T150A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T150A_HUMAN
• UniProt AC: Q86TG1
• Protein Name: Transmembrane protein 150A
• Gene Name: TMEM150A
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures (PubMed:25608530).
• Protein Description: Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. [PubMed: 25608530 Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis]
• Protein Sequence: MTAWILLPVSLSAFSITGIWTVYAMAVMNHHVCPVENWSYNESCPPDPAEQGGPKTCCTLDDVPLISKCGSYPPESCLFSLIGNMGAFMVALICLLRYGQLLEQSRHSWVNTTALITGCTNAAGLLVVGNFQVDHARSLHYVGAGVAFPAGLLFVCLHCALSYQGATAPLDLAVAYLRSVLAVIAFITLVLSGVFFVHESSQLQHGAALCEWVCVIDILIFYGTFSYEFGAVSSDTLVAALQPTPGRACKSSGSSSTSTHLNCAPESIAMI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	N-linked_Glycosylation	HHVCPVENWSYNESC CCCCCCCCCCCCCCC	32.98	UniProtKB CARBOHYD
41	N-linked_Glycosylation	PVENWSYNESCPPDP CCCCCCCCCCCCCCH	29.23	UniProtKB CARBOHYD
98	Phosphorylation	ALICLLRYGQLLEQS HHHHHHHHHHHHHHH	14.81	-
105	Phosphorylation	YGQLLEQSRHSWVNT HHHHHHHHCCCCCCH	23.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T150A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T150A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T150A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR108_HUMAN	KRTAP10-8	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
TYY1_HUMAN	YY1	physical	26186194
CCNT1_HUMAN	CCNT1	physical	26186194
HELLS_HUMAN	HELLS	physical	26186194
ACOX3_HUMAN	ACOX3	physical	26186194
MS18A_HUMAN	MIS18A	physical	26186194
ACOX3_HUMAN	ACOX3	physical	28514442
CCNT1_HUMAN	CCNT1	physical	28514442
TYY1_HUMAN	YY1	physical	28514442
MS18A_HUMAN	MIS18A	physical	28514442
GOSR1_HUMAN	GOSR1	physical	28514442
HELLS_HUMAN	HELLS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.