MPP7_HUMAN - dbPTM
MPP7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPP7_HUMAN
UniProt AC Q5T2T1
Protein Name MAGUK p55 subfamily member 7
Gene Name MPP7
Organism Homo sapiens (Human).
Sequence Length 576
Subcellular Localization Membrane
Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction.
Protein Description Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact..
Protein Sequence MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationALSTGSGSDTGLYEL
CCCCCCCCCCHHHHH		33.42-
54UbiquitinationLHSLVKIHEKLHYYE
HHHHHHHHHHHCCCC		22.0323503661
56UbiquitinationSLVKIHEKLHYYEKQ
HHHHHHHHHCCCCCC		26.8023503661
59PhosphorylationKIHEKLHYYEKQSPV
HHHHHHCCCCCCCCC		24.6120736484
60UbiquitinationIHEKLHYYEKQSPVP
HHHHHCCCCCCCCCC		13.1023503661
62UbiquitinationEKLHYYEKQSPVPIL
HHHCCCCCCCCCCCH		39.7023503661
64PhosphorylationLHYYEKQSPVPILHG
HCCCCCCCCCCCHHH		38.6425159151
113PhosphorylationALLSVHDTVAQKNYD
HHHHHHHHHHHCCCC		11.67-
137UbiquitinationIDDEEDSVKIIRLVK
CCCCHHHHHHHHHHC		8.8023503661
143UbiquitinationSVKIIRLVKNREPLG
HHHHHHHHCCCCCCC		3.5723503661
186UbiquitinationIHVGDELREVNGIPV
EECCHHHHHHCCEEC		43.7123000965
191UbiquitinationELREVNGIPVEDKRP
HHHHHCCEECCCCCH		2.6623000965
220PhosphorylationTFKIIPGSKEETPSK
EEEEECCCCCCCCCC		31.3829396449
224PhosphorylationIPGSKEETPSKEGKM
ECCCCCCCCCCCCCC		33.6729396449
226PhosphorylationGSKEETPSKEGKMFI
CCCCCCCCCCCCCHH		51.2429396449
245UbiquitinationDYNPNEDKAIPCKEA
CCCCCCCCCCCHHHC		41.8729967540
255PhosphorylationPCKEAGLSFKKGDIL
CHHHCCCCCCCCCEE		33.8224719451
260UbiquitinationGLSFKKGDILQIMSQ
CCCCCCCCEEEEEEC		47.5122817900
262UbiquitinationSFKKGDILQIMSQDD
CCCCCCEEEEEECCC		3.1621890473
262UbiquitinationSFKKGDILQIMSQDD
CCCCCCEEEEEECCC		3.1621890473
290PhosphorylationPRAGLIPSKHFQERR
CCCCCCCCHHHHHHH		31.5930266825
308UbiquitinationRRPEILVQPLKVSNR
HCCHHEEEEECCCCC		33.8821890473
308UbiquitinationRRPEILVQPLKVSNR
HCCHHEEEEECCCCC		33.8821890473
309UbiquitinationRPEILVQPLKVSNRK
CCHHEEEEECCCCCC		27.0323000965
311MethylationEILVQPLKVSNRKSS
HHEEEEECCCCCCCC		50.75115973239
311UbiquitinationEILVQPLKVSNRKSS
HHEEEEECCCCCCCC		50.7523000965
313PhosphorylationLVQPLKVSNRKSSGF
EEEEECCCCCCCCCC		29.3626055452
314UbiquitinationVQPLKVSNRKSSGFR
EEEECCCCCCCCCCH		59.3923000965
316UbiquitinationPLKVSNRKSSGFRKS
EECCCCCCCCCCHHH		53.9023000965
323PhosphorylationKSSGFRKSFRLSRKD
CCCCCHHHHCCCCCC		16.0229514088
327PhosphorylationFRKSFRLSRKDKKTN
CHHHHCCCCCCCCCC		32.7833259812
342UbiquitinationKSMYECKKSDQYDTA
CCHHHHHHHCCCCCC		71.5629967540
343PhosphorylationSMYECKKSDQYDTAD
CHHHHHHHCCCCCCC		18.5523312004
346PhosphorylationECKKSDQYDTADVPT
HHHHHCCCCCCCCCC		21.9123312004
348PhosphorylationKKSDQYDTADVPTYE
HHHCCCCCCCCCCCC		21.5923312004
353PhosphorylationYDTADVPTYEEVTPY
CCCCCCCCCCCCCCC		43.3323312004
354PhosphorylationDTADVPTYEEVTPYR
CCCCCCCCCCCCCCC		12.2020007894
358PhosphorylationVPTYEEVTPYRRQTN
CCCCCCCCCCCCCCC		20.2028555341
383UbiquitinationPVGVGLNELKRKLLI
CCCCCHHHHHHHHCC		61.7922817900
385UbiquitinationGVGLNELKRKLLISD
CCCHHHHHHHHCCCC		41.1121890473
387UbiquitinationGLNELKRKLLISDTQ
CHHHHHHHHCCCCCC		46.1621890473
391O-linked_GlycosylationLKRKLLISDTQHYGV
HHHHHCCCCCCCCCC		34.2830379171
392UbiquitinationKRKLLISDTQHYGVT
HHHHCCCCCCCCCCC		43.3123000965
396PhosphorylationLISDTQHYGVTVPHT
CCCCCCCCCCCCCCC		11.9527642862
397UbiquitinationISDTQHYGVTVPHTT
CCCCCCCCCCCCCCC		13.3923000965
409PhosphorylationHTTRARRSQESDGVE
CCCCCCCCCCCCCCE		32.5230266825
412PhosphorylationRARRSQESDGVEYIF
CCCCCCCCCCCEEEE		31.8430266825
417PhosphorylationQESDGVEYIFISKHL
CCCCCCEEEEEECCC		9.9520007894
421PhosphorylationGVEYIFISKHLFETD
CCEEEEEECCCEEEE		11.8628152594
431UbiquitinationLFETDVQNNKFIEYG
CEEEECCCCEEEEEE		54.2121890473
433UbiquitinationETDVQNNKFIEYGEY
EEECCCCEEEEEEEE		56.0922817900
437PhosphorylationQNNKFIEYGEYKNNY
CCCEEEEEEEECCCC		15.5028152594
440PhosphorylationKFIEYGEYKNNYYGT
EEEEEEEECCCCCCC		18.0428152594
444PhosphorylationYGEYKNNYYGTSIDS
EEEECCCCCCCCHHH		16.8020007894
445PhosphorylationGEYKNNYYGTSIDSV
EEECCCCCCCCHHHH		18.9527642862
466UbiquitinationNKVCLLDVQPHTVKH
CCEEEEECCCCCCCC		10.8622817900
468UbiquitinationVCLLDVQPHTVKHLR
EEEEECCCCCCCCCE		25.6021890473
470PhosphorylationLLDVQPHTVKHLRTL
EEECCCCCCCCCEEE		37.6226074081
476PhosphorylationHTVKHLRTLEFKPYV
CCCCCCEEECCCCEE		36.6826074081
482PhosphorylationRTLEFKPYVIFIKPP
EEECCCCEEEEECCC		13.5326074081
490PhosphorylationVIFIKPPSIERLRET
EEEECCCCHHHHHHH		45.6827966365
497PhosphorylationSIERLRETRKNAKII
CHHHHHHHHHHCEEE		40.2727174698
505PhosphorylationRKNAKIISSRDDQGA
HHHCEEECCCCCCCC		23.8524719451
506PhosphorylationKNAKIISSRDDQGAA
HHCEEECCCCCCCCC		29.3527174698
514UbiquitinationRDDQGAAKPFTEEDF
CCCCCCCCCCCHHHH		39.8821890473
535PhosphorylationAQIMESQYGHLFDKI
HHHHHHHHHHHCCEE		18.78-
556UbiquitinationTVAFNELKTTFDKLE
HHHHHHHHHHHHHHH		39.0632015554
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPP7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPP7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPP7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MPP7_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPP7_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.

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