ATL4_HUMAN - dbPTM
ATL4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATL4_HUMAN
UniProt AC Q6UY14
Protein Name ADAMTS-like protein 4
Gene Name ADAMTSL4
Organism Homo sapiens (Human).
Sequence Length 1074
Subcellular Localization Secreted, extracellular space, extracellular matrix . Colocalizes with FMN1 microfibrils in the eye ECM.
Protein Description Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis..
Protein Sequence MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3N-linked_Glycosylation-----MENWTGRPWL
-----CCCCCCHHHH		54.17UniProtKB CARBOHYD
106O-linked_GlycosylationGQGPRPQTSPETLPL
CCCCCCCCCCCCCCC		49.2755830779
107O-linked_GlycosylationQGPRPQTSPETLPLY
CCCCCCCCCCCCCCC		18.5855830785
159PhosphorylationIKPGMFGYGRVPFAL
CCCCCCCCCCCCEEC		7.1819658100
177PhosphorylationRNRRHPRSPPRSELS
CCCCCCCCCCHHHHE		43.6417081983
181PhosphorylationHPRSPPRSELSLISS
CCCCCCHHHHEEHHC		48.9729116813
181O-linked_GlycosylationHPRSPPRSELSLISS
CCCCCCHHHHEEHHC		48.9755824219
187PhosphorylationRSELSLISSRGEEAI
HHHHEEHHCCCCCCC		21.1929116813
188PhosphorylationSELSLISSRGEEAIP
HHHEEHHCCCCCCCC		36.9929116813
188O-linked_GlycosylationSELSLISSRGEEAIP
HHHEEHHCCCCCCCC		36.99OGP
196PhosphorylationRGEEAIPSPTPRAEP
CCCCCCCCCCCCCCC		34.9825002506
198PhosphorylationEEAIPSPTPRAEPFS
CCCCCCCCCCCCCCC		29.7324719451
223O-linked_GlycosylationPTELSVHTPSPQAEP
CCEEEECCCCCCCCC		24.25OGP
232O-linked_GlycosylationSPQAEPLSPETAQTE
CCCCCCCCCCHHCCC		31.26OGP
235O-linked_GlycosylationAEPLSPETAQTEVAP
CCCCCCCHHCCCCCC		27.70OGP
260O-linked_GlycosylationPRAQASGTEPPSPTH
CCHHCCCCCCCCCCC		42.7155826455
260PhosphorylationPRAQASGTEPPSPTH
CCHHCCCCCCCCCCC		42.71-
264PhosphorylationASGTEPPSPTHSLGE
CCCCCCCCCCCCCCC		53.8223917254
266O-linked_GlycosylationGTEPPSPTHSLGEGG
CCCCCCCCCCCCCCC		28.56OGP
268O-linked_GlycosylationEPPSPTHSLGEGGFF
CCCCCCCCCCCCCCC		40.31OGP
278PhosphorylationEGGFFRASPQPRRPS
CCCCCCCCCCCCCCC		21.5827174698
285PhosphorylationSPQPRRPSSQGWASP
CCCCCCCCCCCCCCC		33.2227174698
286PhosphorylationPQPRRPSSQGWASPQ
CCCCCCCCCCCCCCC		35.0827174698
291PhosphorylationPSSQGWASPQVAGRR
CCCCCCCCCCCCCCC		14.8927174698
291O-linked_GlycosylationPSSQGWASPQVAGRR
CCCCCCCCCCCCCCC		14.89OGP
304O-linked_GlycosylationRRPDPFPSVPRGRGQ
CCCCCCCCCCCCCCC		45.1755833435
319O-linked_GlycosylationQGQGPWGTGGTPHGP
CCCCCCCCCCCCCCC		28.6855833063
322O-linked_GlycosylationGPWGTGGTPHGPRLE
CCCCCCCCCCCCCCC		17.29OGP
359PhosphorylationWSLFAPSSPIPRCSG
HHHHCCCCCCCCCCC		26.2824719451
482PhosphorylationGVCGGDDSTCRLVSG
CCCCCCCCCEEEECC		33.86-
490N-linked_GlycosylationTCRLVSGNLTDRGGP
CEEEECCCCCCCCCC		32.0616335952
492PhosphorylationRLVSGNLTDRGGPLG
EEECCCCCCCCCCCC		27.87-
553PhosphorylationGSYRAGGTVFRYNRP
CCCCCCCEEEEECCC		18.6323403867
569PhosphorylationREEGKGESLSAEGPT
CCCCCCCCCCCCCCC		35.97-
571PhosphorylationEGKGESLSAEGPTTQ
CCCCCCCCCCCCCCC		33.29-
576PhosphorylationSLSAEGPTTQPVDVY
CCCCCCCCCCCEEEE		49.25-
610O-linked_GlycosylationPPILENPTPEPPVPQ
CCCCCCCCCCCCCCC		52.44OGP
663PhosphorylationHPRTPLGSPAAYWKR
CCCCCCCCCHHHHHH		21.0322798277
667PhosphorylationPLGSPAAYWKRVGHS
CCCCCHHHHHHHCCC		17.3622798277
696PhosphorylationFLCISRESGEELDER
EEEEECCCCCCCCCC		50.8524719451
759PhosphorylationQEFGGGGSSVPPERC
HHHCCCCCCCCHHHC		31.28-
760PhosphorylationEFGGGGSSVPPERCG
HHCCCCCCCCHHHCC		41.75-
773N-linked_GlycosylationCGHLPRPNITQSCQL
CCCCCCCCCCCCEEE		51.74UniProtKB CARBOHYD
796PhosphorylationGSPWSQCSVRCGRGQ
CCCHHHCCCCCCCCC		12.64-
855PhosphorylationSDWSSKCSAECGTGI
CCCCCHHHCCCCCCC		30.73-
915PhosphorylationCERTWRWYTGPWGEC
CCCCEEEECCCCCCC		8.0130576142
916PhosphorylationERTWRWYTGPWGECS
CCCEEEECCCCCCCC		29.7930576142
924PhosphorylationGPWGECSSECGSGTQ
CCCCCCCCCCCCCCC		48.8730576142
928PhosphorylationECSSECGSGTQRRDI
CCCCCCCCCCCCCEE		50.7730576142
930PhosphorylationSSECGSGTQRRDIIC
CCCCCCCCCCCEEEE		22.1730576142
1005PhosphorylationLSTNQTLSTRCPPQL
EECCCCCCCCCCCCC		19.7324719451
1006PhosphorylationSTNQTLSTRCPPQLR
ECCCCCCCCCCCCCC		39.1328258704
1015PhosphorylationCPPQLRPSRKRPCNS
CCCCCCCCCCCCCCC		43.9624719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATL4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATL4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATL4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLK2_HUMANDLK2physical
16189514
NET4_HUMANNTN4physical
16189514
CTSR1_HUMANCATSPER1physical
16189514
KR412_HUMANKRTAP4-12physical
16189514
FBLN1_HUMANFBLN1physical
21988832
S6A20_HUMANSLC6A20physical
25416956
PCLI1_HUMANPID1physical
25416956
TPSNR_HUMANTAPBPLphysical
25416956
RYDEN_HUMANC19orf66physical
25416956
PPL13_HUMANLGALS14physical
25416956
NMUR2_HUMANNMUR2physical
25416956
RHOJ_HUMANRHOJphysical
25416956
CXL16_HUMANCXCL16physical
25416956
ASPC1_HUMANASPSCR1physical
25416956
F124B_HUMANFAM124Bphysical
25416956
APOL6_HUMANAPOL6physical
25416956
TSSK3_HUMANTSSK3physical
25416956
KR412_HUMANKRTAP4-12physical
25416956
KRA92_HUMANKRTAP9-2physical
25416956
ZN587_HUMANZNF587physical
25416956
RAB2B_HUMANRAB2Bphysical
25416956
KRA94_HUMANKRTAP9-4physical
25416956
KRA42_HUMANKRTAP4-2physical
25416956
LONF1_HUMANLONRF1physical
25416956
NOE3_HUMANOLFM3physical
25416956
T150A_HUMANTMEM150Aphysical
25416956
SPAT8_HUMANSPATA8physical
25416956
ZN417_HUMANZNF417physical
25416956
CF206_HUMANC6orf165physical
25416956
LCE4A_HUMANLCE4Aphysical
25416956
NATD1_HUMANNATD1physical
25416956
MORN3_HUMANMORN3physical
25416956
TRI42_HUMANTRIM42physical
25416956
ATL5_HUMANADAMTSL5physical
25416956
CL18A_HUMANCLEC18Aphysical
25416956
LCE1B_HUMANLCE1Bphysical
25416956
LCE2D_HUMANLCE2Dphysical
25416956
LCE3C_HUMANLCE3Cphysical
25416956
LCE3E_HUMANLCE3Ephysical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR101_HUMANKRTAP10-1physical
25416956
KR10B_HUMANKRTAP10-11physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
KRA56_HUMANKRTAP5-6physical
25416956
KR411_HUMANKRTAP4-11physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
225100Ectopia lentis 2, isolated, autosomal recessive (ECTOL2)
225200Ectopia lentis et pupillae (ECTOLP)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATL4_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-490, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory