RPR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPR1A_HUMAN
• UniProt AC: Q96P16
• Protein Name: Regulation of nuclear pre-mRNA domain-containing protein 1A
• Gene Name: RPRD1A
• Organism: Homo sapiens (Human).
• Sequence Length: 312
• Protein Description: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle..
• Protein Sequence: MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLKQALYGDKKPRKRTYEQIKVDENENCSSLGSPSEPPQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVRKELRSRIQSLPDLSRLPNVTGSHMHLPFAGDIYSED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAFSEAAL ------CCHHHHHHH	37.71	19413330
2	Acetylation	------MSAFSEAAL ------CCHHHHHHH	37.71	19413330
5	Phosphorylation	---MSAFSEAALEKK ---CCHHHHHHHHHH	26.49	28509920
12	Sumoylation	SEAALEKKLSELSNS HHHHHHHHHHHHCCC	48.12	-
12	Sumoylation	SEAALEKKLSELSNS HHHHHHHHHHHHCCC	48.12	-
12	Ubiquitination	SEAALEKKLSELSNS HHHHHHHHHHHHCCC	48.12	-
14	Phosphorylation	AALEKKLSELSNSQQ HHHHHHHHHHCCCHH	45.42	29759185
17	Phosphorylation	EKKLSELSNSQQSVQ HHHHHHHCCCHHHHH	30.31	29759185
19	Phosphorylation	KLSELSNSQQSVQTL HHHHHCCCHHHHHHH	26.65	29759185
25	Phosphorylation	NSQQSVQTLSLWLIH CCHHHHHHHHHHHHH	19.03	29759185
27	Phosphorylation	QQSVQTLSLWLIHHR HHHHHHHHHHHHHCC	22.38	29759185
37	Phosphorylation	LIHHRKHSRPIVTVW HHHCCCCCCCCEEHH	42.67	-
52	Acetylation	ERELRKAKPNRKLTF HHHHHHCCCCCCEEE	45.95	30591095
56	Ubiquitination	RKAKPNRKLTFLYLA HHCCCCCCEEEEHHH	59.52	-
56	Acetylation	RKAKPNRKLTFLYLA HHCCCCCCEEEEHHH	59.52	30591101
71	Ubiquitination	NDVIQNSKRKGPEFT HHHHHHCHHCCCCCC	66.72	-
79	Ubiquitination	RKGPEFTKDFAPVIV HCCCCCCCCCHHHHH	57.05	-
90	Ubiquitination	PVIVEAFKHVSSETD HHHHHHHHHCCCCCC	50.58	-
109	Phosphorylation	KHLGRVLSIWEERSV HHHHHHHHHHHHCCH	23.85	28857561
114	Methylation	VLSIWEERSVYENDV HHHHHHHCCHHCHHH	21.65	115486127
126	Ubiquitination	NDVLEQLKQALYGDK HHHHHHHHHHHHCCC	32.97	-
139	Phosphorylation	DKKPRKRTYEQIKVD CCCCCCCCCCCCCCC	34.15	27966365
140	Phosphorylation	KKPRKRTYEQIKVDE CCCCCCCCCCCCCCC	15.18	30624053
150	N-linked_Glycosylation	IKVDENENCSSLGSP CCCCCCCCCCCCCCC	42.42	12470661
150	N-linked_Glycosylation	IKVDENENCSSLGSP CCCCCCCCCCCCCCC	42.42	-
152	Phosphorylation	VDENENCSSLGSPSE CCCCCCCCCCCCCCC	39.93	30266825
153	Phosphorylation	DENENCSSLGSPSEP CCCCCCCCCCCCCCC	38.66	30266825
156	Phosphorylation	ENCSSLGSPSEPPQT CCCCCCCCCCCCCCH	30.46	25159151
158	Phosphorylation	CSSLGSPSEPPQTLD CCCCCCCCCCCCHHH	65.51	30266825
163	Phosphorylation	SPSEPPQTLDLVRAL CCCCCCCHHHHHHHH	28.19	30266825
189	Phosphorylation	AVHQRIASLPVEVQE HHHHHHHCCCCEEEE	30.73	-
198	Phosphorylation	PVEVQEVSLLDKITD CCEEEEEHHHHHHCC	23.59	-
202	Ubiquitination	QEVSLLDKITDKESG EEEHHHHHHCCCCCC	47.69	-
204	Phosphorylation	VSLLDKITDKESGER EHHHHHHCCCCCCHH	46.92	-
285	Phosphorylation	ELRSRIQSLPDLSRL HHHHHHHCCCCHHHC	39.23	25850435
290	Phosphorylation	IQSLPDLSRLPNVTG HHCCCCHHHCCCCCC	38.87	23186163
294	N-linked_Glycosylation	PDLSRLPNVTGSHMH CCHHHCCCCCCCCCC	48.88	-
294	N-linked_Glycosylation	PDLSRLPNVTGSHMH CCHHHCCCCCCCCCC	48.88	12470661
298	Phosphorylation	RLPNVTGSHMHLPFA HCCCCCCCCCCCCCC	14.31	28555341
309	Phosphorylation	LPFAGDIYSED---- CCCCCCCCCCC----	15.67	28796482
310	Phosphorylation	PFAGDIYSED----- CCCCCCCCCC-----	35.31	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPR1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPR1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433Z_HUMAN	YWHAZ	physical	21988832
KDM1A_HUMAN	KDM1A	physical	23455924
ANKY2_HUMAN	ANKMY2	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
NPL4_HUMAN	NPLOC4	physical	22863883
PLIN3_HUMAN	PLIN3	physical	22863883
DPH2_HUMAN	DPH2	physical	26344197
DXO_HUMAN	DXO	physical	26344197
MITD1_HUMAN	MITD1	physical	26344197
VP37B_HUMAN	VPS37B	physical	26344197
CAVN1_HUMAN	PTRF	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
PKN3_HUMAN	PKN3	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.