHHHHHHHCCCEECC	13.96	-
617	Phosphorylation	IKKYRCFSYLPISPT HHHHCCCEECCCCCC	29.41	18491316
624	Phosphorylation	SYLPISPTFVGYTWK EECCCCCCCCCCEEC	24.94	-
629	Phosphorylation	SPTFVGYTWKGLRKS CCCCCCCEECCCCCC	18.12	18491316
641	Phosphorylation	RKSDNSRSSDEDSQA CCCCCCCCCCHHHHC	41.80	24719451
646	Phosphorylation	SRSSDEDSQATG--- CCCCCHHHHCCC---	21.48	-
649	Phosphorylation	SDEDSQATG------ CCHHHHCCC------	35.47	26853621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of S23A2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of S23A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of S23A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
COA1_HUMAN	COA1	physical	26186194

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of S23A2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, AND MASSSPECTROMETRY.	19690332 [Abstract]