RHG18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG18_HUMAN
• UniProt AC: Q8N392
• Protein Name: Rho GTPase-activating protein 18
• Gene Name: ARHGAP18 {ECO:0000312|HGNC:HGNC:21035}
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Cytoplasm .
• Protein Description: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. [PubMed: 21865595 Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1]
• Protein Sequence: MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSWLSSSQG ------CCCCCCCCC	36.40	23186163
5	Phosphorylation	---MSWLSSSQGVVL ---CCCCCCCCCEEE	22.99	23186163
6	Phosphorylation	--MSWLSSSQGVVLT --CCCCCCCCCEEEE	25.22	23186163
7	Phosphorylation	-MSWLSSSQGVVLTA -CCCCCCCCCEEEEE	27.81	25693802
13	Phosphorylation	SSQGVVLTAYHPSGK CCCCEEEEEECCCCC	17.35	25693802
15	Phosphorylation	QGVVLTAYHPSGKDQ CCEEEEEECCCCCCC	14.72	27642862
18	Phosphorylation	VLTAYHPSGKDQTVG EEEEECCCCCCCCCC	45.20	25693802
36	Phosphorylation	AKAGEEATSSRRYGQ HCCCCCCCCCHHCCE	30.43	-
41	Phosphorylation	EATSSRRYGQYTMNQ CCCCCHHCCEEECCC	13.89	21945579
44	Phosphorylation	SSRRYGQYTMNQEST CCHHCCEEECCCCCC	12.00	21945579
45	Phosphorylation	SRRYGQYTMNQESTT CHHCCEEECCCCCCE	11.19	21945579
50	Phosphorylation	QYTMNQESTTIKVME EEECCCCCCEEEEEC	22.53	27174698
51	O-linked_Glycosylation	YTMNQESTTIKVMEK EECCCCCCEEEEECC	31.61	OGP
51	Phosphorylation	YTMNQESTTIKVMEK EECCCCCCEEEEECC	31.61	27174698
52	O-linked_Glycosylation	TMNQESTTIKVMEKP ECCCCCCEEEEECCC	28.25	OGP
52	Phosphorylation	TMNQESTTIKVMEKP ECCCCCCEEEEECCC	28.25	27174698
64	Phosphorylation	EKPPFDRSISQDSLD CCCCCCCCCCCCCHH	28.56	22617229
66	Phosphorylation	PPFDRSISQDSLDEL CCCCCCCCCCCHHHH	29.22	22617229
69	Phosphorylation	DRSISQDSLDELSME CCCCCCCCHHHHCHH	30.04	22617229
74	Phosphorylation	QDSLDELSMEDYWIE CCCHHHHCHHHHHHH	20.34	23663014
78	Phosphorylation	DELSMEDYWIELENI HHHCHHHHHHHHHHH	8.59	23663014
88	Phosphorylation	ELENIKKSSENSQED HHHHHHCCCCCCCCC	37.57	23312004
89	Phosphorylation	LENIKKSSENSQEDQ HHHHHCCCCCCCCCC	50.07	29970186
92	Phosphorylation	IKKSSENSQEDQEVV HHCCCCCCCCCCEEE	30.78	29970186
154	Phosphorylation	AVQKRVETVSQTLRK HHHHHHHHHHHHHHH	23.70	29255136
156	Phosphorylation	QKRVETVSQTLRKKN HHHHHHHHHHHHHHC	25.52	28060719
158	Phosphorylation	RVETVSQTLRKKNKQ HHHHHHHHHHHHCCC	22.48	29255136
166	Phosphorylation	LRKKNKQYQIPDVRD HHHHCCCCCCCCHHH	15.26	27642862
184	Phosphorylation	QQRESKETAPGGTES HHHHCCCCCCCCCCC	41.72	23403867
189	Phosphorylation	KETAPGGTESQSLRT CCCCCCCCCCHHCCC	38.08	26699800
191	Phosphorylation	TAPGGTESQSLRTNE CCCCCCCCHHCCCCC	25.55	26699800
193	Phosphorylation	PGGTESQSLRTNENK CCCCCCHHCCCCCCC	29.15	26699800
196	Phosphorylation	TESQSLRTNENKYQG CCCHHCCCCCCCCCC	52.78	23312004
201	Phosphorylation	LRTNENKYQGRDDEA CCCCCCCCCCCCCHH	27.99	27642862
209	Phosphorylation	QGRDDEASNLVGEEK CCCCCHHHHHCCCCC	28.75	23312004
254	Phosphorylation	SKEKIQKSKGDDATL HHHHHHHHCCCCCCC	26.04	28060719
255	Ubiquitination	KEKIQKSKGDDATLP HHHHHHHCCCCCCCC	73.69	29967540
260	Phosphorylation	KSKGDDATLPSFRLP HHCCCCCCCCCCCCC	46.31	29255136
263	Phosphorylation	GDDATLPSFRLPKDK CCCCCCCCCCCCCCC	26.55	23401153
271	Phosphorylation	FRLPKDKTGTTRIGD CCCCCCCCCCCCHHH	50.31	29083192
273	Phosphorylation	LPKDKTGTTRIGDLA CCCCCCCCCCHHHCC	20.38	29083192
274	Phosphorylation	PKDKTGTTRIGDLAP CCCCCCCCCHHHCCC	22.95	29083192
303 (in isoform 2)	Ubiquitination	-	15.92	-
310	Acetylation	GIELKQQKAVKIKTK CCCCCCCCCEEEEEC	53.29	90687
348	Ubiquitination	RIPLIFQKLISRIEE CHHHHHHHHHHHHHH	36.72	23503661
395	Ubiquitination	TFNWESVKQHDAASL CCCHHHHCHHCHHHH	51.71	29967540
398	Ubiquitination	WESVKQHDAASLLKL HHHHCHHCHHHHHHH	41.14	23503661
401	Phosphorylation	VKQHDAASLLKLFIR HCHHCHHHHHHHHHH	35.64	24719451
416	Phosphorylation	ELPQPLLSVEYLKAF HCCCCCCCHHHHHHH	22.15	24043423
419	Phosphorylation	QPLLSVEYLKAFQAV CCCCCHHHHHHHHHH	16.02	24043423
427 (in isoform 2)	Ubiquitination	-	49.08	-
431	Phosphorylation	QAVQNLPTKKQQLQA HHHHCCCCHHHHHHH	54.78	22964224
432	Malonylation	AVQNLPTKKQQLQAL HHHCCCCHHHHHHHH	46.79	26320211
432	Acetylation	AVQNLPTKKQQLQAL HHHCCCCHHHHHHHH	46.79	30587001
432	Ubiquitination	AVQNLPTKKQQLQAL HHHCCCCHHHHHHHH	46.79	29967540
450 (in isoform 2)	Ubiquitination	-	50.14	-
468	Ubiquitination	LQRVIDNKEKNKMTV HHHHHCCCHHCCCHH	67.33	23503661
470	Ubiquitination	RVIDNKEKNKMTVMN HHHCCCHHCCCHHHH	64.57	23503661
472	Ubiquitination	IDNKEKNKMTVMNVA HCCCHHCCCHHHHHH	47.19	23503661
495	Ubiquitination	MCHALGLKSSEQREF HHHHCCCCCHHHHHH	50.57	23503661
518	Ubiquitination	TMHLLIKYQKLLWTI HHHHHHHHHHHHHHH	12.13	23503661
520	Ubiquitination	HLLIKYQKLLWTIPK HHHHHHHHHHHHHHH	42.32	23503661
522	Ubiquitination	LIKYQKLLWTIPKFI HHHHHHHHHHHHHHH	4.96	23503661
545	Ubiquitination	TENHKKDKRAMKKLL CHHHHHHHHHHHHHH	51.43	23503661
587	Phosphorylation	RVQAPHLSKVSMAIQ EEECCCHHHHHHHHH	28.16	-
610	Phosphorylation	DVLARFLSQESGVAQ HHHHHHHCCCCCCCH	29.23	14574404
613	Phosphorylation	ARFLSQESGVAQTLK HHHHCCCCCCCHHHH	30.82	28060719
618	Phosphorylation	QESGVAQTLKKGEVF CCCCCCHHHHCCCEE	30.70	28060719
620	Ubiquitination	SGVAQTLKKGEVFLY CCCCHHHHCCCEEEE	63.22	29967540
627	Phosphorylation	KKGEVFLYEIGGNIG HCCCEEEEEECCCCC	8.27	27642862
648	Phosphorylation	DTYMKDLYQLNPNAE CCCHHHHHHHCCCCE	22.53	27642862
660	Phosphorylation	NAEWVIKSKPL---- CCEEEEECCCC----	28.51	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG18_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RHG18_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.