dbPTM

FUS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FUS_HUMAN
UniProt AC	P35637
Protein Name	RNA-binding protein FUS
Gene Name	FUS
Organism	Homo sapiens (Human).
Sequence Length	526
Subcellular Localization	Nucleus .
Protein Description	Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity..
Protein Sequence	MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MASNDYTQQATQSY -CCCCCHHHHHHHHC	19.64	-
11	Phosphorylation	NDYTQQATQSYGAYP CCHHHHHHHHCCCCC	17.45	-
19	Phosphorylation	QSYGAYPTQPGQGYS HHCCCCCCCCCCCCC	34.42	-
19	O-linked_Glycosylation	QSYGAYPTQPGQGYS HHCCCCCCCCCCCCC	34.42	358927213
26	Phosphorylation	TQPGQGYSQQSSQPY CCCCCCCCCCCCCCC	28.68	29897835
30	Phosphorylation	QGYSQQSSQPYGQQS CCCCCCCCCCCCCCC	30.73	29897835
39	O-linked_Glycosylation	PYGQQSYSGYSQSTD CCCCCCCCCCCCCCC	36.18	21740066
42	Phosphorylation	QQSYSGYSQSTDTSG CCCCCCCCCCCCCCC	22.60	22817900
42	O-linked_Glycosylation	QQSYSGYSQSTDTSG CCCCCCCCCCCCCCC	22.60	21740066
45	O-linked_Glycosylation	YSGYSQSTDTSGYGQ CCCCCCCCCCCCCCC	35.34	21740066
47	O-linked_Glycosylation	GYSQSTDTSGYGQSS CCCCCCCCCCCCCCC	24.92	21740066
54	Phosphorylation	TSGYGQSSYSSYGQS CCCCCCCCCCCCCCC	22.58	-
61	Phosphorylation	SYSSYGQSQNTGYGT CCCCCCCCCCCCCCC	22.49	22817900
68	Phosphorylation	SQNTGYGTQSTPQGY CCCCCCCCCCCCCCC	15.74	-
84	Phosphorylation	STGGYGSSQSSQSSY CCCCCCCCCCCCCCC	29.71	22817900
87	Phosphorylation	GYGSSQSSQSSYGQQ CCCCCCCCCCCCCCC	26.84	-
107	O-linked_Glycosylation	YGQQPAPSSTSGSYG CCCCCCCCCCCCCCC	48.64	21740066
108	O-linked_Glycosylation	GQQPAPSSTSGSYGS CCCCCCCCCCCCCCC	26.07	21740066
109	O-linked_Glycosylation	QQPAPSSTSGSYGSS CCCCCCCCCCCCCCC	41.25	21740066
110	O-linked_Glycosylation	QPAPSSTSGSYGSSS CCCCCCCCCCCCCCC	27.91	21740066
112	Phosphorylation	APSSTSGSYGSSSQS CCCCCCCCCCCCCCC	26.53	-
112	O-linked_Glycosylation	APSSTSGSYGSSSQS CCCCCCCCCCCCCCC	26.53	21740066
117	Phosphorylation	SGSYGSSSQSSSYGQ CCCCCCCCCCCCCCC	35.46	-
131	Phosphorylation	QPQSGSYSQQPSYGG CCCCCCCCCCCCCCC	24.84	22817900
142	Phosphorylation	SYGGQQQSYGQQQSY CCCCCCCCCCCCCCC	27.22	-
213	Methylation	GGYGQQDRGGRGRGG CCCCCCCCCCCCCCC	45.16	83108269
215	Methylation	YGQQDRGGRGRGGSG CCCCCCCCCCCCCCC	29.75	15782174
216	Asymmetric dimethylarginine	GQQDRGGRGRGGSGG CCCCCCCCCCCCCCC	34.16	-
216	Methylation	GQQDRGGRGRGGSGG CCCCCCCCCCCCCCC	34.16	24129315
217	Methylation	QQDRGGRGRGGSGGG CCCCCCCCCCCCCCC	35.54	15782174
218	Asymmetric dimethylarginine	QDRGGRGRGGSGGGG CCCCCCCCCCCCCCC	44.96	-
218	Methylation	QDRGGRGRGGSGGGG CCCCCCCCCCCCCCC	44.96	24129315
220 (in isoform 2)	Phosphorylation	-	23.04	21406692
221	Phosphorylation	GGRGRGGSGGGGGGG CCCCCCCCCCCCCCC	36.77	25849741
232	Phosphorylation	GGGGGGGYNRSSGGY CCCCCCCCCCCCCCC	15.63	25367160
234	Methylation	GGGGGYNRSSGGYEP CCCCCCCCCCCCCCC	24.58	16287779
239	Phosphorylation	YNRSSGGYEPRGRGG CCCCCCCCCCCCCCC	26.70	28152594
242	Asymmetric dimethylarginine	SSGGYEPRGRGGGRG CCCCCCCCCCCCCCC	35.19	-
242	Methylation	SSGGYEPRGRGGGRG CCCCCCCCCCCCCCC	35.19	12964758
243	Methylation	SGGYEPRGRGGGRGG CCCCCCCCCCCCCCC	43.21	15782174
244	Asymmetric dimethylarginine	GGYEPRGRGGGRGGR CCCCCCCCCCCCCCC	41.69	-
244	Methylation	GGYEPRGRGGGRGGR CCCCCCCCCCCCCCC	41.69	12964758
248	Asymmetric dimethylarginine	PRGRGGGRGGRGGMG CCCCCCCCCCCCCCC	47.90	-
248	Methylation	PRGRGGGRGGRGGMG CCCCCCCCCCCCCCC	47.90	12964758
251	Asymmetric dimethylarginine	RGGGRGGRGGMGGSD CCCCCCCCCCCCCCC	41.12	-
251	Methylation	RGGGRGGRGGMGGSD CCCCCCCCCCCCCCC	41.12	12964758
257	Phosphorylation	GRGGMGGSDRGGFNK CCCCCCCCCCCCCCC	20.57	10913197
259	Asymmetric dimethylarginine	GGMGGSDRGGFNKFG CCCCCCCCCCCCCCC	49.16	-
259	Methylation	GGMGGSDRGGFNKFG CCCCCCCCCCCCCCC	49.16	12964758
264	Ubiquitination	SDRGGFNKFGGPRDQ CCCCCCCCCCCCCCC	43.03	-
264	Acetylation	SDRGGFNKFGGPRDQ CCCCCCCCCCCCCCC	43.03	26051181
269	Methylation	FNKFGGPRDQGSRHD CCCCCCCCCCCCCCC	52.76	115479339
272 (in isoform 2)	Phosphorylation	-	30.82	21406692
273	Phosphorylation	GGPRDQGSRHDSEQD CCCCCCCCCCCCCCC	22.32	28258704
276 (in isoform 2)	Phosphorylation	-	53.40	21406692
277	Phosphorylation	DQGSRHDSEQDNSDN CCCCCCCCCCCCCCC	30.91	25159151
281 (in isoform 2)	Phosphorylation	-	51.46	21406692
282	Phosphorylation	HDSEQDNSDNNTIFV CCCCCCCCCCCEEEE	50.43	20873877
285 (in isoform 2)	Phosphorylation	-	39.27	21406692
286	Phosphorylation	QDNSDNNTIFVQGLG CCCCCCCEEEEECCC	23.26	28348404
296 (in isoform 2)	Phosphorylation	-	5.06	21406692
297	Phosphorylation	QGLGENVTIESVADY ECCCCCEEHHHHHHH	30.52	20873877
300	Phosphorylation	GENVTIESVADYFKQ CCCEEHHHHHHHHHH	20.82	20068231
304	Phosphorylation	TIESVADYFKQIGII EHHHHHHHHHHCCEE	11.70	20068231
312	Ubiquitination	FKQIGIIKTNKKTGQ HHHCCEEECCCCCCC	44.09	-
312	Acetylation	FKQIGIIKTNKKTGQ HHHCCEEECCCCCCC	44.09	25953088
315	Ubiquitination	IGIIKTNKKTGQPMI CCEEECCCCCCCCCE	57.87	-
315 (in isoform 2)	Ubiquitination	-	57.87	21890473
316	Ubiquitination	GIIKTNKKTGQPMIN CEEECCCCCCCCCEE	61.02	21890473
316	Malonylation	GIIKTNKKTGQPMIN CEEECCCCCCCCCEE	61.02	26320211
317	Phosphorylation	IIKTNKKTGQPMINL EEECCCCCCCCCEEE	42.53	20068231
319 (in isoform 1)	Ubiquitination	-	29.62	21890473
321	Sulfoxidation	NKKTGQPMINLYTDR CCCCCCCCEEEEECC	2.14	28183972
325	Phosphorylation	GQPMINLYTDRETGK CCCCEEEEECCCCCC	11.34	20068231
326	Phosphorylation	QPMINLYTDRETGKL CCCEEEEECCCCCCC	31.57	20068231
332	Acetylation	YTDRETGKLKGEATV EECCCCCCCCCEEEE	55.21	23749302
334	Ubiquitination	DRETGKLKGEATVSF CCCCCCCCCEEEEEC	59.18	-
334	Sumoylation	DRETGKLKGEATVSF CCCCCCCCCEEEEEC	59.18	28112733
334	Acetylation	DRETGKLKGEATVSF CCCCCCCCCEEEEEC	59.18	26051181
338	Phosphorylation	GKLKGEATVSFDDPP CCCCCEEEEECCCCC	16.63	25850435
340	Phosphorylation	LKGEATVSFDDPPSA CCCEEEEECCCCCCC	20.71	25159151
346	Phosphorylation	VSFDDPPSAKAAIDW EECCCCCCCCEEEEE	48.03	25159151
347 (in isoform 2)	Ubiquitination	-	15.98	21890473
348	Ubiquitination	FDDPPSAKAAIDWFD CCCCCCCCEEEEECC	42.56	22053931
348	Sumoylation	FDDPPSAKAAIDWFD CCCCCCCCEEEEECC	42.56	-
351 (in isoform 1)	Ubiquitination	-	6.02	21890473
357	Acetylation	AIDWFDGKEFSGNPI EEEECCCCCCCCCCE	58.38	26051181
357	Ubiquitination	AIDWFDGKEFSGNPI EEEECCCCCCCCCCE	58.38	-
357	Sumoylation	AIDWFDGKEFSGNPI EEEECCCCCCCCCCE	58.38	-
360	Phosphorylation	WFDGKEFSGNPIKVS ECCCCCCCCCCEEEE	38.46	28348404
364 (in isoform 2)	Ubiquitination	-	8.80	21890473
365	Methylation	EFSGNPIKVSFATRR CCCCCCEEEEEEECC	32.84	44491411
365	Ubiquitination	EFSGNPIKVSFATRR CCCCCCEEEEEEECC	32.84	21890473
365	Sumoylation	EFSGNPIKVSFATRR CCCCCCEEEEEEECC	32.84	-
365	Acetylation	EFSGNPIKVSFATRR CCCCCCEEEEEEECC	32.84	26051181
368 (in isoform 1)	Ubiquitination	-	10.10	21890473
371	Methylation	IKVSFATRRADFNRG EEEEEEECCCCCCCC	28.49	54556729
372	Methylation	KVSFATRRADFNRGG EEEEEECCCCCCCCC	33.87	-
377	Asymmetric dimethylarginine	TRRADFNRGGGNGRG ECCCCCCCCCCCCCC	45.16	-
377	Methylation	TRRADFNRGGGNGRG ECCCCCCCCCCCCCC	45.16	12964758
383	Asymmetric dimethylarginine	NRGGGNGRGGRGRGG CCCCCCCCCCCCCCC	48.68	-
383	Methylation	NRGGGNGRGGRGRGG CCCCCCCCCCCCCCC	48.68	12964758
385	Methylation	GGGNGRGGRGRGGPM CCCCCCCCCCCCCCC	27.75	15782174
386	Asymmetric dimethylarginine	GGNGRGGRGRGGPMG CCCCCCCCCCCCCCC	34.16	-
386	Methylation	GGNGRGGRGRGGPMG CCCCCCCCCCCCCCC	34.16	12964758
387	Methylation	GNGRGGRGRGGPMGR CCCCCCCCCCCCCCC	35.54	15782174
388	Asymmetric dimethylarginine	NGRGGRGRGGPMGRG CCCCCCCCCCCCCCC	45.60	-
388	Methylation	NGRGGRGRGGPMGRG CCCCCCCCCCCCCCC	45.60	12964758
394	Asymmetric dimethylarginine	GRGGPMGRGGYGGGG CCCCCCCCCCCCCCC	29.16	-
394	Methylation	GRGGPMGRGGYGGGG CCCCCCCCCCCCCCC	29.16	12964758
397	Phosphorylation	GPMGRGGYGGGGSGG CCCCCCCCCCCCCCC	18.54	24667141
407	Asymmetric dimethylarginine	GGSGGGGRGGFPSGG CCCCCCCCCCCCCCC	45.39	-
407	Methylation	GGSGGGGRGGFPSGG CCCCCCCCCCCCCCC	45.39	12964758
412	O-linked_Glycosylation	GGRGGFPSGGGGGGG CCCCCCCCCCCCCCC	48.05	21740066
427	Acetylation	QQRAGDWKCPNPTCE CCCCCCCCCCCCCCC	44.55	25953088
436	Sulfoxidation	PNPTCENMNFSWRNE CCCCCCCCCCCCCCC	2.21	28465586
439	Phosphorylation	TCENMNFSWRNECNQ CCCCCCCCCCCCCCC	21.81	28857561
448	Ubiquitination	RNECNQCKAPKPDGP CCCCCCCCCCCCCCC	58.94	-
451	Acetylation	CNQCKAPKPDGPGGG CCCCCCCCCCCCCCC	61.68	26051181
462	Phosphorylation	PGGGPGGSHMGGNYG CCCCCCCCCCCCCCC	19.06	25849741
464	Sulfoxidation	GGPGGSHMGGNYGDD CCCCCCCCCCCCCCC	8.66	21406390
468	Phosphorylation	GSHMGGNYGDDRRGG CCCCCCCCCCCCCCC	25.80	25884760
468	Nitration	GSHMGGNYGDDRRGG CCCCCCCCCCCCCCC	25.80	-
473	Asymmetric dimethylarginine	GNYGDDRRGGRGGYD CCCCCCCCCCCCCCC	59.93	-
473	Methylation	GNYGDDRRGGRGGYD CCCCCCCCCCCCCCC	59.93	12964758
476	Asymmetric dimethylarginine	GDDRRGGRGGYDRGG CCCCCCCCCCCCCCC	37.88	-
476	Methylation	GDDRRGGRGGYDRGG CCCCCCCCCCCCCCC	37.88	12964758
481	Asymmetric dimethylarginine	GGRGGYDRGGYRGRG CCCCCCCCCCCCCCC	31.77	-
481	Methylation	GGRGGYDRGGYRGRG CCCCCCCCCCCCCCC	31.77	12964758
485	Asymmetric dimethylarginine	GYDRGGYRGRGGDRG CCCCCCCCCCCCCCC	31.44	-
485	Methylation	GYDRGGYRGRGGDRG CCCCCCCCCCCCCCC	31.44	12964758
486	Methylation	YDRGGYRGRGGDRGG CCCCCCCCCCCCCCC	24.89	15782174
487	Asymmetric dimethylarginine	DRGGYRGRGGDRGGF CCCCCCCCCCCCCCC	36.60	-
487	Methylation	DRGGYRGRGGDRGGF CCCCCCCCCCCCCCC	36.60	12964758
491	Asymmetric dimethylarginine	YRGRGGDRGGFRGGR CCCCCCCCCCCCCCC	50.86	-
491	Methylation	YRGRGGDRGGFRGGR CCCCCCCCCCCCCCC	50.86	12964758
495	Asymmetric dimethylarginine	GGDRGGFRGGRGGGD CCCCCCCCCCCCCCC	50.35	-
495	Methylation	GGDRGGFRGGRGGGD CCCCCCCCCCCCCCC	50.35	12964758
498	Asymmetric dimethylarginine	RGGFRGGRGGGDRGG CCCCCCCCCCCCCCC	43.33	-
498	Methylation	RGGFRGGRGGGDRGG CCCCCCCCCCCCCCC	43.33	12964758
503	Asymmetric dimethylarginine	GGRGGGDRGGFGPGK CCCCCCCCCCCCCCC	50.86	-
503	Methylation	GGRGGGDRGGFGPGK CCCCCCCCCCCCCCC	50.86	24129315
510	Acetylation	RGGFGPGKMDSRGEH CCCCCCCCCCCCCCC	42.54	25953088
514	Methylation	GPGKMDSRGEHRQDR CCCCCCCCCCCCCCH	50.70	54556721
526	Phosphorylation	QDRRERPY------- CCHHCCCC-------	37.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
11	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
19	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
26	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
30	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
42	S	Phosphorylation	Kinase	ATM	Q13315	Uniprot
42	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
54	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
61	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
68	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
84	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
87	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
112	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
117	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
131	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
142	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
257	S	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
257	S	Phosphorylation	Kinase	KPCB	P05771	PhosphoELM
526	Y	Phosphorylation	Kinase	SRC	P12931	PSP
526	Y	Phosphorylation	Kinase	FYN	P06241	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:31632968

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
216	R	Methylation	24129315
Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
218	R	Methylation	24129315
Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FUS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTBP2_HUMAN	PTBP2	physical	12581738
ANM1_HUMAN	PRMT1	physical	16169070
SPI1_HUMAN	SPI1	physical	9478924
ILF3_HUMAN	ILF3	physical	11438536
SF01_HUMAN	SF1	physical	9660765
SRS10_HUMAN	SRSF10	physical	10779324
THA_HUMAN	THRA	physical	9440806
RXRA_HUMAN	RXRA	physical	9440806
TF65_HUMAN	RELA	physical	11278855
TADBP_HUMAN	TARDBP	physical	20720006
ARG28_HUMAN	ARHGEF28	physical	22941224
PA2G4_HUMAN	PA2G4	physical	19946338
UBC9_HUMAN	UBE2I	physical	19946338
ROA3_HUMAN	HNRNPA3	physical	22939629
NONO_HUMAN	NONO	physical	22939629
GSE1_HUMAN	GSE1	physical	22939629
MBD3_HUMAN	MBD3	physical	22939629
RT18B_HUMAN	MRPS18B	physical	22939629
S30BP_HUMAN	SAP30BP	physical	22939629
RLA1_HUMAN	RPLP1	physical	22939629
P63_HUMAN	TP63	physical	20085233
IL7RA_HUMAN	IL7R	physical	23151878
CTNB1_HUMAN	CTNNB1	physical	16230076
ECM32_YEAST	ECM32	genetic	21541368
NAM8_YEAST	NAM8	genetic	21541368
SSBP1_YEAST	SBP1	genetic	21541368
SKO1_YEAST	SKO1	genetic	21541368
VHR1_YEAST	VHR1	genetic	21541368
RENT1_HUMAN	UPF1	genetic	21541368
TDRD3_HUMAN	TDRD3	physical	21988832
RBMX_HUMAN	RBMX	physical	21988832
PSB7_HUMAN	PSMB7	physical	21988832
MDHC_HUMAN	MDH1	physical	21988832
RBP56_HUMAN	TAF15	physical	21988832
SRSF9_HUMAN	SRSF9	physical	21988832
SAFB2_HUMAN	SAFB2	physical	21988832
TNIP1_HUMAN	TNIP1	physical	21988832
KHDR3_HUMAN	KHDRBS3	physical	21988832
NKD2_HUMAN	NKD2	physical	21988832
SUV91_HUMAN	SUV39H1	physical	23455924
HNRPU_HUMAN	HNRNPU	physical	22863883
SYLC_HUMAN	LARS	physical	22863883
YBOX1_HUMAN	YBX1	physical	22863883
TERA_HUMAN	VCP	physical	25192599
SFPQ_HUMAN	SFPQ	physical	25192599
1433Z_HUMAN	YWHAZ	physical	25192599
1433T_HUMAN	YWHAQ	physical	25192599
PROF1_HUMAN	PFN1	physical	25192599
FAS_HUMAN	FASN	physical	25192599
PGK1_HUMAN	PGK1	physical	25192599
KCRB_HUMAN	CKB	physical	25192599
ENOA_HUMAN	ENO1	physical	25192599
LDHB_HUMAN	LDHB	physical	25192599
PUR6_HUMAN	PAICS	physical	25192599
SERA_HUMAN	PHGDH	physical	25192599
LDHA_HUMAN	LDHA	physical	25192599
G3P_HUMAN	GAPDH	physical	25192599
KPYM_HUMAN	PKM	physical	25192599
ATX2L_HUMAN	ATXN2L	physical	25192599
C1TC_HUMAN	MTHFD1	physical	25192599
ACACA_HUMAN	ACACA	physical	25192599
CAH2_HUMAN	CA2	physical	25192599
ALDOA_HUMAN	ALDOA	physical	25192599
G6PI_HUMAN	GPI	physical	25192599
P5CR3_HUMAN	PYCRL	physical	25192599
PFKAL_HUMAN	PFKL	physical	25192599
PGM1_HUMAN	PGM1	physical	25192599
ABCA1_HUMAN	ABCA1	physical	25192599
HPRT_HUMAN	HPRT1	physical	25192599
P20D2_HUMAN	PM20D2	physical	25192599
TKT_HUMAN	TKT	physical	25192599
CADH4_HUMAN	CDH4	physical	25192599
GNAS3_HUMAN	GNAS	physical	25192599
GNAS2_HUMAN	GNAS	physical	25192599
ALEX_HUMAN	GNAS	physical	25192599
GNAS1_HUMAN	GNAS	physical	25192599
PLCE1_HUMAN	PLCE1	physical	25192599
TRPM4_HUMAN	TRPM4	physical	25192599
AAAT_HUMAN	SLC1A5	physical	25192599
UBAP2_HUMAN	UBAP2	physical	25192599
UBP2L_HUMAN	UBAP2L	physical	25192599
LYSC_HUMAN	LYZ	physical	25192599
CKAP4_HUMAN	CKAP4	physical	25192599
YPEL1_HUMAN	YPEL1	physical	25192599
H33_HUMAN	H3F3A	physical	25192599
H2B2E_HUMAN	HIST2H2BE	physical	25192599
DDX42_HUMAN	DDX42	physical	25192599
HNRPD_HUMAN	HNRNPD	physical	25192599
HNRPQ_HUMAN	SYNCRIP	physical	25192599
DHX40_HUMAN	DHX40	physical	25192599
SF01_HUMAN	SF1	physical	25192599
SF3A1_HUMAN	SF3A1	physical	25192599
SF3B3_HUMAN	SF3B3	physical	25192599
SF3B4_HUMAN	SF3B4	physical	25192599
PAIRB_HUMAN	SERBP1	physical	25192599
FANCM_HUMAN	FANCM	physical	25192599
FSBP_HUMAN	RAD54B	physical	25192599
RA54B_HUMAN	RAD54B	physical	25192599
PCNA_HUMAN	PCNA	physical	25192599
PHB_HUMAN	PHB	physical	25192599
P73_HUMAN	TP73	physical	25192599
RL18_HUMAN	RPL18	physical	25192599
RL9_HUMAN	RPL9	physical	25192599
RS9_HUMAN	RPS9	physical	25192599
TBPL1_HUMAN	TBPL1	physical	25192599
TRIP4_HUMAN	TRIP4	physical	25192599
DJC10_HUMAN	DNAJC10	physical	25192599
ANM1_HUMAN	PRMT1	physical	25192599
SAE1_HUMAN	SAE1	physical	25192599
DLDH_HUMAN	DLD	physical	25192599
AATM_HUMAN	GOT2	physical	25192599
ATPA_HUMAN	ATP5A1	physical	25192599
GSTP1_HUMAN	GSTP1	physical	25192599
SYHM_HUMAN	HARS2	physical	25192599
MPCP_HUMAN	SLC25A3	physical	25192599
IMA1_HUMAN	KPNA2	physical	25192599
RAB7A_HUMAN	RAB7A	physical	25192599
SPAT6_HUMAN	SPATA6	physical	25192599
UACA_HUMAN	UACA	physical	25192599
STAT_HUMAN	STATH	physical	25192599
ANXA5_HUMAN	ANXA5	physical	25192599
M3K3_HUMAN	MAP3K3	physical	25192599
UBC_HUMAN	UBC	physical	25192599
UBA1_HUMAN	UBA1	physical	25192599
TBB5_HUMAN	TUBB	physical	25192599
COF1_HUMAN	CFL1	physical	25192599
TBA1A_HUMAN	TUBA1A	physical	25192599
ACTB_HUMAN	ACTB	physical	25192599
HNRPF_HUMAN	HNRNPF	physical	25192599
HNRH1_HUMAN	HNRNPH1	physical	25192599
DHX15_HUMAN	DHX15	physical	25192599
CPSF6_HUMAN	CPSF6	physical	25192599
SF3A3_HUMAN	SF3A3	physical	25192599
HNRPK_HUMAN	HNRNPK	physical	25192599
HNRPU_HUMAN	HNRNPU	physical	25192599
PSPC1_HUMAN	PSPC1	physical	25192599
HNRPL_HUMAN	HNRNPL	physical	25192599
NONO_HUMAN	NONO	physical	25192599
RS5_HUMAN	RPS5	physical	25192599
RS8_HUMAN	RPS8	physical	25192599
RL12_HUMAN	RPL12	physical	25192599
RPN2_HUMAN	RPN2	physical	25192599
EF1A1_HUMAN	EEF1A1	physical	25192599
EF2_HUMAN	EEF2	physical	25192599
EF1G_HUMAN	EEF1G	physical	25192599
HS90A_HUMAN	HSP90AA1	physical	25192599
TCPE_HUMAN	CCT5	physical	25192599
TCPZ_HUMAN	CCT6A	physical	25192599
HS90B_HUMAN	HSP90AB1	physical	25192599
TCPB_HUMAN	CCT2	physical	25192599
TCPD_HUMAN	CCT4	physical	25192599
GRP78_HUMAN	HSPA5	physical	25192599
ENPL_HUMAN	HSP90B1	physical	25192599
TCPG_HUMAN	CCT3	physical	25192599
TCPH_HUMAN	CCT7	physical	25192599
TCPQ_HUMAN	CCT8	physical	25192599
HSP7C_HUMAN	HSPA8	physical	25192599
PPIL4_HUMAN	PPIL4	physical	25192599
TCPA_HUMAN	TCP1	physical	25192599
PDIA3_HUMAN	PDIA3	physical	25192599
PPIA_HUMAN	PPIA	physical	25192599
SSBP_HUMAN	SSBP1	physical	25192599
DHE3_HUMAN	GLUD1	physical	25192599
ATPB_HUMAN	ATP5B	physical	25192599
GRP75_HUMAN	HSPA9	physical	25192599
ERAL1_HUMAN	ERAL1	physical	25192599
EFTU_HUMAN	TUFM	physical	25192599
CH60_HUMAN	HSPD1	physical	25192599
P5CR1_HUMAN	PYCR1	physical	25192599
MDHM_HUMAN	MDH2	physical	25192599
ABCF2_HUMAN	ABCF2	physical	25192599
IMB1_HUMAN	KPNB1	physical	25192599
PRDX1_HUMAN	PRDX1	physical	25192599
ERP44_HUMAN	ERP44	physical	25192599
FA7_HUMAN	F7	physical	25192599
ALBU_HUMAN	ALB	physical	25192599
ARMC6_HUMAN	ARMC6	physical	25192599
ADCK5_HUMAN	ADCK5	physical	25192599
GRDN_HUMAN	CCDC88A	physical	25192599
GP101_HUMAN	GPR101	physical	25192599
ITK_HUMAN	ITK	physical	25192599
DGKA_HUMAN	DGKA	physical	25192599
S22AB_HUMAN	SLC22A11	physical	25192599
PSD12_HUMAN	PSMD12	physical	25192599
HERC6_HUMAN	HERC6	physical	25192599
TBA1B_HUMAN	TUBA1B	physical	25192599
MTSSL_HUMAN	MTSS1L	physical	25192599
CE112_HUMAN	CEP112	physical	25192599
COIA1_HUMAN	COL18A1	physical	25192599
LMNA_HUMAN	LMNA	physical	25192599
SEC13_HUMAN	SEC13	physical	25192599
NP1L1_HUMAN	NAP1L1	physical	25192599
SMD2_HUMAN	SNRPD2	physical	25192599
CNDG2_HUMAN	NCAPG2	physical	25192599
RBBP4_HUMAN	RBBP4	physical	25192599
LSM12_HUMAN	LSM12	physical	25192599
CPSF5_HUMAN	NUDT21	physical	25192599
DDX1_HUMAN	DDX1	physical	25192599
CN166_HUMAN	C14orf166	physical	25192599
DDX5_HUMAN	DDX5	physical	25192599
ZEP3_HUMAN	HIVEP3	physical	25192599
NCOA6_HUMAN	NCOA6	physical	25192599
RAVR1_HUMAN	RAVER1	physical	25192599
ELOC_HUMAN	TCEB1	physical	25192599
TXN4B_HUMAN	TXNL4B	physical	25192599
TTI2_HUMAN	TTI2	physical	25192599
GEN_HUMAN	GEN1	physical	25192599
RL14_HUMAN	RPL14	physical	25192599
RS14_HUMAN	RPS14	physical	25192599
NPM_HUMAN	NPM1	physical	25192599
RL11_HUMAN	RPL11	physical	25192599
RL4_HUMAN	RPL4	physical	25192599
IF4A1_HUMAN	EIF4A1	physical	25192599
PCBP2_HUMAN	PCBP2	physical	25192599
F10A1_HUMAN	ST13	physical	25192599
NSDHL_HUMAN	NSDHL	physical	25192599
MTAP_HUMAN	MTAP	physical	25192599
METK2_HUMAN	MAT2A	physical	25192599
SAHH_HUMAN	AHCY	physical	25192599
OAT_HUMAN	OAT	physical	25192599
BCS1_HUMAN	BCS1L	physical	25192599
ADT2_HUMAN	SLC25A5	physical	25192599
TIM50_HUMAN	TIMM50	physical	25192599
MYH10_HUMAN	MYH10	physical	25192599
GOLI4_HUMAN	GOLIM4	physical	25192599
XPO2_HUMAN	CSE1L	physical	25192599
RAN_HUMAN	RAN	physical	25192599
KLH40_HUMAN	KLHL40	physical	25192599
KLHL5_HUMAN	KLHL5	physical	25192599
CO6_HUMAN	C6	physical	25192599
GIMA8_HUMAN	GIMAP8	physical	25192599
CDC5L_HUMAN	CDC5L	physical	25192599
CEP78_HUMAN	CEP78	physical	25192599
DBF4B_HUMAN	DBF4B	physical	25192599
AMOT_HUMAN	AMOT	physical	25192599
F71F1_HUMAN	FAM71F1	physical	25192599
MFGM_HUMAN	MFGE8	physical	25192599
FA98A_HUMAN	FAM98A	physical	25192599
CK070_HUMAN	C11orf70	physical	25192599
RTCB_HUMAN	RTCB	physical	25192599
UFL1_HUMAN	UFL1	physical	25192599
LRIQ4_HUMAN	LRRIQ4	physical	25192599
DBR1_YEAST	DBR1	genetic	23104007
RENT2_HUMAN	UPF2	genetic	21541368
REN3A_HUMAN	UPF3A	genetic	21541368
HS104_YEAST	HSP104	genetic	25062688
THIL_HUMAN	ACAT1	physical	26344197
ARMC1_HUMAN	ARMC1	physical	26344197
ASHWN_HUMAN	C2orf49	physical	26344197
DDX17_HUMAN	DDX17	physical	26344197
DNJC7_HUMAN	DNAJC7	physical	26344197
IF4H_HUMAN	EIF4H	physical	26344197
ROA3_HUMAN	HNRNPA3	physical	26344197
HNRPD_HUMAN	HNRNPD	physical	26344197
HNRDL_HUMAN	HNRNPDL	physical	26344197
HNRPL_HUMAN	HNRNPL	physical	26344197
MEF2D_HUMAN	MEF2D	physical	26344197
NAA50_HUMAN	NAA50	physical	26344197
NONO_HUMAN	NONO	physical	26344197
NPL4_HUMAN	NPLOC4	physical	26344197
PFKAP_HUMAN	PFKP	physical	26344197
PGK1_HUMAN	PGK1	physical	26344197
PICAL_HUMAN	PICALM	physical	26344197
SFPQ_HUMAN	SFPQ	physical	26344197
SYTC_HUMAN	TARS	physical	26344197
TF7L2_HUMAN	TCF7L2	physical	16230076
KCTD6_HUMAN	KCTD6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
	Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12
	16)(q13
	p11) with DDIT3.
612160
608030	Amyotrophic lateral sclerosis 6 (ALS6)
614782	Tremor, hereditary essential 4 (ETM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FUS_HUMAN

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-216 AND ARG-218, AND MASSSPECTROMETRY.	15782174 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; THR-286 ANDSER-346, AND MASS SPECTROMETRY.	19690332 [Abstract]

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