CDD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDD_HUMAN
• UniProt AC: P32320
• Protein Name: Cytidine deaminase
• Gene Name: CDA
• Organism: Homo sapiens (Human).
• Sequence Length: 146
• Protein Description: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis..
• Protein Sequence: MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	KRPACTLKPECVQQL CCCCCCCCHHHHHHH	22.18	26051181
11	Ubiquitination	KRPACTLKPECVQQL CCCCCCCCHHHHHHH	22.18	29967540
28	Phosphorylation	CSQEAKKSAYCPYSH CCHHHHHHCCCCCCC	24.62	21945579
30	Phosphorylation	QEAKKSAYCPYSHFP HHHHHHCCCCCCCCC	10.88	21945579
33	Phosphorylation	KKSAYCPYSHFPVGA HHHCCCCCCCCCCCC	15.94	21945579
34	Phosphorylation	KSAYCPYSHFPVGAA HHCCCCCCCCCCCCE	12.09	21945579
44	Phosphorylation	PVGAALLTQEGRIFK CCCCEEECCCCCEEC	25.98	21945579
51	Acetylation	TQEGRIFKGCNIENA CCCCCEECCCCCCCC	61.25	26051181
51	Ubiquitination	TQEGRIFKGCNIENA CCCCCEECCCCCCCC	61.25	21963094
73	Ubiquitination	AERTAIQKAVSEGYK HHHHHHHHHHHCCCC	44.64	29967540
73	2-Hydroxyisobutyrylation	AERTAIQKAVSEGYK HHHHHHHHHHHCCCC	44.64	-
76	Phosphorylation	TAIQKAVSEGYKDFR HHHHHHHHCCCCCHH	30.11	23532336
79	Phosphorylation	QKAVSEGYKDFRAIA HHHHHCCCCCHHHHH	11.88	28152594
80	Succinylation	KAVSEGYKDFRAIAI HHHHCCCCCHHHHHH	62.34	23954790
89	Phosphorylation	FRAIAIASDMQDDFI HHHHHHHCCCCCCCC	27.74	29978859
97	Phosphorylation	DMQDDFISPCGACRQ CCCCCCCCCCHHHHH	17.71	29978859
123	Phosphorylation	YMTKPDGTYIVMTVQ EEECCCCCEEEEEHH	19.91	20068231
124	Phosphorylation	MTKPDGTYIVMTVQE EECCCCCEEEEEHHH	9.31	20068231
128	Phosphorylation	DGTYIVMTVQELLPS CCCEEEEEHHHHCCC	14.24	20068231
135	Phosphorylation	TVQELLPSSFGPEDL EHHHHCCCCCCHHHH	37.96	20068231
136	Phosphorylation	VQELLPSSFGPEDLQ HHHHCCCCCCHHHHH	32.08	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RC3H1_HUMAN	RC3H1	physical	22939629
PSA1_HUMAN	PSMA1	physical	25416956
PE2R3_HUMAN	PTGER3	physical	25416956
SDCB1_HUMAN	SDCBP	physical	25416956
ZBT24_HUMAN	ZBTB24	physical	25416956
PKHB2_HUMAN	PLEKHB2	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
FND11_HUMAN	C20orf195	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
CLIC4_HUMAN	CLIC4	physical	26344197
CPNE1_HUMAN	CPNE1	physical	26344197
CPNE3_HUMAN	CPNE3	physical	26344197
DPYL2_HUMAN	DPYSL2	physical	26344197
EVPL_HUMAN	EVPL	physical	26344197
GLGB_HUMAN	GBE1	physical	26344197
LYPA1_HUMAN	LYPLA1	physical	26344197
PFKAP_HUMAN	PFKP	physical	26344197
SH3K1_HUMAN	SH3KBP1	physical	26344197
TIM8A_HUMAN	TIMM8A	physical	26344197
TRI25_HUMAN	TRIM25	physical	26344197
TTC38_HUMAN	TTC38	physical	26344197
SYWC_HUMAN	WARS	physical	26344197
XPO1_HUMAN	XPO1	physical	26344197
MPP2_HUMAN	MPP2	physical	28514442
MTMR9_HUMAN	MTMR9	physical	28514442
MPP6_HUMAN	MPP6	physical	28514442
CDN2C_HUMAN	CDKN2C	physical	28514442
APBA3_HUMAN	APBA3	physical	28514442
LIN7A_HUMAN	LIN7A	physical	28514442
MTMR6_HUMAN	MTMR6	physical	28514442
RN181_HUMAN	RNF181	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
PYM1_HUMAN	WIBG	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00928: Azacitidine
• DB01101: Capecitabine
• DB00987: Cytarabine
• DB00441: Gemcitabine