dbPTM

SMCA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMCA4_HUMAN
UniProt AC	P51532
Protein Name	Transcription activator BRG1
Gene Name	SMARCA4
Organism	Homo sapiens (Human).
Sequence Length	1647
Subcellular Localization	Nucleus . Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds.
Protein Description	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity)..
Protein Sequence	MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTPDPPLG ------CCCCCCCCC	61.01	23401153
3	Phosphorylation	-----MSTPDPPLGG -----CCCCCCCCCC	43.50	29255136
11	Phosphorylation	PDPPLGGTPRPGPSP CCCCCCCCCCCCCCC	17.83	25159151
17	Phosphorylation	GTPRPGPSPGPGPSP CCCCCCCCCCCCCCC	48.69	26074081
23	Phosphorylation	PSPGPGPSPGAMLGP CCCCCCCCCCCCCCC	41.71	26074081
31	Phosphorylation	PGAMLGPSPGPSPGS CCCCCCCCCCCCCCC	40.46	26074081
35	Phosphorylation	LGPSPGPSPGSAHSM CCCCCCCCCCCCCCC	48.05	26074081
38	Phosphorylation	SPGPSPGSAHSMMGP CCCCCCCCCCCCCCC	26.62	26074081
41	Phosphorylation	PSPGSAHSMMGPSPG CCCCCCCCCCCCCCC	15.35	26074081
90	Phosphorylation	GMSDDPRYNQMKGMG CCCCCCCHHHHCCCC	18.35	26074081
94	Acetylation	DPRYNQMKGMGMRSG CCCHHHHCCCCCCCC	35.66	25953088
100	Phosphorylation	MKGMGMRSGGHAGMG HCCCCCCCCCCCCCC	39.99	26074081
111	Phosphorylation	AGMGPPPSPMDQHSQ CCCCCCCCCCCCCCC	38.33	26074081
117	Phosphorylation	PSPMDQHSQGYPSPL CCCCCCCCCCCCCCC	21.48	26074081
120	Phosphorylation	MDQHSQGYPSPLGGS CCCCCCCCCCCCCCC	7.90	26074081
122	Phosphorylation	QHSQGYPSPLGGSEH CCCCCCCCCCCCCCC	25.03	26074081
127	Phosphorylation	YPSPLGGSEHASSPV CCCCCCCCCCCCCCC	25.14	26074081
131	Phosphorylation	LGGSEHASSPVPASG CCCCCCCCCCCCCCC	36.76	26074081
132	Phosphorylation	GGSEHASSPVPASGP CCCCCCCCCCCCCCC	30.60	26074081
137	Phosphorylation	ASSPVPASGPSSGPQ CCCCCCCCCCCCCCC	45.20	26074081
140	Phosphorylation	PVPASGPSSGPQMSS CCCCCCCCCCCCCCC	51.99	26074081
141	Phosphorylation	VPASGPSSGPQMSSG CCCCCCCCCCCCCCC	58.59	26074081
146	Phosphorylation	PSSGPQMSSGPGGAP CCCCCCCCCCCCCCC	27.22	26074081
147	Phosphorylation	SSGPQMSSGPGGAPL CCCCCCCCCCCCCCC	43.60	26074081
170	Phosphorylation	GQQNRGPTPFNQNQL CCCCCCCCCCCHHHH	43.25	28555341
181	Methylation	QNQLHQLRAQIMAYK HHHHHHHHHHHHHHH	20.20	30761079
188	Acetylation	RAQIMAYKMLARGQP HHHHHHHHHHHCCCC	20.21	19608861
192	Methylation	MAYKMLARGQPLPDH HHHHHHHCCCCCCHH	40.08	115917181
207	Acetylation	LQMAVQGKRPMPGMQ HHHHHCCCCCCCCHH	35.92	25953088
207	Ubiquitination	LQMAVQGKRPMPGMQ HHHHHCCCCCCCCHH	35.92	-
296	Phosphorylation	MANAAAPTSTPQKLI CCCCCCCCCCCCCCC	40.27	25627689
297	Phosphorylation	ANAAAPTSTPQKLIP CCCCCCCCCCCCCCC	36.71	25627689
298	Phosphorylation	NAAAPTSTPQKLIPP CCCCCCCCCCCCCCC	32.01	25159151
308	Phosphorylation	KLIPPQPTGRPSPAP CCCCCCCCCCCCCCC	40.34	28348404
312	Phosphorylation	PQPTGRPSPAPPAVP CCCCCCCCCCCCCCC	32.12	29449344
323	Phosphorylation	PAVPPAASPVMPPQT CCCCCCCCCCCCCCC	21.82	25850435
330	Phosphorylation	SPVMPPQTQSPGQPA CCCCCCCCCCCCCCC	36.47	25850435
332	Phosphorylation	VMPPQTQSPGQPAQP CCCCCCCCCCCCCCC	34.09	25850435
353	Phosphorylation	HQKQSRITPIQKPRG CCCCCCCCCCCCCCC	17.15	25159151
357	Acetylation	SRITPIQKPRGLDPV CCCCCCCCCCCCCHH	37.08	25953088
357	Ubiquitination	SRITPIQKPRGLDPV CCCCCCCCCCCCCHH	37.08	-
391	Phosphorylation	ELENLPGSLAGDLRT HHHCCCCCCCCCCCC	17.07	20068231
399	Ubiquitination	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	21890473
399	Ubiquitination	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	21890473
399	Ubiquitination	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	21890473
399	Ubiquitination	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	21890473
399	2-Hydroxyisobutyrylation	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	-
399	Ubiquitination	LAGDLRTKATIELKA CCCCCCCCHHHHHHH	36.78	21890473
405	Ubiquitination	TKATIELKALRLLNF CCHHHHHHHHHHHHH	32.36	21890473
405	Ubiquitination	TKATIELKALRLLNF CCHHHHHHHHHHHHH	32.36	21890473
405	Ubiquitination	TKATIELKALRLLNF CCHHHHHHHHHHHHH	32.36	21890473
405	Ubiquitination	TKATIELKALRLLNF CCHHHHHHHHHHHHH	32.36	21890473
405	Ubiquitination	TKATIELKALRLLNF CCHHHHHHHHHHHHH	32.36	21890473
428	Phosphorylation	VVCMRRDTALETALN HHHCCCHHHHHHHHH	31.19	28555341
437	Ubiquitination	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	21890473
437	Ubiquitination	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	21890473
437	Ubiquitination	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	21890473
437	Ubiquitination	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	21890473
437	Methylation	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	30795557
437	Ubiquitination	LETALNAKAYKRSKR HHHHHHHHHHHHHHH	51.69	21890473
446	Phosphorylation	YKRSKRQSLREARIT HHHHHHHHHHHHHHH	33.17	26074081
453	Phosphorylation	SLREARITEKLEKQQ HHHHHHHHHHHHHHH	22.86	24702127
455	Acetylation	REARITEKLEKQQKI HHHHHHHHHHHHHHH	53.98	23749302
455	Ubiquitination	REARITEKLEKQQKI HHHHHHHHHHHHHHH	53.98	-
458	Ubiquitination	RITEKLEKQQKIEQE HHHHHHHHHHHHHHH	69.35	-
461	Acetylation	EKLEKQQKIEQERKR HHHHHHHHHHHHHHH	45.80	30592461
471	Ubiquitination	QERKRRQKHQEYLNS HHHHHHHHHHHHHHH	45.50	21890473
471	Ubiquitination	QERKRRQKHQEYLNS HHHHHHHHHHHHHHH	45.50	21890473
471	Ubiquitination	QERKRRQKHQEYLNS HHHHHHHHHHHHHHH	45.50	21890473
471	Ubiquitination	QERKRRQKHQEYLNS HHHHHHHHHHHHHHH	45.50	21890473
471	Ubiquitination	QERKRRQKHQEYLNS HHHHHHHHHHHHHHH	45.50	21890473
487	Ubiquitination	LQHAKDFKEYHRSVT HHHHHHHHHHHHHHH	68.45	-
496	2-Hydroxyisobutyrylation	YHRSVTGKIQKLTKA HHHHHHHHHHHHHHH	32.38	-
496	Acetylation	YHRSVTGKIQKLTKA HHHHHHHHHHHHHHH	32.38	25953088
496	Ubiquitination	YHRSVTGKIQKLTKA HHHHHHHHHHHHHHH	32.38	-
502	Acetylation	GKIQKLTKAVATYHA HHHHHHHHHHHHHHH	51.83	26051181
502	Ubiquitination	GKIQKLTKAVATYHA HHHHHHHHHHHHHHH	51.83	-
529	Methylation	IEKERMRRLMAEDEE HHHHHHHHHHHHCHH	21.33	-
538	Phosphorylation	MAEDEEGYRKLIDQK HHHCHHHHHHHHHHH	14.09	21406692
588	Acetylation	KKKKKKKKAENAEGQ HHHHHHHHHHCCCCC	70.57	26051181
596	Phosphorylation	AENAEGQTPAIGPDG HHCCCCCCCCCCCCC	26.08	23927012
609	Phosphorylation	DGEPLDETSQMSDLP CCCCCCCCCCCCCCC	24.75	29255136
610	Phosphorylation	GEPLDETSQMSDLPV CCCCCCCCCCCCCCE	23.10	29255136
613	Phosphorylation	LDETSQMSDLPVKVI CCCCCCCCCCCEEEE	28.49	29255136
618	Acetylation	QMSDLPVKVIHVESG CCCCCCEEEEEEECC	33.27	26051181
624	Phosphorylation	VKVIHVESGKILTGT EEEEEEECCCEEECC	44.27	23312004
626	Ubiquitination	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	21890473
626	Ubiquitination	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	21890473
626	Ubiquitination	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	21890473
626	Ubiquitination	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	21890473
626	Acetylation	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	23954790
626	Ubiquitination	VIHVESGKILTGTDA EEEEECCCEEECCCC	43.77	21890473
649	Phosphorylation	WLEMNPGYEVAPRSD HHHCCCCCCCCCCCC	14.42	17081983
655	Phosphorylation	GYEVAPRSDSEESGS CCCCCCCCCCCCCCC	44.42	28985074
657	Phosphorylation	EVAPRSDSEESGSEE CCCCCCCCCCCCCHH	44.50	22817900
660	Phosphorylation	PRSDSEESGSEEEEE CCCCCCCCCCHHHHH	43.50	28985074
662	Phosphorylation	SDSEESGSEEEEEEE CCCCCCCCHHHHHHH	51.63	28985074
681	Phosphorylation	PQAAQPPTLPVEEKK CCCCCCCCCCHHHHC	50.83	24144214
689	Acetylation	LPVEEKKKIPDPDSD CCHHHHCCCCCCCCC	71.22	26051181
689	Ubiquitination	LPVEEKKKIPDPDSD CCHHHHCCCCCCCCC	71.22	-
695	Phosphorylation	KKIPDPDSDDVSEVD CCCCCCCCCCCCHHH	40.89	29255136
699	Phosphorylation	DPDSDDVSEVDARHI CCCCCCCCHHHHHHH	38.61	29255136
711	Acetylation	RHIIENAKQDVDDEY HHHHHHHHHCCCCCC	59.62	26051181
711	Ubiquitination	RHIIENAKQDVDDEY HHHHHHHHHCCCCCC	59.62	21890473
718	Phosphorylation	KQDVDDEYGVSQALA HHCCCCCCHHHHHHH	29.80	-
721	Phosphorylation	VDDEYGVSQALARGL CCCCCHHHHHHHHHH	12.84	17525332
730	Phosphorylation	ALARGLQSYYAVAHA HHHHHHHHHHHHHHH	25.75	28796482
731	Phosphorylation	LARGLQSYYAVAHAV HHHHHHHHHHHHHHH	5.18	28796482
732	Phosphorylation	ARGLQSYYAVAHAVT HHHHHHHHHHHHHHH	10.39	28796482
746	Phosphorylation	TERVDKQSALMVNGV HHCCCHHHHHHHCCE	29.16	22210691
767	Phosphorylation	KGLEWLVSLYNNNLN CCHHHHHHHHHCCCC	23.98	24248375
769	Phosphorylation	LEWLVSLYNNNLNGI HHHHHHHHHCCCCCH	14.34	24248375
786	Phosphorylation	DEMGLGKTIQTIALI HHCCCCHHHHHHHHH	19.27	21406692
789	Phosphorylation	GLGKTIQTIALITYL CCCHHHHHHHHHHHH	12.36	21406692
794	Phosphorylation	IQTIALITYLMEHKR HHHHHHHHHHHHCCC	16.08	21406692
795	Phosphorylation	QTIALITYLMEHKRI HHHHHHHHHHHCCCC	9.32	21406692
831	Ubiquitination	KWAPSVVKVSYKGSP CCCCCEEEEEECCCH	24.25	-
833	Phosphorylation	APSVVKVSYKGSPAA CCCEEEEEECCCHHH	18.53	20860994
834	Phosphorylation	PSVVKVSYKGSPAAR CCEEEEEECCCHHHH	23.50	20860994
835	Ubiquitination	SVVKVSYKGSPAARR CEEEEEECCCHHHHH	45.46	-
837	Phosphorylation	VKVSYKGSPAARRAF EEEEECCCHHHHHHH	13.76	30624053
850	Phosphorylation	AFVPQLRSGKFNVLL HHHHHHHCCCCCEEE	55.73	29083192
858	Phosphorylation	GKFNVLLTTYEYIIK CCCCEEEEEHHHHHC	24.15	25954137
859	Phosphorylation	KFNVLLTTYEYIIKD CCCEEEEEHHHHHCC	17.83	24719451
860	Phosphorylation	FNVLLTTYEYIIKDK CCEEEEEHHHHHCCC	11.08	24719451
862	Phosphorylation	VLLTTYEYIIKDKHI EEEEEHHHHHCCCHH	9.49	25954137
872	Ubiquitination	KDKHILAKIRWKYMI CCCHHHHEEEEEEEE	29.38	-
991	Acetylation	VEAQLPEKVEYVIKC HHHHCCCCCEEEHHC	38.13	26051181
991	Ubiquitination	VEAQLPEKVEYVIKC HHHHCCCCCEEEHHC	38.13	-
997	Acetylation	EKVEYVIKCDMSALQ CCCEEEHHCCHHHHH	17.71	25953088
997	Ubiquitination	EKVEYVIKCDMSALQ CCCEEEHHCCHHHHH	17.71	-
1008	Phosphorylation	SALQRVLYRHMQAKG HHHHHHHHHHHHHCC	8.80	23403867
1014	2-Hydroxyisobutyrylation	LYRHMQAKGVLLTDG HHHHHHHCCEEECCC	32.43	-
1014	Ubiquitination	LYRHMQAKGVLLTDG HHHHHHHCCEEECCC	32.43	-
1024	Acetylation	LLTDGSEKDKKGKGG EECCCCCCCCCCCCC	76.25	25953088
1024	Ubiquitination	LLTDGSEKDKKGKGG EECCCCCCCCCCCCC	76.25	-
1033	Acetylation	KKGKGGTKTLMNTIM CCCCCCHHHHHHHHH	42.83	19608861
1050	Phosphorylation	RKICNHPYMFQHIEE HHHCCCHHHHHHHHH	11.74	-
1081	Ubiquitination	DLYRASGKFELLDRI HHHHHCCCHHHHHHH	32.92	21890473
1081	Ubiquitination	DLYRASGKFELLDRI HHHHHCCCHHHHHHH	32.92	21890473
1081	Ubiquitination	DLYRASGKFELLDRI HHHHHCCCHHHHHHH	32.92	21890473
1081	Ubiquitination	DLYRASGKFELLDRI HHHHHCCCHHHHHHH	32.92	21890473
1081	Ubiquitination	DLYRASGKFELLDRI HHHHHCCCHHHHHHH	32.92	21890473
1087	Methylation	GKFELLDRILPKLRA CCHHHHHHHHHHHHH	32.11	-
1122	Acetylation	YFAYRGFKYLRLDGT HHHHCCCCEEEECCC	46.31	26051181
1123	Phosphorylation	FAYRGFKYLRLDGTT HHHCCCCEEEECCCC	8.52	18083107
1131	Ubiquitination	LRLDGTTKAEDRGML EEECCCCCHHHHCEE	50.01	21890473
1213	Ubiquitination	TVNSVEEKILAAAKY ECCCHHHHHHHHHHH	29.52	-
1219	Acetylation	EKILAAAKYKLNVDQ HHHHHHHHHCCCCCH	37.89	19822091
1219	Ubiquitination	EKILAAAKYKLNVDQ HHHHHHHHHCCCCCH	37.89	-
1220	Phosphorylation	KILAAAKYKLNVDQK HHHHHHHHCCCCCHH	18.91	-
1221	Ubiquitination	ILAAAKYKLNVDQKV HHHHHHHCCCCCHHH	32.64	-
1227	Sumoylation	YKLNVDQKVIQAGMF HCCCCCHHHHHHCCC	36.52	-
1227	Sumoylation	YKLNVDQKVIQAGMF HCCCCCHHHHHHCCC	36.52	-
1227	Ubiquitination	YKLNVDQKVIQAGMF HCCCCCHHHHHHCCC	36.52	-
1237	Ubiquitination	QAGMFDQKSSSHERR HHCCCCCCCCHHHHH	54.90	-
1238	Phosphorylation	AGMFDQKSSSHERRA HCCCCCCCCHHHHHH	31.29	21406692
1239	Phosphorylation	GMFDQKSSSHERRAF CCCCCCCCHHHHHHH	42.63	21406692
1240	Phosphorylation	MFDQKSSSHERRAFL CCCCCCCHHHHHHHH	36.14	21406692
1291	Sumoylation	DLEEPPLKEEDEVPD CCCCCCCCCCCCCCC	65.90	-
1345	Phosphorylation	MEEDELPSWIIKDDA CCCCCCCCEEECCCH	43.46	22199227
1349	Sumoylation	ELPSWIIKDDAEVER CCCCEEECCCHHCEE	40.18	-
1349	Ubiquitination	ELPSWIIKDDAEVER CCCCEEECCCHHCEE	40.18	21890473
1353 (in isoform 3)	Ubiquitination	-	52.48	-
1358	Phosphorylation	DAEVERLTCEEEEEK CHHCEECCCHHHHHH	24.88	21130716
1365	Sumoylation	TCEEEEEKMFGRGSR CCHHHHHHHHCCCCC	42.69	28112733
1365	Ubiquitination	TCEEEEEKMFGRGSR CCHHHHHHHHCCCCC	42.69	-
1366	Sulfoxidation	CEEEEEKMFGRGSRH CHHHHHHHHCCCCCC	4.94	21406390
1371	Phosphorylation	EKMFGRGSRHRKEVD HHHHCCCCCCCCCCC	24.45	21406692
1375	Ubiquitination	GRGSRHRKEVDYSDS CCCCCCCCCCCCCCC	56.83	-
1379	Phosphorylation	RHRKEVDYSDSLTEK CCCCCCCCCCCCCHH	21.39	23927012
1380	Phosphorylation	HRKEVDYSDSLTEKQ CCCCCCCCCCCCHHH	19.09	23401153
1382	Phosphorylation	KEVDYSDSLTEKQWL CCCCCCCCCCHHHHH	31.11	29255136
1384	Phosphorylation	VDYSDSLTEKQWLKA CCCCCCCCHHHHHHH	45.12	29255136
1386	Ubiquitination	YSDSLTEKQWLKAIE CCCCCCHHHHHHHHH	41.35	-
1396	Phosphorylation	LKAIEEGTLEEIEEE HHHHHHCCHHHHHHH	33.99	21712546
1410	Phosphorylation	EVRQKKSSRKRKRDS HHHHHHHHCCCCCCC	51.18	29457462
1417	Phosphorylation	SRKRKRDSDAGSSTP HCCCCCCCCCCCCCC	33.13	23401153
1421	Phosphorylation	KRDSDAGSSTPTTST CCCCCCCCCCCCCCC	32.53	25159151
1422	Phosphorylation	RDSDAGSSTPTTSTR CCCCCCCCCCCCCCC	37.17	29255136
1423	Phosphorylation	DSDAGSSTPTTSTRS CCCCCCCCCCCCCCC	26.76	29255136
1425	Phosphorylation	DAGSSTPTTSTRSRD CCCCCCCCCCCCCCC	33.20	28176443
1426	Phosphorylation	AGSSTPTTSTRSRDK CCCCCCCCCCCCCCC	29.33	28176443
1427	Phosphorylation	GSSTPTTSTRSRDKD CCCCCCCCCCCCCCC	25.05	28176443
1428	Phosphorylation	SSTPTTSTRSRDKDD CCCCCCCCCCCCCCC	30.48	28176443
1430	Phosphorylation	TPTTSTRSRDKDDES CCCCCCCCCCCCCHH	44.94	26074081
1448 (in isoform 5)	Phosphorylation	-	29.28	-
1450	Acetylation	RGRPPAEKLSPNPPN CCCCCHHHCCCCCCC	57.27	23236377
1451 (in isoform 3)	Phosphorylation	-	8.50	-
1452	Phosphorylation	RPPAEKLSPNPPNLT CCCHHHCCCCCCCHH	33.43	29255136
1459	Phosphorylation	SPNPPNLTKKMKKIV CCCCCCHHHHHHHHH	34.95	23927012
1464	Acetylation	NLTKKMKKIVDAVIK CHHHHHHHHHHHHHH	44.45	26051181
1490	Phosphorylation	EVFIQLPSRKELPEY EEEEECCCCCCCHHH	65.66	-
1492	Ubiquitination	FIQLPSRKELPEYYE EEECCCCCCCHHHHH	68.86	-
1497	Phosphorylation	SRKELPEYYELIRKP CCCCCHHHHHHHHCC	10.57	-
1519	Phosphorylation	ERIRNHKYRSLNDLE HHHHHCCCCCHHHHH	9.62	20873877
1521	Phosphorylation	IRNHKYRSLNDLEKD HHHCCCCCHHHHHHH	28.56	20873877
1570	Phosphorylation	KIEKEDDSEGEESEE HHHHCCCCCCCCCHH	60.88	20164059
1575	Phosphorylation	DDSEGEESEEEEEGE CCCCCCCCHHHHHCC	46.11	20164059
1586	Phosphorylation	EEGEEEGSESESRSV HHCCCCCCCCCCCCE	41.03	23927012
1588	Phosphorylation	GEEEGSESESRSVKV CCCCCCCCCCCCEEE	42.44	23927012
1590	Phosphorylation	EEGSESESRSVKVKI CCCCCCCCCCEEEEE	38.85	23927012
1592	Phosphorylation	GSESESRSVKVKIKL CCCCCCCCEEEEEEE	35.25	-
1617	Phosphorylation	KGGRRRPSRGSRAKP CCCCCCCCCCCCCCC	47.68	24144214
1620	Phosphorylation	RRRPSRGSRAKPVVS CCCCCCCCCCCCCCC	28.14	24144214
1627	Phosphorylation	SRAKPVVSDDDSEEE CCCCCCCCCCCCHHH	35.24	29255136
1631	Phosphorylation	PVVSDDDSEEEQEED CCCCCCCCHHHHHHH	54.63	29255136
1640	Phosphorylation	EEQEEDRSGSGSEED HHHHHHCCCCCCCCC	50.02	28355574
1642	Phosphorylation	QEEDRSGSGSEED-- HHHHCCCCCCCCC--	40.15	21955146
1644	Phosphorylation	EDRSGSGSEED---- HHCCCCCCCCC----	39.24	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	S	Phosphorylation	Kinase	CK1D	P48730	PSP
35	S	Phosphorylation	Kinase	CK1D	P48730	PSP
721	S	Phosphorylation	Kinase	ATM	Q13315	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	CHFR	Q96EP1	PMID:22285184

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMCA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMCA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	9099865
BRCA1_HUMAN	BRCA1	physical	10943845
CTNB1_HUMAN	CTNNB1	physical	11532957
FANCA_HUMAN	FANCA	physical	11726552
RPB1_HUMAN	POLR2A	physical	11238380
SMRC1_HUMAN	SMARCC1	physical	11238380
SIN3A_HUMAN	SIN3A	physical	11238380
HDAC2_HUMAN	HDAC2	physical	11238380
RBBP4_HUMAN	RBBP4	physical	11238380
PHB_HUMAN	PHB	physical	12065415
STAT2_HUMAN	STAT2	physical	12244326
ARI1A_HUMAN	ARID1A	physical	8895581
SMRC2_HUMAN	SMARCC2	physical	8895581
SMRC1_HUMAN	SMARCC1	physical	8895581
SMCE1_HUMAN	SMARCE1	physical	8895581
SNF5_HUMAN	SMARCB1	physical	8895581
RPB1_HUMAN	POLR2A	physical	8895581
ACL6A_HUMAN	ACTL6A	physical	8895581
SMRC2_HUMAN	SMARCC2	physical	11726552
SMRC1_HUMAN	SMARCC1	physical	11726552
SNF5_HUMAN	SMARCB1	physical	11726552
ENPL_HUMAN	HSP90B1	physical	11726552
ARI1B_HUMAN	ARID1B	physical	12200431
ARI1A_HUMAN	ARID1A	physical	9845365
SMRC2_HUMAN	SMARCC2	physical	9845365
SMRC1_HUMAN	SMARCC1	physical	9845365
SMCE1_HUMAN	SMARCE1	physical	9845365
ACTB_HUMAN	ACTB	physical	9845365
SNF5_HUMAN	SMARCB1	physical	9845365
RPB1_HUMAN	POLR2A	physical	9845365
ACL6A_HUMAN	ACTL6A	physical	9845365
CBP_HUMAN	CREBBP	genetic	11003650
NCOA1_HUMAN	NCOA1	genetic	11003650
ING1_HUMAN	ING1	physical	11784859
SIN3A_HUMAN	SIN3A	physical	11784859
SMCA2_HUMAN	SMARCA2	physical	9128241
SNF5_HUMAN	SMARCB1	physical	9128241
RB_HUMAN	RB1	physical	9128241
GCR_HUMAN	NR3C1	physical	9128241
JUNB_HUMAN	JUNB	physical	9128241
RPB1_HUMAN	POLR2A	physical	9128241
LMNB1_HUMAN	LMNB1	physical	9128241
SRF_HUMAN	SRF	physical	19342595
MYCD_HUMAN	MYOCD	physical	19342595
CREST_HUMAN	SS18L1	physical	19081374
DDX5_HUMAN	DDX5	physical	17011493
NF2L2_HUMAN	NFE2L2	physical	16923960
SNF5_HUMAN	SMARCB1	physical	18809673
SMCE1_HUMAN	SMARCE1	physical	18809673
SMRC1_HUMAN	SMARCC1	physical	18809673
SIN3A_HUMAN	SIN3A	physical	16800816
HDAC2_HUMAN	HDAC2	physical	16800816
PAX6_HUMAN	PAX6	physical	16675956
SMRC1_HUMAN	SMARCC1	physical	16452305
MYOG_HUMAN	MYOG	physical	16424906
MYEF2_HUMAN	MYEF2	physical	16424906
ARI1A_HUMAN	ARID1A	physical	14559996
SMRC2_HUMAN	SMARCC2	physical	14559996
SMRC1_HUMAN	SMARCC1	physical	14559996
ANM5_HUMAN	PRMT5	physical	14559996
SMRD1_HUMAN	SMARCD1	physical	14559996
SMRD2_HUMAN	SMARCD2	physical	14559996
SMCE1_HUMAN	SMARCE1	physical	14559996
ACL6A_HUMAN	ACTL6A	physical	14559996
SNF5_HUMAN	SMARCB1	physical	14559996
SIN3A_HUMAN	SIN3A	physical	14559996
HDAC2_HUMAN	HDAC2	physical	14559996
CHD4_HUMAN	CHD4	physical	14530259
ARI1A_HUMAN	ARID1A	physical	16287714
SMRC1_HUMAN	SMARCC1	physical	16287714
SMCE1_HUMAN	SMARCE1	physical	16287714
SNF5_HUMAN	SMARCB1	physical	16287714
CHD4_HUMAN	CHD4	physical	16217013
SMRC1_HUMAN	SMARCC1	physical	16217013
HNRPC_HUMAN	HNRNPC	physical	16217013
STAT1_HUMAN	STAT1	physical	16195385
USF1_HUMAN	USF1	physical	16195385
IRF1_HUMAN	IRF1	physical	16195385
RPB1_HUMAN	POLR2A	physical	16195385
SP1_HUMAN	SP1	physical	12192045
REST_HUMAN	REST	physical	12192000
RCOR1_HUMAN	RCOR1	physical	12192000
HDAC1_HUMAN	HDAC1	physical	12192000
HDAC2_HUMAN	HDAC2	physical	12192000
C2TA_HUMAN	CIITA	physical	12077331
GEMI_HUMAN	GMNN	physical	16024661
NGN2_HUMAN	NEUROG2	physical	16024661
NDF1_HUMAN	NEUROD1	physical	16024661
NF1_HUMAN	NF1	physical	15999204
RPB1_HUMAN	POLR2A	physical	15999204
PBX1_HUMAN	PBX1	physical	15870273
MYOD1_HUMAN	MYOD1	physical	15870273
MYEF2_HUMAN	MYEF2	physical	15870273
RB_HUMAN	RB1	physical	15485920
SP1_HUMAN	SP1	physical	15317818
STAT3_HUMAN	STAT3	physical	15286705
RB_HUMAN	RB1	physical	10778858
PHB_HUMAN	PHB	physical	15141164
ARI1A_HUMAN	ARID1A	physical	18086889
SMRC1_HUMAN	SMARCC1	physical	18086889
SMRC2_HUMAN	SMARCC2	physical	18086889
NONO_HUMAN	NONO	physical	18042045
SMCA2_HUMAN	SMARCA2	physical	18042045
SNF5_HUMAN	SMARCB1	physical	18042045
SNF5_HUMAN	SMARCB1	physical	9584200
SMAD2_HUMAN	SMAD2	physical	18003620
SMAD3_HUMAN	SMAD3	physical	18003620
CARM1_HUMAN	CARM1	physical	14729568
ADNP_HUMAN	ADNP	physical	17878164
STA5A_HUMAN	STAT5A	physical	17387179
CEBPB_HUMAN	CEBPB	physical	17387179
GCR_HUMAN	NR3C1	physical	17387179
P53_HUMAN	TP53	physical	17666433
RB_HUMAN	RB1	physical	17666433
PML_HUMAN	PML	physical	21360626
REQU_HUMAN	DPF2	physical	20460684
SMRC1_HUMAN	SMARCC1	physical	20460684
ARI1A_HUMAN	ARID1A	physical	20460684
SMRC2_HUMAN	SMARCC2	physical	20460684
SNF5_HUMAN	SMARCB1	physical	20460684
SMRD1_HUMAN	SMARCD1	physical	20460684
ACL6A_HUMAN	ACTL6A	physical	20460684
SMCE1_HUMAN	SMARCE1	physical	20460684
HDAC2_HUMAN	HDAC2	physical	20460684
NPM_HUMAN	NPM1	physical	20460684
NONO_HUMAN	NONO	physical	20460684
IMA1_HUMAN	KPNA2	physical	20460684
BCL7A_HUMAN	BCL7A	physical	20460684
ZEB1_HUMAN	ZEB1	physical	20418909
TOPB1_HUMAN	TOPBP1	physical	20571081
SNF5_HUMAN	SMARCB1	physical	20506188
RUNX1_HUMAN	RUNX1	physical	20506188
H31_HUMAN	HIST1H3A	physical	20011120
CBX5_HUMAN	CBX5	physical	20011120
ARID2_HUMAN	ARID2	physical	15985610
HSF1_HUMAN	HSF1	physical	21079652
SNF5_HUMAN	SMARCB1	physical	16687403
TAT_HV1H2	tat	physical	16687403
SNF5_HUMAN	SMARCB1	physical	21520050
SMRC1_HUMAN	SMARCC1	physical	21520050
ATF3_HUMAN	ATF3	physical	21300803
ACTB_HUMAN	ACTB	physical	21300803
CDK8_HUMAN	CDK8	physical	22668559
CDK19_HUMAN	CDK19	physical	22668559
MED6_HUMAN	MED6	physical	22668559
MED17_HUMAN	MED17	physical	22668559
ANGL4_HUMAN	ANGPTL4	physical	22573825
SMRC2_HUMAN	SMARCC2	physical	22573825
SNF5_HUMAN	SMARCB1	physical	22573825
ACTC_HUMAN	ACTC1	physical	22573825
ACTB_HUMAN	ACTB	physical	22573825
SMRC1_HUMAN	SMARCC1	physical	18303029
P53_MOUSE	Trp53	physical	18303029
CHFR_HUMAN	CHFR	physical	22285184
KDM6A_HUMAN	KDM6A	physical	22192413
SMRD3_HUMAN	SMARCD3	physical	22068056
H32_HUMAN	HIST2H3C	physical	17274598
H2B2E_HUMAN	HIST2H2BE	physical	17274598
SMRC1_HUMAN	SMARCC1	physical	22939629
SNF5_HUMAN	SMARCB1	physical	22939629
SMCE1_HUMAN	SMARCE1	physical	22939629
SMRC2_HUMAN	SMARCC2	physical	22939629
SMRD1_HUMAN	SMARCD1	physical	22939629
SMRD2_HUMAN	SMARCD2	physical	22939629
SMRD3_HUMAN	SMARCD3	physical	22939629
TOP2B_HUMAN	TOP2B	physical	22939629
SUH_HUMAN	RBPJ	physical	23022380
NOTC1_HUMAN	NOTCH1	physical	23022380
BRCA1_HUMAN	BRCA1	physical	23438604
RB_HUMAN	RB1	physical	23438604
HDAC1_HUMAN	HDAC1	genetic	11003650
ACL6A_HUMAN	ACTL6A	physical	26344197
BYST_HUMAN	BYSL	physical	26344197
REQU_HUMAN	DPF2	physical	26344197
DPF3_HUMAN	DPF3	physical	26344197
EP400_HUMAN	EP400	physical	26344197
HMGB1_HUMAN	HMGB1	physical	26344197
MDC1_HUMAN	MDC1	physical	26344197
MY18A_HUMAN	MYO18A	physical	26344197
PELO_HUMAN	PELO	physical	26344197
SNF5_HUMAN	SMARCB1	physical	26344197
SMRC1_HUMAN	SMARCC1	physical	26344197
SMRC2_HUMAN	SMARCC2	physical	26344197
SSXT_HUMAN	SS18	physical	26344197
SMRC2_HUMAN	SMARCC2	physical	9584200
ARI1A_HUMAN	ARID1A	physical	9584200
SNF5_HUMAN	SMARCB1	genetic	28319113
SPTA1_HUMAN	SPTA1	physical	16889989

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613325	Rhabdoid tumor predisposition syndrome 2 (RTPS2)
614609	Mental retardation, autosomal dominant 16 (MRD16)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMCA4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-188 AND LYS-455, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609; SER-610; SER-613;SER-695; SER-699; SER-1382; SER-1452; SER-1570; SER-1575; SER-1627 ANDSER-1631, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609; SER-610; SER-613;SER-1382 AND SER-1452, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-1382; SER-1452;SER-1570; SER-1575; SER-1586; SER-1627; SER-1631; SER-1640; SER-1642AND SER-1644, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610 AND SER-721, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11; SER-655; SER-657;SER-660; SER-662 AND SER-1452, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-695 AND SER-1382, ANDMASS SPECTROMETRY.	15302935 [Abstract]