COA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COA6_HUMAN
• UniProt AC: Q5JTJ3
• Protein Name: Cytochrome c oxidase assembly factor 6 homolog
• Gene Name: COA6
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Mitochondrion intermembrane space .
• Protein Description: Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV..
• Protein Sequence: MGPGGPLLSPSRGFLLCKTGWHSNRLLGDCGPHTPVSTALSFIAVGMAAPSMKERQVCWGARDEYWKCLDENLEDASQCKKLRSSFESSCPQQWIKYFDKRRDYLKFKEKFEAGQFEPSETTAKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 3)	Acetylation	-		22814378
9	Phosphorylation	GPGGPLLSPSRGFLL CCCCCCCCCCCCEEE		30619164
34	Ubiquitination	LGDCGPHTPVSTALS CCCCCCCCCHHHHHH		32015554
50 (in isoform 3)	Ubiquitination	-		21890473
50	Ubiquitination	IAVGMAAPSMKERQV HHHHCCCCCHHHHCC		21890473
51	Phosphorylation	AVGMAAPSMKERQVC HHHCCCCCHHHHCCH		20068231
53	Acetylation	GMAAPSMKERQVCWG HCCCCCHHHHCCHHH		25953088
64 (in isoform 3)	Ubiquitination	-		21890473
64	Ubiquitination	VCWGARDEYWKCLDE CHHHCCHHHHHHHHH		21890473
71 (in isoform 2)	Phosphorylation	-		20068231
72 (in isoform 2)	Phosphorylation	-		20068231
80	Acetylation	LEDASQCKKLRSSFE CCCHHHHHHHHHHHH		25953088
80	Ubiquitination	LEDASQCKKLRSSFE CCCHHHHHHHHHHHH		32015554
82 (in isoform 2)	Phosphorylation	-		20068231
84	Phosphorylation	SQCKKLRSSFESSCP HHHHHHHHHHHHCCC		25159151
85	Phosphorylation	QCKKLRSSFESSCPQ HHHHHHHHHHHCCCH		25159151
88	Phosphorylation	KLRSSFESSCPQQWI HHHHHHHHCCCHHHH		26074081
89	Phosphorylation	LRSSFESSCPQQWIK HHHHHHHCCCHHHHH		27080861
96 (in isoform 1)	Ubiquitination	-		21890473
96	Ubiquitination	SCPQQWIKYFDKRRD CCCHHHHHHHHHHHH		21890473
97	Phosphorylation	CPQQWIKYFDKRRDY CCHHHHHHHHHHHHH		26074081
110	Acetylation	DYLKFKEKFEAGQFE HHHHHHHHHHCCCCC		25038526
110 (in isoform 1)	Ubiquitination	-		21890473
110	Ubiquitination	DYLKFKEKFEAGQFE HHHHHHHHHHCCCCC		32015554
119	Phosphorylation	EAGQFEPSETTAKS- HCCCCCCCCCCCCC-		25627689
121	Phosphorylation	GQFEPSETTAKS--- CCCCCCCCCCCC---		25159151
122	Phosphorylation	QFEPSETTAKS---- CCCCCCCCCCC----		27251275
125	Phosphorylation	PSETTAKS------- CCCCCCCC-------		25159151
126	Ubiquitination	SETTAKS-------- CCCCCCC--------		21890473
127 (in isoform 2)	Ubiquitination	-		21890473
140	Ubiquitination	---------------------- ----------------------		21890473
141 (in isoform 2)	Ubiquitination	-		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COA6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCO2_HUMAN	SCO2	physical	25959673
COX2_HUMAN	COX2	physical	25959673

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.