MANBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MANBA_HUMAN
• UniProt AC: O00462
• Protein Name: Beta-mannosidase
• Gene Name: MANBA
• Organism: Homo sapiens (Human).
• Sequence Length: 879
• Subcellular Localization: Lysosome.
• Protein Description: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides..
• Protein Sequence: MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	TAAELSYSLRGNWSI HHHHHHHHHCCCEEE	14.28	24719451
28	N-linked_Glycosylation	LSYSLRGNWSICNGN HHHHHCCCEEEECCC	23.92	UniProtKB CARBOHYD
35	N-linked_Glycosylation	NWSICNGNGSLELPG CEEEECCCCCEECCC	23.92	UniProtKB CARBOHYD
70	Phosphorylation	YRFNDLNYRWVSLDN EEECCCCEEEEECCC	17.10	29514088
74	Phosphorylation	DLNYRWVSLDNWTYS CCCEEEEECCCCEEC	24.05	29514088
77	N-linked_Glycosylation	YRWVSLDNWTYSKEF EEEEECCCCEECEEE	37.98	UniProtKB CARBOHYD
79	Phosphorylation	WVSLDNWTYSKEFKI EEECCCCEECEEECC	24.95	29514088
80	Phosphorylation	VSLDNWTYSKEFKIP EECCCCEECEEECCC	14.90	29514088
81	Phosphorylation	SLDNWTYSKEFKIPF ECCCCEECEEECCCE	20.52	29514088
85	Ubiquitination	WTYSKEFKIPFEISK CEECEEECCCEEECC	51.03	29967540
92	Ubiquitination	KIPFEISKWQKVNLI CCCEEECCCCEEEEE	60.34	29967540
161	Phosphorylation	QSKAHTRYQVPPDCP HCCCCCCCCCCCCCC	18.28	-
280	N-linked_Glycosylation	RIVELFVNISKNITV EEEEEEEEECCCEEE	26.02	UniProtKB CARBOHYD
284	N-linked_Glycosylation	LFVNISKNITVETWW EEEEECCCEEEEEEE	28.51	UniProtKB CARBOHYD
297	N-linked_Glycosylation	WWPHGHGNQTGYNMT EECCCCCCCCCEEEE	30.48	UniProtKB CARBOHYD
302	N-linked_Glycosylation	HGNQTGYNMTVLFEL CCCCCCEEEEEEEEE	22.46	UniProtKB CARBOHYD
325	Phosphorylation	SAKVYFRTVELIEEP EEEEEEEEEEEEECC	14.40	-
477	Phosphorylation	SFTDRPIYIKDYVTL ECCCCCEEECCEEEE	12.47	22817900
481	Phosphorylation	RPIYIKDYVTLYVKN CCEEECCEEEEEECC	7.13	22817900
485	Phosphorylation	IKDYVTLYVKNIREL ECCEEEEEECCHHHH	10.46	22817900
544	Acetylation	ISDCWNWKVFPKARF ECCCCCCCCCCCHHH	30.68	19413330
570	Phosphorylation	FSTLEKVSSTEDWSF CHHEEECCCCCCCCC	42.48	27251275
571	Phosphorylation	STLEKVSSTEDWSFN HHEEECCCCCCCCCC	38.51	27251275
572	Phosphorylation	TLEKVSSTEDWSFNS HEEECCCCCCCCCCC	30.38	27251275
597	Phosphorylation	GGNKQMLYQAGLHFK CCCEEEEEEEEEEEE	7.32	24719451
609	Phosphorylation	HFKLPQSTDPLRTFK EEECCCCCCCCCCCC	36.07	24719451
763	N-linked_Glycosylation	ELLRRCGNCTRESCV HHHHHHCCCCHHHEE	27.84	UniProtKB CARBOHYD
847	Phosphorylation	SDNGFLMTEKTRTIL CCCCEEEECCEEEEE	36.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MANBA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MANBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MANBA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MANBA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=Defects in MANBA are the cause of a mild disorder that affects peripheral and central nervous system myelin.
• 248510:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.