DPH1_HUMAN - dbPTM
DPH1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DPH1_HUMAN
UniProt AC Q9BZG8
Protein Name 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 {ECO:0000305}
Gene Name DPH1
Organism Homo sapiens (Human).
Sequence Length 443
Subcellular Localization Nucleus . Cytoplasm . Punctate, primarily perinuclear localization.
Protein Description Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity)..
Protein Sequence MRRQVMAALVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVNHGQDRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationVMAALVVSGAAEQGG
HHHHHHHHCHHHHCC		18.4224043423
43 (in isoform 1)Ubiquitination-72.7121890473
43UbiquitinationQIPPEILKNPQLQAA
CCCHHHHHCHHHHHH		72.7121906983
56PhosphorylationAAIRVLPSNYNFEIP
HHHEECCCCCCCCCC		48.0318767875
58PhosphorylationIRVLPSNYNFEIPKT
HEECCCCCCCCCCHH		26.0918767875
64UbiquitinationNYNFEIPKTIWRIQQ
CCCCCCCHHHHHHHH		59.3021890473
64 (in isoform 1)Ubiquitination-59.3021890473
69UbiquitinationIPKTIWRIQQAQAKK
CCHHHHHHHHHHHHH		1.8221963094
75UbiquitinationRIQQAQAKKVALQMP
HHHHHHHHHHHHCCC		35.38-
86 (in isoform 3)Ubiquitination-5.6321890473
86UbiquitinationLQMPEGLLLFACTIV
HCCCHHHHHHHHHHH		5.6322817900
121UbiquitinationACCVDDFTARALGAD
EEEECHHHHHHHCCC		23.4127667366
121 (in isoform 3)Ubiquitination-23.4121890473
146 (in isoform 2)Ubiquitination-50.5821890473
148 (in isoform 3)Ubiquitination-3.7521890473
148UbiquitinationMDTSAQDFRVLYVFV
CCCCCCCEEEEEEEE		3.7521890473
181 (in isoform 2)Ubiquitination-3.8421890473
198UbiquitinationQAAAQELKAEYRVSV
HHHHHHHHHHHCCCC		38.1221963094
204PhosphorylationLKAEYRVSVPQCKPL
HHHHHCCCCCCCCCC		21.0523186163
208 (in isoform 2)Ubiquitination-3.9221890473
209UbiquitinationRVSVPQCKPLSPGEI
CCCCCCCCCCCCCCC		43.6921963094
212PhosphorylationVPQCKPLSPGEILGC
CCCCCCCCCCCCCCC		39.1127050516
215UbiquitinationCKPLSPGEILGCTSP
CCCCCCCCCCCCCCC		38.1222817900
220PhosphorylationPGEILGCTSPRLSKE
CCCCCCCCCCCCCCC		39.7125159151
221PhosphorylationGEILGCTSPRLSKEV
CCCCCCCCCCCCCCE		16.4625159151
226 (in isoform 1)Ubiquitination-71.0721890473
226UbiquitinationCTSPRLSKEVEAVVY
CCCCCCCCCEEEEEE		71.0722817900
243PhosphorylationDGRFHLESVMIANPN
CCCEEEEEEEECCCC		24.28-
250UbiquitinationSVMIANPNVPAYRYD
EEEECCCCCCCHHCC		52.8127667366
256PhosphorylationPNVPAYRYDPYSKVL
CCCCCHHCCCHHHHH		14.48-
261UbiquitinationYRYDPYSKVLSREHY
HHCCCHHHHHCHHHH		41.1521906983
261 (in isoform 1)Ubiquitination-41.1521890473
274UbiquitinationHYDHQRMQAARQEAI
HHHHHHHHHHHHHHH		33.7821963094
288 (in isoform 1)Ubiquitination-48.2421890473
288UbiquitinationIATARSAKSWGLILG
HHHHHHHHHHHHHHH		48.2421963094
304UbiquitinationLGRQGSPKILEHLES
CCCCCCHHHHHHHHH		62.71-
311PhosphorylationKILEHLESRLRALGL
HHHHHHHHHHHHHHH		42.87-
382UbiquitinationISWQQPYPMDFYAGS
CCCCCCCCCCEECCC		23.6621963094
393UbiquitinationYAGSSLGPWTVNHGQ
ECCCCCCCCCCCCCC		28.9421963094
414UbiquitinationPGRPARGKVQEGSAR
CCCCCCCCCCCCCCC		34.8821963094
419PhosphorylationRGKVQEGSARPPSAV
CCCCCCCCCCCCCCE		21.9827251275
424PhosphorylationEGSARPPSAVACEDC
CCCCCCCCCEEECCC		37.7525849741
432PhosphorylationAVACEDCSCRDEKVA
CEEECCCCCCCCCCC		25.2223312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DPH1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DPH1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DPH1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RBM8A_HUMANRBM8Aphysical
11013075
UBC_HUMANUBCphysical
18931663
TFCP2_HUMANTFCP2physical
25416956
EF2_HUMANEEF2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DPH1_HUMAN

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Related Literatures of Post-Translational Modification

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