RIDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIDA_HUMAN
• UniProt AC: P52758
• Protein Name: 2-iminobutanoate/2-iminopropanoate deaminase {ECO:0000305|PubMed:22094463}
• Gene Name: RIDA {ECO:0000312|HGNC:HGNC:16897}
• Organism: Homo sapiens (Human).
• Sequence Length: 137
• Subcellular Localization: Cytoplasm . Nucleus . Peroxisome . Mitochondrion . Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.
• Protein Description: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; May also function as an endoribonuclease, cleaving mRNA phosphodiester bonds of single-stranded RNA (By similarity). Thereby, may inhibit protein translation. [PubMed: 8973653]
• Protein Sequence: MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSLIRRVI ------CCHHHHHHH		20068231
2	Phosphorylation	------MSSLIRRVI ------CCHHHHHHH		20068231
3	Phosphorylation	-----MSSLIRRVIS -----CCHHHHHHHH		20068231
10	Phosphorylation	SLIRRVISTAKAPGA HHHHHHHHHCCCCCC		29759185
11	Phosphorylation	LIRRVISTAKAPGAI HHHHHHHHCCCCCCC		29759185
13	Acetylation	RRVISTAKAPGAIGP HHHHHHCCCCCCCCC		25953088
13	Ubiquitination	RRVISTAKAPGAIGP HHHHHHCCCCCCCCC		2205393
13	Succinylation	RRVISTAKAPGAIGP HHHHHHCCCCCCCCC		22053931
13	Succinylation	RRVISTAKAPGAIGP HHHHHHCCCCCCCCC		-
21	Phosphorylation	APGAIGPYSQAVLVD CCCCCCCCCCEEEEE		24927040
22	Phosphorylation	PGAIGPYSQAVLVDR CCCCCCCCCEEEEEC		28258704
42	Phosphorylation	GQIGMDPSSGQLVSG EECCCCCCCCCCCCC		27732954
43	Phosphorylation	QIGMDPSSGQLVSGG ECCCCCCCCCCCCCC		27732954
48	Phosphorylation	PSSGQLVSGGVAEEA CCCCCCCCCCHHHHH		27732954
60	Succinylation	EEAKQALKNMGEILK HHHHHHHHHHHHHHH		23954790
60	Acetylation	EEAKQALKNMGEILK HHHHHHHHHHHHHHH		25038526
60	Succinylation	EEAKQALKNMGEILK HHHHHHHHHHHHHHH		-
67	Succinylation	KNMGEILKAAGCDFT HHHHHHHHHCCCCCC		-
67	Succinylation	KNMGEILKAAGCDFT HHHHHHHHHCCCCCC		-
74	Phosphorylation	KAAGCDFTNVVKTTV HHCCCCCCHHCEEEE		24275569
91	Phosphorylation	ADINDFNTVNEIYKQ ECCCCCCHHHHHHHH		24275569
97	Acetylation	NTVNEIYKQYFKSNF CHHHHHHHHHHHCCC		25038526
101	Acetylation	EIYKQYFKSNFPARA HHHHHHHHCCCCHHH		25825284
102	Phosphorylation	IYKQYFKSNFPARAA HHHHHHHCCCCHHHH		26437602
110	Phosphorylation	NFPARAAYQVAALPK CCCHHHHHHHEECCC		28152594
117	Malonylation	YQVAALPKGSRIEIE HHHEECCCCCCEEEE		26320211
117	Succinylation	YQVAALPKGSRIEIE HHHEECCCCCCEEEE		27452117
133	Phosphorylation	VAIQGPLTTASL--- EEEECCCCCCCC---		20068231
134	Phosphorylation	AIQGPLTTASL---- EEECCCCCCCC----		28258704
136	Phosphorylation	QGPLTTASL------ ECCCCCCCC------		28258704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MINT_HUMAN	SPEN	physical	21988832
MDM2_HUMAN	MDM2	physical	21988832
IPSP_HUMAN	SERPINA5	physical	21988832
T176A_HUMAN	TMEM176A	physical	21988832
RIDA_HUMAN	HRSP12	physical	25416956
BROX_HUMAN	BROX	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
ACOX1_HUMAN	ACOX1	physical	28514442
CARM1_HUMAN	CARM1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
OGA_HUMAN	MGEA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.