PITH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PITH1_HUMAN
• UniProt AC: Q9GZP4
• Protein Name: PITH domain-containing protein 1
• Gene Name: PITHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Protein Sequence: MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHGHSHGG ------CCCCCCCCC	37.87	-
6	Phosphorylation	--MSHGHSHGGGGCR --CCCCCCCCCCCCC	28.55	-
52	Methylation	ESREGSGRGVFKPWE CCCCCCCCCCCCCHH	39.54	115487587
56	Ubiquitination	GSGRGVFKPWEERTD CCCCCCCCCHHHCCC	46.98	-
65 (in isoform 2)	Ubiquitination	-	33.00	21890473
66 (in isoform 1)	Ubiquitination	-	55.08	21890473
66	Ubiquitination	EERTDRSKFVESDAD HHCCCHHHCCCCCCC	55.08	21906983
87	Ubiquitination	IPFTGNVKLKGIIIM CCCCCCEEEEEEEEE	48.78	-
89	Acetylation	FTGNVKLKGIIIMGE CCCCEEEEEEEEECC	42.20	26051181
89	Ubiquitination	FTGNVKLKGIIIMGE CCCCEEEEEEEEECC	42.20	-
108 (in isoform 2)	Ubiquitination	-	7.51	21890473
109 (in isoform 1)	Ubiquitination	-	53.65	21890473
109	Ubiquitination	PSEMRLYKNIPQMSF HHHHHHHHCCCCCCC	53.65	21906983
141 (in isoform 2)	Ubiquitination	-	28.19	21890473
142	Ubiquitination	GELEYATKISRFSNV CCHHHHHEEECCCCE	30.43	21890473
142 (in isoform 1)	Ubiquitination	-	30.43	21890473
150	Phosphorylation	ISRFSNVYHLSIHIS EECCCCEEEEEEEEE	10.99	-
169	Phosphorylation	ADTTKVFYIGLRGEW CCCEEEEEEEECCCC	9.32	-
185	Phosphorylation	ELRRHEVTICNYEAS ECEEEEEEEECCCHH	19.48	21945579
189	Phosphorylation	HEVTICNYEASANPA EEEEEECCCHHCCCC	14.41	21945579
192	Phosphorylation	TICNYEASANPADHR EEECCCHHCCCCCCC	19.35	21945579
192	O-linked_Glycosylation	TICNYEASANPADHR EEECCCHHCCCCCCC	19.35	OGP
204	Phosphorylation	DHRVHQVTPQTHFIS CCCCEECCCCCCCCC	11.78	26462736
204	O-linked_Glycosylation	DHRVHQVTPQTHFIS CCCCEECCCCCCCCC	11.78	54901545
207	Phosphorylation	VHQVTPQTHFIS--- CEECCCCCCCCC---	21.69	20068231
207	O-linked_Glycosylation	VHQVTPQTHFIS--- CEECCCCCCCCC---	21.69	55828789
211	Phosphorylation	TPQTHFIS------- CCCCCCCC-------	32.97	25159151
211	O-linked_Glycosylation	TPQTHFIS------- CCCCCCCC-------	32.97	72257159

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PITH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PITH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PITH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC73_HUMAN	CDC73	physical	16169070
CETN2_HUMAN	CETN2	physical	26344197
SLK_HUMAN	SLK	physical	26344197
1433B_HUMAN	YWHAB	physical	26344197
WDR59_HUMAN	WDR59	physical	28514442
DPYL1_HUMAN	CRMP1	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
RPR1A_HUMAN	RPRD1A	physical	28514442
RECQ5_HUMAN	RECQL5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-189, AND MASSSPECTROMETRY.
PubMed: 15592455