| UniProt ID | ACOX3_HUMAN | |
|---|---|---|
| UniProt AC | O15254 | |
| Protein Name | Peroxisomal acyl-coenzyme A oxidase 3 | |
| Gene Name | ACOX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 700 | |
| Subcellular Localization | Peroxisome . | |
| Protein Description | Oxidizes the CoA-esters of 2-methyl-branched fatty acids.. | |
| Protein Sequence | MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASTVEGGD ------CCCEECCCC | 17.57 | 22223895 | |
| 3 | Phosphorylation | -----MASTVEGGDT -----CCCEECCCCC | 31.52 | 30108239 | |
| 4 | Phosphorylation | ----MASTVEGGDTA ----CCCEECCCCCC | 17.03 | 30108239 | |
| 49 | Ubiquitination | EGMLRFKKTIFSALE CCHHHHHHHHHHHHH | 44.11 | 22505724 | |
| 64 | Phosphorylation | NDPLFARSPGADLSL CCCCCCCCCCCCCCH | 25.02 | 102778277 | |
| 73 (in isoform 2) | Ubiquitination | - | 55.70 | 21906983 | |
| 73 (in isoform 1) | Ubiquitination | - | 55.70 | 21906983 | |
| 73 | Ubiquitination | GADLSLEKYRELNFL CCCCCHHHHHHCCCE | 55.70 | 21906983 | |
| 74 | Phosphorylation | ADLSLEKYRELNFLR CCCCHHHHHHCCCEE | 10.43 | 69301809 | |
| 187 | Phosphorylation | TEEFIIHSPDFEAAK CCEEEEECCCHHHHC | 18.76 | 110736247 | |
| 212 | Acetylation | THAVVFAKLCVPGDQ HHHHHEEEECCCHHH | 30.84 | 25953088 | |
| 235 | Phosphorylation | VQIRDPKTLLPMPGV EEECCCCCCCCCCCE | 38.63 | 46157937 | |
| 250 | Ubiquitination | MVGDIGKKLGQNGLD EHHHHHHHHCCCCCC | 53.27 | - | |
| 265 | Ubiquitination | NGFAMFHKVRVPRQS CCCCEEECCCCCCHH | 22.07 | - | |
| 281 | Phosphorylation | LNRMGDVTPEGTYVS HHHCCCCCCCCCEEC | 21.99 | 25850435 | |
| 285 | Phosphorylation | GDVTPEGTYVSPFKD CCCCCCCCEECCCHH | 21.06 | 29449344 | |
| 286 | Phosphorylation | DVTPEGTYVSPFKDV CCCCCCCEECCCHHH | 15.13 | 142363 | |
| 288 | Phosphorylation | TPEGTYVSPFKDVRQ CCCCCEECCCHHHHH | 17.76 | 16292399 | |
| 291 | Ubiquitination | GTYVSPFKDVRQRFG CCEECCCHHHHHHHC | 59.71 | 21906983 | |
| 291 (in isoform 1) | Ubiquitination | - | 59.71 | 21906983 | |
| 291 | Acetylation | GTYVSPFKDVRQRFG CCEECCCHHHHHHHC | 59.71 | 25953088 | |
| 291 (in isoform 2) | Ubiquitination | - | 59.71 | 21906983 | |
| 407 | Phosphorylation | IHALASASKPLASWT HHHHHHCCCCCCCCC | 32.10 | 24719451 | |
| 408 | Ubiquitination | HALASASKPLASWTT HHHHHCCCCCCCCCC | 43.71 | - | |
| 415 | Phosphorylation | KPLASWTTQQGIQEC CCCCCCCCHHHHHHH | 16.79 | 28387310 | |
| 484 | Ubiquitination | ACFRSPLKSVDFLDA CCCCCCCCCCCHHHC | 52.39 | 22817900 | |
| 484 (in isoform 1) | Ubiquitination | - | 52.39 | 21906983 | |
| 484 (in isoform 2) | Ubiquitination | - | 52.39 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACOX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACOX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACOX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YTHD1_HUMAN | YTHDF1 | physical | 28514442 | |
| HERC3_HUMAN | HERC3 | physical | 28514442 | |
| CENPH_HUMAN | CENPH | physical | 28514442 | |
| HAUS7_HUMAN | HAUS7 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-281, AND MASSSPECTROMETRY. | |
