GATA2_HUMAN - dbPTM
GATA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GATA2_HUMAN
UniProt AC P23769
Protein Name Endothelial transcription factor GATA-2
Gene Name GATA2
Organism Homo sapiens (Human).
Sequence Length 480
Subcellular Localization Nucleus.
Protein Description Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'..
Protein Sequence MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
71PhosphorylationAHARARVSYSPAHAR
HHHHCCEECCCCHHH		17.8420068231
72PhosphorylationHARARVSYSPAHARL
HHHCCEECCCCHHHC		18.8020068231
73PhosphorylationARARVSYSPAHARLT
HHCCEECCCCHHHCC		14.2223401153
86Asymmetric dimethylarginineLTGGQMCRPHLLHSP
CCCCCCCCCHHCCCC		19.14-
86MethylationLTGGQMCRPHLLHSP
CCCCCCCCCHHCCCC		19.1424129315
102AcetylationLPWLDGGKAALSAAA
CCCCCHHHHHHHHHH		35.7015001660
119PhosphorylationHHNPWTVSPFSKTPL
HCCCCCCCCCCCCCC		16.92-
176PhosphorylationHLFGFPPTPPKEVSP
CCCCCCCCCCCCCCC		53.08-
182PhosphorylationPTPPKEVSPDPSTTG
CCCCCCCCCCCCCCC		25.3625159151
186PhosphorylationKEVSPDPSTTGAASP
CCCCCCCCCCCCCCC		46.0821815630
187PhosphorylationEVSPDPSTTGAASPA
CCCCCCCCCCCCCCC		34.3420639409
188PhosphorylationVSPDPSTTGAASPAS
CCCCCCCCCCCCCCC		29.2130576142
192PhosphorylationPSTTGAASPASSSAG
CCCCCCCCCCCCCCC		22.0623401153
192O-linked_GlycosylationPSTTGAASPASSSAG
CCCCCCCCCCCCCCC		22.0630379171
195PhosphorylationTGAASPASSSAGGSA
CCCCCCCCCCCCCCC		28.3620639409
196PhosphorylationGAASPASSSAGGSAA
CCCCCCCCCCCCCCC		26.7220639409
197PhosphorylationAASPASSSAGGSAAR
CCCCCCCCCCCCCCC		28.5620639409
201PhosphorylationASSSAGGSAARGEDK
CCCCCCCCCCCCCCC		20.1730576142
213PhosphorylationEDKDGVKYQVSLTES
CCCCCCEEEEEECHH		16.25-
216PhosphorylationDGVKYQVSLTESMKM
CCCEEEEEECHHHCC		17.6623917254
218O-linked_GlycosylationVKYQVSLTESMKMES
CEEEEEECHHHCCCC		20.6430379171
218PhosphorylationVKYQVSLTESMKMES
CEEEEEECHHHCCCC		20.6423186163
220PhosphorylationYQVSLTESMKMESGS
EEEEECHHHCCCCCC		20.6125159151
222SumoylationVSLTESMKMESGSPL
EEECHHHCCCCCCCC		49.12-
276PhosphorylationGFLGGPASSFTPKQR
CCCCCCHHHCCHHHH		29.17-
281AcetylationPASSFTPKQRSKARS
CHHHCCHHHHHHCCC		56.1115001660
285AcetylationFTPKQRSKARSCSEG
CCHHHHHHCCCCCCC		50.4315001660
288PhosphorylationKQRSKARSCSEGREC
HHHHHCCCCCCCCCC		27.1922210691
290PhosphorylationRSKARSCSEGRECVN
HHHCCCCCCCCCCCC		44.3123401153
301PhosphorylationECVNCGATATPLWRR
CCCCCCCCCCCCCCC		19.1528102081
303PhosphorylationVNCGATATPLWRRDG
CCCCCCCCCCCCCCC		17.9828102081
314PhosphorylationRRDGTGHYLCNACGL
CCCCCCCHHHHHHHC		17.8117360941
322PhosphorylationLCNACGLYHKMNGQN
HHHHHHCHHHHCCCC		5.6717360941
334AcetylationGQNRPLIKPKRRLSA
CCCCCCCCHHHHHHH		52.7715001660
336AcetylationNRPLIKPKRRLSAAR
CCCCCCHHHHHHHHH		45.1915001660
340PhosphorylationIKPKRRLSAARRAGT
CCHHHHHHHHHHHCC		20.33-
376PhosphorylationVCNACGLYYKLHNVN
CHHHHHHHHHHCCCC		5.48-
389SumoylationVNRPLTMKKEGIQTR
CCCCCCHHHHHHHHH		42.30-
389SumoylationVNRPLTMKKEGIQTR
CCCCCCHHHHHHHHH		42.3028112733
389AcetylationVNRPLTMKKEGIQTR
CCCCCCHHHHHHHHH		42.3015001660
390AcetylationNRPLTMKKEGIQTRN
CCCCCHHHHHHHHHH		50.8015001660
395UbiquitinationMKKEGIQTRNRKMSN
HHHHHHHHHHHHHCC		28.1729967540
399AcetylationGIQTRNRKMSNKSKK
HHHHHHHHHCCHHHH		50.6715001660
401PhosphorylationQTRNRKMSNKSKKSK
HHHHHHHCCHHHHHH		44.1115837948
403AcetylationRNRKMSNKSKKSKKG
HHHHHCCHHHHHHHH		57.2415001660
405AcetylationRKMSNKSKKSKKGAE
HHHCCHHHHHHHHHH		63.7815001660
406AcetylationKMSNKSKKSKKGAEC
HHCCHHHHHHHHHHH		74.6915001660
408AcetylationSNKSKKSKKGAECFE
CCHHHHHHHHHHHHH		65.1915001660
409AcetylationNKSKKSKKGAECFEE
CHHHHHHHHHHHHHH		71.1415001660
409UbiquitinationNKSKKSKKGAECFEE
CHHHHHHHHHHHHHH		71.1429967540
473PhosphorylationSFGHPHPSSMVTAMG
CCCCCCHHHHCCCCC		28.2125332170
477PhosphorylationPHPSSMVTAMG----
CCHHHHCCCCC----		11.4125332170
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
176TPhosphorylationKinaseCDK1P06493
PSP
192SPhosphorylationKinaseP38AQ16539
PSP
401SPhosphorylationKinaseAKT1P31749
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GATA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GATA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PML_HUMANPMLphysical
10938104
HDAC3_HUMANHDAC3physical
11567998
HDAC5_HUMANHDAC5physical
11567998
ZBT16_HUMANZBTB16physical
11964310
ZBT32_HUMANZBTB32physical
11964310
RBTN2_HUMANLMO2physical
7568177
JUN_HUMANJUNphysical
11278891
FOG1_HUMANZFPM1physical
12483298
SMAD4_HUMANSMAD4physical
20211142
OBF1_HUMANPOU2AF1physical
20211142
MED1_HUMANMED1physical
16396960
PIT1_HUMANPOU1F1physical
16396960
SPI1_HUMANSPI1physical
18250304
SMAD4_HUMANSMAD4physical
21988832
GOGA2_HUMANGOLGA2physical
25416956
MDFI_HUMANMDFIphysical
25416956
PSA3_HUMANPSMA3physical
25416956
TRAF1_HUMANTRAF1physical
25416956
ATL4_HUMANADAMTSL4physical
25416956
PR20E_HUMANPRR20Aphysical
25416956
PR20C_HUMANPRR20Aphysical
25416956
PR20D_HUMANPRR20Aphysical
25416956
PR20B_HUMANPRR20Aphysical
25416956
PR20A_HUMANPRR20Aphysical
25416956
K1C40_HUMANKRT40physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
FBXW7_HUMANFBXW7physical
25670854
SKP1_HUMANSKP1physical
25670854
CUL1_HUMANCUL1physical
25670854
RBX1_HUMANRBX1physical
25670854
FOG1_HUMANZFPM1physical
28514442
TPPC9_HUMANTRAPPC9physical
28514442
TPC10_HUMANTRAPPC10physical
28514442
TPPC4_HUMANTRAPPC4physical
28514442
IMDH1_HUMANIMPDH1physical
28514442
CCNA2_HUMANCCNA2physical
17255359
CDK2_HUMANCDK2physical
17255359
CDK4_HUMANCDK4physical
17255359
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614172Immunodeficiency 21 (IMD21)
614038Lymphedema, primary, with myelodysplasia (LMPM)
614286Myelodysplastic syndrome (MDS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GATA2_HUMAN

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Related Literatures of Post-Translational Modification

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