KR411_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KR411_HUMAN
• UniProt AC: Q9BYQ6
• Protein Name: Keratin-associated protein 4-11
• Gene Name: KRTAP4-11
• Organism: Homo sapiens (Human).
• Sequence Length: 195
• Protein Description: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
• Protein Sequence: MVNSCCGSVCSHQGCGRDLCQETCCRPSCCETTCCRTTYCRPSCCVSSCCRPQCCQSVCCQPTCCRPRCCISSCCRPSCCVSSCCKPQCCQSMCCQPTCCRPRCCISSCCRPSCCVSSCCRPQCCQSVCCQPTCCHPSCSISSCCRPSCCESSCCRPCCCLRPVCGRVSCHTTCYRPTCVISSCPRPLCCASSCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	CETTCCRTTYCRPSC CCCCCCCCCCCCCCE	14.27	22210691
108	Phosphorylation	RPRCCISSCCRPSCC CCCEEECCCCCCHHH	9.42	30576142
113	Phosphorylation	ISSCCRPSCCVSSCC ECCCCCCHHHHHHCC	10.78	30576142
117	Phosphorylation	CRPSCCVSSCCRPQC CCCHHHHHHCCCCCH	12.07	30576142
118	Phosphorylation	RPSCCVSSCCRPQCC CCHHHHHHCCCCCHH	9.24	30576142
169	Phosphorylation	RPVCGRVSCHTTCYR CCCCCEEEECCCCCC	9.98	30576142
178	Phosphorylation	HTTCYRPTCVISSCP CCCCCCCEEEEECCC	15.48	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KR411_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KR411_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KR411_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KR411_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.