DPH2_HUMAN - dbPTM
DPH2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DPH2_HUMAN
UniProt AC Q9BQC3
Protein Name 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 {ECO:0000305}
Gene Name DPH2
Organism Homo sapiens (Human).
Sequence Length 489
Subcellular Localization
Protein Description Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2)..
Protein Sequence MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MESMFSSP
-------CCCCCCCH		8.5222814378
3Phosphorylation-----MESMFSSPAE
-----CCCCCCCHHH		24.6723186163
6Phosphorylation--MESMFSSPAEAAL
--CCCCCCCHHHHHH		27.1125159151
7Phosphorylation-MESMFSSPAEAALQ
-CCCCCCCHHHHHHH		19.5025159151
88UbiquitinationGDTAYGSCCVDVLGA
CCCCCCCHHHHHHCC		1.97-
121UbiquitinationPARPLPVAFVLRQRS
CCCCCCCCHHHCCHH		6.21-
146UbiquitinationEAQNPDPKAPVVLLS
HHCCCCCCCCEEEEC		73.10-
177UbiquitinationPRYLDLLVSSPAFPQ
HHHHHHHCCCCCCCC		7.47-
188PhosphorylationAFPQPVGSLSPEPMP
CCCCCCCCCCCCCCC		26.3829523821
190PhosphorylationPQPVGSLSPEPMPLE
CCCCCCCCCCCCCHH		28.9929523821
223UbiquitinationAFYVGGSKASPDPDL
CEEECCCCCCCCCCC		57.042190698
256UbiquitinationSCCPDTGKTQDEGAR
CCCCCCCCCCCHHHH		45.14-
289UbiquitinationRVVGLLAGTLGVAQH
HHHHHHHHHHHHHHH		22.80-
312UbiquitinationNLTQAAGKRSYVLAL
HHHHHCCCCEEEEEE		33.18-
314PhosphorylationTQAAGKRSYVLALGR
HHHCCCCEEEEEECC		24.0720068231
315PhosphorylationQAAGKRSYVLALGRP
HHCCCCEEEEEECCC		11.9620068231
323PhosphorylationVLALGRPTPAKLANF
EEEECCCCHHHHCCC		34.2220068231
424UbiquitinationLRPPPAWKSSNDHGS
CCCCCCCCCCCCCCC		46.22-
426PhosphorylationPPPAWKSSNDHGSLA
CCCCCCCCCCCCCCC		42.42-
431PhosphorylationKSSNDHGSLALTPRP
CCCCCCCCCCCCCCC		13.67-
435PhosphorylationDHGSLALTPRPQLEL
CCCCCCCCCCCHHHH		16.1925159151
445PhosphorylationPQLELAESSPAASFL
CHHHHCCCCCCHHHH		35.6920068231
446PhosphorylationQLELAESSPAASFLS
HHHHCCCCCCHHHHH		15.2925159151
450PhosphorylationAESSPAASFLSSRSW
CCCCCCHHHHHCCCC		28.9120068231
453PhosphorylationSPAASFLSSRSWQGL
CCCHHHHHCCCCCCC		22.9925690035
454PhosphorylationPAASFLSSRSWQGLE
CCHHHHHCCCCCCCC		32.2620068231
456PhosphorylationASFLSSRSWQGLEPR
HHHHHCCCCCCCCCC		26.2125159151
467PhosphorylationLEPRLGQTPVTEAVS
CCCCCCCCCCHHHHC		20.2329255136
470PhosphorylationRLGQTPVTEAVSGRR
CCCCCCCHHHHCCCC		21.3029255136
470O-linked_GlycosylationRLGQTPVTEAVSGRR
CCCCCCCHHHHCCCC		21.3030059200
474O-linked_GlycosylationTPVTEAVSGRRGIAI
CCCHHHHCCCCEEEE		33.3630059200
474PhosphorylationTPVTEAVSGRRGIAI
CCCHHHHCCCCEEEE		33.3628985074
483PhosphorylationRRGIAIAYEDEGSG-
CCEEEEEEECCCCC-		20.1423312004
488PhosphorylationIAYEDEGSG------
EEEECCCCC------		39.0030266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DPH2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DPH2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DPH2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IL17_HUMANIL17Aphysical
25416956
CDD_HUMANCDAphysical
26344197
DPH1_HUMANDPH1physical
26344197
DPYL2_HUMANDPYSL2physical
26344197
EF2_HUMANEEF2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DPH2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-435; SER-446 ANDTHR-467, AND MASS SPECTROMETRY.

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