FUS_HUMAN - dbPTM
FUS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FUS_HUMAN
UniProt AC P35637
Protein Name RNA-binding protein FUS
Gene Name FUS
Organism Homo sapiens (Human).
Sequence Length 526
Subcellular Localization Nucleus .
Protein Description Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity..
Protein Sequence MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MASNDYTQQATQSY
-CCCCCHHHHHHHHC
19.64-
11PhosphorylationNDYTQQATQSYGAYP
CCHHHHHHHHCCCCC
17.45-
19PhosphorylationQSYGAYPTQPGQGYS
HHCCCCCCCCCCCCC
34.42-
19O-linked_GlycosylationQSYGAYPTQPGQGYS
HHCCCCCCCCCCCCC
34.42358927213
26PhosphorylationTQPGQGYSQQSSQPY
CCCCCCCCCCCCCCC
28.6829897835
30PhosphorylationQGYSQQSSQPYGQQS
CCCCCCCCCCCCCCC
30.7329897835
39O-linked_GlycosylationPYGQQSYSGYSQSTD
CCCCCCCCCCCCCCC
36.1821740066
42PhosphorylationQQSYSGYSQSTDTSG
CCCCCCCCCCCCCCC
22.6022817900
42O-linked_GlycosylationQQSYSGYSQSTDTSG
CCCCCCCCCCCCCCC
22.6021740066
45O-linked_GlycosylationYSGYSQSTDTSGYGQ
CCCCCCCCCCCCCCC
35.3421740066
47O-linked_GlycosylationGYSQSTDTSGYGQSS
CCCCCCCCCCCCCCC
24.9221740066
54PhosphorylationTSGYGQSSYSSYGQS
CCCCCCCCCCCCCCC
22.58-
61PhosphorylationSYSSYGQSQNTGYGT
CCCCCCCCCCCCCCC
22.4922817900
68PhosphorylationSQNTGYGTQSTPQGY
CCCCCCCCCCCCCCC
15.74-
84PhosphorylationSTGGYGSSQSSQSSY
CCCCCCCCCCCCCCC
29.7122817900
87PhosphorylationGYGSSQSSQSSYGQQ
CCCCCCCCCCCCCCC
26.84-
107O-linked_GlycosylationYGQQPAPSSTSGSYG
CCCCCCCCCCCCCCC
48.6421740066
108O-linked_GlycosylationGQQPAPSSTSGSYGS
CCCCCCCCCCCCCCC
26.0721740066
109O-linked_GlycosylationQQPAPSSTSGSYGSS
CCCCCCCCCCCCCCC
41.2521740066
110O-linked_GlycosylationQPAPSSTSGSYGSSS
CCCCCCCCCCCCCCC
27.9121740066
112PhosphorylationAPSSTSGSYGSSSQS
CCCCCCCCCCCCCCC
26.53-
112O-linked_GlycosylationAPSSTSGSYGSSSQS
CCCCCCCCCCCCCCC
26.5321740066
117PhosphorylationSGSYGSSSQSSSYGQ
CCCCCCCCCCCCCCC
35.46-
131PhosphorylationQPQSGSYSQQPSYGG
CCCCCCCCCCCCCCC
24.8422817900
142PhosphorylationSYGGQQQSYGQQQSY
CCCCCCCCCCCCCCC
27.22-
213MethylationGGYGQQDRGGRGRGG
CCCCCCCCCCCCCCC
45.1683108269
215MethylationYGQQDRGGRGRGGSG
CCCCCCCCCCCCCCC
29.7515782174
216Asymmetric dimethylarginineGQQDRGGRGRGGSGG
CCCCCCCCCCCCCCC
34.16-
216MethylationGQQDRGGRGRGGSGG
CCCCCCCCCCCCCCC
34.1624129315
217MethylationQQDRGGRGRGGSGGG
CCCCCCCCCCCCCCC
35.5415782174
218Asymmetric dimethylarginineQDRGGRGRGGSGGGG
CCCCCCCCCCCCCCC
44.96-
218MethylationQDRGGRGRGGSGGGG
CCCCCCCCCCCCCCC
44.9624129315
220 (in isoform 2)Phosphorylation-23.0421406692
221PhosphorylationGGRGRGGSGGGGGGG
CCCCCCCCCCCCCCC
36.7725849741
232PhosphorylationGGGGGGGYNRSSGGY
CCCCCCCCCCCCCCC
15.6325367160
234MethylationGGGGGYNRSSGGYEP
CCCCCCCCCCCCCCC
24.5816287779
239PhosphorylationYNRSSGGYEPRGRGG
CCCCCCCCCCCCCCC
26.7028152594
242Asymmetric dimethylarginineSSGGYEPRGRGGGRG
CCCCCCCCCCCCCCC
35.19-
242MethylationSSGGYEPRGRGGGRG
CCCCCCCCCCCCCCC
35.1912964758
243MethylationSGGYEPRGRGGGRGG
CCCCCCCCCCCCCCC
43.2115782174
244Asymmetric dimethylarginineGGYEPRGRGGGRGGR
CCCCCCCCCCCCCCC
41.69-
244MethylationGGYEPRGRGGGRGGR
CCCCCCCCCCCCCCC
41.6912964758
248Asymmetric dimethylargininePRGRGGGRGGRGGMG
CCCCCCCCCCCCCCC
47.90-
248MethylationPRGRGGGRGGRGGMG
CCCCCCCCCCCCCCC
47.9012964758
251Asymmetric dimethylarginineRGGGRGGRGGMGGSD
CCCCCCCCCCCCCCC
41.12-
251MethylationRGGGRGGRGGMGGSD
CCCCCCCCCCCCCCC
41.1212964758
257PhosphorylationGRGGMGGSDRGGFNK
CCCCCCCCCCCCCCC
20.5710913197
259Asymmetric dimethylarginineGGMGGSDRGGFNKFG
CCCCCCCCCCCCCCC
49.16-
259MethylationGGMGGSDRGGFNKFG
CCCCCCCCCCCCCCC
49.1612964758
264UbiquitinationSDRGGFNKFGGPRDQ
CCCCCCCCCCCCCCC
43.03-
264AcetylationSDRGGFNKFGGPRDQ
CCCCCCCCCCCCCCC
43.0326051181
269MethylationFNKFGGPRDQGSRHD
CCCCCCCCCCCCCCC
52.76115479339
272 (in isoform 2)Phosphorylation-30.8221406692
273PhosphorylationGGPRDQGSRHDSEQD
CCCCCCCCCCCCCCC
22.3228258704
276 (in isoform 2)Phosphorylation-53.4021406692
277PhosphorylationDQGSRHDSEQDNSDN
CCCCCCCCCCCCCCC
30.9125159151
281 (in isoform 2)Phosphorylation-51.4621406692
282PhosphorylationHDSEQDNSDNNTIFV
CCCCCCCCCCCEEEE
50.4320873877
285 (in isoform 2)Phosphorylation-39.2721406692
286PhosphorylationQDNSDNNTIFVQGLG
CCCCCCCEEEEECCC
23.2628348404
296 (in isoform 2)Phosphorylation-5.0621406692
297PhosphorylationQGLGENVTIESVADY
ECCCCCEEHHHHHHH
30.5220873877
300PhosphorylationGENVTIESVADYFKQ
CCCEEHHHHHHHHHH
20.8220068231
304PhosphorylationTIESVADYFKQIGII
EHHHHHHHHHHCCEE
11.7020068231
312UbiquitinationFKQIGIIKTNKKTGQ
HHHCCEEECCCCCCC
44.09-
312AcetylationFKQIGIIKTNKKTGQ
HHHCCEEECCCCCCC
44.0925953088
315UbiquitinationIGIIKTNKKTGQPMI
CCEEECCCCCCCCCE
57.87-
315 (in isoform 2)Ubiquitination-57.8721890473
316UbiquitinationGIIKTNKKTGQPMIN
CEEECCCCCCCCCEE
61.0221890473
316MalonylationGIIKTNKKTGQPMIN
CEEECCCCCCCCCEE
61.0226320211
317PhosphorylationIIKTNKKTGQPMINL
EEECCCCCCCCCEEE
42.5320068231
319 (in isoform 1)Ubiquitination-29.6221890473
321SulfoxidationNKKTGQPMINLYTDR
CCCCCCCCEEEEECC
2.1428183972
325PhosphorylationGQPMINLYTDRETGK
CCCCEEEEECCCCCC
11.3420068231
326PhosphorylationQPMINLYTDRETGKL
CCCEEEEECCCCCCC
31.5720068231
332AcetylationYTDRETGKLKGEATV
EECCCCCCCCCEEEE
55.2123749302
334UbiquitinationDRETGKLKGEATVSF
CCCCCCCCCEEEEEC
59.18-
334SumoylationDRETGKLKGEATVSF
CCCCCCCCCEEEEEC
59.1828112733
334AcetylationDRETGKLKGEATVSF
CCCCCCCCCEEEEEC
59.1826051181
338PhosphorylationGKLKGEATVSFDDPP
CCCCCEEEEECCCCC
16.6325850435
340PhosphorylationLKGEATVSFDDPPSA
CCCEEEEECCCCCCC
20.7125159151
346PhosphorylationVSFDDPPSAKAAIDW
EECCCCCCCCEEEEE
48.0325159151
347 (in isoform 2)Ubiquitination-15.9821890473
348UbiquitinationFDDPPSAKAAIDWFD
CCCCCCCCEEEEECC
42.5622053931
348SumoylationFDDPPSAKAAIDWFD
CCCCCCCCEEEEECC
42.56-
351 (in isoform 1)Ubiquitination-6.0221890473
357AcetylationAIDWFDGKEFSGNPI
EEEECCCCCCCCCCE
58.3826051181
357UbiquitinationAIDWFDGKEFSGNPI
EEEECCCCCCCCCCE
58.38-
357SumoylationAIDWFDGKEFSGNPI
EEEECCCCCCCCCCE
58.38-
360PhosphorylationWFDGKEFSGNPIKVS
ECCCCCCCCCCEEEE
38.4628348404
364 (in isoform 2)Ubiquitination-8.8021890473
365MethylationEFSGNPIKVSFATRR
CCCCCCEEEEEEECC
32.8444491411
365UbiquitinationEFSGNPIKVSFATRR
CCCCCCEEEEEEECC
32.8421890473
365SumoylationEFSGNPIKVSFATRR
CCCCCCEEEEEEECC
32.84-
365AcetylationEFSGNPIKVSFATRR
CCCCCCEEEEEEECC
32.8426051181
368 (in isoform 1)Ubiquitination-10.1021890473
371MethylationIKVSFATRRADFNRG
EEEEEEECCCCCCCC
28.4954556729
372MethylationKVSFATRRADFNRGG
EEEEEECCCCCCCCC
33.87-
377Asymmetric dimethylarginineTRRADFNRGGGNGRG
ECCCCCCCCCCCCCC
45.16-
377MethylationTRRADFNRGGGNGRG
ECCCCCCCCCCCCCC
45.1612964758
383Asymmetric dimethylarginineNRGGGNGRGGRGRGG
CCCCCCCCCCCCCCC
48.68-
383MethylationNRGGGNGRGGRGRGG
CCCCCCCCCCCCCCC
48.6812964758
385MethylationGGGNGRGGRGRGGPM
CCCCCCCCCCCCCCC
27.7515782174
386Asymmetric dimethylarginineGGNGRGGRGRGGPMG
CCCCCCCCCCCCCCC
34.16-
386MethylationGGNGRGGRGRGGPMG
CCCCCCCCCCCCCCC
34.1612964758
387MethylationGNGRGGRGRGGPMGR
CCCCCCCCCCCCCCC
35.5415782174
388Asymmetric dimethylarginineNGRGGRGRGGPMGRG
CCCCCCCCCCCCCCC
45.60-
388MethylationNGRGGRGRGGPMGRG
CCCCCCCCCCCCCCC
45.6012964758
394Asymmetric dimethylarginineGRGGPMGRGGYGGGG
CCCCCCCCCCCCCCC
29.16-
394MethylationGRGGPMGRGGYGGGG
CCCCCCCCCCCCCCC
29.1612964758
397PhosphorylationGPMGRGGYGGGGSGG
CCCCCCCCCCCCCCC
18.5424667141
407Asymmetric dimethylarginineGGSGGGGRGGFPSGG
CCCCCCCCCCCCCCC
45.39-
407MethylationGGSGGGGRGGFPSGG
CCCCCCCCCCCCCCC
45.3912964758
412O-linked_GlycosylationGGRGGFPSGGGGGGG
CCCCCCCCCCCCCCC
48.0521740066
427AcetylationQQRAGDWKCPNPTCE
CCCCCCCCCCCCCCC
44.5525953088
436SulfoxidationPNPTCENMNFSWRNE
CCCCCCCCCCCCCCC
2.2128465586
439PhosphorylationTCENMNFSWRNECNQ
CCCCCCCCCCCCCCC
21.8128857561
448UbiquitinationRNECNQCKAPKPDGP
CCCCCCCCCCCCCCC
58.94-
451AcetylationCNQCKAPKPDGPGGG
CCCCCCCCCCCCCCC
61.6826051181
462PhosphorylationPGGGPGGSHMGGNYG
CCCCCCCCCCCCCCC
19.0625849741
464SulfoxidationGGPGGSHMGGNYGDD
CCCCCCCCCCCCCCC
8.6621406390
468PhosphorylationGSHMGGNYGDDRRGG
CCCCCCCCCCCCCCC
25.8025884760
468NitrationGSHMGGNYGDDRRGG
CCCCCCCCCCCCCCC
25.80-
473Asymmetric dimethylarginineGNYGDDRRGGRGGYD
CCCCCCCCCCCCCCC
59.93-
473MethylationGNYGDDRRGGRGGYD
CCCCCCCCCCCCCCC
59.9312964758
476Asymmetric dimethylarginineGDDRRGGRGGYDRGG
CCCCCCCCCCCCCCC
37.88-
476MethylationGDDRRGGRGGYDRGG
CCCCCCCCCCCCCCC
37.8812964758
481Asymmetric dimethylarginineGGRGGYDRGGYRGRG
CCCCCCCCCCCCCCC
31.77-
481MethylationGGRGGYDRGGYRGRG
CCCCCCCCCCCCCCC
31.7712964758
485Asymmetric dimethylarginineGYDRGGYRGRGGDRG
CCCCCCCCCCCCCCC
31.44-
485MethylationGYDRGGYRGRGGDRG
CCCCCCCCCCCCCCC
31.4412964758
486MethylationYDRGGYRGRGGDRGG
CCCCCCCCCCCCCCC
24.8915782174
487Asymmetric dimethylarginineDRGGYRGRGGDRGGF
CCCCCCCCCCCCCCC
36.60-
487MethylationDRGGYRGRGGDRGGF
CCCCCCCCCCCCCCC
36.6012964758
491Asymmetric dimethylarginineYRGRGGDRGGFRGGR
CCCCCCCCCCCCCCC
50.86-
491MethylationYRGRGGDRGGFRGGR
CCCCCCCCCCCCCCC
50.8612964758
495Asymmetric dimethylarginineGGDRGGFRGGRGGGD
CCCCCCCCCCCCCCC
50.35-
495MethylationGGDRGGFRGGRGGGD
CCCCCCCCCCCCCCC
50.3512964758
498Asymmetric dimethylarginineRGGFRGGRGGGDRGG
CCCCCCCCCCCCCCC
43.33-
498MethylationRGGFRGGRGGGDRGG
CCCCCCCCCCCCCCC
43.3312964758
503Asymmetric dimethylarginineGGRGGGDRGGFGPGK
CCCCCCCCCCCCCCC
50.86-
503MethylationGGRGGGDRGGFGPGK
CCCCCCCCCCCCCCC
50.8624129315
510AcetylationRGGFGPGKMDSRGEH
CCCCCCCCCCCCCCC
42.5425953088
514MethylationGPGKMDSRGEHRQDR
CCCCCCCCCCCCCCH
50.7054556721
526PhosphorylationQDRRERPY-------
CCHHCCCC-------
37.09-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
7TPhosphorylationKinasePRKDCP78527
GPS
11TPhosphorylationKinasePRKDCP78527
GPS
19TPhosphorylationKinasePRKDCP78527
GPS
26SPhosphorylationKinasePRKDCP78527
GPS
30SPhosphorylationKinasePRKDCP78527
GPS
42SPhosphorylationKinaseATMQ13315
Uniprot
42SPhosphorylationKinasePRKDCP78527
GPS
54SPhosphorylationKinasePRKDCP78527
GPS
61SPhosphorylationKinasePRKDCP78527
GPS
68TPhosphorylationKinasePRKDCP78527
GPS
84SPhosphorylationKinasePRKDCP78527
GPS
87SPhosphorylationKinasePRKDCP78527
GPS
112SPhosphorylationKinasePRKDCP78527
GPS
117SPhosphorylationKinasePRKDCP78527
GPS
131SPhosphorylationKinasePRKDCP78527
GPS
142SPhosphorylationKinasePRKDCP78527
GPS
257SPhosphorylationKinasePRKCBP05771-2
GPS
257SPhosphorylationKinaseKPCBP05771
PhosphoELM
526YPhosphorylationKinaseSRCP12931
PSP
526YPhosphorylationKinaseFYNP06241
PSP
-KUbiquitinationE3 ubiquitin ligaseMDM2Q00987
PMID:31632968

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
216RMethylation

24129315
218RMethylation

24129315

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FUS_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTBP2_HUMANPTBP2physical
12581738
ANM1_HUMANPRMT1physical
16169070
SPI1_HUMANSPI1physical
9478924
ILF3_HUMANILF3physical
11438536
SF01_HUMANSF1physical
9660765
SRS10_HUMANSRSF10physical
10779324
THA_HUMANTHRAphysical
9440806
RXRA_HUMANRXRAphysical
9440806
TF65_HUMANRELAphysical
11278855
TADBP_HUMANTARDBPphysical
20720006
ARG28_HUMANARHGEF28physical
22941224
PA2G4_HUMANPA2G4physical
19946338
UBC9_HUMANUBE2Iphysical
19946338
ROA3_HUMANHNRNPA3physical
22939629
NONO_HUMANNONOphysical
22939629
GSE1_HUMANGSE1physical
22939629
MBD3_HUMANMBD3physical
22939629
RT18B_HUMANMRPS18Bphysical
22939629
S30BP_HUMANSAP30BPphysical
22939629
RLA1_HUMANRPLP1physical
22939629
P63_HUMANTP63physical
20085233
IL7RA_HUMANIL7Rphysical
23151878
CTNB1_HUMANCTNNB1physical
16230076
ECM32_YEASTECM32genetic
21541368
NAM8_YEASTNAM8genetic
21541368
SSBP1_YEASTSBP1genetic
21541368
SKO1_YEASTSKO1genetic
21541368
VHR1_YEASTVHR1genetic
21541368
RENT1_HUMANUPF1genetic
21541368
TDRD3_HUMANTDRD3physical
21988832
RBMX_HUMANRBMXphysical
21988832
PSB7_HUMANPSMB7physical
21988832
MDHC_HUMANMDH1physical
21988832
RBP56_HUMANTAF15physical
21988832
SRSF9_HUMANSRSF9physical
21988832
SAFB2_HUMANSAFB2physical
21988832
TNIP1_HUMANTNIP1physical
21988832
KHDR3_HUMANKHDRBS3physical
21988832
NKD2_HUMANNKD2physical
21988832
SUV91_HUMANSUV39H1physical
23455924
HNRPU_HUMANHNRNPUphysical
22863883
SYLC_HUMANLARSphysical
22863883
YBOX1_HUMANYBX1physical
22863883
TERA_HUMANVCPphysical
25192599
SFPQ_HUMANSFPQphysical
25192599
1433Z_HUMANYWHAZphysical
25192599
1433T_HUMANYWHAQphysical
25192599
PROF1_HUMANPFN1physical
25192599
FAS_HUMANFASNphysical
25192599
PGK1_HUMANPGK1physical
25192599
KCRB_HUMANCKBphysical
25192599
ENOA_HUMANENO1physical
25192599
LDHB_HUMANLDHBphysical
25192599
PUR6_HUMANPAICSphysical
25192599
SERA_HUMANPHGDHphysical
25192599
LDHA_HUMANLDHAphysical
25192599
G3P_HUMANGAPDHphysical
25192599
KPYM_HUMANPKMphysical
25192599
ATX2L_HUMANATXN2Lphysical
25192599
C1TC_HUMANMTHFD1physical
25192599
ACACA_HUMANACACAphysical
25192599
CAH2_HUMANCA2physical
25192599
ALDOA_HUMANALDOAphysical
25192599
G6PI_HUMANGPIphysical
25192599
P5CR3_HUMANPYCRLphysical
25192599
PFKAL_HUMANPFKLphysical
25192599
PGM1_HUMANPGM1physical
25192599
ABCA1_HUMANABCA1physical
25192599
HPRT_HUMANHPRT1physical
25192599
P20D2_HUMANPM20D2physical
25192599
TKT_HUMANTKTphysical
25192599
CADH4_HUMANCDH4physical
25192599
GNAS3_HUMANGNASphysical
25192599
GNAS2_HUMANGNASphysical
25192599
ALEX_HUMANGNASphysical
25192599
GNAS1_HUMANGNASphysical
25192599
PLCE1_HUMANPLCE1physical
25192599
TRPM4_HUMANTRPM4physical
25192599
AAAT_HUMANSLC1A5physical
25192599
UBAP2_HUMANUBAP2physical
25192599
UBP2L_HUMANUBAP2Lphysical
25192599
LYSC_HUMANLYZphysical
25192599
CKAP4_HUMANCKAP4physical
25192599
YPEL1_HUMANYPEL1physical
25192599
H33_HUMANH3F3Aphysical
25192599
H2B2E_HUMANHIST2H2BEphysical
25192599
DDX42_HUMANDDX42physical
25192599
HNRPD_HUMANHNRNPDphysical
25192599
HNRPQ_HUMANSYNCRIPphysical
25192599
DHX40_HUMANDHX40physical
25192599
SF01_HUMANSF1physical
25192599
SF3A1_HUMANSF3A1physical
25192599
SF3B3_HUMANSF3B3physical
25192599
SF3B4_HUMANSF3B4physical
25192599
PAIRB_HUMANSERBP1physical
25192599
FANCM_HUMANFANCMphysical
25192599
FSBP_HUMANRAD54Bphysical
25192599
RA54B_HUMANRAD54Bphysical
25192599
PCNA_HUMANPCNAphysical
25192599
PHB_HUMANPHBphysical
25192599
P73_HUMANTP73physical
25192599
RL18_HUMANRPL18physical
25192599
RL9_HUMANRPL9physical
25192599
RS9_HUMANRPS9physical
25192599
TBPL1_HUMANTBPL1physical
25192599
TRIP4_HUMANTRIP4physical
25192599
DJC10_HUMANDNAJC10physical
25192599
ANM1_HUMANPRMT1physical
25192599
SAE1_HUMANSAE1physical
25192599
DLDH_HUMANDLDphysical
25192599
AATM_HUMANGOT2physical
25192599
ATPA_HUMANATP5A1physical
25192599
GSTP1_HUMANGSTP1physical
25192599
SYHM_HUMANHARS2physical
25192599
MPCP_HUMANSLC25A3physical
25192599
IMA1_HUMANKPNA2physical
25192599
RAB7A_HUMANRAB7Aphysical
25192599
SPAT6_HUMANSPATA6physical
25192599
UACA_HUMANUACAphysical
25192599
STAT_HUMANSTATHphysical
25192599
ANXA5_HUMANANXA5physical
25192599
M3K3_HUMANMAP3K3physical
25192599
UBC_HUMANUBCphysical
25192599
UBA1_HUMANUBA1physical
25192599
TBB5_HUMANTUBBphysical
25192599
COF1_HUMANCFL1physical
25192599
TBA1A_HUMANTUBA1Aphysical
25192599
ACTB_HUMANACTBphysical
25192599
HNRPF_HUMANHNRNPFphysical
25192599
HNRH1_HUMANHNRNPH1physical
25192599
DHX15_HUMANDHX15physical
25192599
CPSF6_HUMANCPSF6physical
25192599
SF3A3_HUMANSF3A3physical
25192599
HNRPK_HUMANHNRNPKphysical
25192599
HNRPU_HUMANHNRNPUphysical
25192599
PSPC1_HUMANPSPC1physical
25192599
HNRPL_HUMANHNRNPLphysical
25192599
NONO_HUMANNONOphysical
25192599
RS5_HUMANRPS5physical
25192599
RS8_HUMANRPS8physical
25192599
RL12_HUMANRPL12physical
25192599
RPN2_HUMANRPN2physical
25192599
EF1A1_HUMANEEF1A1physical
25192599
EF2_HUMANEEF2physical
25192599
EF1G_HUMANEEF1Gphysical
25192599
HS90A_HUMANHSP90AA1physical
25192599
TCPE_HUMANCCT5physical
25192599
TCPZ_HUMANCCT6Aphysical
25192599
HS90B_HUMANHSP90AB1physical
25192599
TCPB_HUMANCCT2physical
25192599
TCPD_HUMANCCT4physical
25192599
GRP78_HUMANHSPA5physical
25192599
ENPL_HUMANHSP90B1physical
25192599
TCPG_HUMANCCT3physical
25192599
TCPH_HUMANCCT7physical
25192599
TCPQ_HUMANCCT8physical
25192599
HSP7C_HUMANHSPA8physical
25192599
PPIL4_HUMANPPIL4physical
25192599
TCPA_HUMANTCP1physical
25192599
PDIA3_HUMANPDIA3physical
25192599
PPIA_HUMANPPIAphysical
25192599
SSBP_HUMANSSBP1physical
25192599
DHE3_HUMANGLUD1physical
25192599
ATPB_HUMANATP5Bphysical
25192599
GRP75_HUMANHSPA9physical
25192599
ERAL1_HUMANERAL1physical
25192599
EFTU_HUMANTUFMphysical
25192599
CH60_HUMANHSPD1physical
25192599
P5CR1_HUMANPYCR1physical
25192599
MDHM_HUMANMDH2physical
25192599
ABCF2_HUMANABCF2physical
25192599
IMB1_HUMANKPNB1physical
25192599
PRDX1_HUMANPRDX1physical
25192599
ERP44_HUMANERP44physical
25192599
FA7_HUMANF7physical
25192599
ALBU_HUMANALBphysical
25192599
ARMC6_HUMANARMC6physical
25192599
ADCK5_HUMANADCK5physical
25192599
GRDN_HUMANCCDC88Aphysical
25192599
GP101_HUMANGPR101physical
25192599
ITK_HUMANITKphysical
25192599
DGKA_HUMANDGKAphysical
25192599
S22AB_HUMANSLC22A11physical
25192599
PSD12_HUMANPSMD12physical
25192599
HERC6_HUMANHERC6physical
25192599
TBA1B_HUMANTUBA1Bphysical
25192599
MTSSL_HUMANMTSS1Lphysical
25192599
CE112_HUMANCEP112physical
25192599
COIA1_HUMANCOL18A1physical
25192599
LMNA_HUMANLMNAphysical
25192599
SEC13_HUMANSEC13physical
25192599
NP1L1_HUMANNAP1L1physical
25192599
SMD2_HUMANSNRPD2physical
25192599
CNDG2_HUMANNCAPG2physical
25192599
RBBP4_HUMANRBBP4physical
25192599
LSM12_HUMANLSM12physical
25192599
CPSF5_HUMANNUDT21physical
25192599
DDX1_HUMANDDX1physical
25192599
CN166_HUMANC14orf166physical
25192599
DDX5_HUMANDDX5physical
25192599
ZEP3_HUMANHIVEP3physical
25192599
NCOA6_HUMANNCOA6physical
25192599
RAVR1_HUMANRAVER1physical
25192599
ELOC_HUMANTCEB1physical
25192599
TXN4B_HUMANTXNL4Bphysical
25192599
TTI2_HUMANTTI2physical
25192599
GEN_HUMANGEN1physical
25192599
RL14_HUMANRPL14physical
25192599
RS14_HUMANRPS14physical
25192599
NPM_HUMANNPM1physical
25192599
RL11_HUMANRPL11physical
25192599
RL4_HUMANRPL4physical
25192599
IF4A1_HUMANEIF4A1physical
25192599
PCBP2_HUMANPCBP2physical
25192599
F10A1_HUMANST13physical
25192599
NSDHL_HUMANNSDHLphysical
25192599
MTAP_HUMANMTAPphysical
25192599
METK2_HUMANMAT2Aphysical
25192599
SAHH_HUMANAHCYphysical
25192599
OAT_HUMANOATphysical
25192599
BCS1_HUMANBCS1Lphysical
25192599
ADT2_HUMANSLC25A5physical
25192599
TIM50_HUMANTIMM50physical
25192599
MYH10_HUMANMYH10physical
25192599
GOLI4_HUMANGOLIM4physical
25192599
XPO2_HUMANCSE1Lphysical
25192599
RAN_HUMANRANphysical
25192599
KLH40_HUMANKLHL40physical
25192599
KLHL5_HUMANKLHL5physical
25192599
CO6_HUMANC6physical
25192599
GIMA8_HUMANGIMAP8physical
25192599
CDC5L_HUMANCDC5Lphysical
25192599
CEP78_HUMANCEP78physical
25192599
DBF4B_HUMANDBF4Bphysical
25192599
AMOT_HUMANAMOTphysical
25192599
F71F1_HUMANFAM71F1physical
25192599
MFGM_HUMANMFGE8physical
25192599
FA98A_HUMANFAM98Aphysical
25192599
CK070_HUMANC11orf70physical
25192599
RTCB_HUMANRTCBphysical
25192599
UFL1_HUMANUFL1physical
25192599
LRIQ4_HUMANLRRIQ4physical
25192599
DBR1_YEASTDBR1genetic
23104007
RENT2_HUMANUPF2genetic
21541368
REN3A_HUMANUPF3Agenetic
21541368
HS104_YEASTHSP104genetic
25062688
THIL_HUMANACAT1physical
26344197
ARMC1_HUMANARMC1physical
26344197
ASHWN_HUMANC2orf49physical
26344197
DDX17_HUMANDDX17physical
26344197
DNJC7_HUMANDNAJC7physical
26344197
IF4H_HUMANEIF4Hphysical
26344197
ROA3_HUMANHNRNPA3physical
26344197
HNRPD_HUMANHNRNPDphysical
26344197
HNRDL_HUMANHNRNPDLphysical
26344197
HNRPL_HUMANHNRNPLphysical
26344197
MEF2D_HUMANMEF2Dphysical
26344197
NAA50_HUMANNAA50physical
26344197
NONO_HUMANNONOphysical
26344197
NPL4_HUMANNPLOC4physical
26344197
PFKAP_HUMANPFKPphysical
26344197
PGK1_HUMANPGK1physical
26344197
PICAL_HUMANPICALMphysical
26344197
SFPQ_HUMANSFPQphysical
26344197
SYTC_HUMANTARSphysical
26344197
TF7L2_HUMANTCF7L2physical
16230076
KCTD6_HUMANKCTD6physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12
16)(q13
p11) with DDIT3.
612160
608030Amyotrophic lateral sclerosis 6 (ALS6)
614782Tremor, hereditary essential 4 (ETM4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FUS_HUMAN

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC.";
Ong S.E., Mittler G., Mann M.;
Nat. Methods 1:119-126(2004).
Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-216 AND ARG-218, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; THR-286 ANDSER-346, AND MASS SPECTROMETRY.

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