SCO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCO2_HUMAN
• UniProt AC: O43819
• Protein Name: Protein SCO2 homolog, mitochondrial
• Gene Name: SCO2
• Organism: Homo sapiens (Human).
• Sequence Length: 266
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. [PubMed: 15229189]
• Protein Sequence: MLLLTRSPTAWHRLSQLKPRVLPGTLGGQALHLRSWLLSRQGPAETGGQGQPQGPGLRTRLLITGLFGAGLGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLLLTRSPTAWHRL -CCCCCCCCCHHHHH	22.74	24719451
9	Phosphorylation	LLLTRSPTAWHRLSQ CCCCCCCCHHHHHHH	43.56	24719451
15	Phosphorylation	PTAWHRLSQLKPRVL CCHHHHHHHCCCCCC	33.16	24719451
35	Phosphorylation	GQALHLRSWLLSRQG HHHHHHHHHHHHCCC	28.56	-
39	Phosphorylation	HLRSWLLSRQGPAET HHHHHHHHCCCCCCC	22.01	-
46	Phosphorylation	SRQGPAETGGQGQPQ HCCCCCCCCCCCCCC	49.03	-
59	Phosphorylation	PQGPGLRTRLLITGL CCCCCHHHHHHHHCC	30.61	-
180	Phosphorylation	DVEAMARYVQDFHPR HHHHHHHHHHHHHHH	7.91	29496907
192	Phosphorylation	HPRLLGLTGSTKQVA HHHHHCCCCCHHHHH	27.56	30108239
194	Phosphorylation	RLLGLTGSTKQVAQA HHHCCCCCHHHHHHH	27.48	30108239
195	Phosphorylation	LLGLTGSTKQVAQAS HHCCCCCHHHHHHHH	27.17	30108239
196	Malonylation	LGLTGSTKQVAQASH HCCCCCHHHHHHHHC	44.46	26320211
196	Ubiquitination	LGLTGSTKQVAQASH HCCCCCHHHHHHHHC	44.46	21963094
202	Phosphorylation	TKQVAQASHSYRVYY HHHHHHHHCCEEEEE	10.82	21406692
204	Phosphorylation	QVAQASHSYRVYYNA HHHHHHCCEEEEEEC	16.49	21406692
205	Phosphorylation	VAQASHSYRVYYNAG HHHHHCCEEEEEECC	9.93	21406692
243	Methylation	LFTDYYGRSRSAEQI CCCCCCCCCCCHHHH	16.87	30760971
266	Phosphorylation	AAFRSVLS------- HHHHHHHC-------	35.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCO2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCO2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
VDAC3_HUMAN	VDAC3	physical	22939629
THY1_HUMAN	THY1	physical	22939629
VATE1_HUMAN	ATP6V1E1	physical	22939629
SEPT9_HUMAN	SEPT9	physical	22939629
SRPRB_HUMAN	SRPRB	physical	22939629
SPRE_HUMAN	SPR	physical	22939629
STX7_HUMAN	STX7	physical	22939629
TIAR_HUMAN	TIAL1	physical	22939629
STOM_HUMAN	STOM	physical	22939629
TIM44_HUMAN	TIMM44	physical	22939629
SUGP1_HUMAN	SUGP1	physical	22939629
ZO1_HUMAN	TJP1	physical	22939629
UBE4B_HUMAN	UBE4B	physical	22939629
RIDA_HUMAN	HRSP12	physical	22939629
COX2_HUMAN	COX2	physical	25959673

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604377: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 (CEMCOX1)
• 608908: Myopia 6 (MYP6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.