UniProt ID | OGA_HUMAN | |
---|---|---|
UniProt AC | O60502 | |
Protein Name | Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610} | |
Gene Name | MGEA5 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 916 | |
Subcellular Localization |
Isoform 3: Nucleus . Isoform 1: Cytoplasm . |
|
Protein Description | Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). [PubMed: 11148210 Does not bind acetyl-CoA and does not have histone acetyltransferase activity] | |
Protein Sequence | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
4 | Ubiquitination | ----MVQKESQATLE ----CCCHHHHHHHH | 24816145 | ||
6 | Phosphorylation | --MVQKESQATLEER --CCCHHHHHHHHHH | 21815630 | ||
9 | Phosphorylation | VQKESQATLEERESE CCHHHHHHHHHHHHH | 22210691 | ||
15 | Phosphorylation | ATLEERESELSSNPA HHHHHHHHHHHCCCC | 28555341 | ||
24 | Phosphorylation | LSSNPAASAGASLEP HHCCCCHHCCCCCCC | 22210691 | ||
42 | Ubiquitination | PAPGEDNPAGAGGAA CCCCCCCCCCCCHHH | 22505724 | ||
87 | Ubiquitination | ELFRRLQKWELNTYL HHHHHHHHHCHHCCE | 21890473 | ||
87 (in isoform 2) | Ubiquitination | - | 21890473 | ||
87 (in isoform 3) | Ubiquitination | - | 21890473 | ||
98 | Ubiquitination | NTYLYAPKDDYKHRM HCCEECCCCCHHHHC | 29967540 | ||
102 | Ubiquitination | YAPKDDYKHRMFWRE ECCCCCHHHHCHHHH | 21890473 | ||
115 | Ubiquitination | REMYSVEEAEQLMTL HHCCCHHHHHHHHHH | 23503661 | ||
119 | Ubiquitination | SVEEAEQLMTLISAA CHHHHHHHHHHHHHH | 27667366 | ||
125 | Ubiquitination | QLMTLISAAREYEIE HHHHHHHHHHHCCEE | 21890473 | ||
138 | Ubiquitination | IEFIYAISPGLDITF EEEEEEECCCCEEEC | 23503661 | ||
142 | Ubiquitination | YAISPGLDITFSNPK EEECCCCEEECCCHH | 27667366 | ||
151 | Ubiquitination | TFSNPKEVSTLKRKL ECCCHHHHHHHHHHH | 27667366 | ||
157 | Ubiquitination | EVSTLKRKLDQVSQF HHHHHHHHHHHHHHH | - | ||
157 | Ubiquitination | EVSTLKRKLDQVSQF HHHHHHHHHHHHHHH | 22505724 | ||
159 | Ubiquitination | STLKRKLDQVSQFGC HHHHHHHHHHHHHCH | 21890473 | ||
169 (in isoform 1) | Ubiquitination | - | 21890473 | ||
174 | Ubiquitination | RSFALLFDDIDHNMC HHHHHHCCCCCCCCC | 27667366 | ||
182 | Ubiquitination | DIDHNMCAADKEVFS CCCCCCCCCCHHHHH | 21890473 | ||
240 | Ubiquitination | YLRTVGEKLLPGIEV CHHCHHCCCCCCCEE | - | ||
240 | Ubiquitination | YLRTVGEKLLPGIEV CHHCHHCCCCCCCEE | 21906983 | ||
240 (in isoform 2) | Ubiquitination | - | 21890473 | ||
240 (in isoform 3) | Ubiquitination | - | 21890473 | ||
253 | Ubiquitination | EVLWTGPKVVSKEIP EEEEECCCEECCCCC | - | ||
253 | Ubiquitination | EVLWTGPKVVSKEIP EEEEECCCEECCCCC | 23503661 | ||
257 | Ubiquitination | TGPKVVSKEIPVESI ECCCEECCCCCCCCH | - | ||
257 | Ubiquitination | TGPKVVSKEIPVESI ECCCEECCCCCCCCH | 21906983 | ||
257 (in isoform 2) | Ubiquitination | - | - | ||
257 (in isoform 3) | Ubiquitination | - | 21890473 | ||
263 | Phosphorylation | SKEIPVESIEEVSKI CCCCCCCCHHHHHHH | 21406692 | ||
268 | Phosphorylation | VESIEEVSKIIKRAP CCCHHHHHHHHHHCC | 21406692 | ||
269 | Ubiquitination | ESIEEVSKIIKRAPV CCHHHHHHHHHHCCC | - | ||
269 | Ubiquitination | ESIEEVSKIIKRAPV CCHHHHHHHHHHCCC | 29967540 | ||
272 | Ubiquitination | EEVSKIIKRAPVIWD HHHHHHHHHCCCCCC | 29967540 | ||
289 | Ubiquitination | HANDYDQKRLFLGPY CCCCCCCCCEECCCC | - | ||
289 | Ubiquitination | HANDYDQKRLFLGPY CCCCCCCCCEECCCC | 27667366 | ||
289 (in isoform 2) | Ubiquitination | - | - | ||
296 | Phosphorylation | KRLFLGPYKGRSTEL CCEECCCCCCCCCCH | 23532336 | ||
297 | Ubiquitination | RLFLGPYKGRSTELI CEECCCCCCCCCCHH | - | ||
297 | Ubiquitination | RLFLGPYKGRSTELI CEECCCCCCCCCCHH | 21906983 | ||
297 (in isoform 2) | Ubiquitination | - | 21890473 | ||
297 (in isoform 3) | Ubiquitination | - | 21890473 | ||
300 | Phosphorylation | LGPYKGRSTELIPRL CCCCCCCCCCHHHHH | 23532336 | ||
301 | Phosphorylation | GPYKGRSTELIPRLK CCCCCCCCCHHHHHH | 23532336 | ||
312 | Phosphorylation | PRLKGVLTNPNCEFE HHHHCCCCCCCCCCH | 30174305 | ||
315 | Ubiquitination | KGVLTNPNCEFEANY HCCCCCCCCCCHHCE | 23503661 | ||
319 | Ubiquitination | TNPNCEFEANYVAIH CCCCCCCHHCEEHHH | 23503661 | ||
320 | Ubiquitination | NPNCEFEANYVAIHT CCCCCCHHCEEHHHH | 23503661 | ||
322 | Phosphorylation | NCEFEANYVAIHTLA CCCCHHCEEHHHHHH | 30174305 | ||
322 (in isoform 1) | Ubiquitination | - | 21890473 | ||
332 | Phosphorylation | IHTLATWYKSNMNGV HHHHHHHHHHHCCCC | 30174305 | ||
333 | Ubiquitination | HTLATWYKSNMNGVR HHHHHHHHHHCCCCC | 23503661 | ||
334 | Phosphorylation | TLATWYKSNMNGVRK HHHHHHHHHCCCCCC | 30174305 | ||
338 | Ubiquitination | WYKSNMNGVRKDVVM HHHHHCCCCCCEEEE | 23503661 | ||
339 (in isoform 1) | Ubiquitination | - | 21890473 | ||
342 | Ubiquitination | NMNGVRKDVVMTDSE HCCCCCCEEEECCCC | 23503661 | ||
343 | Ubiquitination | MNGVRKDVVMTDSED CCCCCCEEEECCCCC | 23503661 | ||
346 | Phosphorylation | VRKDVVMTDSEDSTV CCCEEEECCCCCCEE | 29083192 | ||
348 | Phosphorylation | KDVVMTDSEDSTVSI CEEEECCCCCCEEEE | 23403867 | ||
351 | Phosphorylation | VMTDSEDSTVSIQIK EECCCCCCEEEEEEE | 29083192 | ||
352 | Phosphorylation | MTDSEDSTVSIQIKL ECCCCCCEEEEEEEE | 29083192 | ||
354 | Phosphorylation | DSEDSTVSIQIKLEN CCCCCEEEEEEEEEC | 29083192 | ||
356 | Ubiquitination | EDSTVSIQIKLENEG CCCEEEEEEEEECCC | 23503661 | ||
358 | Sumoylation | STVSIQIKLENEGSD CEEEEEEEEECCCCC | - | ||
364 | Phosphorylation | IKLENEGSDEDIETD EEEECCCCCCCCCCC | 19664994 | ||
370 | Phosphorylation | GSDEDIETDVLYSPQ CCCCCCCCCCCCCHH | 30278072 | ||
374 | Phosphorylation | DIETDVLYSPQMALK CCCCCCCCCHHHHHH | 29632367 | ||
375 | Phosphorylation | IETDVLYSPQMALKL CCCCCCCCHHHHHHH | 23403867 | ||
378 | Sulfoxidation | DVLYSPQMALKLALT CCCCCHHHHHHHHHH | 30846556 | ||
379 (in isoform 1) | Ubiquitination | - | 21890473 | ||
398 | O-linked_Glycosylation | FGVPHQYSSRQVAHS HCCCCCCCCCCCCCC | 16434389 | ||
399 | O-linked_Glycosylation | GVPHQYSSRQVAHSG CCCCCCCCCCCCCCC | 16434389 | ||
400 | Ubiquitination | VPHQYSSRQVAHSGA CCCCCCCCCCCCCCC | 23503661 | ||
404 | Ubiquitination | YSSRQVAHSGAKASV CCCCCCCCCCCCEEE | 23503661 | ||
405 | Ubiquitination | SSRQVAHSGAKASVV CCCCCCCCCCCEEEE | - | ||
405 | O-linked_Glycosylation | SSRQVAHSGAKASVV CCCCCCCCCCCEEEE | 16434389 | ||
405 | Ubiquitination | SSRQVAHSGAKASVV CCCCCCCCCCCEEEE | 23503661 | ||
405 (in isoform 2) | Ubiquitination | - | - | ||
410 | O-linked_Glycosylation | AHSGAKASVVDGTPL CCCCCCEEEECCCCC | 16434389 | ||
415 | O-linked_Glycosylation | KASVVDGTPLVAAPS CEEEECCCCCEECCC | 16434389 | ||
418 | Ubiquitination | VVDGTPLVAAPSLNA EECCCCCEECCCCCC | - | ||
418 | Ubiquitination | VVDGTPLVAAPSLNA EECCCCCEECCCCCC | 23503661 | ||
418 (in isoform 2) | Ubiquitination | - | - | ||
453 | Ubiquitination | GEPTTLTKEEEKKQP CCCCCCCHHHHHCCC | 23503661 | ||
457 | Ubiquitination | TLTKEEEKKQPDEEP CCCHHHHHCCCCCCC | 23503661 | ||
458 | Phosphorylation | LTKEEEKKQPDEEPM CCHHHHHCCCCCCCC | 32142685 | ||
458 | Ubiquitination | LTKEEEKKQPDEEPM CCHHHHHCCCCCCCC | 23503661 | ||
459 | Ubiquitination | TKEEEKKQPDEEPMD CHHHHHCCCCCCCCC | 27667366 | ||
471 | Ubiquitination | PMDMVVEKQEETDHK CCCCCEEEHHHCCCC | 23503661 | ||
482 | Ubiquitination | TDHKNDNQILSEIVE CCCCCHHHHHHHHHH | 27667366 | ||
501 | Phosphorylation | EELKPMDTDKESIAE HHHCCCCCCHHHHHH | 29255136 | ||
505 | Phosphorylation | PMDTDKESIAESKSP CCCCCHHHHHHCCCC | 29255136 | ||
509 | Phosphorylation | DKESIAESKSPEMSM CHHHHHHCCCCCHHC | 29255136 | ||
511 | Phosphorylation | ESIAESKSPEMSMQE HHHHHCCCCCHHCCC | 25159151 | ||
515 | Phosphorylation | ESKSPEMSMQEDCIS HCCCCCHHCCCCHHH | 25849741 | ||
522 | Phosphorylation | SMQEDCISDIAPMQT HCCCCHHHHCCCCCC | 26074081 | ||
529 | Phosphorylation | SDIAPMQTDEQTNKE HHCCCCCCCCCCCHH | 26074081 | ||
533 | Phosphorylation | PMQTDEQTNKEQFVP CCCCCCCCCHHHCCC | 26074081 | ||
544 | Ubiquitination | QFVPGPNEKPLYTAE HCCCCCCCCCCEECC | - | ||
544 | Ubiquitination | QFVPGPNEKPLYTAE HCCCCCCCCCCEECC | 32015554 | ||
546 | Ubiquitination | VPGPNEKPLYTAEPV CCCCCCCCCEECCCC | - | ||
560 | Ubiquitination | VTLEDLQLLADLFYL CCHHHHHHHHHHHCC | - | ||
585 | Ubiquitination | MLREFQWLRANSSVV HHHHHHHHHCCCCEE | 21890473 | ||
592 | Ubiquitination | LRANSSVVSVNCKGK HHCCCCEEEEECCCC | 23000965 | ||
597 | Ubiquitination | SVVSVNCKGKDSEKI CEEEEECCCCCHHHH | 32015554 | ||
599 | Ubiquitination | VSVNCKGKDSEKIEE EEEECCCCCHHHHHH | - | ||
608 | Ubiquitination | SEKIEEWRSRAAKFE HHHHHHHHHHHHHHH | 21890473 | ||
613 | Ubiquitination | EWRSRAAKFEEMCGL HHHHHHHHHHHHHHH | - | ||
615 | Ubiquitination | RSRAAKFEEMCGLVM HHHHHHHHHHHHHHH | 23000965 | ||
656 (in isoform 2) | Ubiquitination | - | 21890473 | ||
660 | Ubiquitination | MVKSFVQWLGCRSHS HHHHHHHHHCCCCCC | - | ||
665 | Phosphorylation | VQWLGCRSHSSAQFL HHHHCCCCCCCCEEE | 27080861 | ||
667 | Phosphorylation | WLGCRSHSSAQFLIG HHCCCCCCCCEEEEC | 27080861 | ||
668 | Phosphorylation | LGCRSHSSAQFLIGD HCCCCCCCCEEEECC | 27080861 | ||
670 | Ubiquitination | CRSHSSAQFLIGDQE CCCCCCCEEEECCCC | - | ||
670 | Ubiquitination | CRSHSSAQFLIGDQE CCCCCCCEEEECCCC | 23000965 | ||
677 | Ubiquitination | QFLIGDQEPWAFRGG EEEECCCCCCCCCCC | - | ||
677 | Ubiquitination | QFLIGDQEPWAFRGG EEEECCCCCCCCCCC | 23000965 | ||
709 | Phosphorylation | FFQPPPLTPTSKVYT CCCCCCCCCCCCEEE | 28176443 | ||
711 | Phosphorylation | QPPPLTPTSKVYTIR CCCCCCCCCCEEEEC | 22199227 | ||
712 | Phosphorylation | PPPLTPTSKVYTIRP CCCCCCCCCEEEECC | 22199227 | ||
713 | Ubiquitination | PPLTPTSKVYTIRPY CCCCCCCCEEEECCC | - | ||
716 | Phosphorylation | TPTSKVYTIRPYFPK CCCCCEEEECCCCCC | 24719451 | ||
720 | Phosphorylation | KVYTIRPYFPKDEAS CEEEECCCCCCCHHH | 20068231 | ||
720 | Ubiquitination | KVYTIRPYFPKDEAS CEEEECCCCCCCHHH | 21963094 | ||
723 | Ubiquitination | TIRPYFPKDEASVYK EECCCCCCCHHHHHH | 23000965 | ||
730 | Ubiquitination | KDEASVYKICREMYD CCHHHHHHHHHHHHC | 23000965 | ||
731 | Ubiquitination | DEASVYKICREMYDD CHHHHHHHHHHHHCC | 21963094 | ||
741 | Ubiquitination | EMYDDGVGLPFQSQP HHHCCCCCCCCCCCC | - | ||
743 | Ubiquitination | YDDGVGLPFQSQPDL HCCCCCCCCCCCCCH | 21963094 | ||
754 | Ubiquitination | QPDLIGDKLVGGLLS CCCHHCCCHHHHHHH | - | ||
754 | Ubiquitination | QPDLIGDKLVGGLLS CCCHHCCCHHHHHHH | 21963094 | ||
755 | Ubiquitination | PDLIGDKLVGGLLSL CCHHCCCHHHHHHHC | 21963094 | ||
778 | Ubiquitination | EDEDGICGYALGTVD ECCCCCCCEEEEECC | 21963094 | ||
794 | Ubiquitination | TPFIKKCKISWIPFM HHHHHHCCEEECHHC | - | ||
797 | Ubiquitination | IKKCKISWIPFMQEK HHHCCEEECHHCCCC | 29967540 | ||
805 | Ubiquitination | IPFMQEKYTKPNGDK CHHCCCCCCCCCCCH | - | ||
805 | Phosphorylation | IPFMQEKYTKPNGDK CHHCCCCCCCCCCCH | 27642862 | ||
805 | Ubiquitination | IPFMQEKYTKPNGDK CHHCCCCCCCCCCCH | 21963094 | ||
805 (in isoform 1) | Ubiquitination | - | 21890473 | ||
807 | Ubiquitination | FMQEKYTKPNGDKEL HCCCCCCCCCCCHHH | - | ||
816 | Ubiquitination | NGDKELSEAEKIMLS CCCHHHHHHHHHHHH | - | ||
816 | Ubiquitination | NGDKELSEAEKIMLS CCCHHHHHHHHHHHH | 21963094 | ||
832 | Ubiquitination | HEEQEVLPETFLANF HHHHHCCCHHHHHHC | - | ||
832 | Ubiquitination | HEEQEVLPETFLANF HHHHHCCCHHHHHHC | 29967540 | ||
840 | Ubiquitination | ETFLANFPSLIKMDI HHHHHHCHHHHCCCC | - | ||
840 | Ubiquitination | ETFLANFPSLIKMDI HHHHHHCHHHHCCCC | 21963094 | ||
841 | Phosphorylation | TFLANFPSLIKMDIH HHHHHCHHHHCCCCC | 24719451 | ||
848 | Ubiquitination | SLIKMDIHKKVTDPS HHHCCCCCCCCCCHH | - | ||
848 | Ubiquitination | SLIKMDIHKKVTDPS HHHCCCCCCCCCCHH | 29967540 | ||
850 | Ubiquitination | IKMDIHKKVTDPSVA HCCCCCCCCCCHHHH | 29967540 | ||
854 | Ubiquitination | IHKKVTDPSVAKSMM CCCCCCCHHHHHHHH | 29967540 | ||
855 | Phosphorylation | HKKVTDPSVAKSMMA CCCCCCHHHHHHHHH | 28122231 | ||
858 | Ubiquitination | VTDPSVAKSMMACLL CCCHHHHHHHHHHHH | 21963094 | ||
859 | Phosphorylation | TDPSVAKSMMACLLS CCHHHHHHHHHHHHH | 20068231 | ||
866 | Phosphorylation | SMMACLLSSLKANGS HHHHHHHHHHHHCCC | 24719451 | ||
867 | Phosphorylation | MMACLLSSLKANGSR HHHHHHHHHHHCCCC | 20068231 | ||
869 | Ubiquitination | ACLLSSLKANGSRGA HHHHHHHHHCCCCCC | 21963094 | ||
873 | Phosphorylation | SSLKANGSRGAFCEV HHHHHCCCCCCCEEE | 20068231 | ||
885 | Ubiquitination | CEVRPDDKRILEFYS EEECCCCHHHHHHHH | 29967540 | ||
893 | Ubiquitination | RILEFYSKLGCFEIA HHHHHHHHHCCHHHH | 21963094 | ||
896 | S-nitrosocysteine | EFYSKLGCFEIAKME HHHHHHCCHHHHHCC | - | ||
901 | Ubiquitination | LGCFEIAKMEGFPKD HCCHHHHHCCCCCCC | 29967540 | ||
907 | Ubiquitination | AKMEGFPKDVVILGR HHCCCCCCCEEEEEC | 29967540 | ||
915 | Phosphorylation | DVVILGRSL------ CEEEEECCC------ | 22199227 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OGA_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OGA_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OGA_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
OGT1_HUMAN | OGT | physical | 16505006 | |
SIN3A_HUMAN | SIN3A | physical | 16505006 | |
CDC37_HUMAN | CDC37 | physical | 22863883 | |
FKBP4_HUMAN | FKBP4 | physical | 22863883 | |
FKBP5_HUMAN | FKBP5 | physical | 22863883 | |
HS90A_HUMAN | HSP90AA1 | physical | 22863883 | |
MAGD2_HUMAN | MAGED2 | physical | 22863883 | |
MCM3_HUMAN | MCM3 | physical | 22863883 | |
TPM3_HUMAN | TPM3 | physical | 22863883 | |
CDC37_HUMAN | CDC37 | physical | 26344197 | |
PITH1_HUMAN | PITHD1 | physical | 26344197 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...