| UniProt ID | CL18A_HUMAN | |
|---|---|---|
| UniProt AC | A5D8T8 | |
| Protein Name | C-type lectin domain family 18 member A | |
| Gene Name | CLEC18A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 446 | |
| Subcellular Localization | Secreted . Endoplasmic reticulum . Golgi apparatus . Endosome . | |
| Protein Description | Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans. [PubMed: 26170455] | |
| Protein Sequence | MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 98 | Phosphorylation | TPTPSLASGLWRTLQ CCCHHHHHCHHHHCC | 39.45 | - | |
| 144 | N-linked_Glycosylation | AAGECARNATCTHYT CCCHHHHCCCCCCHH | 22.52 | UniProtKB CARBOHYD | |
| 183 | Phosphorylation | EAFVCAYSPRGNWEV HHHHCCCCCCCCEEE | 6.92 | 24719451 | |
| 194 | Phosphorylation | NWEVNGKTIVPYKKG CEEECCEEEECCCCC | 28.71 | - | |
| 355 | Phosphorylation | FYLGRLETTNEVIDS HHHCCCCCCCCCCCC | 39.24 | 28857561 | |
| 356 | O-linked_Glycosylation | YLGRLETTNEVIDSD HHCCCCCCCCCCCCC | 21.73 | OGP | |
| 356 | Phosphorylation | YLGRLETTNEVIDSD HHCCCCCCCCCCCCC | 21.73 | 28857561 | |
| 362 | Phosphorylation | TTNEVIDSDFETRNF CCCCCCCCCCCCCCE | 32.83 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CL18A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CL18A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CL18A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| DNJC3_HUMAN | DNAJC3 | physical | 26186194 | |
| GRP78_HUMAN | HSPA5 | physical | 26186194 | |
| SCRIB_HUMAN | SCRIB | physical | 26186194 | |
| 2ABD_HUMAN | PPP2R2D | physical | 26186194 | |
| MANBA_HUMAN | MANBA | physical | 26186194 | |
| DNJB9_HUMAN | DNAJB9 | physical | 26186194 | |
| PDP1_HUMAN | PDP1 | physical | 26186194 | |
| SCRIB_HUMAN | SCRIB | physical | 28514442 | |
| GRP78_HUMAN | HSPA5 | physical | 28514442 | |
| DNJB9_HUMAN | DNAJB9 | physical | 28514442 | |
| 2ABD_HUMAN | PPP2R2D | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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