SPB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPB4_HUMAN
• UniProt AC: P48594
• Protein Name: Serpin B4
• Gene Name: SERPINB4
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Cytoplasm . Seems to also be secreted in plasma by cancerous cells but at a low level.
• Protein Description: May act as a protease inhibitor to modulate the host immune response against tumor cells..
• Protein Sequence: MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSLSEAN -------CCCHHHHH	7.49	-
3	Phosphorylation	-----MNSLSEANTK -----CCCHHHHHHH	31.79	29759185
5	Phosphorylation	---MNSLSEANTKFM ---CCCHHHHHHHHH	34.19	29759185
9	Phosphorylation	NSLSEANTKFMFDLF CCHHHHHHHHHHHHH	32.48	20068231
22	Phosphorylation	LFQQFRKSKENNIFY HHHHHHHHCCCCCCC	40.73	22210691
29	Phosphorylation	SKENNIFYSPISITS HCCCCCCCCCCCHHH	15.11	25850435
30	Phosphorylation	KENNIFYSPISITSA CCCCCCCCCCCHHHH	12.66	22210691
33	Phosphorylation	NIFYSPISITSALGM CCCCCCCCHHHHHHH	24.17	25850435
35	Phosphorylation	FYSPISITSALGMVL CCCCCCHHHHHHHHH	10.93	-
72	Phosphorylation	NTTEKAATYHVDRSG CCCHHHEEEEECCCC	21.01	26356563
73	Phosphorylation	TTEKAATYHVDRSGN CCHHHEEEEECCCCC	8.63	26356563
127	Phosphorylation	LDAIKKFYQTSVEST HHHHHHHHHHCHHCC	21.54	-
130	Phosphorylation	IKKFYQTSVESTDFA HHHHHHHCHHCCCCC	14.36	-
143	Phosphorylation	FANAPEESRKKINSW CCCCCHHHHHHHHHH	47.97	22468782
149	Phosphorylation	ESRKKINSWVESQTN HHHHHHHHHHHHHCH	35.65	27966365
153	Phosphorylation	KINSWVESQTNEKIK HHHHHHHHHCHHHHH	32.46	21406692
155	Phosphorylation	NSWVESQTNEKIKNL HHHHHHHCHHHHHHH	55.41	21406692
181	Phosphorylation	LVLVNAIYFKGQWEN EEEEEEEECCCHHHH	9.23	27259358
292	Phosphorylation	PRFKMEESYDLKDTL CCCCCCCCCCHHHHH	15.61	23025827
324	Phosphorylation	MTWSHGLSVSKVLHK CCHHCCCCHHHHHHH	29.01	24719451
347	Phosphorylation	GVEAAAATAVVVVEL HHHHHHEEEEEEEEC	18.43	-
355	Phosphorylation	AVVVVELSSPSTNEE EEEEEECCCCCCCCC	27.05	-
356	Phosphorylation	VVVVELSSPSTNEEF EEEEECCCCCCCCCC	35.18	-
359	Phosphorylation	VELSSPSTNEEFCCN EECCCCCCCCCCCCC	50.46	-
378	Phosphorylation	FFIRQNKTNSILFYG EEEECCCCCCEEEEE	41.57	24719451
384	Phosphorylation	KTNSILFYGRFSSP- CCCCEEEEEECCCC-	12.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK08_HUMAN	MAPK8	physical	16549498
MET13_HUMAN	METTL13	physical	26186194
MET13_HUMAN	METTL13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.