DNJB9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJB9_HUMAN
• UniProt AC: Q9UBS3
• Protein Name: DnaJ homolog subfamily B member 9 {ECO:0000305}
• Gene Name: DNAJB9
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. [PubMed: 18400946 In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity]
• Protein Sequence: MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANRRKEYDTLGHSAFTSGKGQRGSGSSFEQSFNFNFDDLFKDFGFFGQNQNTGSKKRFENHFQTRQDGGSSRQRHHFQEFSFGGGLFDDMFEDMEKMFSFSGFDSTNQHTVQTENRFHGSSKHCRTVTQRRGNMVTTYTDCSGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATPQSIFIF -----CCCHHHHHHH	22.14	24043423
6	Phosphorylation	--MATPQSIFIFAIC --CCCHHHHHHHHHH	22.22	24043423
18	Phosphorylation	AICILMITELILASK HHHHHHHHHHHHHCC	15.69	24043423
24	Phosphorylation	ITELILASKSYYDIL HHHHHHHCCCHHHHH	20.77	24043423
35	"N6,N6-dimethyllysine"	YDILGVPKSASERQI HHHHCCCCCCCHHHH	57.14	-
35	Methylation	YDILGVPKSASERQI HHHHCCCCCCCHHHH	57.14	-
66	Ubiquitination	KSPDAEAKFREIAEA CCCCHHHHHHHHHHH	36.14	-
84	Ubiquitination	LSDANRRKEYDTLGH HHHHHHHHHCCCCCC	58.34	-
98	Ubiquitination	HSAFTSGKGQRGSGS CCCCCCCCCCCCCCC	52.19	21906983
103	Phosphorylation	SGKGQRGSGSSFEQS CCCCCCCCCCCCHHH	37.38	20166139
105	Phosphorylation	KGQRGSGSSFEQSFN CCCCCCCCCCHHHCC	33.29	25072903
106	Phosphorylation	GQRGSGSSFEQSFNF CCCCCCCCCHHHCCC	36.01	26657352
110	Phosphorylation	SGSSFEQSFNFNFDD CCCCCHHHCCCCHHH	18.24	29691806
133	Phosphorylation	GQNQNTGSKKRFENH CCCCCCCCCHHHHHC	32.72	23917254
134	Ubiquitination	QNQNTGSKKRFENHF CCCCCCCCHHHHHCC	49.68	21906983
136	Methylation	QNTGSKKRFENHFQT CCCCCCHHHHHCCEE	48.09	-
143	O-linked_Glycosylation	RFENHFQTRQDGGSS HHHHCCEECCCCCCC	29.38	OGP
178	Phosphorylation	EDMEKMFSFSGFDST HHHHHHHHCCCCCCC	18.27	29691806
180	Phosphorylation	MEKMFSFSGFDSTNQ HHHHHHCCCCCCCCC	37.03	29691806
184	Phosphorylation	FSFSGFDSTNQHTVQ HHCCCCCCCCCCEEE	27.31	20166139
185	Phosphorylation	SFSGFDSTNQHTVQT HCCCCCCCCCCEEEC	40.52	24275569
189	Phosphorylation	FDSTNQHTVQTENRF CCCCCCCEEECCCCC	12.44	29691806
192	Phosphorylation	TNQHTVQTENRFHGS CCCCEEECCCCCCCC	30.78	29691806
215	Phosphorylation	QRRGNMVTTYTDCSG ECCCCEEEEEECCCC	11.87	24043423
216	Phosphorylation	RRGNMVTTYTDCSGQ CCCCEEEEEECCCCC	17.02	24043423
217	Phosphorylation	RGNMVTTYTDCSGQ- CCCEEEEEECCCCC-	7.39	24043423
218	Phosphorylation	GNMVTTYTDCSGQ-- CCEEEEEECCCCC--	28.56	24043423
221	Phosphorylation	VTTYTDCSGQ----- EEEEECCCCC-----	42.93	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJB9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJB9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJB9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIFK_HUMAN	RFK	physical	16169070
MOT3_HUMAN	SLC16A8	physical	16169070
DYL1_HUMAN	DYNLL1	physical	16169070
FSCN1_HUMAN	FSCN1	physical	16169070
MYL6_HUMAN	MYL6	physical	16169070
TCEA2_HUMAN	TCEA2	physical	16169070
PLK1_HUMAN	PLK1	physical	16169070
ECM29_HUMAN	KIAA0368	physical	20682791
GRP78_HUMAN	HSPA5	physical	18400946
FA71C_HUMAN	FAM71C	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.