LIN7A_HUMAN - dbPTM
LIN7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LIN7A_HUMAN
UniProt AC O14910
Protein Name Protein lin-7 homolog A
Gene Name LIN7A
Organism Homo sapiens (Human).
Sequence Length 233
Subcellular Localization Cell membrane
Peripheral membrane protein . Basolateral cell membrane
Peripheral membrane protein . Cell junction. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Peripheral membrane protein. Cell junction, tight junction. Ce
Protein Description Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells..
Protein Sequence MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MLKPSVTSAPTADM
-CCCCCCCCCCCCCC		24.4128270605
8PhosphorylationMLKPSVTSAPTADMA
CCCCCCCCCCCCCCE		30.0528270605
11PhosphorylationPSVTSAPTADMATLT
CCCCCCCCCCCEEEE		34.7028270605
16PhosphorylationAPTADMATLTVVQPL
CCCCCCEEEEEEEEC		19.1428270605
18PhosphorylationTADMATLTVVQPLTL
CCCCEEEEEEEECCC		17.8028270605
20UbiquitinationDMATLTVVQPLTLDR
CCEEEEEEEECCCCH		4.0122053931
24PhosphorylationLTVVQPLTLDRDVAR
EEEEEECCCCHHHHH		33.0428270605
49UbiquitinationSGEVPVHKLQSLKKV
CCCCCHHHHHHHHHH		48.7530230243
55UbiquitinationHKLQSLKKVLQSEFC
HHHHHHHHHHHHHHH		54.1730230243
91UbiquitinationFRARATAKATVAAFA
HHHHHHHHHHHHHHH		39.9922053931
100PhosphorylationTVAAFAASEGHSHPR
HHHHHHHHCCCCCCE		40.4528857561
104PhosphorylationFAASEGHSHPRVVEL
HHHHCCCCCCEEEEC		46.1528857561
112UbiquitinationHPRVVELPKTDEGLG
CCEEEECCCCCCCCC		24.8033845483
120UbiquitinationKTDEGLGFNVMGGKE
CCCCCCCCEECCCCC		8.1823000965
126UbiquitinationGFNVMGGKEQNSPIY
CCEECCCCCCCCCEE		50.8530230243
130PhosphorylationMGGKEQNSPIYISRI
CCCCCCCCCEEEEEE		16.6321815630
133PhosphorylationKEQNSPIYISRIIPG
CCCCCCEEEEEECCC		9.0228152594
135PhosphorylationQNSPIYISRIIPGGV
CCCCEEEEEECCCCH		10.6428152594
183UbiquitinationKAAKDSVKLVVRYTP
HHHHHHHEEEEEECH		39.2433845483
191UbiquitinationLVVRYTPKVLEEMEA
EEEEECHHHHHHHHH		52.2123000965
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LIN7A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LIN7A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LIN7A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSKP_HUMANCASKphysical
14960569
DLG1_HUMANDLG1physical
14960569
A4_HUMANAPPphysical
21832049
MPP5_HUMANMPP5physical
23718855
MPP5_HUMANMPP5physical
25416956
FAM9B_HUMANFAM9Bphysical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
CADM1_HUMANCADM1physical
24366813
CSKP_HUMANCASKphysical
24366813
DLG1_HUMANDLG1physical
24366813
E41L2_HUMANEPB41L2physical
24366813
GCYA2_HUMANGUCY1A2physical
24366813
GCYB1_HUMANGUCY1B3physical
24366813
INADL_HUMANINADLphysical
24366813
MPDZ_HUMANMPDZphysical
24366813
MPP2_HUMANMPP2physical
24366813
MPP5_HUMANMPP5physical
24366813
MPP6_HUMANMPP6physical
24366813
MPP7_HUMANMPP7physical
24366813
PI42B_HUMANPIP4K2Bphysical
24366813
PXDC1_HUMANPXDC1physical
24366813
S20A1_HUMANSLC20A1physical
24366813
SNTB2_HUMANSNTB2physical
24366813
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LIN7A_HUMAN

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Related Literatures of Post-Translational Modification

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