UniProt ID | FUS_HUMAN | |
---|---|---|
UniProt AC | P35637 | |
Protein Name | RNA-binding protein FUS | |
Gene Name | FUS | |
Organism | Homo sapiens (Human). | |
Sequence Length | 526 | |
Subcellular Localization | Nucleus . | |
Protein Description | Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.. | |
Protein Sequence | MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
7 | Phosphorylation | -MASNDYTQQATQSY -CCCCCHHHHHHHHC | 19.64 | - | |
11 | Phosphorylation | NDYTQQATQSYGAYP CCHHHHHHHHCCCCC | 17.45 | - | |
19 | Phosphorylation | QSYGAYPTQPGQGYS HHCCCCCCCCCCCCC | 34.42 | - | |
19 | O-linked_Glycosylation | QSYGAYPTQPGQGYS HHCCCCCCCCCCCCC | 34.42 | 358927213 | |
26 | Phosphorylation | TQPGQGYSQQSSQPY CCCCCCCCCCCCCCC | 28.68 | 29897835 | |
30 | Phosphorylation | QGYSQQSSQPYGQQS CCCCCCCCCCCCCCC | 30.73 | 29897835 | |
39 | O-linked_Glycosylation | PYGQQSYSGYSQSTD CCCCCCCCCCCCCCC | 36.18 | 21740066 | |
42 | Phosphorylation | QQSYSGYSQSTDTSG CCCCCCCCCCCCCCC | 22.60 | 22817900 | |
42 | O-linked_Glycosylation | QQSYSGYSQSTDTSG CCCCCCCCCCCCCCC | 22.60 | 21740066 | |
45 | O-linked_Glycosylation | YSGYSQSTDTSGYGQ CCCCCCCCCCCCCCC | 35.34 | 21740066 | |
47 | O-linked_Glycosylation | GYSQSTDTSGYGQSS CCCCCCCCCCCCCCC | 24.92 | 21740066 | |
54 | Phosphorylation | TSGYGQSSYSSYGQS CCCCCCCCCCCCCCC | 22.58 | - | |
61 | Phosphorylation | SYSSYGQSQNTGYGT CCCCCCCCCCCCCCC | 22.49 | 22817900 | |
68 | Phosphorylation | SQNTGYGTQSTPQGY CCCCCCCCCCCCCCC | 15.74 | - | |
84 | Phosphorylation | STGGYGSSQSSQSSY CCCCCCCCCCCCCCC | 29.71 | 22817900 | |
87 | Phosphorylation | GYGSSQSSQSSYGQQ CCCCCCCCCCCCCCC | 26.84 | - | |
107 | O-linked_Glycosylation | YGQQPAPSSTSGSYG CCCCCCCCCCCCCCC | 48.64 | 21740066 | |
108 | O-linked_Glycosylation | GQQPAPSSTSGSYGS CCCCCCCCCCCCCCC | 26.07 | 21740066 | |
109 | O-linked_Glycosylation | QQPAPSSTSGSYGSS CCCCCCCCCCCCCCC | 41.25 | 21740066 | |
110 | O-linked_Glycosylation | QPAPSSTSGSYGSSS CCCCCCCCCCCCCCC | 27.91 | 21740066 | |
112 | Phosphorylation | APSSTSGSYGSSSQS CCCCCCCCCCCCCCC | 26.53 | - | |
112 | O-linked_Glycosylation | APSSTSGSYGSSSQS CCCCCCCCCCCCCCC | 26.53 | 21740066 | |
117 | Phosphorylation | SGSYGSSSQSSSYGQ CCCCCCCCCCCCCCC | 35.46 | - | |
131 | Phosphorylation | QPQSGSYSQQPSYGG CCCCCCCCCCCCCCC | 24.84 | 22817900 | |
142 | Phosphorylation | SYGGQQQSYGQQQSY CCCCCCCCCCCCCCC | 27.22 | - | |
213 | Methylation | GGYGQQDRGGRGRGG CCCCCCCCCCCCCCC | 45.16 | 83108269 | |
215 | Methylation | YGQQDRGGRGRGGSG CCCCCCCCCCCCCCC | 29.75 | 15782174 | |
216 | Asymmetric dimethylarginine | GQQDRGGRGRGGSGG CCCCCCCCCCCCCCC | 34.16 | - | |
216 | Methylation | GQQDRGGRGRGGSGG CCCCCCCCCCCCCCC | 34.16 | 24129315 | |
217 | Methylation | QQDRGGRGRGGSGGG CCCCCCCCCCCCCCC | 35.54 | 15782174 | |
218 | Asymmetric dimethylarginine | QDRGGRGRGGSGGGG CCCCCCCCCCCCCCC | 44.96 | - | |
218 | Methylation | QDRGGRGRGGSGGGG CCCCCCCCCCCCCCC | 44.96 | 24129315 | |
220 (in isoform 2) | Phosphorylation | - | 23.04 | 21406692 | |
221 | Phosphorylation | GGRGRGGSGGGGGGG CCCCCCCCCCCCCCC | 36.77 | 25849741 | |
232 | Phosphorylation | GGGGGGGYNRSSGGY CCCCCCCCCCCCCCC | 15.63 | 25367160 | |
234 | Methylation | GGGGGYNRSSGGYEP CCCCCCCCCCCCCCC | 24.58 | 16287779 | |
239 | Phosphorylation | YNRSSGGYEPRGRGG CCCCCCCCCCCCCCC | 26.70 | 28152594 | |
242 | Asymmetric dimethylarginine | SSGGYEPRGRGGGRG CCCCCCCCCCCCCCC | 35.19 | - | |
242 | Methylation | SSGGYEPRGRGGGRG CCCCCCCCCCCCCCC | 35.19 | 12964758 | |
243 | Methylation | SGGYEPRGRGGGRGG CCCCCCCCCCCCCCC | 43.21 | 15782174 | |
244 | Asymmetric dimethylarginine | GGYEPRGRGGGRGGR CCCCCCCCCCCCCCC | 41.69 | - | |
244 | Methylation | GGYEPRGRGGGRGGR CCCCCCCCCCCCCCC | 41.69 | 12964758 | |
248 | Asymmetric dimethylarginine | PRGRGGGRGGRGGMG CCCCCCCCCCCCCCC | 47.90 | - | |
248 | Methylation | PRGRGGGRGGRGGMG CCCCCCCCCCCCCCC | 47.90 | 12964758 | |
251 | Asymmetric dimethylarginine | RGGGRGGRGGMGGSD CCCCCCCCCCCCCCC | 41.12 | - | |
251 | Methylation | RGGGRGGRGGMGGSD CCCCCCCCCCCCCCC | 41.12 | 12964758 | |
257 | Phosphorylation | GRGGMGGSDRGGFNK CCCCCCCCCCCCCCC | 20.57 | 10913197 | |
259 | Asymmetric dimethylarginine | GGMGGSDRGGFNKFG CCCCCCCCCCCCCCC | 49.16 | - | |
259 | Methylation | GGMGGSDRGGFNKFG CCCCCCCCCCCCCCC | 49.16 | 12964758 | |
264 | Ubiquitination | SDRGGFNKFGGPRDQ CCCCCCCCCCCCCCC | 43.03 | - | |
264 | Acetylation | SDRGGFNKFGGPRDQ CCCCCCCCCCCCCCC | 43.03 | 26051181 | |
269 | Methylation | FNKFGGPRDQGSRHD CCCCCCCCCCCCCCC | 52.76 | 115479339 | |
272 (in isoform 2) | Phosphorylation | - | 30.82 | 21406692 | |
273 | Phosphorylation | GGPRDQGSRHDSEQD CCCCCCCCCCCCCCC | 22.32 | 28258704 | |
276 (in isoform 2) | Phosphorylation | - | 53.40 | 21406692 | |
277 | Phosphorylation | DQGSRHDSEQDNSDN CCCCCCCCCCCCCCC | 30.91 | 25159151 | |
281 (in isoform 2) | Phosphorylation | - | 51.46 | 21406692 | |
282 | Phosphorylation | HDSEQDNSDNNTIFV CCCCCCCCCCCEEEE | 50.43 | 20873877 | |
285 (in isoform 2) | Phosphorylation | - | 39.27 | 21406692 | |
286 | Phosphorylation | QDNSDNNTIFVQGLG CCCCCCCEEEEECCC | 23.26 | 28348404 | |
296 (in isoform 2) | Phosphorylation | - | 5.06 | 21406692 | |
297 | Phosphorylation | QGLGENVTIESVADY ECCCCCEEHHHHHHH | 30.52 | 20873877 | |
300 | Phosphorylation | GENVTIESVADYFKQ CCCEEHHHHHHHHHH | 20.82 | 20068231 | |
304 | Phosphorylation | TIESVADYFKQIGII EHHHHHHHHHHCCEE | 11.70 | 20068231 | |
312 | Ubiquitination | FKQIGIIKTNKKTGQ HHHCCEEECCCCCCC | 44.09 | - | |
312 | Acetylation | FKQIGIIKTNKKTGQ HHHCCEEECCCCCCC | 44.09 | 25953088 | |
315 | Ubiquitination | IGIIKTNKKTGQPMI CCEEECCCCCCCCCE | 57.87 | - | |
315 (in isoform 2) | Ubiquitination | - | 57.87 | 21890473 | |
316 | Ubiquitination | GIIKTNKKTGQPMIN CEEECCCCCCCCCEE | 61.02 | 21890473 | |
316 | Malonylation | GIIKTNKKTGQPMIN CEEECCCCCCCCCEE | 61.02 | 26320211 | |
317 | Phosphorylation | IIKTNKKTGQPMINL EEECCCCCCCCCEEE | 42.53 | 20068231 | |
319 (in isoform 1) | Ubiquitination | - | 29.62 | 21890473 | |
321 | Sulfoxidation | NKKTGQPMINLYTDR CCCCCCCCEEEEECC | 2.14 | 28183972 | |
325 | Phosphorylation | GQPMINLYTDRETGK CCCCEEEEECCCCCC | 11.34 | 20068231 | |
326 | Phosphorylation | QPMINLYTDRETGKL CCCEEEEECCCCCCC | 31.57 | 20068231 | |
332 | Acetylation | YTDRETGKLKGEATV EECCCCCCCCCEEEE | 55.21 | 23749302 | |
334 | Ubiquitination | DRETGKLKGEATVSF CCCCCCCCCEEEEEC | 59.18 | - | |
334 | Sumoylation | DRETGKLKGEATVSF CCCCCCCCCEEEEEC | 59.18 | 28112733 | |
334 | Acetylation | DRETGKLKGEATVSF CCCCCCCCCEEEEEC | 59.18 | 26051181 | |
338 | Phosphorylation | GKLKGEATVSFDDPP CCCCCEEEEECCCCC | 16.63 | 25850435 | |
340 | Phosphorylation | LKGEATVSFDDPPSA CCCEEEEECCCCCCC | 20.71 | 25159151 | |
346 | Phosphorylation | VSFDDPPSAKAAIDW EECCCCCCCCEEEEE | 48.03 | 25159151 | |
347 (in isoform 2) | Ubiquitination | - | 15.98 | 21890473 | |
348 | Ubiquitination | FDDPPSAKAAIDWFD CCCCCCCCEEEEECC | 42.56 | 22053931 | |
348 | Sumoylation | FDDPPSAKAAIDWFD CCCCCCCCEEEEECC | 42.56 | - | |
351 (in isoform 1) | Ubiquitination | - | 6.02 | 21890473 | |
357 | Acetylation | AIDWFDGKEFSGNPI EEEECCCCCCCCCCE | 58.38 | 26051181 | |
357 | Ubiquitination | AIDWFDGKEFSGNPI EEEECCCCCCCCCCE | 58.38 | - | |
357 | Sumoylation | AIDWFDGKEFSGNPI EEEECCCCCCCCCCE | 58.38 | - | |
360 | Phosphorylation | WFDGKEFSGNPIKVS ECCCCCCCCCCEEEE | 38.46 | 28348404 | |
364 (in isoform 2) | Ubiquitination | - | 8.80 | 21890473 | |
365 | Methylation | EFSGNPIKVSFATRR CCCCCCEEEEEEECC | 32.84 | 44491411 | |
365 | Ubiquitination | EFSGNPIKVSFATRR CCCCCCEEEEEEECC | 32.84 | 21890473 | |
365 | Sumoylation | EFSGNPIKVSFATRR CCCCCCEEEEEEECC | 32.84 | - | |
365 | Acetylation | EFSGNPIKVSFATRR CCCCCCEEEEEEECC | 32.84 | 26051181 | |
368 (in isoform 1) | Ubiquitination | - | 10.10 | 21890473 | |
371 | Methylation | IKVSFATRRADFNRG EEEEEEECCCCCCCC | 28.49 | 54556729 | |
372 | Methylation | KVSFATRRADFNRGG EEEEEECCCCCCCCC | 33.87 | - | |
377 | Asymmetric dimethylarginine | TRRADFNRGGGNGRG ECCCCCCCCCCCCCC | 45.16 | - | |
377 | Methylation | TRRADFNRGGGNGRG ECCCCCCCCCCCCCC | 45.16 | 12964758 | |
383 | Asymmetric dimethylarginine | NRGGGNGRGGRGRGG CCCCCCCCCCCCCCC | 48.68 | - | |
383 | Methylation | NRGGGNGRGGRGRGG CCCCCCCCCCCCCCC | 48.68 | 12964758 | |
385 | Methylation | GGGNGRGGRGRGGPM CCCCCCCCCCCCCCC | 27.75 | 15782174 | |
386 | Asymmetric dimethylarginine | GGNGRGGRGRGGPMG CCCCCCCCCCCCCCC | 34.16 | - | |
386 | Methylation | GGNGRGGRGRGGPMG CCCCCCCCCCCCCCC | 34.16 | 12964758 | |
387 | Methylation | GNGRGGRGRGGPMGR CCCCCCCCCCCCCCC | 35.54 | 15782174 | |
388 | Asymmetric dimethylarginine | NGRGGRGRGGPMGRG CCCCCCCCCCCCCCC | 45.60 | - | |
388 | Methylation | NGRGGRGRGGPMGRG CCCCCCCCCCCCCCC | 45.60 | 12964758 | |
394 | Asymmetric dimethylarginine | GRGGPMGRGGYGGGG CCCCCCCCCCCCCCC | 29.16 | - | |
394 | Methylation | GRGGPMGRGGYGGGG CCCCCCCCCCCCCCC | 29.16 | 12964758 | |
397 | Phosphorylation | GPMGRGGYGGGGSGG CCCCCCCCCCCCCCC | 18.54 | 24667141 | |
407 | Asymmetric dimethylarginine | GGSGGGGRGGFPSGG CCCCCCCCCCCCCCC | 45.39 | - | |
407 | Methylation | GGSGGGGRGGFPSGG CCCCCCCCCCCCCCC | 45.39 | 12964758 | |
412 | O-linked_Glycosylation | GGRGGFPSGGGGGGG CCCCCCCCCCCCCCC | 48.05 | 21740066 | |
427 | Acetylation | QQRAGDWKCPNPTCE CCCCCCCCCCCCCCC | 44.55 | 25953088 | |
436 | Sulfoxidation | PNPTCENMNFSWRNE CCCCCCCCCCCCCCC | 2.21 | 28465586 | |
439 | Phosphorylation | TCENMNFSWRNECNQ CCCCCCCCCCCCCCC | 21.81 | 28857561 | |
448 | Ubiquitination | RNECNQCKAPKPDGP CCCCCCCCCCCCCCC | 58.94 | - | |
451 | Acetylation | CNQCKAPKPDGPGGG CCCCCCCCCCCCCCC | 61.68 | 26051181 | |
462 | Phosphorylation | PGGGPGGSHMGGNYG CCCCCCCCCCCCCCC | 19.06 | 25849741 | |
464 | Sulfoxidation | GGPGGSHMGGNYGDD CCCCCCCCCCCCCCC | 8.66 | 21406390 | |
468 | Phosphorylation | GSHMGGNYGDDRRGG CCCCCCCCCCCCCCC | 25.80 | 25884760 | |
468 | Nitration | GSHMGGNYGDDRRGG CCCCCCCCCCCCCCC | 25.80 | - | |
473 | Asymmetric dimethylarginine | GNYGDDRRGGRGGYD CCCCCCCCCCCCCCC | 59.93 | - | |
473 | Methylation | GNYGDDRRGGRGGYD CCCCCCCCCCCCCCC | 59.93 | 12964758 | |
476 | Asymmetric dimethylarginine | GDDRRGGRGGYDRGG CCCCCCCCCCCCCCC | 37.88 | - | |
476 | Methylation | GDDRRGGRGGYDRGG CCCCCCCCCCCCCCC | 37.88 | 12964758 | |
481 | Asymmetric dimethylarginine | GGRGGYDRGGYRGRG CCCCCCCCCCCCCCC | 31.77 | - | |
481 | Methylation | GGRGGYDRGGYRGRG CCCCCCCCCCCCCCC | 31.77 | 12964758 | |
485 | Asymmetric dimethylarginine | GYDRGGYRGRGGDRG CCCCCCCCCCCCCCC | 31.44 | - | |
485 | Methylation | GYDRGGYRGRGGDRG CCCCCCCCCCCCCCC | 31.44 | 12964758 | |
486 | Methylation | YDRGGYRGRGGDRGG CCCCCCCCCCCCCCC | 24.89 | 15782174 | |
487 | Asymmetric dimethylarginine | DRGGYRGRGGDRGGF CCCCCCCCCCCCCCC | 36.60 | - | |
487 | Methylation | DRGGYRGRGGDRGGF CCCCCCCCCCCCCCC | 36.60 | 12964758 | |
491 | Asymmetric dimethylarginine | YRGRGGDRGGFRGGR CCCCCCCCCCCCCCC | 50.86 | - | |
491 | Methylation | YRGRGGDRGGFRGGR CCCCCCCCCCCCCCC | 50.86 | 12964758 | |
495 | Asymmetric dimethylarginine | GGDRGGFRGGRGGGD CCCCCCCCCCCCCCC | 50.35 | - | |
495 | Methylation | GGDRGGFRGGRGGGD CCCCCCCCCCCCCCC | 50.35 | 12964758 | |
498 | Asymmetric dimethylarginine | RGGFRGGRGGGDRGG CCCCCCCCCCCCCCC | 43.33 | - | |
498 | Methylation | RGGFRGGRGGGDRGG CCCCCCCCCCCCCCC | 43.33 | 12964758 | |
503 | Asymmetric dimethylarginine | GGRGGGDRGGFGPGK CCCCCCCCCCCCCCC | 50.86 | - | |
503 | Methylation | GGRGGGDRGGFGPGK CCCCCCCCCCCCCCC | 50.86 | 24129315 | |
510 | Acetylation | RGGFGPGKMDSRGEH CCCCCCCCCCCCCCC | 42.54 | 25953088 | |
514 | Methylation | GPGKMDSRGEHRQDR CCCCCCCCCCCCCCH | 50.70 | 54556721 | |
526 | Phosphorylation | QDRRERPY------- CCHHCCCC------- | 37.09 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
7 | T | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
11 | T | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
19 | T | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
26 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
30 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
42 | S | Phosphorylation | Kinase | ATM | Q13315 | Uniprot |
42 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
54 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
61 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
68 | T | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
84 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
87 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
112 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
117 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
131 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
142 | S | Phosphorylation | Kinase | PRKDC | P78527 | GPS |
257 | S | Phosphorylation | Kinase | PRKCB | P05771-2 | GPS |
257 | S | Phosphorylation | Kinase | KPCB | P05771 | PhosphoELM |
526 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
526 | Y | Phosphorylation | Kinase | FYN | P06241 | PSP |
- | K | Ubiquitination | E3 ubiquitin ligase | MDM2 | Q00987 | PMID:31632968 |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FUS_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12 | ||||||
16)(q13 | ||||||
p11) with DDIT3. | ||||||
612160 | ||||||
608030 | Amyotrophic lateral sclerosis 6 (ALS6) | |||||
614782 | Tremor, hereditary essential 4 (ETM4) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Methylation | |
Reference | PubMed |
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-216 AND ARG-218, AND MASSSPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; THR-286 ANDSER-346, AND MASS SPECTROMETRY. |