HXA10_HUMAN - dbPTM
HXA10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXA10_HUMAN
UniProt AC P31260
Protein Name Homeobox protein Hox-A10
Gene Name HOXA10
Organism Homo sapiens (Human).
Sequence Length 410
Subcellular Localization Nucleus.
Protein Description Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'..
Protein Sequence MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAHGGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationPNYPTTMSCSESPAA
CCCCCCCCCCCCCCC		16.64-
93PhosphorylationGKRNEAASPGSGGGG
CCCCCCCCCCCCCCC		36.5223401153
96PhosphorylationNEAASPGSGGGGGGL
CCCCCCCCCCCCCCC		37.3328450419
110PhosphorylationLGPGAHGYGPSPIDL
CCCCCCCCCCCCCCE		18.9223312004
113PhosphorylationGAHGYGPSPIDLWLD
CCCCCCCCCCCEEEC		30.0827251275
124PhosphorylationLWLDAPRSCRMEPPD
EEECCCCCCCCCCCC		12.6722210691
169PhosphorylationNIKEESSYCLYDSAD
HHCHHCCEEEEECCC		8.8529978859
172PhosphorylationEESSYCLYDSADKCP
HHCCEEEEECCCCCC		12.3229978859
174PhosphorylationSSYCLYDSADKCPKV
CCEEEEECCCCCCCC		25.4729978859
182PhosphorylationADKCPKVSATAAELA
CCCCCCCCCCHHHHC		26.4828555341
193MethylationAELAPFPRGPPPDGC
HHHCCCCCCCCCCCC		71.30115479531
226PhosphorylationAYGTAKGYGSGGGGA
HCCCCCCCCCCCCHH		13.8628555341
228PhosphorylationGTAKGYGSGGGGAQQ
CCCCCCCCCCCHHHC		26.2728555341
272PhosphorylationRKERALDSPPPPTLA
HHHHHHCCCCCCEEE		39.9130624053
277PhosphorylationLDSPPPPTLACGSGG
HCCCCCCEEECCCCC		32.5330624053
282PhosphorylationPPTLACGSGGGSQGD
CCEEECCCCCCCCCC		33.8630624053
286PhosphorylationACGSGGGSQGDEEAH
ECCCCCCCCCCHHHH		33.9730624053
295PhosphorylationGDEEAHASSSAAEEL
CCHHHHHCCHHHHHH		18.2430624053
296PhosphorylationDEEAHASSSAAEELS
CHHHHHCCHHHHHHC		25.4430624053
297PhosphorylationEEAHASSSAAEELSP
HHHHHCCHHHHHHCC		29.0630624053
303PhosphorylationSSAAEELSPAPSESS
CHHHHHHCCCCCCCC		23.4626471730
313PhosphorylationPSESSKASPEKDSLG
CCCCCCCCCCCCCCC		37.0123312004
318PhosphorylationKASPEKDSLGNSKGE
CCCCCCCCCCCCCCH		49.6028450419
322PhosphorylationEKDSLGNSKGENAAN
CCCCCCCCCCHHHHH		39.9928450419
323UbiquitinationKDSLGNSKGENAANW
CCCCCCCCCHHHHHH		74.3929967540
326PhosphorylationLGNSKGENAANWLTA
CCCCCCHHHHHHHHH		53.6912145285
335PhosphorylationANWLTAKSGRKKRCP
HHHHHHCCCCCCCCC		41.17-
338AcetylationLTAKSGRKKRCPYTK
HHHCCCCCCCCCCCC		48.3662188833
339UbiquitinationTAKSGRKKRCPYTKH
HHCCCCCCCCCCCCC		58.85-
339AcetylationTAKSGRKKRCPYTKH
HHCCCCCCCCCCCCC		58.8562188831
343PhosphorylationGRKKRCPYTKHQTLE
CCCCCCCCCCCCCHH		31.8512145285
343DephosphorylationGRKKRCPYTKHQTLE
CCCCCCCCCCCCCHH		31.8512145285
345UbiquitinationKKRCPYTKHQTLELE
CCCCCCCCCCCHHHH		28.07-
348PhosphorylationCPYTKHQTLELEKEF
CCCCCCCCHHHHHHH		23.17-
360PhosphorylationKEFLFNMYLTRERRL
HHHHHHHHHHHHHHH		13.1612145285
360DephosphorylationKEFLFNMYLTRERRL
HHHHHHHHHHHHHHH		13.1612145285
378MethylationRSVHLTDRQVKIWFQ
CEECCCHHHHHHHHH		37.65115479525
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HXA10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXA10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXA10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNPC1_HUMANSNAPC1physical
20211142
PBX1_HUMANPBX1physical
14512427
SPI1_HUMANSPI1physical
18692240
KAT2B_HUMANKAT2Bphysical
24037888
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXA10_HUMAN

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Related Literatures of Post-Translational Modification

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