COA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COA1_HUMAN
• UniProt AC: Q9GZY4
• Protein Name: Cytochrome c oxidase assembly factor 1 homolog
• Gene Name: COA1
• Organism: Homo sapiens (Human).
• Sequence Length: 146
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV..
• Protein Sequence: MMWQKYAGSRRSMPLGARILFHGVFYAGGFAIVYYLIQKFHSRALYYKLAVEQLQSHPEAQEALGPPLNIHYLKLIDRENFVDIVDAKLKIPVSGSKSEGLLYVHSSRGGPFQRWHLDEVFLELKDGQQIPVFKLSGENGDEVKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MMWQKYAGSRRS ---CCCCCCCCCCCC		-
74	Ubiquitination	PLNIHYLKLIDRENF CCEEEEEEECCCCCC		21906983
88	Ubiquitination	FVDIVDAKLKIPVSG CEEEEEEEEECCCCC		21906983
90	Ubiquitination	DIVDAKLKIPVSGSK EEEEEEEECCCCCCC		21906983
97	Ubiquitination	KIPVSGSKSEGLLYV ECCCCCCCCCEEEEE		21906983
125	Ubiquitination	DEVFLELKDGQQIPV CEEEEEECCCCEEEE		21906983
134	Ubiquitination	GQQIPVFKLSGENGD CCEEEEEEEECCCCC		21906983
144	Ubiquitination	GENGDEVKKE----- CCCCCCCCCC-----		-
145	Ubiquitination	ENGDEVKKE------ CCCCCCCCC------		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COX17_HUMAN	COX17	physical	22356826
COA6_HUMAN	COA6	physical	22356826

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.