| UniProt ID | USF1_HUMAN | |
|---|---|---|
| UniProt AC | P22415 | |
| Protein Name | Upstream stimulatory factor 1 | |
| Gene Name | USF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 310 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.. | |
| Protein Sequence | MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | FPDPNVKYVFRTENG CCCCCCEEEEECCCC | 10.67 | 22468782 | |
| 53 | Phosphorylation | NVKYVFRTENGGQVM CCEEEEECCCCCEEE | 23.49 | 22468782 | |
| 61 | Phosphorylation | ENGGQVMYRVIQVSE CCCCEEEEEEEEEEC | 11.67 | 22468782 | |
| 67 | Phosphorylation | MYRVIQVSEGQLDGQ EEEEEEEECCCCCCC | 21.45 | 22468782 | |
| 75 | Phosphorylation | EGQLDGQTEGTGAIS CCCCCCCCCCCCCCC | 41.74 | 22468782 | |
| 153 | Phosphorylation | EALLGQATPPGTGQF CCCCCCCCCCCCCEE | 23.33 | 16622840 | |
| 155 | Ubiquitination | LLGQATPPGTGQFFV CCCCCCCCCCCEEEE | 48.93 | 21890473 | |
| 174 | Phosphorylation | QEVLQGGSQRSIAPR HHHHCCCCCCCCCCC | 29.28 | 26074081 | |
| 177 | Phosphorylation | LQGGSQRSIAPRTHP HCCCCCCCCCCCCCC | 18.57 | 26074081 | |
| 182 | Phosphorylation | QRSIAPRTHPYSPKS CCCCCCCCCCCCCCC | 26.58 | 23927012 | |
| 185 | Phosphorylation | IAPRTHPYSPKSEAP CCCCCCCCCCCCCCC | 29.96 | 23927012 | |
| 186 | Phosphorylation | APRTHPYSPKSEAPR CCCCCCCCCCCCCCC | 30.24 | 23927012 | |
| 189 | Phosphorylation | THPYSPKSEAPRTTR CCCCCCCCCCCCCCH | 42.23 | 23403867 | |
| 194 | Phosphorylation | PKSEAPRTTRDEKRR CCCCCCCCCHHHHHH | 25.73 | 26074081 | |
| 195 | Phosphorylation | KSEAPRTTRDEKRRA CCCCCCCCHHHHHHH | 37.09 | 26074081 | |
| 199 | Acetylation | PRTTRDEKRRAQHNE CCCCHHHHHHHHHHH | 52.02 | 15303999 | |
| 214 | Ubiquitination | VERRRRDKINNWIVQ HHHHHHHHHHHHHHH | 45.59 | 21890473 | |
| 214 | Acetylation | VERRRRDKINNWIVQ HHHHHHHHHHHHHHH | 45.59 | 25953088 | |
| 223 | Phosphorylation | NNWIVQLSKIIPDCS HHHHHHHHHHCCCCC | 12.52 | 20068231 | |
| 230 | Phosphorylation | SKIIPDCSMESTKSG HHHCCCCCCCCCCCC | 32.72 | 20068231 | |
| 233 | Phosphorylation | IPDCSMESTKSGQSK CCCCCCCCCCCCCCC | 32.28 | 20068231 | |
| 234 | Phosphorylation | PDCSMESTKSGQSKG CCCCCCCCCCCCCCC | 18.87 | 20068231 | |
| 235 | Acetylation | DCSMESTKSGQSKGG CCCCCCCCCCCCCCH | 62.96 | 19303849 | |
| 235 | Ubiquitination | DCSMESTKSGQSKGG CCCCCCCCCCCCCCH | 62.96 | - | |
| 240 | Ubiquitination | STKSGQSKGGILSKA CCCCCCCCCHHHHHH | 53.95 | - | |
| 246 | Acetylation | SKGGILSKACDYIQE CCCHHHHHHHHHHHH | 49.98 | 19303849 | |
| 246 | Ubiquitination | SKGGILSKACDYIQE CCCHHHHHHHHHHHH | 49.98 | - | |
| 262 | Phosphorylation | RQSNHRLSEELQGLD HHCCHHHHHHHCCCH | 29.05 | - | |
| 286 | Ubiquitination | RQQVEDLKNKNLLLR HHHHHHHCCCCHHHH | 77.52 | - | |
| 288 | Sumoylation | QVEDLKNKNLLLRAQ HHHHHCCCCHHHHHH | 47.59 | - | |
| 288 | Sumoylation | QVEDLKNKNLLLRAQ HHHHHCCCCHHHHHH | 47.59 | - | |
| 288 | Ubiquitination | QVEDLKNKNLLLRAQ HHHHHCCCCHHHHHH | 47.59 | - | |
| 306 | Sumoylation | HGLEVVIKNDSN--- CCEEEEEECCCC--- | 42.99 | 28112733 | |
| 306 | Sumoylation | HGLEVVIKNDSN--- CCEEEEEECCCC--- | 42.99 | - | |
| 309 | Phosphorylation | EVVIKNDSN------ EEEEECCCC------ | 54.56 | 30108239 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 153 | T | Phosphorylation | Kinase | GSK3A | P49840 | GPS |
| 153 | T | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| 153 | T | Phosphorylation | Kinase | MAPK14 | Q16539 | GPS |
| 186 | S | Phosphorylation | Kinase | GSK3A | P49840 | GPS |
| 186 | S | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| 262 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of USF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of USF1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 602491 | Hyperlipidemia combined 1 (HYPLIP1) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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