MPP6_HUMAN - dbPTM
MPP6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPP6_HUMAN
UniProt AC Q9NZW5
Protein Name MAGUK p55 subfamily member 6
Gene Name MPP6
Organism Homo sapiens (Human).
Sequence Length 540
Subcellular Localization Membrane
Peripheral membrane protein.
Protein Description
Protein Sequence MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNNLELVNEILEDITPLINVDENVAELVGILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTITPQQVFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCGTISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISWVY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
104PhosphorylationDIVASKCYDSPPSSP
HHHHHHCCCCCCCCC		24.1629255136
106PhosphorylationVASKCYDSPPSSPEM
HHHHCCCCCCCCCCC		16.5529255136
109PhosphorylationKCYDSPPSSPEMNNS
HCCCCCCCCCCCCCC		63.0129255136
110PhosphorylationCYDSPPSSPEMNNSS
CCCCCCCCCCCCCCC		30.5629255136
116PhosphorylationSSPEMNNSSINNQLL
CCCCCCCCCCCCCCC		27.8229255136
117PhosphorylationSPEMNNSSINNQLLP
CCCCCCCCCCCCCCC		31.3029255136
136MethylationRILGIHKRAGEPLGV
HHEEEHHCCCCCEEC		33.3954429701
162SulfoxidationARILHGGMIDRQGLL
EEEECCCCCCCCCCC		3.2221406390
195UbiquitinationKELQELLKNISGSVT
HHHHHHHHHCCCCEE		65.9321890473
195UbiquitinationKELQELLKNISGSVT
HHHHHHHHHCCCCEE		65.9321890473
198PhosphorylationQELLKNISGSVTLKI
HHHHHHCCCCEEEEE		34.12-
202PhosphorylationKNISGSVTLKILPSY
HHCCCCEEEEECCCC		24.8322210691
208PhosphorylationVTLKILPSYRDTITP
EEEEECCCCCCCCCH		29.3824719451
209PhosphorylationTLKILPSYRDTITPQ
EEEECCCCCCCCCHH		15.5722210691
214PhosphorylationPSYRDTITPQQVFVK
CCCCCCCCHHHEEEE		19.6923312004
237UbiquitinationNDNLIPCKEAGLKFS
CCCEEEHHHHCCCCC		45.29-
242UbiquitinationPCKEAGLKFSKGEIL
EHHHHCCCCCCCCEE		46.83-
245UbiquitinationEAGLKFSKGEILQIV
HHCCCCCCCCEEEEE		64.79-
266UbiquitinationWWQASHVKEGGSAGL
CEECCCCCCCCCCCC		45.26-
282UbiquitinationPSQFLEEKRKAFVRR
CHHHHHHHHHHHHHC		50.23-
300PhosphorylationNSGPFCGTISSKKKK
CCCCCCCEECCCCCC		20.9027080861
302PhosphorylationGPFCGTISSKKKKKM
CCCCCEECCCCCCEE		35.6225159151
303PhosphorylationPFCGTISSKKKKKMM
CCCCEECCCCCCEEE		44.6421815630
311PhosphorylationKKKKKMMYLTTRNAE
CCCCEEEEEEECCCC		9.4427642862
313PhosphorylationKKKMMYLTTRNAEFD
CCEEEEEEECCCCCC		13.2628857561
314PhosphorylationKKMMYLTTRNAEFDR
CEEEEEEECCCCCCH		21.2328857561
321MethylationTRNAEFDRHEIQIYE
ECCCCCCHHHHHHHH		34.3624391053
327PhosphorylationDRHEIQIYEEVAKMP
CHHHHHHHHHHHCCC		6.9420007894
340PhosphorylationMPPFQRKTLVLIGAQ
CCCCCCCEEEEECCC		25.0421406692
353PhosphorylationAQGVGRRSLKNRFIV
CCCCCHHHCCCCEEE		42.19-
368PhosphorylationLNPTRFGTTVPFTSR
ECCCCCCCCCCCCCC		23.1621406692
369PhosphorylationNPTRFGTTVPFTSRK
CCCCCCCCCCCCCCC		26.9321406692
373PhosphorylationFGTTVPFTSRKPRED
CCCCCCCCCCCCCCC		22.8821406692
374PhosphorylationGTTVPFTSRKPREDE
CCCCCCCCCCCCCCC		38.3921406692
387PhosphorylationDEKDGQAYKFVSRSE
CCCCCCEEEEECHHH		9.32-
391PhosphorylationGQAYKFVSRSEMEAD
CCEEEEECHHHHHHH		32.9725159151
393PhosphorylationAYKFVSRSEMEADIK
EEEEECHHHHHHHHH		33.5125159151
403UbiquitinationEADIKAGKYLEHGEY
HHHHHHCCCCCCCEE		52.0721890473
403UbiquitinationEADIKAGKYLEHGEY
HHHHHHCCCCCCCEE		52.0721890473
404PhosphorylationADIKAGKYLEHGEYE
HHHHHCCCCCCCEEC		19.1921406692
410PhosphorylationKYLEHGEYEGNLYGT
CCCCCCEECCCEECC		33.4621406692
415PhosphorylationGEYEGNLYGTKIDSI
CEECCCEECCCHHHH		27.0921406692
417PhosphorylationYEGNLYGTKIDSILE
ECCCEECCCHHHHHH		15.9821406692
442UbiquitinationDVNPQALKVLRTSEF
ECCHHHHHHHHHCCC		42.09-
446PhosphorylationQALKVLRTSEFMPYV
HHHHHHHHCCCCCEE		28.57-
482PhosphorylationGITTKLLTDSDLKKT
CCCCEECCHHHHHHH		43.84-
493PhosphorylationLKKTVDESARIQRAY
HHHHHCHHHHHHHHH		20.55-
500PhosphorylationSARIQRAYNHYFDLI
HHHHHHHHHHHCCEE		12.5019060867
503PhosphorylationIQRAYNHYFDLIIIN
HHHHHHHHCCEEEEC		8.6427811184
515UbiquitinationIINDNLDKAFEKLQT
EECCCHHHHHHHHHH		59.1321890473
515UbiquitinationIINDNLDKAFEKLQT
EECCCHHHHHHHHHH		59.1321890473
519UbiquitinationNLDKAFEKLQTAIEK
CHHHHHHHHHHHHHH		39.1721890473
519UbiquitinationNLDKAFEKLQTAIEK
CHHHHHHHHHHHHHH		39.1721890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPP6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPP6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPP6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FRIL_HUMANFTLphysical
15231747
THOP1_HUMANTHOP1physical
15231747
EIF3G_HUMANEIF3Gphysical
15231747
RHG18_HUMANARHGAP18physical
15231747
SKAP_HUMANKNSTRNphysical
15231747
EXOSX_HUMANEXOSC10physical
15231747
SNX9_HUMANSNX9physical
15231747
SK2L2_HUMANSKIV2L2physical
15231747
AATF_HUMANAATFphysical
15231747
LIN7A_HUMANLIN7Aphysical
11311936
DLRB1_HUMANDYNLRB1physical
15231747
RS20_HUMANRPS20physical
15231747
SMCA4_HUMANSMARCA4physical
15231747
DYN2_HUMANDNM2physical
15231747
PARN_HUMANPARNphysical
15231747
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPP6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-500, AND MASSSPECTROMETRY.

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