OGA_HUMAN - dbPTM
OGA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OGA_HUMAN
UniProt AC O60502
Protein Name Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610}
Gene Name MGEA5
Organism Homo sapiens (Human).
Sequence Length 916
Subcellular Localization Isoform 3: Nucleus .
Isoform 1: Cytoplasm .
Protein Description Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). [PubMed: 11148210 Does not bind acetyl-CoA and does not have histone acetyltransferase activity]
Protein Sequence MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
4Ubiquitination----MVQKESQATLE
----CCCHHHHHHHH
24816145
6Phosphorylation--MVQKESQATLEER
--CCCHHHHHHHHHH
21815630
9PhosphorylationVQKESQATLEERESE
CCHHHHHHHHHHHHH
22210691
15PhosphorylationATLEERESELSSNPA
HHHHHHHHHHHCCCC
28555341
24PhosphorylationLSSNPAASAGASLEP
HHCCCCHHCCCCCCC
22210691
42UbiquitinationPAPGEDNPAGAGGAA
CCCCCCCCCCCCHHH
22505724
87UbiquitinationELFRRLQKWELNTYL
HHHHHHHHHCHHCCE
21890473
87 (in isoform 2)Ubiquitination-21890473
87 (in isoform 3)Ubiquitination-21890473
98UbiquitinationNTYLYAPKDDYKHRM
HCCEECCCCCHHHHC
29967540
102UbiquitinationYAPKDDYKHRMFWRE
ECCCCCHHHHCHHHH
21890473
115UbiquitinationREMYSVEEAEQLMTL
HHCCCHHHHHHHHHH
23503661
119UbiquitinationSVEEAEQLMTLISAA
CHHHHHHHHHHHHHH
27667366
125UbiquitinationQLMTLISAAREYEIE
HHHHHHHHHHHCCEE
21890473
138UbiquitinationIEFIYAISPGLDITF
EEEEEEECCCCEEEC
23503661
142UbiquitinationYAISPGLDITFSNPK
EEECCCCEEECCCHH
27667366
151UbiquitinationTFSNPKEVSTLKRKL
ECCCHHHHHHHHHHH
27667366
157UbiquitinationEVSTLKRKLDQVSQF
HHHHHHHHHHHHHHH
-
157UbiquitinationEVSTLKRKLDQVSQF
HHHHHHHHHHHHHHH
22505724
159UbiquitinationSTLKRKLDQVSQFGC
HHHHHHHHHHHHHCH
21890473
169 (in isoform 1)Ubiquitination-21890473
174UbiquitinationRSFALLFDDIDHNMC
HHHHHHCCCCCCCCC
27667366
182UbiquitinationDIDHNMCAADKEVFS
CCCCCCCCCCHHHHH
21890473
240UbiquitinationYLRTVGEKLLPGIEV
CHHCHHCCCCCCCEE
-
240UbiquitinationYLRTVGEKLLPGIEV
CHHCHHCCCCCCCEE
21906983
240 (in isoform 2)Ubiquitination-21890473
240 (in isoform 3)Ubiquitination-21890473
253UbiquitinationEVLWTGPKVVSKEIP
EEEEECCCEECCCCC
-
253UbiquitinationEVLWTGPKVVSKEIP
EEEEECCCEECCCCC
23503661
257UbiquitinationTGPKVVSKEIPVESI
ECCCEECCCCCCCCH
-
257UbiquitinationTGPKVVSKEIPVESI
ECCCEECCCCCCCCH
21906983
257 (in isoform 2)Ubiquitination--
257 (in isoform 3)Ubiquitination-21890473
263PhosphorylationSKEIPVESIEEVSKI
CCCCCCCCHHHHHHH
21406692
268PhosphorylationVESIEEVSKIIKRAP
CCCHHHHHHHHHHCC
21406692
269UbiquitinationESIEEVSKIIKRAPV
CCHHHHHHHHHHCCC
-
269UbiquitinationESIEEVSKIIKRAPV
CCHHHHHHHHHHCCC
29967540
272UbiquitinationEEVSKIIKRAPVIWD
HHHHHHHHHCCCCCC
29967540
289UbiquitinationHANDYDQKRLFLGPY
CCCCCCCCCEECCCC
-
289UbiquitinationHANDYDQKRLFLGPY
CCCCCCCCCEECCCC
27667366
289 (in isoform 2)Ubiquitination--
296PhosphorylationKRLFLGPYKGRSTEL
CCEECCCCCCCCCCH
23532336
297UbiquitinationRLFLGPYKGRSTELI
CEECCCCCCCCCCHH
-
297UbiquitinationRLFLGPYKGRSTELI
CEECCCCCCCCCCHH
21906983
297 (in isoform 2)Ubiquitination-21890473
297 (in isoform 3)Ubiquitination-21890473
300PhosphorylationLGPYKGRSTELIPRL
CCCCCCCCCCHHHHH
23532336
301PhosphorylationGPYKGRSTELIPRLK
CCCCCCCCCHHHHHH
23532336
312PhosphorylationPRLKGVLTNPNCEFE
HHHHCCCCCCCCCCH
30174305
315UbiquitinationKGVLTNPNCEFEANY
HCCCCCCCCCCHHCE
23503661
319UbiquitinationTNPNCEFEANYVAIH
CCCCCCCHHCEEHHH
23503661
320UbiquitinationNPNCEFEANYVAIHT
CCCCCCHHCEEHHHH
23503661
322PhosphorylationNCEFEANYVAIHTLA
CCCCHHCEEHHHHHH
30174305
322 (in isoform 1)Ubiquitination-21890473
332PhosphorylationIHTLATWYKSNMNGV
HHHHHHHHHHHCCCC
30174305
333UbiquitinationHTLATWYKSNMNGVR
HHHHHHHHHHCCCCC
23503661
334PhosphorylationTLATWYKSNMNGVRK
HHHHHHHHHCCCCCC
30174305
338UbiquitinationWYKSNMNGVRKDVVM
HHHHHCCCCCCEEEE
23503661
339 (in isoform 1)Ubiquitination-21890473
342UbiquitinationNMNGVRKDVVMTDSE
HCCCCCCEEEECCCC
23503661
343UbiquitinationMNGVRKDVVMTDSED
CCCCCCEEEECCCCC
23503661
346PhosphorylationVRKDVVMTDSEDSTV
CCCEEEECCCCCCEE
29083192
348PhosphorylationKDVVMTDSEDSTVSI
CEEEECCCCCCEEEE
23403867
351PhosphorylationVMTDSEDSTVSIQIK
EECCCCCCEEEEEEE
29083192
352PhosphorylationMTDSEDSTVSIQIKL
ECCCCCCEEEEEEEE
29083192
354PhosphorylationDSEDSTVSIQIKLEN
CCCCCEEEEEEEEEC
29083192
356UbiquitinationEDSTVSIQIKLENEG
CCCEEEEEEEEECCC
23503661
358SumoylationSTVSIQIKLENEGSD
CEEEEEEEEECCCCC
-
364PhosphorylationIKLENEGSDEDIETD
EEEECCCCCCCCCCC
19664994
370PhosphorylationGSDEDIETDVLYSPQ
CCCCCCCCCCCCCHH
30278072
374PhosphorylationDIETDVLYSPQMALK
CCCCCCCCCHHHHHH
29632367
375PhosphorylationIETDVLYSPQMALKL
CCCCCCCCHHHHHHH
23403867
378SulfoxidationDVLYSPQMALKLALT
CCCCCHHHHHHHHHH
30846556
379 (in isoform 1)Ubiquitination-21890473
398O-linked_GlycosylationFGVPHQYSSRQVAHS
HCCCCCCCCCCCCCC
16434389
399O-linked_GlycosylationGVPHQYSSRQVAHSG
CCCCCCCCCCCCCCC
16434389
400UbiquitinationVPHQYSSRQVAHSGA
CCCCCCCCCCCCCCC
23503661
404UbiquitinationYSSRQVAHSGAKASV
CCCCCCCCCCCCEEE
23503661
405UbiquitinationSSRQVAHSGAKASVV
CCCCCCCCCCCEEEE
-
405O-linked_GlycosylationSSRQVAHSGAKASVV
CCCCCCCCCCCEEEE
16434389
405UbiquitinationSSRQVAHSGAKASVV
CCCCCCCCCCCEEEE
23503661
405 (in isoform 2)Ubiquitination--
410O-linked_GlycosylationAHSGAKASVVDGTPL
CCCCCCEEEECCCCC
16434389
415O-linked_GlycosylationKASVVDGTPLVAAPS
CEEEECCCCCEECCC
16434389
418UbiquitinationVVDGTPLVAAPSLNA
EECCCCCEECCCCCC
-
418UbiquitinationVVDGTPLVAAPSLNA
EECCCCCEECCCCCC
23503661
418 (in isoform 2)Ubiquitination--
453UbiquitinationGEPTTLTKEEEKKQP
CCCCCCCHHHHHCCC
23503661
457UbiquitinationTLTKEEEKKQPDEEP
CCCHHHHHCCCCCCC
23503661
458PhosphorylationLTKEEEKKQPDEEPM
CCHHHHHCCCCCCCC
32142685
458UbiquitinationLTKEEEKKQPDEEPM
CCHHHHHCCCCCCCC
23503661
459UbiquitinationTKEEEKKQPDEEPMD
CHHHHHCCCCCCCCC
27667366
471UbiquitinationPMDMVVEKQEETDHK
CCCCCEEEHHHCCCC
23503661
482UbiquitinationTDHKNDNQILSEIVE
CCCCCHHHHHHHHHH
27667366
501PhosphorylationEELKPMDTDKESIAE
HHHCCCCCCHHHHHH
29255136
505PhosphorylationPMDTDKESIAESKSP
CCCCCHHHHHHCCCC
29255136
509PhosphorylationDKESIAESKSPEMSM
CHHHHHHCCCCCHHC
29255136
511PhosphorylationESIAESKSPEMSMQE
HHHHHCCCCCHHCCC
25159151
515PhosphorylationESKSPEMSMQEDCIS
HCCCCCHHCCCCHHH
25849741
522PhosphorylationSMQEDCISDIAPMQT
HCCCCHHHHCCCCCC
26074081
529PhosphorylationSDIAPMQTDEQTNKE
HHCCCCCCCCCCCHH
26074081
533PhosphorylationPMQTDEQTNKEQFVP
CCCCCCCCCHHHCCC
26074081
544UbiquitinationQFVPGPNEKPLYTAE
HCCCCCCCCCCEECC
-
544UbiquitinationQFVPGPNEKPLYTAE
HCCCCCCCCCCEECC
32015554
546UbiquitinationVPGPNEKPLYTAEPV
CCCCCCCCCEECCCC
-
560UbiquitinationVTLEDLQLLADLFYL
CCHHHHHHHHHHHCC
-
585UbiquitinationMLREFQWLRANSSVV
HHHHHHHHHCCCCEE
21890473
592UbiquitinationLRANSSVVSVNCKGK
HHCCCCEEEEECCCC
23000965
597UbiquitinationSVVSVNCKGKDSEKI
CEEEEECCCCCHHHH
32015554
599UbiquitinationVSVNCKGKDSEKIEE
EEEECCCCCHHHHHH
-
608UbiquitinationSEKIEEWRSRAAKFE
HHHHHHHHHHHHHHH
21890473
613UbiquitinationEWRSRAAKFEEMCGL
HHHHHHHHHHHHHHH
-
615UbiquitinationRSRAAKFEEMCGLVM
HHHHHHHHHHHHHHH
23000965
656 (in isoform 2)Ubiquitination-21890473
660UbiquitinationMVKSFVQWLGCRSHS
HHHHHHHHHCCCCCC
-
665PhosphorylationVQWLGCRSHSSAQFL
HHHHCCCCCCCCEEE
27080861
667PhosphorylationWLGCRSHSSAQFLIG
HHCCCCCCCCEEEEC
27080861
668PhosphorylationLGCRSHSSAQFLIGD
HCCCCCCCCEEEECC
27080861
670UbiquitinationCRSHSSAQFLIGDQE
CCCCCCCEEEECCCC
-
670UbiquitinationCRSHSSAQFLIGDQE
CCCCCCCEEEECCCC
23000965
677UbiquitinationQFLIGDQEPWAFRGG
EEEECCCCCCCCCCC
-
677UbiquitinationQFLIGDQEPWAFRGG
EEEECCCCCCCCCCC
23000965
709PhosphorylationFFQPPPLTPTSKVYT
CCCCCCCCCCCCEEE
28176443
711PhosphorylationQPPPLTPTSKVYTIR
CCCCCCCCCCEEEEC
22199227
712PhosphorylationPPPLTPTSKVYTIRP
CCCCCCCCCEEEECC
22199227
713UbiquitinationPPLTPTSKVYTIRPY
CCCCCCCCEEEECCC
-
716PhosphorylationTPTSKVYTIRPYFPK
CCCCCEEEECCCCCC
24719451
720PhosphorylationKVYTIRPYFPKDEAS
CEEEECCCCCCCHHH
20068231
720UbiquitinationKVYTIRPYFPKDEAS
CEEEECCCCCCCHHH
21963094
723UbiquitinationTIRPYFPKDEASVYK
EECCCCCCCHHHHHH
23000965
730UbiquitinationKDEASVYKICREMYD
CCHHHHHHHHHHHHC
23000965
731UbiquitinationDEASVYKICREMYDD
CHHHHHHHHHHHHCC
21963094
741UbiquitinationEMYDDGVGLPFQSQP
HHHCCCCCCCCCCCC
-
743UbiquitinationYDDGVGLPFQSQPDL
HCCCCCCCCCCCCCH
21963094
754UbiquitinationQPDLIGDKLVGGLLS
CCCHHCCCHHHHHHH
-
754UbiquitinationQPDLIGDKLVGGLLS
CCCHHCCCHHHHHHH
21963094
755UbiquitinationPDLIGDKLVGGLLSL
CCHHCCCHHHHHHHC
21963094
778UbiquitinationEDEDGICGYALGTVD
ECCCCCCCEEEEECC
21963094
794UbiquitinationTPFIKKCKISWIPFM
HHHHHHCCEEECHHC
-
797UbiquitinationIKKCKISWIPFMQEK
HHHCCEEECHHCCCC
29967540
805UbiquitinationIPFMQEKYTKPNGDK
CHHCCCCCCCCCCCH
-
805PhosphorylationIPFMQEKYTKPNGDK
CHHCCCCCCCCCCCH
27642862
805UbiquitinationIPFMQEKYTKPNGDK
CHHCCCCCCCCCCCH
21963094
805 (in isoform 1)Ubiquitination-21890473
807UbiquitinationFMQEKYTKPNGDKEL
HCCCCCCCCCCCHHH
-
816UbiquitinationNGDKELSEAEKIMLS
CCCHHHHHHHHHHHH
-
816UbiquitinationNGDKELSEAEKIMLS
CCCHHHHHHHHHHHH
21963094
832UbiquitinationHEEQEVLPETFLANF
HHHHHCCCHHHHHHC
-
832UbiquitinationHEEQEVLPETFLANF
HHHHHCCCHHHHHHC
29967540
840UbiquitinationETFLANFPSLIKMDI
HHHHHHCHHHHCCCC
-
840UbiquitinationETFLANFPSLIKMDI
HHHHHHCHHHHCCCC
21963094
841PhosphorylationTFLANFPSLIKMDIH
HHHHHCHHHHCCCCC
24719451
848UbiquitinationSLIKMDIHKKVTDPS
HHHCCCCCCCCCCHH
-
848UbiquitinationSLIKMDIHKKVTDPS
HHHCCCCCCCCCCHH
29967540
850UbiquitinationIKMDIHKKVTDPSVA
HCCCCCCCCCCHHHH
29967540
854UbiquitinationIHKKVTDPSVAKSMM
CCCCCCCHHHHHHHH
29967540
855PhosphorylationHKKVTDPSVAKSMMA
CCCCCCHHHHHHHHH
28122231
858UbiquitinationVTDPSVAKSMMACLL
CCCHHHHHHHHHHHH
21963094
859PhosphorylationTDPSVAKSMMACLLS
CCHHHHHHHHHHHHH
20068231
866PhosphorylationSMMACLLSSLKANGS
HHHHHHHHHHHHCCC
24719451
867PhosphorylationMMACLLSSLKANGSR
HHHHHHHHHHHCCCC
20068231
869UbiquitinationACLLSSLKANGSRGA
HHHHHHHHHCCCCCC
21963094
873PhosphorylationSSLKANGSRGAFCEV
HHHHHCCCCCCCEEE
20068231
885UbiquitinationCEVRPDDKRILEFYS
EEECCCCHHHHHHHH
29967540
893UbiquitinationRILEFYSKLGCFEIA
HHHHHHHHHCCHHHH
21963094
896S-nitrosocysteineEFYSKLGCFEIAKME
HHHHHHCCHHHHHCC
-
901UbiquitinationLGCFEIAKMEGFPKD
HCCHHHHHCCCCCCC
29967540
907UbiquitinationAKMEGFPKDVVILGR
HHCCCCCCCEEEEEC
29967540
915PhosphorylationDVVILGRSL------
CEEEEECCC------
22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OGA_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OGA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OGA_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OGT1_HUMANOGTphysical
16505006
SIN3A_HUMANSIN3Aphysical
16505006
CDC37_HUMANCDC37physical
22863883
FKBP4_HUMANFKBP4physical
22863883
FKBP5_HUMANFKBP5physical
22863883
HS90A_HUMANHSP90AA1physical
22863883
MAGD2_HUMANMAGED2physical
22863883
MCM3_HUMANMCM3physical
22863883
TPM3_HUMANTPM3physical
22863883
CDC37_HUMANCDC37physical
26344197
PITH1_HUMANPITHD1physical
26344197

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OGA_HUMAN

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Related Literatures of Post-Translational Modification

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