USF2_HUMAN - dbPTM
USF2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID USF2_HUMAN
UniProt AC Q15853
Protein Name Upstream stimulatory factor 2
Gene Name USF2
Organism Homo sapiens (Human).
Sequence Length 346
Subcellular Localization Nucleus.
Protein Description Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters..
Protein Sequence MDMLDPGLDPAASATAAAAASHDKGPEAEEGVELQEGGDGPGAEEQTAVAITSVQQAAFGDHNIQYQFRTETNGGQVTYRVVQVTDGQLDGQGDTAGAVSVVSTAAFAGGQQAVTQVGVDGAAQRPGPAAASVPPGPAAPFPLAVIQNPFSNGGSPAAEAVSGEARFAYFPASSVGDTTAVSVQTTDQSLQAGGQFYVMMTPQDVLQTGTQRTIAPRTHPYSPKIDGTRTPRDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQRMQETFKEAERLQMDNELLRQQIEELKNENALLRAQLQQHNLEMVGEGTRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
70 (in isoform 3)Phosphorylation-48.7422210691
72 (in isoform 4)Phosphorylation-38.2522468782
72 (in isoform 3)Phosphorylation-38.2522210691
77 (in isoform 4)Phosphorylation-6.0122468782
79 (in isoform 4)Phosphorylation-11.5330257219
84 (in isoform 3)Phosphorylation-3.3928348404
85O-linked_GlycosylationTYRVVQVTDGQLDGQ
EEEEEEECCCCCCCC		19.8129351928
88 (in isoform 3)Phosphorylation-38.9127050516
93UbiquitinationDGQLDGQGDTAGAVS
CCCCCCCCCCCCCEE		39.5033845483
95 (in isoform 3)Phosphorylation-33.5422210691
95O-linked_GlycosylationQLDGQGDTAGAVSVV
CCCCCCCCCCCEEEE		33.5429351928
103O-linked_GlycosylationAGAVSVVSTAAFAGG
CCCEEEEEEEHHCCC		15.3529351928
119UbiquitinationQAVTQVGVDGAAQRP
CEEEEEECCCCCCCC		6.8821890473
119UbiquitinationQAVTQVGVDGAAQRP
CEEEEEECCCCCCCC		6.8821890473
140UbiquitinationVPPGPAAPFPLAVIQ
CCCCCCCCCCEEEEE		33.2332015554
151PhosphorylationAVIQNPFSNGGSPAA
EEEECCCCCCCCCHH		35.5026074081
155PhosphorylationNPFSNGGSPAAEAVS
CCCCCCCCCHHHHHC		16.8626657352
155 (in isoform 3)Phosphorylation-16.8624719451
157UbiquitinationFSNGGSPAAEAVSGE
CCCCCCCHHHHHCCC		21.4533845483
163 (in isoform 3)Phosphorylation-26.4524719451
171UbiquitinationEARFAYFPASSVGDT
CCEEEEEECHHCCCC		20.6832015554
183 (in isoform 3)Ubiquitination-4.7521890473
183UbiquitinationGDTTAVSVQTTDQSL
CCCEEEEEEECCCCH		4.7521890473
191UbiquitinationQTTDQSLQAGGQFYV
EECCCCHHCCCEEEE		43.1132015554
204UbiquitinationYVMMTPQDVLQTGTQ
EEEECHHHHHHCCCC		44.2732015554
218PhosphorylationQRTIAPRTHPYSPKI
CCCCCCCCCCCCCCC		26.5823403867
221PhosphorylationIAPRTHPYSPKIDGT
CCCCCCCCCCCCCCC		29.9628176443
222PhosphorylationAPRTHPYSPKIDGTR
CCCCCCCCCCCCCCC		24.9428176443
224UbiquitinationRTHPYSPKIDGTRTP
CCCCCCCCCCCCCCC		47.7133845483
228PhosphorylationYSPKIDGTRTPRDER
CCCCCCCCCCCHHHH		27.8523312004
230PhosphorylationPKIDGTRTPRDERRR
CCCCCCCCCHHHHHH		23.6330576142
235UbiquitinationTRTPRDERRRAQHNE
CCCCHHHHHHHHHHH		37.3632015554
250 (in isoform 2)Ubiquitination-45.5921890473
250 (in isoform 1)Ubiquitination-45.5921890473
250UbiquitinationVERRRRDKINNWIVQ
HHHHHHHHHHHHHHH		45.5921890473
255UbiquitinationRDKINNWIVQLSKII
HHHHHHHHHHHHHHC		1.2132015554
270PhosphorylationPDCNADNSKTGASKG
CCCCCCCCCCCCCCC		31.9429759185
271UbiquitinationDCNADNSKTGASKGG
CCCCCCCCCCCCCCH		58.1832015554
272PhosphorylationCNADNSKTGASKGGI
CCCCCCCCCCCCCHH		37.4921712546
275PhosphorylationDNSKTGASKGGILSK
CCCCCCCCCCHHHHH		32.9329759185
281PhosphorylationASKGGILSKACDYIR
CCCCHHHHHHHHHHH		19.11-
282AcetylationSKGGILSKACDYIRE
CCCHHHHHHHHHHHH		49.9826051181
293PhosphorylationYIRELRQTNQRMQET
HHHHHHHHHHHHHHH		27.2127174698
300PhosphorylationTNQRMQETFKEAERL
HHHHHHHHHHHHHHH		24.1027174698
302UbiquitinationQRMQETFKEAERLQM
HHHHHHHHHHHHHHH		64.5332015554
309SulfoxidationKEAERLQMDNELLRQ
HHHHHHHHHHHHHHH		7.6621406390
322UbiquitinationRQQIEELKNENALLR
HHHHHHHHCHHHHHH		66.5532015554
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
155SPhosphorylationKinaseCDK5Q00535
PSP
155SPhosphorylationKinaseGSK3BP49841
PSP
222SPhosphorylationKinaseCDK5Q00535
PSP
230TPhosphorylationKinaseGSK3BP49841
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of USF2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of USF2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
USF2_HUMANUSF2physical
17353931
USF1_HUMANUSF1physical
17353931
BIRC5_HUMANBIRC5physical
17353931
SPB3_HUMANSERPINB3physical
17353931
S10A9_HUMANS100A9physical
17353931
SPB4_HUMANSERPINB4physical
17353931
HS74L_HUMANHSPA4Lphysical
17353931
TP4A2_HUMANPTP4A2physical
17353931
S10A8_HUMANS100A8physical
17353931
NPM_HUMANNPM1physical
17353931
FUS_HUMANFUSphysical
17353931
BRCA1_HUMANBRCA1physical
14502648
USF2_HUMANUSF2physical
8576131
USF1_HUMANUSF1physical
15014447
TEAD2_HUMANTEAD2physical
25416956
LZTS2_HUMANLZTS2physical
25416956
PRGC1_HUMANPPARGC1Aphysical
12611894
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of USF2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY.

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