MOT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOT3_HUMAN
• UniProt AC: O95907
• Protein Name: Monocarboxylate transporter 3
• Gene Name: SLC16A8
• Organism: Homo sapiens (Human).
• Sequence Length: 504
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)..
• Protein Sequence: MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	FVVTGFAYGFPKAVS EEEHHHHHCCHHHHH	19.62	-
40	Phosphorylation	YGFPKAVSVFFRALM HCCHHHHHHHHHHHH	20.33	-
61	Phosphorylation	YSDTAWVSSIMLAML CCCHHHHHHHHHHHH	11.93	25332170
71	Phosphorylation	MLAMLYGTGPVSSIL HHHHHHCCCCHHHHH	25.42	25332170
153	Phosphorylation	NGLAAAGSPVFLSAL CCHHHCCCCHHHHHC	17.11	-
343	Phosphorylation	SSARARSYGALVAFC HHHHHHHHHHHHHHH	10.81	22210691
356	Phosphorylation	FCVAFGLSYGMVGAL HHHHHCCCCCHHHHH	21.73	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOT3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MOT3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.