dbPTM

SPI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPI1_HUMAN
UniProt AC	P17947
Protein Name	Transcription factor PU.1
Gene Name	SPI1
Organism	Homo sapiens (Human).
Sequence Length	270
Subcellular Localization	Nucleus .
Protein Description	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity)..
Protein Sequence	MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRHPPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	FPLVPPPSEDLVPYD CCCCCCCHHHCCCCC	49.90	-
106	Phosphorylation	PMVPPHPSLGHQVSY CCCCCCCCCCCCHHH	43.90	24247654
140	Phosphorylation	EEEGERQSPPLEVSD CCCCCCCCCCEECCC	34.40	24275569
146	Phosphorylation	QSPPLEVSDGEADGL CCCCEECCCCCCCCC	30.44	23532336
173	Phosphorylation	SKKKIRLYQFLLDLL CHHHHHHHHHHHHHH	6.33	23025827
182	Phosphorylation	FLLDLLRSGDMKDSI HHHHHHHCCCCCCCE	38.83	23025827
253	Phosphorylation	KKLTYQFSGEVLGRG CEEEEEECCCCCCCC	20.65	27251275
254	Phosphorylation	KLTYQFSGEVLGRGG EEEEEECCCCCCCCC	30.25	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPI1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CREM_HUMAN	CREM	physical	7730336
ATF1_HUMAN	ATF1	physical	7730336
ETS1_HUMAN	ETS1	physical	9681824
ETS2_HUMAN	ETS2	physical	9681824
ETV1_HUMAN	ETV1	physical	9681824
FOS_HUMAN	FOS	physical	9681824
JUN_HUMAN	JUN	physical	9681824
GATA2_HUMAN	GATA2	physical	10411939
FUS_HUMAN	FUS	physical	9478924
NONO_HUMAN	NONO	physical	8626664
MITF_HUMAN	MITF	physical	9918847
MECP2_HUMAN	MECP2	physical	14647463
DNM3A_HUMAN	DNMT3A	physical	16331260
DNM3B_HUMAN	DNMT3B	physical	16331260
MECP2_HUMAN	MECP2	physical	16331260
BCL6_HUMAN	BCL6	physical	19564417
SIN3A_HUMAN	SIN3A	physical	11593411
SKI_HUMAN	SKI	physical	17621263
RARA_HUMAN	RARA	physical	20159610
PML_HUMAN	PML	physical	20159610
GATA2_HUMAN	GATA2	physical	18250304
EBNA2_EBVB9	BYRF1	physical	21504384
IRF1_HUMAN	IRF1	physical	9593745
IRF8_HUMAN	IRF8	physical	9593745
GFI1_HUMAN	GFI1	physical	17197705
VAV_HUMAN	VAV1	physical	19747912
GATA1_HUMAN	GATA1	physical	10364157
GATA2_HUMAN	GATA2	physical	10364157
GATA3_HUMAN	GATA3	physical	10364157
IRF1_HUMAN	IRF1	physical	11483597
IRF8_HUMAN	IRF8	physical	11483597
HXA10_HUMAN	HOXA10	physical	18692240
TMX1_HUMAN	TMX1	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPI1_HUMAN

Related Literatures of Post-Translational Modification